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| 1 | Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus显示文摘Since December 2019,an epidemic caused by novel coronavirus (2019-nCoV) infection has occurred unexpectedly in China.As of 8 pm,31 January 2020,more than 20 pediatric cases have been reported in China.Of these cases,ten patients were identified in Zhejiang Province,with an age of onset ranging from 112 days to 17 years.Following the latest National recommendations for diagnosis and treatment of pneumonia caused by 2019-nCo V (the 4th edition) and current status of clinical practice in Zhejiang Province,recommendations for the diagnosis and treatment of respiratory infection caused by 2019-nCoV for children were drafted by the National Clinical Research Center for Child Health,the National Children's Regional Medical Center,Children's Hospital,Zhejiang University School of Medicine to further standardize the protocol for diagnosis and treatment of respiratory infection in children caused by 2019-nCoV. | Zhi-Min Chen Jun-Fen Fu Qiang Shu Ying-Hu Chen Chun-Zhen Hua Fu-Bang Li Ru Lin Lan-Fang Tang Tian-Lin Wang Wei Wang Ying-Shuo Wang Wei-Ze Xu Zi-Hao Yang Sheng Ye Tian-Ming Yuan Chen-Mei Zhang Yuan-Yuan Zhang | 2020 | World Journal of Pediatrics2020，16，3： | 45 |
| 2 | SlMYB75,an MYB-type transcription factor,promotes anthocyanin accumulation and enhances volatile aroma production in tomato fruits显示文摘Genetic manipulation of genes to upregulate specific branches of metabolic pathways is a method that is commonly used to improve fruit quality.However,the use of a single gene to impact several metabolic pathways is difficult.Here,we show that overexpression of the single gene SlMYB75(SlMYB75-OE)is effective at improving multiple fruit quality traits.In these engineered fruits,the anthocyanin content reached 1.86mg g−1 fresh weight at the red-ripe stage,and these SlMYB75-OE tomatoes displayed a series of physiological changes,including delayed ripening and increased ethylene production.In addition to anthocyanin,the total contents of phenolics,flavonoids and soluble solids in SlMYB75-OE fruits were enhanced by 2.6,4,and 1.2 times,respectively,compared to those of wild-type(WT)fruits.Interestingly,a number of aroma volatiles,such as aldehyde,phenylpropanoid-derived and terpene volatiles,were significantly increased in SlMYB75-OE fruits,with some terpene volatiles showing more than 10 times higher levels than those in WT fruits.Consistent with the metabolic assessment,transcriptomic profiling indicated that the genes involved in the ethylene signaling,phenylpropanoid and isoprenoid pathways were greatly upregulated in SlMYB75-OE fruits.Yeast one-hybrid and transactivation assays revealed that SlMYB75 is able to directly bind to the MYBPLANT and MYBPZM cis-regulatory elements and to activate the promoters of the LOXC,AADC2 and TPS genes.The identification of SlMYB75 as a key regulator of fruit quality attributes through the transcriptional regulation of downstream genes involved in several metabolic pathways opens new avenues towards engineering fruits with a higher sensory and nutritional quality. | Wei Jian Haohao Cao Shu Yuan Yudong Liu Juanfang Lu Wang Lu Ning Li Jianhui Wang Jian Zou Ning Tang Chan Xu Yulin Cheng Yanqiang Gao Wanpeng Xi Mondher Bouzayen Zhengguo Li | 2019 | Horticulture Research2019，6，1： | 39 |
