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| 1 | Hepatocellular carcinoma in extremely elderly patients:An analysis of clinical characteristics,prognosis and patient survival显示文摘瞄准:80 年或更多与肝细胞癌(HCC ) 识别病人的临床、预示的特征。方法:有 HCC 的 1310 个病人的一个总数在这研究被包括。80 年或更多的 91 个病人在 HCC 的诊断的时候被定义为极其老的组。>
或 = 的 234 个病人 50 年但是不到 60 年被认为是非老的组。结果:两性比率(到女性的男性) 比在非老的组在极其老的组(0.90:1 ) 是显著地更低的(3.9:1, P <
0.001 ) 。为 HBsAg 的积极的率在极其老的组和为显然在极其老的组增加的 HBsAg 和 HCVAb 否定的病人的比例是显著地更低的(P <
0.001 ) 。在下列参数没有有效差量:肿瘤,分级的孩子呸,肿瘤阶段,门静脉血栓形成或腹水的存在,和为 HCVAb 的积极的率的直径和数字。极其老的病人经常没收到外科疗法(P <
0.001 ) 并且他们是更可能的收到保守疗法(P <
0.01 ) 。基于与在二个组之间的全面病人比较的 Kaplan-Meier 方法在幸存曲线没有有效差量。然而,幸存曲线在有阶段 I/II 的极其老的病人是显著地更坏的,上演 I/II,孩子呸分级与非老的组比较的肝硬化。死亡的原因没在病人之中不同,并且大多数盒子甚至在极其老的病人死于肝相关的疾病。结论:在有好肝功能和好表演地位的病人,为 HCC 的好攻击的治疗可能改进幸存率,甚至在极其老的病人。 | Gengo Tsukioka Satoru Kakizaki Naondo Sohara Ken Sato Hitoshi Takagi Hirotaka Arai Takehiko Abe Mitsuo Toyoda Kenji Katakai Akira Kojima Yuichi Yamazaki Toshiyuki Otsuka Yutaka Matsuzaki Fujio Makita Daisuke Kanda Katsuhiko Horiuchi Tetsuya Hamada Mieko Kaneko Hideyuki Suzuki Masatomo Mori | 2006 | World Journal of Gastroenterology2006，12，1： | 7 |
| 2 | A radical scavenger edaravone and oligodendrocyte protection/regeneration显示文摘Cerebral white matter is vulnerable to oxidative stress:Oxidative stress is one of the major harmful conditions for the central nervous system(CNS).Oxidative stress is a state from an imbalance between free radical production and their removal by antioxidants,resulting in an excessive amount of reactive oxygen species(ROS)in cells and tissues.ROS causes cell damage due to oxidation of cellular components,including DNAs,proteins,and lipids. | Hajime Takase Josephine Lok Ken Arai | 2018 | Neural Regeneration Research2018，13，9： | 4 |
| 3 | Therapeutic potential of prophylactic exercise for intracerebral hemorrhage显示文摘Exercise and brain health:Physical activity helps promote and maintain our brain health,including memory and cognitive performance.Research has shown that exercise is a safe behavioral intervention that reduces the risk of hypokinetic diseases,such as hypertension,diabetes,and lipid metabolic disorders.In addition. | Keita Kinoshita Kelly K.Chung Hiroshi Katsuki Ken Arai | 2022 | Neural Regeneration Research2022，17，7： | 3 |
| 4 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 5 | Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro显示文摘 | Brian J. Lee Yasuhiro Egi Klaus van Leyen Eng H. Lo Ken Arai | 2009 | Brain Research2009，，： | 2 |
| 6 | Dual mode regulation of migration by lysophosphatidic acid in human gastric cancer cells显示文摘 | Dai Shida Joji Kitayama Hironori Yamaguchi Kotaro Hama Junken Aoki Hiroyuki Arai Hiroharu Yamashita Ken Mori Akihiro Sako Tsuyoshi Konishi Toshiaki Watanabe Teruyuki Sakai Rika Suzuki Hideo Ohta Yoh Takuwa Hirokazu Nagawa | 2004 | Experimental Cell Research2004，，2： | 2 |
| 7 | Curcumin Maintenance Therapy for Ulcerative Colitis: Randomized, Multicenter, Double-Blind, Placebo-Controlled Trial显示文摘 | Hiroyuki Hanai Takayuki Iida Ken Takeuchi Fumitoshi Watanabe Yasuhiko Maruyama Akira Andoh Tomoyuki Tsujikawa Yosihihide Fujiyama Keiichi Mitsuyama Michio Sata Masami Yamada Yasushi Iwaoka Kazunari Kanke Hideyuki Hiraishi Kazuhisa Hirayama Hajime Arai Shi | 2006 | Clinical Gastroenterology and Hepatology2006，，12： | 2 |
