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| 1 | Plasma levels of acylated ghrelin in patients with functional dyspepsia显示文摘AIM:To investigate the relationship between plasma acylated ghrelin levels and the pathophysiology of functional dyspepsia.METHODS:Twenty-two female patients with functional dyspepsia and twelve healthy volunteers were recruited for the study.The functional dyspepsia patients were each diagnosed based on the Rome Ⅲ criteria.Eligible patients completed a questionnaire concerning the severity of 10 symptoms.Plasma acylated ghrelin levels before and after a meal were determined in the study participants using a commercial human acylated enzyme immunoassay kit;electrogastrograms were performed for 50 min before and after a standardized 10-min meal containing 265 kcal.RESULTS:There were no significant differences in plasma acylated ghrelin levels between healthy volunteers and patients with functional dyspepsia.However,in patients with functional dyspepsia,there was a negative correlation between fasting plasma acylated ghrelin levels and the sum score of epigastric pain(r =-0.427,P = 0.047) and a positive correlation between the postprandial/fasting plasma acylated ghrelin ratio and the sum score of early satiety(r = 0.428,P =0.047).Additionally,there was a negative correlation between fasting acylated ghrelin plasma levels and fasting normogastria(%)(r =-0.522,P = 0.013).Interestingly,two functional dyspepsia patients showed paradoxically elevated plasma acylated ghrelin levels after the meal.CONCLUSION:Abnormal plasma acylated ghrelin levels before or after a meal may be related to several of the dyspeptic symptoms seen in patients with functional dyspepsia. | Yeon Soo Kim Joon Seong Lee Tae Hee Lee Joo Young Cho Jin Oh Kim Wan Jung Kim Hyun Gun Kim Seong Ran Jeon Hoe Su Jeong | 2012 | World Journal of Gastroenterology2012，18，18： | 12 |
| 2 | Conventional endoscopic features are not sufficient to differentiate small, early colorectal cancer显示文摘AIM:To evaluate the depth of invasion of small,early colorectal cancers(ECCs)using conventional endoscopic features.METHODS:From January 2005 to September 2011,colonoscopy cohort showed that a total of 72 patients with small colorectal cancers with the size less than 20mm underwent colonoscopy at the Yonsei University College of Medicine,Seoul,South Korea.Among them,8 patients were excluded due to incomplete medical records.Finally,a total of 64 ECCs with submucosa(SM)invasion and size less than 20 mm were included.One hundred fifty-two adenomas with size less than 20 mm were included as controls.Nine endoscopic features,including seven morphological findings(i.e.,loss of lobulation,excavation,demarcated and depressed areas,stalk swelling,fullness,fold convergence,and bleeding ulcers),pit patterns,and non-lifting signs,were evalu-ated retrospectively.All endoscopic features were evaluated by two experienced endoscopists who have each performed over 1000 colonoscopies annually for more than five years without knowledge of the histology.RESULTS:Among the morphological findings,the size of deep submucosal cancers was bigger than that of superficial lesions(16.9 mm vs 12.3 mm,P<0.001).Also,demarcated depressed areas,stalk swelling,and fullness were more common in deep SM cancers than in superficial tumors(demarcated