| 3 | Effects of Traditional Chinese Medicine Shensong Yangxin Capsules on Heart Rhythm and Function in Congestive Heart Failure Patients with Frequent Ventricular Premature Complexes:A Randomized, Double-blind, Multicenter Clinical Trial显示文摘 | Xi Wang Dan HU Song Dang He Huang Cong-Xin Huang Ming-Jie Yuan Yan-Hong Tang Qing-Shan Zheng Fang Yin Shu Zhang Bo-Li Zhang Run-Lin Gao | 2017 | Chinese Medical Journal2017，，14： | 33 |
| 4 | FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers显示文摘forkhead 盒子抄写因素 A2 (FOXA2 ) 是在动物开发和身体动态平衡的一个重要管理者。然而, FOXA2 是否涉及转变生长因素尾 1 (TGF-尾 1 ) ,调停了 epithelial-to-mesenchymal 转变(EMT ) 和肿瘤转移仍然保持未知。现在的学习证明在人的肺癌症房间线,许多 FOXA2 断然与上皮的显型相关并且否定地与房间的间充质的显型相关,并且 TGF-尾 1 治疗减少了 FOXA2 蛋白质水平。一致地, FOXA2 击倒肺癌症房间的支持的 EMT 和侵略,而 FOXA2 的 overexpression 减少了侵略并且压制了 TGF- ,尾 1 导致了 EMT。另外, FOXA2 击倒禁止的 FOXA2 的导致的蛞蝓表示,和宫外的表示猛击抄写。而且,我们鉴别 FOXA2 能绑通过一个保存有约束力的地点猛击倡导者,并且 FOXA2 的 DNA 有约束力的区域和 transactivation 区域 II 为蛞蝓倡导者的压抑被要求。这些数据证明 FOXA2 由 EMT 的抑制作为肿瘤转移的 suppressor 工作。 | Yunneng Tang Guangwen Shu Xinwang Yuan Naihe Jing Jianguo Song | 2011 | Cell Research2011，21，2： | 27 |
| 5 | Furazolidone-based triple and quadruple eradication therapy for Helicobacter pylori infection显示文摘AIM: To evaluate the efficacy of furazolidone-based triple and quadruple therapy in eradicating Helicobacter pylori(H. pylori) in a multi-center randomized controlled trial.METHODS: A total of 720 H. pylori positive patients with duodenal ulcer disease were enrolled at 10 different hospitals in Jiangxi province in China. The patients were randomly assigned to four treatment groups as follows: patients in Groups 1 and 3 received rabeprazole(10 mg), amoxicillin(1000 mg) and furazolidone(100 mg) twice daily for 7 and 10 d, respectively; patients in Groups 2 and 4 received rabeprazole(10 mg), bismuth(220 mg), amoxicillin(1000 mg) and furazolidone(100 mg) twice daily for 7 and 10 d, respectively. The primary outcome measure was H. pylori eradication rate 4 wk after treatment by intention-to-treat and per protocol analysis, while the secondary outcome measures were symptom and sign changes at the end of treatment and 4 wk after the end of treatment, as well as the proportion of patients who developed adverse events.RESULTS: The demographic data of the four groups were not significantly different. Overall, 666 patients completed the scheme and were re-assessed with the 13C-urea breath test. The intention-to-treat analysis of the H. pylori eradication rates in Groups 1, 2, 3 and 4 were 74.44%, 82.78%, 78.89% and 86.11%, respectively. The H. pylori eradication rate in Group 4 was significantly higher than that in Group 1. According tothe per protocol analysis, the H. pylori eradication rates in Groups 1, 2, 3 and 4 were 81.21%, 89.22%, 85.54% and 92.26%, respectively. The H. pylori eradication rate in Group 4 was significantly higher than that in Group 1. The number of adverse events was 15(8.3%), 16(8.9%), 15(8.3%) and 17(9.4%) in Groups 1, 2, 3 and 4, respectively, including dizziness, vomiting, diarrhea, nausea, skin rash, itchy skin, and malaise. The symptoms were relieved without special treatment in all of the patients.CONCLUSION: Both 7- and 10-d quadruple furazolidone-based therapies achieve satisfactory H. pylori eradication rates. | Yong Xie Yin Zhu Hong Zhou Zhi-Fa Lu Zhen Yang Xu Shu Xiao-Bai Guo Hui-Zhen Fan Jian-Hua Tang Xue-Ping Zeng Jian-Bo Wen Xiao-Qing Li Xing-Xing He Jiu-Hong Ma Dong-Sheng Liu Cai-Bin Huang Ning-Jian Xu Nong-Rong Wang Nong-Hua Lu | 2014 | World Journal of Gastroenterology2014，20，32： | 24 |
