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| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | In-vitro fer- tilization and the ovarian hyperstimulation syn- drome显示文摘 | MacDougall MJ Tan SL Jacobs HS | 1992 | HumReprod1992，7，5： | 1 |
| 3 | Doppler for artery-artery anastomosis and stage-independent survival in twin-twin transfusion显示文摘 | Tan TY Taylor MJ Wee LY | | 0，，06： | 1 |
| 4 | Age-associated differences in activation of Akt/GSK-313 signaling pathways and inhibition of mitochondrial permeability transition pore opening in the rat heart 显示文摘 | Zhu J Rebecehi MJ Tan M | 2010 | J Gerontol A Biol Sei Med Sei2010，65，6： | 1 |
| 5 | Electroenhanced solidphase microextraction of methamphetamine with commercial fibers显示文摘 | Tan TY Basheer C Yan Ang MJ | 2013 | J Chromatogr A2013，1297，： | 1 |
| 6 | Angiopoietin-like 4 protein elevates the prosurvival intracellular O2 -:H2O2 ratio and confers anoikis resistance to tumors显示文摘 | Zhu P Tan MJ Huang RL Tan CK Chong HC Pal M Lam CR Boukamp P Pan JY Tan SH Kersten S Li HY Ding JL Tan NS | | 0，，03： | 1 |
| 7 | Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by o steoprotegerin l igand显示文摘 | Hsu H Lacey DL Dunstan CR Solovyev I Colombero A Timms E Tan HL Elliott G Kelley MJ Sarosi I Wang L Xia XZ Elliott R Chiu L Black T Scully S Capparelli C Morony S Shimamoto G Bass MB Boyle WJ | | 0，，： | 1 |
| 8 | Comprehensive analysis of host cellular interactions with human papillomavirus E6 proteins identifies new E6 binding partners and reflects viral diversity显示文摘 | White EA Kramer RE Tan MJ | 2012 | J Virol2012，86，13： | 1 |
| 9 | Autoantibodies to a nuclear antigen in proliferation cell显示文摘 | FRIZIER MJ TAN EM | 1987 | J Immunol1987，121，6： | 1 |
| 10 | A prospective randomized clinical trial of the use of fluoroscopy in obtaining femoral arterial access显示文摘 | Huggins CE Gillespie MJ Tan WA | | 0，，03： | 1 |
| 11 | The effects of oral antihyperglycaemic medications on serum lipid profiles in patients with type 2 diabetes显示文摘 | Buse JB Tan MH Prince MJ | 2004 | Diabetes Obes Metab2004，6，2： | 1 |
| 12 | Fgfr3 is a transcriptional target of Ap2delta and Ash21-containing histone methyltransferase complexes显示文摘 | Tan CC Walsh MJ Gelb BD | | 0，，： | 1 |
| 13 | Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases显示文摘 | Soon F F Ng L M Zhou X E West G M Kovach A Tan M H Suino-Powell KM He Y Xu Y Chalmers MJ Brunzelle JS Zhang H Yang H Jiang H Li J Yong EL Cutler S Zhu JK Griffin PR Melcher K Xu HE | 2012 | Science2012，335，6064： | 1 |
| 14 | Comparison of natural with clomiphene citrate-stimulated cycles in in vitro fertilization:a prospective,randomized trial显示文摘 | MacDougall MJ Tan SL Hall V | 1994 | Fertil Steril1994，61，6： | 1 |
| 15 | Antidiabeticactivities of Triterpenoids Isolated From Bitter Melon Associated with Activation of the AMPK Pathway显示文摘 | Tan MJ | 2008 | Chem Biol2008，15，2： | 1 |
| 16 | Papillary and neuroendocrine breast lesions : the WHO stance 显示文摘 | Tan PH Schnitt SJ van de Vijver MJ | 2015 | Histopathology2015，66，6： | 1 |
| 17 | Doppler for artery-artery anastomosis and stage-independent survival in twin-twin transfusion 显示文摘 | Tan TY Taylor MJ Wee LY | 2004 | Obstet Gynecol2004，103，6： | 1 |
| 18 | Improving head growth in very preterm infants-a randomised controlled trial I:neonatal outcomes显示文摘 | Tan MJ Cooke RW | 2008 | Arch Dis Child Fetal Neonatal Ed2008，93，5： | 1 |
| 19 | Patterns of baseline autonomic nerve activity and the development of pacing-induced sustained atrial fibrillation 显示文摘 | Shen MJ Choi EK Tan A Y | 2011 | Heart Rhythm2011，8，： | 1 |
| 20 | SYNTHESIS OF FULLERENE PYRROLIDINES CONTAINING SUBSTITUTED PHENYL GROUPS THROUGH AZOMETHINE YLIDE ADDITION显示文摘SYNTHESIS OF FULLERENE PYRROLIDINES CONTAINING SUBSTITUTED PHENYL GROUPS THROUGH AZOMETHINE YLIDE ADDITIONDeJianZHOU;LiangBin... | Zhou, DJ Gan, LB Tan, HS Luo, CP Huang, CH Pan, JQ Lu, MJ Wu, Y | 1995 | Chinese Chemical Letters1995，6，12： | 1 |
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