depressed areas:52.0%vs 15.7%,P<0.001;stalk swelling:100%vs4.2%,P<0.001;fullness:25.0%vs 0%,P=0.001).Among deep SM cancers,96%of polyps showed invasive pit patterns,whereas 19.4%of superficial tumors showed invasive pit patterns(P<0.001).A positive non-lifting sign was more common in deep SM cancers(85.0%vs 28.6%,P<0.001).Diagnostic accuracy of invasive morphology,invasive pit patterns,and nonlifting signs for deep SM cancers were 71%,82%,and75%,respectively.CONCLUSION:Conventional endoscopic findings were insufficient to discriminate small,deep SM cancers from superficial SM cancers by white light,standard colonoscopy. | Wan Park Bun Kim Soo Jung Park Jae Hee Cheon Tae Il Kim Won Ho Kim Sung Pil Hong | 2014 | World Journal of Gastroenterology2014，20，21： | 11 |
| 3 | Clinicopathologic factors influencing the accuracy of EUS for superficial esophageal carcinoma显示文摘AIM:To identify clinicopathologic factors influencing the accuracy of a high-frequency catheter probe endoscopic ultrasonography(EUS)for superficial esophageal carcinomas(SECs).METHODS:A total of 126 patients with endoscopically suspected SEC,who underwent EUS and curative treatment at Pusan National University Hospital during2005-2013,were enrolled.We reviewed the medical records of the 126 patients and compared EUS findings with histopathologic results according to clinicopathologic factors.RESULTS:A total of 114 lesions in 113 patients were included in the final analysis.The EUS assessment of tumor invasion depth was accurate in 78.9%(90/114)patients.Accuracy did not differ according to histologic type,tumor differentiation,tumor location,or macroscopic shape.However,accuracy significantly decreased for tumors≥3 cm in size(P=0.002).Overestimation and underestimation of the invasion depth occurred for 11(9.6%)and 13 lesions(11.4%),respectively.In multivariate analyses,tumor size≥3 cm was the only factor significantly associated with EUS accuracy(P=0.031),and was specifically associated with the underestimation of invasion depth.CONCLUSION:EUS using a high-frequency catheter probe generally provides highly accurate assessments of SEC invasion depth,but its accuracy decreases for tumors≥3 cm. | Jung Im Jung Gwang Ha Kim Hoseok I Do Youn Park Tae Kyun Kim Young Hwa Cho Yong Wan Sung Mun Ki Choi Bong Eun Lee Geun Am Song | 2014 | World Journal of Gastroenterology2014，20，20： | 9 |
| 4 | Endoscopic ultrasound-guided choledochoduodenostomies with fully covered self-expandable metallic stents显示文摘AIM:To investigate the long-term outcomes of endoscopic ultrasound-guided choledochoduodenostomy(EUS-CDS) with a fully covered self-expandable metallic stent(FCSEMS).METHODS:From April 2009 to August 2010,15 patients with distal malignant biliary obstructions who were candidates for alternative techniques for biliary decompression due to a failed endoscopic retrograde cholangiopancreatography(ERCP) were included.These 15 patients consisted of 8 men and 7 women and had a median age of 61 years(range:30-91 years).The underlying causes of the distal malignant biliary obstruction were pancreatic cancer(n = 9),ampulla of Vater cancer(n = 2),renal cell carcinoma(n = 1),advanced gastric cancer(n = 1),lymphoma(n = 1),and duodenal cancer(n = 1).RESULTS:The technical success rate of EUS-CDS with an FCSEMS was 86.7%(13/15),and functional success was