| 6 | Left posterior fascicular block: a new endpoint of ablation for verapamil-sensitive idiopathic ventricular tachycardia显示文摘Background Verapamil-sensitive, idiopathic left ventricular tachycardia (ILVT) with right bundle branch block configuration and left-axis deviation is known to be due to re-entry mechanism but the exact nature of reentrant circuit in ILVT is not fully elucidated. Radiofrequency (RF) ablation was applied during ventricular tachycardia (VT) and termination of the VT or abolishing the inducibility of the tachycardia was used as an endpoint for successful RF. In this study, the left posterior fascicular block in surface electrocardiogram (ECG) was used as a new endpoint of ablation to cure ILVT. Methods Electrophysiological studies and radiofrequency ablation were performed in 39 consecutive patients [30 men, 9 women; age ranging from 10 to 64 years, mean (29±16) years] with verapamil-sensitive ILVT and structurally normal hearts. VT could be terminated by the intravenous administration of verapamil in all patients. The target site was the midseptum of LV where the earliest Purkinje potentials were recorded during VT. RF current was applied to the target site with or without late diastolic potential (LDP) during sinus rhythm in 37 patients and during VT in 2 patients to meet the ablation endpoint: the left posterior fascicular block in the surface ECG. Results Thirty-seven patients with ILVT had been treated by RF ablation during sinus rhythm and two had been treated during VT. All of them met the endpoint of the left posterior fascicular block. Thirty-eight cases were symptom-free without medications during the follow-up period (range from 3 to 95 months, median 17 months). One patient developed a clinical recurrence and the left posterior fascicular block in surface ECG disappeared. The patient received another treatment. The endpoint was met and the procedure was successful. Conclusions The left posterior fascicular block in surface ECG used as an endpoint of RF ablation to treat ILVT is effective. It is important especially in those patients whose VT can not be induced or the inducible condition is unstable. The effective endpoint implied that the left posterior fascicle might be a critical part of the re-entrant circuit. | MA Fu-sheng MA Jian TANG Kai HAN Hao JIAYu-he FANG Pi-hua CHU Jian-min PU Jie-lin ZHANG Shu | 2006 | Chinese Medical Journal2006，，5： | 21 |
| 7 | Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway显示文摘This study aimed to verify the effects of berberine(BBR)on the fat metabolism proteins involved in the sirtuin 3(SIRT3)/adenosine 5'-monophosphate(AMP)-activated protein kinase(AMPK)/acetyl-CoA carboxylase(ACC)pathway in the liver tissues of rats with high-fat diet(HFD)-induced non-alcoholic fatty liver disease(NAFLD).Forty-eight rats were randomly divided into the normal control(NC)group,HFD group or BBR group,with 16 rats in each group.After 8 and 16 weeks of treatment,serum and liver samples were collected.Subsequently,body parameters,biochemical parameters and liver pathology were examined.The expression levels of proteins involved in the SIRT3/AMPK/ACC pathway in the liver were detected by Western blotting.After 8 and 16 weeks of a HFD,the successful establishment of rat models with different degrees of NAFLD was confirmed by hematoxylin and eosin(H&E)and Oil Red O staining.NAFLD rat models exhibited obesity and hyperlipidemia,and the protein expression levels of SIRT3,p-AMPK.p-ACC,and CPT-1A in the liver were significantly decreased compared to those in the NC group.The concurrent administration of BBR with the HFD effectively improved serum and liver lipid profiles and ameliorated liver injury.Furthermore,the protein expression levels of SIRT3,p-AMPK,p-ACC,and CPT-1 A in the liver were significantly increased in the BBR group as compared with those in the HFD group.In conclusion,our data suggest that the mechanism by which BBR ameliorates HFD-induced hepatic steatosis may be related to the activation of the SIRT3/AMPK/ACC pathway in the liver. | Yu-pei ZHANG Yuan-jun DENG Kai-rui TANG Run-sen CHEN Shu LIANG Yin-ji LIANG Li HAN Ling JIN Zi-en LIANG Yan-ning CHEN Qin-he YANG | 2019 | Current Medical Science2019，39，1： | 21 |