| 8 | Lithium upregulates vascular endothelial growth factor in brain endothelial cells and astrocytes显示文摘 | Guo Shu-zhen Arai Ken Stins Monique F | 2009 | Stroke2009，40，2： | 1 |
| 9 | Deficiency of choresteryl ester transfer protein and gene polymorphisms of lipoprotein lipase and hepatic lipase are not associated with longevity显示文摘 | Yasymichi Arai Nobuyoshi Hirose Ken Yamamura Susumu Nakazawa Ken-ichirou Shimizu Michiyo Takayama Yoshinori Ebihara Satoki Homma Yasuyuki Gondo Yukie Masui Hiroki Inagaki | 2003 | Journal of Molecular Medicine2003，，： | 1 |
| 10 | Curcumin Maintenance Therapy for Ulcerative Colitis: Randomized, Multicenter, Double-Blind, Placebo-Controlled Trial显示文摘 | Hiroyuki Hanai Takayuki Iida Ken Takeuchi Fumitoshi Watanabe Yasuhiko Maruyama Akira Andoh Tomoyuki Tsujikawa Yosihihide Fujiyama Keiichi Mitsuyama Michio Sata Masami Yamada Yasushi Iwaoka Kazunari Kanke Hideyuki Hiraishi Kazuhisa Hirayama Hajime Arai Shi | 2006 | Clinical Gastroenterology and Hepatology2006，，12： | 1 |
| 11 | Effect of omeprazole on changes in gastric and upper small intestine pH levels in patients with chronic pancreatitis显示文摘 | Teruo Nakamura Yuki Arai Yusuke Tando Akinori Terada Naoko Yamada Moriyasu Tsujino Ken’ichi Imamura Koji Machida Hiroaki Kikuchi Kazuo Takebe | 1995 | Clinical Therapeutics1995，，3： | 1 |
| 12 | Thrombocytopenia associated with hepatitis C viral infection显示文摘 | Takeaki Nagamine Tosiyuki Ohtuka Ken Takehara Takayuki Arai Hitoshi Takagi Masatomo Mori | 1996 | Journal of Hepatology1996，，2： | 1 |
| 13 | Thrombocytopenia associated with hepatitis C viral infection显示文摘 | Takeaki Nagamine Tosiyuki Ohtuka Ken Takehara Takayuki Arai Hitoshi Takagi Masatomo Mori | 1996 | Journal of Hepatology1996，，2： | 1 |
| 14 | Rolled Texture and Magnetic Properties of 3% Silicon Steel显示文摘 | Ken Ichi Arai Kazushi Ishiyama | 1988 | J Appl Phys1988，64，10： | 1 |
| 15 | Spleen Stiffness Correlates with the Presence of Ascites but Not Esophageal Varices in Chronic Hepatitis C Patients显示文摘 | Kazuyo Mori Hirotaka Arai Takehiko Abe Hisashi Takayama Mitsuo Toyoda Takashi Ueno Ken Sato John N. Plevris | 2013 | BioMed Research International2013，，： | 1 |
| 16 | Reactive astrocytes promote adhesive interactions between brain endothelium and endothelial progenitor cells via HMGB1 and beta-2 integrin signaling显示文摘 | Kazuhide Hayakawa Loc-Duyen D. Pham Ken Arai Eng H. Lo | 2013 | Stem Cell Research2013，，： | 1 |
| 17 | Do phagocytotic mechanisms regulate soluble factor secretion in microglia?显示文摘Microglia are responsible for phagocytosis in the brain:Phagocytosis,one of the major mechanisms of innate immune defense,is the process by which several types of cells in the immune system recognize,engulf,and digest large particles,such as pathogens and cell debris.In the brain,microglia play phagocytotic roles to regulate the micro-environment of brains under both physiological and pathological conditions. | Gen Hamanaka Kelly K.Chung Ken Arai | 2021 | Neural Regeneration Research2021，16，5： | 0 |
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