achieved in 100%(13/13) of those cases.In two patients,the EUS-CDS failed because an FCSEMS with a delivery device could not be passed into the common bile duct.The mean duration of stent patency was 264 d.Early adverse events developed in three patients(3/13,23.1%),including self-limited pneumoperitoneum in two patients and cholangitis requiring stent reposition in one patient.During the follow-up period(median:186 d,range:52-388 d),distal stent migration occurred in four patients(4/13,30.8%).In 3 patients,the FCSEMS could be reinserted through the existing choledochoduodenal fistula tract.CONCLUSION:EUS-CDS with an FCSEMS is technically feasible and can lead to effective palliation of distal malignant biliary obstructions after failed ERCP. | Tae Jun Song Yil Sik Hyun Sang Soo Lee Do Hyun Park Dong Wan Seo Sung Koo Lee Myung-Hwan Kim | 2012 | World Journal of Gastroenterology2012，18，32： | 8 |
| 5 | Absolute monocyte and lymphocyte count prognostic score for patients with gastric cancer显示文摘AIM:To measure the prognostic significance of absolute monocyte count/absolute lymphocyte count prognostic score(AMLPS) in patients with gastric cancer.METHODS:We retrospectively examined the combination of absolute monocyte count(AMC) and absolute lymphocyte count(ALC) as prognostic variables in a cohort of 299 gastric cancer patients who underwent surgical resection between 2006 and 2013 and were followed at a single institution.Both AMC and ALC were dichotomized into two groups using cut-off points determined by receiving operator characteristic curve analysis.An AMLPS was generated,which stratified patients into three risk groups:low risk(both low AMC and high ALC),intermediate risk(either high AMC or low ALC),and high risk(both high AMC and low ALC).The primary objective of the study was to validate the impact of AMLPS on both disease-free survival(DFS) and overall survival(OS),and the second objective was to assess the AMLPS as an independent prognostic factor for survival in comparison with known prognostic factors.RESULTS:Using data from the entire cohort,the most discriminative cut-off values of AMC and ALC selected on the receiver operating characteristic curve were 672.4/μL and 1734/μL for DFS and OS.AMLPS risk groups included 158(52.8%) patients in the lowrisk,128(42.8%) in the intermediate-risk,and 13(4.3%) in the high-risk group.With a median followup of 37.2 mo(range:1.7-91.4 mo),five-year DFS rates in the low-,intermediate-,and high-risk groups were 83.4%,78.7%,and 19.8%,respectively.And fiveyear OS rates in the low-,intermediate-,and high-risk groups were 89.3%,81.1%,and 14.4%,respectively.On multivariate analysis performed with patient- and tumor-related factors,we identified AMLPS,age,and pathologic tumor-node-metastasis stage as the most valuable prognostic factors impacting DFS and OS.CONCLUSION:AMLPS identified patients with a poor DFS and OS,and it was independent of age,pathologic stage,and various inflammatory markers. | Wan Kyu Eo Da Wun Jeong Hye Jung Chang Kyu Yeoun Won Sung Il Choi Se Hyun Kim Sung Wook Chun Young Lim Oh Tae Hwa Lee Young Ok Kim Ki Hyung Kim Yong Il Ji Ari Kim Heung Yeol Kim | 2015 | World Journal of Gastroenterology2015，21，9： | 6 |
| 6 | Preliminary report on a new hybrid metal stent for EUS-guided biliary drainage (with videos)显示文摘 | Tae Jun Song Sang Soo Lee Do Hyun Park Dong Wan Seo Sung Koo Lee Myung-Hwan Kim | 2014 | Gastrointestinal Endoscopy2014，，： | 4 |