| 8 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 9 | Lunar topographic model CLTM-s01 from Chang’E-1 laser altimeter显示文摘More than 3 million range measurements from the Chang’E-1 Laser Altimeter have been used to produce a global topographic model of the Moon with improved accuracy. Our topographic model, a 360th degree and order spherical harmonic expansion of the lunar radii, is designated as Chang’E-1 Lunar Topography Model s01 (CLTM-s01). This topographic field, referenced to a mean radius of 1738 km, has an absolute vertical accuracy of approximately 31 m and a spatial resolution of 0.25o (~7.5 km). This new lunar topographic model has greatly improved previous models in spatial coverage, accuracy and spatial resolution, and also shows the polar regions with the altimeter results for the first time. From CLTM-s01, the mean, equatorial, and polar radii of the Moon are 1737103, 1737646, and 1735843 m, respectively. In the lunar-fixed coordinate system, this model shows a COM/COF offset to be (-1.777, -0.730, 0.237) km along the x, y, and z directions, respectively. All the basic lunar shape parameters derived from CLTM-s01 are in agreement with the results of Clementine GLTM2, but CLTM-s01 offers higher accuracy and reliability due to its better global samplings. | PING JinSong HUANG Qian YAN JianGuo CAO JianFeng TANG GeShi SHU Rong | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，7： | 19 |
| 10 | Percutaneous catheter drainage in combination with choledochoscope-guided debridement in treatment of peripancreatic infection显示文摘AIM:To introduce and evaluate the new method used in treatment of pancreatic and peripancreatic infections secondary to severe acute pancreatitis(SAP).METHODS:A total of 42 SAP patients initially underwent ultrasound-guided percutaneous puncture and catheterization.An 8-Fr drainage catheter was used to drain the infected peripancreatic necrotic foci for 3-5 d.The sinus tract of the drainage catheter was expanded gradually with a skin expander,and the 8-Fr drainage catheter was replaced with a 22-Fr drainage tube after 7-10 d.Choledochoscope-guided debridement was performed repeatedly until the infected peripancreatic tissue was effectively removed through the drainage sinus tract.RESULTS:Among the 42 patients,the infected peripancreatic tissue or abscess was completely removed from 38 patients and elective cyst-jejunum anastomosis was performed in 4 patients due to formation of pancreatic pseudocysts.No death and complication occurred during the procedure.CONCLUSION:Percutaneous catheter drainage in combination with choledochoscope-guided debridement is a simple,safe and reliable treatment procedure for peripancreatic infections secondary to SAP. | Tang, Li-Jun Wang, Tao Cui, Jian-Feng Zhang, Bing-Yin Li, Shi Li, Dong-Xuan Zhou, Shu | 2010 | World Journal of Gastroenterology2010，16，4： | 17 |