| 7 | Evaluation of lubrication performance of crank pin bearing in a marine diesel engine显示文摘In this study, the lubrication performance of the crank pin bearing in a marine two–stroke diesel engine is evaluated to investigate the adhesional failure on the crank pin bearing. A numerical algorithm for the lubrication analysis considering motion analysis of the crank pin system is developed. The film pressure and thickness for three clearances and three lubricant temperatures are calculated. The results show that the lubricant temperature has a higher effect on film thickness than clearance. In terms of the film parameter, the operating condition that can result in solid–solid contact is investigated. We also suggest the desirable operating conditions of clearance and lubricant temperature to prevent the solid–solid contact. | Suk Man MOON Yong Joo CHO Tae Wan KIM | 2018 | Friction2018，6，4： | 3 |
| 8 | 从铜合金渣中选择性回收锡及其热处理合成SnO_2(英文)显示文摘采用选择性溶解方法对铜合金废渣中的锡进行富集和分离。使用HNO3溶液溶解铜合金废渣,渣中的锡不会溶解从而使其从中得到分离。通过离心分离生成的H2SnO3沉淀相,然后经过干燥加热生成SnO2粉末。对SnO2粉末的相组成、表面形貌和化学成分进行分析。 | Jung-Il LEE Jong Bum PARK Tae Wan KIM Man-Sik KONG Jeong Ho RYU | 2014 | Transactions of Nonferrous Metals Society of China2014，24，S1： | 2 |
| 9 | Stress Oriented Hydrogen Induced Cracking of Linepipe Steel显示文摘The stress oriented hydrogen induced cracking (SOHIC) is a typical hydrogen embrittlement phenomenon occurring in the linepipe steels exposed to sour environment containing H 2 S gas.However,even recently,the cracking mechanism of SOHIC has not been clarified because of lacking in the empirical data on the actual failure mode of SOHIC cracking.The factors affecting SOHIC are discussed in terms of metallurgy of high strength linepipe steel and hydrogen electrochemistry.The cracking mechanisms of SOHIC are examined by comparing them with the empirical failure mode of SOHIC which is developed by observation of the actual fracture sites of the hydrogen induced blister cracking (HIBC) and secondary cracks.Finally,the correlation between SOHIC and HIC is discussed. | Wan Keun Kim Gyu Tae Park Kyoo Young Kim | 2011 | Journal of Iron and Steel Research(International)2011，18，S1： | 2 |
| 10 | <ce:link locator='fx1'/> Substitution of Aspartic Acid at Position 57 of the DQβ1 Affects Relapse of Autoimmune Pancreatitis显示文摘 | Do Hyun Park Myung–Hwan Kim Heung Bum Oh Oh–Joong Kwon Young–Jin Choi Sang–Soo Lee Tae Yoon Lee Dong–Wan Seo Sung–Koo Lee | 2008 | Gastroenterology2008，，2： | 2 |
| 11 | Expression of survivin and clinical correlation in patients with breast cancer显示文摘 | Doo Min Sohn Sung Yong Kim Moo Jun Baek Cheol Wan Lim Min Hyuk Lee Moo Sik Cho Tae Yoon Kim | 2006 | Biomedicine & Pharmacotherapy2006，，6： | 2 |
| 12 | 每日一次与按需使用乌地那非对治疗2型糖尿病患者勃起功能障碍的有效性和安全性比较显示文摘通过一项为期12周的多中心、随机、开放、平行组试验,比较每日一次与按需使用乌地那非对治疗2型糖尿病患者勃起功能障碍的有效性和安全性。按需服用乌地那非200mg能够改善勃起功能障碍的161名患者,被随机分为200mg按需治疗组(n=80)和50mg每日一次组仰=81),两组分别接受相应治疗8周,8周后停药并随访4周,这些患者均通过性活动日志中Q2(插入成功率)和Q3(性交中保持勃起至完成性交的成功率)进行评估。主要的疗效指标是国际勃起功能问卷.勃起功能分级(IIEF.EFD)评分的变化。次要的疗效指标包括性活动日志02、Q3,国际勃起功能问卷的Q3、Q4及其他部分,全球评估问卷,以及正常率(EFD_〉26)的变化。我们也对血管内皮细胞标志物进行了检测。经过8周的治疗,两组的IIEF.EFD评分都得到改善fP〈O.0001),且两组之间没有显著的统计学差异。但这种改善并没有维持到无治疗随访期之后。次要的疗效指标也有类似的结果。在血管内皮标志物方面,两组之间无显著差异。患者对每日一次乌地那非具有更好的耐受性,且两组之间药物不良反应以及不良事件方面无显著性差异。其中脸红和头痛是最常见的不良反应。这两种方案都能改善糖尿病患者的勃起功能障碍,且均有良好的患者耐受性。乌地那非每日给药对糖尿病患者勃起功能障碍的治疗作用值得进一步研究。 | Soon Hyun Park Sung Woo Park Bong Yun Cha Ie Byung Park Kyung Wan Min Yeon Ah Sung Tae Hwa Kim Jae Min Lee Kang Seo Park | 2015 | Asian Journal of Andrology2015，17，1： | 2 |
| 13 | 微波辐射辅助柠檬酸络合法制备的Ho^(3+)/Tm^(3+)/Yb^(3+)共掺杂CaWO_4的白光性能(英文)显示文摘采用微波辐射辅助柠檬酸络合法制备Ho3+/Tm3+/Yb3+共掺杂CaWO4纳米晶升频转换荧光粉。将柠檬酸络合物前驱体在300~700°C热处理3 h。Ho3+/Tm3+/Yb3+共掺杂CaWO4C在400°C时开始结晶,在600°C时结晶完成。经600°C热处理的Ho3+/Tm3+/Yb3+共掺杂CaWO4主要呈球形,且形态均匀。在980 nm的激光激发下,Ho3+/Tm3+/Yb3+共掺杂CaWO4纳米晶出现肉眼可见的明亮的白色升频转换发射,这种现象来自Tm3+的475 nm蓝光发射以及Ho3+的543 nm绿光和651 nm红光发射。通过调整Tm3+和Ho3+的浓度可以控制Ho3+/Tm3+/Yb3+共掺杂CaWO4的CIE色度图从冷到暖白色之间变化。讨论了Tm3+和Ho3+浓度对升频转换光性能的影响以及与激光泵功率相关的影响机制。 | Hyun CHO Seok Min HWANG Jae Bin LEE Dong Hyun KA Tae Wan KIM Bo Seul LEE Ji Young LEE Jung-Il LEE Jeong Ho RYU | 2014 | Transactions of Nonferrous Metals Society of China2014，24，S1： | 2 |
| 14 | A pilot proof-of-concept study of a modified device for one-step endoscopic ultrasound-guided biliary drainage in a new experimental biliary dilatation animal model显示文摘AIM:To evaluate the technical feasibility of a modified tapered metal tip and low profile introducer for onestep endoscopic ultrasound(EUS)-guided biliary drainage(EUS-BD)in a new experimental biliary dilatation porcine model.METHODS:A novel dedicated device for one-step EUS-guided biliary drainage system(DEUS)introducer has size 3F tapered catheter with size 4F metal tip for simple puncture of the intestinal wall and liver parenchyma without graded dilation.A self-expandable metal stent,consisting of both uncovered and nitinol-covered portions,was preloaded into DEUS introducer.After establishment of a biliary dilatation model using endoscopic hemoclips or band ligation with argon plasma coagulation in 9 mini-pigs,EUS-BD using a DEUS was performed following 19-G needle puncture without the use of fistula dilation devices.RESULTS:One-step EUS-BD was technically successful in seven pigs[7/9(77.8%)as intention to treat]without the aid of devices for fistula dilation from the high body of stomach or far distal esophagus to the intrahepatic(n=2)or common hepatic(n=5)duct.Primary technical failure occurred in two cases that did not show adequate biliary dilatation.In seven pigs with a successful bile duct dilatation,the technical success rate was 100%(7/7 as per protocol).Median procedure time from confirmation of the dilated bile duct to successful placement of a metallic stent was 10 min(IQR;8.9-18.1).There were no immediate procedure-related complications.CONCLUSION:Modified tapered metal tip and low profile introducer may be technically feasible for onestep EUS-BD in experimental porcine model. | Tae Hoon Lee Jun Hyuck Choi Sang Soo Lee Hyun Deuk Cho Dong Wan Seo Sang-Heum Park Sung Koo Lee Myung-Hwan Kim Do Hyun Park | 2014 | World Journal of Gastroenterology2014，20，19： | 2 |
| 15 | Thermodynamics of Titanium,Nitrogen and TiN formation in liquid iron显示文摘 | Wan Yi Kim Jong Oh Jo Tae In Chung | 2007 | ISIJ International2007，47，8： | 1 |
| 16 | Surgical strategy for T2 and T3 gallbladder cancer: is extrahepatic bile duct resection always necessary?显示文摘 | Sae Byeol Choi Hyung Joon Han Wan Bae Kim Tae Jin Song Sung Ock Suh Sang Yong Choi | 2013 | Langenbeck’s Archives of Surgery2013，，8： | 1 |