| 11 | Nickel accumulation and its effects on the survival rate of Spodoptera litura Fabricius under continuous nickel stress显示文摘The artificial diets mixed with various concentrations of nickel were offered to the larvae of the phytophagous insect Spodoptera litura Fabricius for 3 generations. Nickel accumulations in the 6th instar larvae, pupae and newly emerged adults of the corresponding generations of S. litura were investigated by Inductively Coupled Plasma-Atomic Emission Spectrometer (ICP-AES), and the effects of nickel accumulations on the survival rate of S. litura were also evaluated by individual rearing. The results showed that nickel accumulated in the 6th instar larvae, pupae and adults of S. litura, and the accu- mulated nickel in all the tested developmental stages within a generation increased with the increase of the nickel doses in the treated diets and showed significant dose-dependent relationship with the nickel doses in the artificial diets. The results also indicated that the nickel accumulations in the 6th instar larvae, pupae, and newly emerged adults from the 3rd generation were higher than those from the 2nd generation, which were also higher than those from the 1st generation. Nickel concentrations in pupae and adults were significantly lower than those in larvae, which indicated that the excessive nickel might be excreted during metamorphosis. Furthermore, larval survival rate, pupation rate and eclosion rate of S. litura in the tested three generations all decreased with the increase of the nickel doses in the treated diets. | SUN HongXia SHU YingHua TANG WenCheng WANG Qi ZHOU Qiang ZHANG GuRen | 2007 | Chinese Science Bulletin2007，52，14： | 16 |
| 12 | A comparative analysis of five global cropland datasets in China显示文摘Accurate information of cropland area and spatial location is critical for studies of national food security, global environmental change, terrestrial ecosystem geophysics and the geochemical cycle. In this paper, we compared five global cropland datasets in circa 2010 of China from in terms of cropland area and spatial location, including Global Land30, FROM-GLC, Glob Cover, MODIS Collection 5, and MODIS Cropland. The results showed that the accuracies of cropland area and spatial location of Globe Land30 were higher than the other four products. The cropland areas of the five products varied in most of the provinces. Compared with the statistical data, the best goodness of fit was obtained using Globe Land30, followed by MODIS Collection 5 and FROM-GLC, with MODIS Cropland and Glob Cover having the poorer accuracies. Regarding the spatial location of cropland, Globe Land30 achieved the best accuracy, followed by FROM-GLC and MODIS Collection 5, with Glob Cover and MODIS Cropland having the poorer accuracies. In addition, the spatial agreement of the five datasets was reduced from agricultural production area to pastoral area and significantly affected by elevation and slope factors. Although the spatial resolution of MODIS Collection 5 was the lowest, accuracies of the cropland area and spatial location were better than those of Glob Cover and MODIS Cropland. Therefore, high spatial resolution remote sensing images can help to improve the accuracy of the dataset during land cover mapping, while it is also important to select a suitable classification method. Furthermore, in northwestern and southeastern China, spectral mixing pixels are universal because of the complicated landscape and fragmentized topography and result in uncertainty and poor consistency when using the five products. Therefore, these regions require additional attention in future cropland mapping studies. | LU Miao WU WenBin ZHANG Li LIAO AnPing PENG Shu TANG HuaJun | 2016 | Science China(Information Sciences)2016，59，12： | 15 |