| 17 | Bee venom phospholipase A2 ameliorates amyloidogenesis and neuroinflammation through inhibition of signal transducer and activator of transcription-3 pathway in Tg2576 mice显示文摘Background:Neuroinflammation and accumulation ofβ-amyloid(Aβ)play a significant role in the onset and progression of Alzheimer’s disease(AD).Our previous study demonstrated that signal transducer and activator of transcription-3(STAT3)plays a major role in neuroinflammation and amyloidogenesis.Methods:In the present study,we investigated the inhibitory effect of bee venom phospholipase A2(bvPLA2)on memory deficiency in Tg2576 mice,which demonstrate genetic characteristics of AD and the mechanism of its action at the cellular and animal level.For in vivo study,we examined the effect of bvPLA2 on improving memory by conducting several behavioral tests with the administration of bvPLA2(1 mg/kg)to Tg2576 mice.For in vitro study,we examined the effect of bvPLA2 on amyloidogenesis and neuroinflammation by treating bvPLA2 on LPSactivated BV2 cells.Results:We found that bvPLA2 alleviated memory impairment in Tg2576 mice,as demonstrated in the behavioral tests assessing memory.In the bvPLA2-treated group,Aβ,amyloid precursor protein(APP),and β-secretase 1(BACE1)levels and β-secretase activity were significantly decreased.Expression of pro-inflammatory cytokines and inflammation-related proteins decreased in the brain of bvPLA2-treated group,whereas anti-inflammatory cytokines increased.In addition,bvPLA2 reduced STAT3 phosphorylation in the brains of the bvPLA2-treated group.At the cellular level,bvPLA2 inhibits production of nitric oxide,pro-inflammatory cytokines,and inflammation-related proteins including p-STAT3.Additionally,bvPLA2 inhibits the production of Aβin cultured BV-2 cells.Results from the docking experiment,pull-down assay,and the luciferase assay show that bvPLA2 directly binds STAT3 and,thus,regulates gene expression levels.Moreover,when the STAT3 inhibitor and bvPLA2 were administered together,the anti-amyloidogenic and anti-inflammatory effects were further enhanced than when they were administered alone.Conclusion:These results suggest that bvPLA2 could restore memory by inhibiting the accumulation of Aβ and inflammatory responses via blockage of STAT3 activity. | Hyeon Joo Ham Sang-Bae Han Jaesuk Yun In Jun Yeo Young Wan Ham Se Hyun Kim Pil-Hoon Park Dong-Young Choi Jin Tae Hong | 2019 | Translational Neurodegeneration2019，8，1： | 1 |
| 18 | Relationship be tween hydrogen-induced cracking and type I sulfide stress cracki ng of high-strength linepipe steel显示文摘 | Wan Keun Kim Hwan Gyo Jung Gyu Tae Park | 2010 | Scripta Materialia2010，，62： | 1 |
| 19 | The role of endoscopic retrograde cholangiography for biliary stricture after adult living donor liver transplantation: Technical aspect and outcome显示文摘 | Tae Hyup Kim Sung Koo Lee Jung Hye Han Do Hyun Park Sang Soo Lee Dong Wan Seo Myung-Hwan Kim Gi-Won Song Tae-Yong Ha Ki-Hun Kim Shin Hwang Sung Gyu Lee | 2011 | Scandinavian Journal of Gastroenterology2011，，2： | 1 |
| 20 | Clinicopathological Analysis and Survival outcome of Duodenal Adenocarcinoma显示文摘 | Myung Jin Kim Sae Byeol Choi Hyung Joon Han Pyoung Jae Park Wan Bae Kim Tae Jin Song Sung Ock Suh Sang Yong Choi | 2013 | Kaohsiung Journal of Medical Sciences2013，，： | 1 |
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