| 13 | Analysis and Recommendations for the Adaptability of China’s Power System Security and Stability Relevant Standards显示文摘In developing power grids,setting standards is critical to its success.The development of China’s power industry has proposed new requirements for power systems to ensure secure and stable operations.The principal standards for the security and stability of China’s current power systems are analyzed in terms of operational control,generator-grid coordination and simulation.The shortcomings are pointed out and the directions of future development are discussed.In the end,the study highlighted the following key areas that require further research and improvement:the evaluation criteria of power system security and stability should be improved to ensure the secure and stable operation of China’s power systems;the operational control standards should be constantly enhanced to increase the reliability and flexibility of operational control strategies;generatorgrid coordination standards should be upgraded to improve the coordination between the generator control protection system and the grid;and the simulation methodology should be standardized in future power system security and stability research. | Yinbiao Shu Yong Tang | 2017 | CSEE Journal of Power and Energy Systems2017，3，4： | 14 |
| 14 | Simultaneous virus identification and characterization of severe unexplained pneumonia cases using a metagenomics sequencing technique显示文摘Many viruses can cause respiratory diseases in humans.Although great advances have been achieved in methods of diagnosis,it remains challenging to identify pathogens in unexplained pneumonia(UP) cases.In this study,we applied next-generation sequencing(NGS) technology and a metagenomic approach to detect and characterize respiratory viruses in UP cases from Guizhou Province,China.A total of 33 oropharyngeal swabs were obtained from hospitalized UP patients and subjected to NGS.An unbiased metagenomic analysis pipeline identified 13 virus species in 16 samples.Human rhinovirus C was the virus most frequently detected and was identified in seven samples.Human measles virus,adenovirus B 55 and coxsackievirus A10 were also identified.Metagenomic sequencing also provided virus genomic sequences,which enabled genotype characterization and phylogenetic analysis.For cases of multiple infection,metagenomic sequencing afforded information regarding the quantity of each virus in the sample,which could be used to evaluate each viruses' role in the disease.Our study highlights the potential of metagenomic sequencing for pathogen identification in UP cases. | Xiaohui Zou Guangpeng Tang Xiang Zhao Yan Huang Tao Chen Mingyu Lei Wenbing Chen Lei Yang Wenfei Zhu Li Zhuang Jing Yang Zhaomin Feng Dayan Wang Dingming Wang Yuelong Shu | 2017 | Science China(Life Sciences)2017，60，3： | 14 |
| 15 | Two new terpenoids from fruits of Ziziphus jujuba显示文摘一新 ceanothane 类型 triterpene 和一新 sesquiterpene,和二,已知的 triterpenes 从 Ziziphus jujuba 米尔的水果被孤立。(Rhamnaceae ) 。基于光谱分析,二新混合物的结构作为 2 α 被阐明; -aldehydo-A(1)-norlup-20(29)-en-27,28-dioic 酸(zizyberanal 酸)(1 ) ,和 zizyberanone (2 ) 。当二已知的 triterpenes 作为 zizyberanalic 酸(3 ) 和 ursolic 酸(4 ) 被识别时。 | Sheng Guo Yu Ping Tang Jin Ao Duan Shu Lan Su An Wei Ding | 2009 | Chinese Chemical Letters2009，20，2： | 13 |
| 16 | Marginal Land-based Biomass Energy Production in China显示文摘Fast economic development in China has resulted in a significant increase in energy demand. Coal accounts for 70% of China's primary energy consumption and its combustion has caused many environmental and health problems. Energy security and environmental protection requirements are the main drivers for renewable energy development in China. Small farmland and food security make bioenergy derived from corn or sugarcane unacceptable to China: the focus should be on generating bioenergy from lignocellulosic feedstock sources. As China cannot afford biomass energy production from its croplands, marginal lands may play an important role in biomass energy production. Although on a small scale, marginal land has already been used for various purposes. It is estimated that some 45 million hm2 of marginal land could be brought into high potential biomass energy production. For the success of such an initiative, it will likely be necessary to develop multipurpose plants. A case study, carried out on marginal land in Ningnan County, Sichuan Province with per capita cropland of 0.07 ha, indicated that some 380 000 tons of dry biomass could be produced each year from annual pruning of mulberry trees. This study supports the feasibility of producing large quantities of biomass from marginal land sources. | Ya Tang Jia-Sui Xie Shu Geng | 2010 | Journal of Integrative Plant Biology2010，52，1： | 12 |
| 17 | A randomized prospective comparison of CartoMerge and CartoXP to guide circumferential pulmonary vein isolation for the treatment of paroxysmal atrial fibrillation显示文摘背景:CartoXP 和 CartoMerge 在伊朗的银币纤维性颤动(AF ) 习惯于对待几年了。我们的使随机化的未来的学习比较了三件维的电镀物品的这二个版本的临床的结果在指导导管脱离为的解剖印射系统在伊朗的银币纤维性颤动(PAF ) 发作性。方法:81 个病人与征兆,倔强的 PAF 随机被分到 CartoMerge 的药组织(n=42,吝啬的年龄(54.5+/-13.1 ) 年, AF=3.2 年的历史) 或 CartoXP 组(n=39,吝啬的年龄(59.8+/-15.6 ) 年, AF 2.9 年的历史) 。所有病人经历了 64 片计算断层摄影术(MSCT ) 在脱离过程以前的 1 ~ 3 天。用 CartoMerge (TM ) 图象集成模块,左中庭(LA ) 和肺的静脉(PV ) 的解剖图象从 CartoMerge 组的 MSCT 导出的 3D 被建立并且把解剖地图与电镀物品合并了。综合图象被用来指导环绕的肺的静脉隔离(CPVI ) 的过程。在另外的组, CPVI 就被 CartoXP 指导。在两个组的 CPVI 的端点是肺的静脉潜力(PVP ) 的废除或分离。结果:印射指证实 LA/PVs 的电镀物品解剖学模型在 CartoXP 组(P<0.001 ) 是在 CartoMerge 组和 62.5+/-15.7 的 48.7+/-13.4。在在 CartoMerge 组印射点和 MSCT 表面之间的吝啬的距离是(1.59+/-0.33 ) 公里。废除的成就或 PVP 的分离被完成 95.2% 在 CartoMerge 组织, 92.3% 在 CartoXP 组织。到 X 光检查的过程和暴露的持续时间是(156+/-25 ) 纪录,(179+/-21 ) 分钟(P<0.001 ) 并且(19.6+/-7.5 ) 分钟,(28.5+/-12.8 ) 分钟(P<0.001 ) 分别地。在有持续时间的后续以后(11.9+/-3.1 ) 月对(12.4+/-3.6 ) 月张贴第一个脱离过程,没有 AF 的病人是 33 (78.6%) 在 CartoMerge 组织,(74.4%) 29 在 CartoXP 组织(P>0.50 ) 。没有耐心的承受肺的静脉狭窄, atrioesophageal 管,击或死亡。结论:比作 CartoXP, CartoMerge 弄短导管脱离过程和暴露到 X 光检查,没有为治疗影响环绕的肺的静脉隔离的临床的结果在在富有经验的中心的伊朗的银币纤维性颤动发作性。 | TANG Kai MA Jian ZHANG Shu ZHANG Jing-ying WEI Yi-dong CHEN Yan-qing YU Xue-jing XU Ya-wei | 2008 | Chinese Medical Journal2008，，6： | 10 |
| 18 | Idiopathic ventricular fibrillation with fragmented QRS complex and J wave in resting electrocardiogram显示文摘ObjectiveTo 在放松从 21 大小写的考察数据在我们的医院里使遭到的 electrocardiogram.MethodsWe 与碎裂的 QRS 建筑群( f-QRS )和 J 波浪描述自发的室的纤维性颤动( IVF )的临床的特征由于 IVF 在心脏的拘捕以后被复活并且在放松心电图估计了 f-QRS 和 J 波浪的流行( ECG )。所有盒子题目基于 electrocardiographic 形态学在三个组之中被分类:组我, f-QRS 和 J 波浪被观察(n = 6 ) ,组 II,仅仅 J 波浪被观察(n = 9 ) ,组 III,两 f-QRS 也不 J 波浪被观察(n = 6 ) 。人口特征,中略的历史或突然的心脏的拘捕,室的纤维性颤动( VF )的发生,和 VF 的情形在索引事件的三 groups.ResultsThe 发生之中被评估(中略,在可植入的 cardioverter 使用高压脉冲来消减心脏( ICD )或心律调整器记录的熬过的心脏的拘捕和 VF 事件)是 13.4 ± ;在组的 5.6 每年我, 10.8 ±在组 II 的 3.9 每年,和 9.8 ±在组 III 的 4.2 每年。在在三个组,之中的发生有重要差别最经常的索引事件在组被观察我。为发生的危险比率是 3.2 (95%CI, 1.1-7.9;P = 0.01 ) 。索引事件的历史和情形在这些组之中是不同的。在组我,所有索引事件在清早发生在睡觉期间。在组 II,四个题目在奋发的物理活动或焦虑状态期间承受了 VF,二在在清早的睡觉期间,三在里面平常的活动。在组 III ,一个题目在清早在睡觉期间承受了 VF ,处于焦虑状态的,四在平常的 activity.ConclusionsThis ,学习建议有在休息 ECG 的 f-QRS 和 J 波浪的联合外观的 IVF 病人承受 VF 的增加的风险, IVF 病人的这亚群有一个唯一的临床的特征。 | Jing Wang Min Tang Ke-Xiu Mao Jian-Min Chu Wei Hua Yu-He Jia Ying-Jie Zhao Wei Wei Xu-Hua Chen Jie-Lin Pu Shu Zhang | 2012 | Journal of Geriatric Cardiology2012，9，2： | 10 |
| 19 | Plasma metabolomic and lipidomic alterations associated with COVID-19显示文摘The pandemic of the coronavirus disease 2019(COVID-19)has become a global public health crisis.The symptoms of COVID-19 range from mild to severe,but the physiological changes associated with COVID-19 are barely understood.In this study,we performed targeted metabolomic and lipidomic analyses of plasma from a cohort of patients with COVID-19 who had experienced different symptoms.We found that metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients,indicating that the development of COVID-19 affected their whole-body metabolism.In particular,malic acid of the TCA cycle and carbamoyl phosphate of the urea cycle result in altered energy metabolism and hepatic dysfunction,respectively.It should be noted that carbamoyl phosphate is profoundly down-regulated in patients who died compared with patients with mild symptoms.And,more importantly,guanosine monophosphate(GMP),which is mediated not only by GMP synthase but also by CD39 and CD73,is significantly changed between healthy subjects and patients with COVID-19,as well as between the mild and fatal cases.In addition,dyslipidemia was observed in patients with COVID-19.Overall,the disturbed metabolic patterns have been found to align with the progress and severity of COVID-19.This work provides valuable knowledge about plasma biomarkers associated with COVID-19 and potential therapeutic targets,as well as an important resource for further studies of the pathogenesis of COVID-19. | Di Wu Ting Shu Xiaobo Yang Jian-Xin Song Mingliang Zhang Chengye Yao Wen Liu Muhan Huang Yuan Yu Qingyu Yang Tingju Zhu Jiqian Xu Jingfang Mu Yaxin Wang Hong Wang Tang Tang Yujie Ren Yongran Wu Shu-Hai Lin Yang Qiu Ding-Yu Zhang You Shang Xi Zhou | 2020 | National Science Review2020，7，7： | 9 |
| 20 | Productivity matching and quantitative prediction of coalbed methane wells based on BP neural network显示文摘It is a great challenge to match and predict the production performance of coalbed methane (CBM) wells in the initial production stage due to heterogeneity of coalbed, uniqueness of CBM production process, complexity of porosity-permeability variation and difficulty in obtaining some key parameters which are critical for the conventional prediction methods (type curve, material balance and numerical simulation). BP neural network, a new intelligent technique, is an effective method to deal with nonlinear, instable and complex system problems and predict the short-term change quantitatively. In this paper a BP neural model for the CBM productivity of high-rank CBM wells in Qinshui Basin was established and used to match the past gas production and predict the futural production performance. The results from two case studies showed that this model has high accuracy and good reliability in matching and predicting gas production with different types and different temporal resolutions, and the accuracy increases as the number of outliers in gas production data decreases. Therefore, the BP network can provide a reliable tool to predict the production performance of CBM wells without clear knowledge of coalbed reservoir and sufficient production data in the early development stage. | LU YuMin TANG DaZhen XU Hao TAO Shu | 2011 | Science China(Technological Sciences)2011，54，5： | 9 |
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