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| 1 | Intraductal neoplasm of the intrahepatic bile duct: Clinicopathological study of 24 cases显示文摘AIM: To investigate the clinicopathological features of intraductal neoplasm of the intrahepatic bile duct (INihB). METHODS: Clinicopathological features of 24 cases of INihB, which were previously diagnosed as biliary papillomatosis or intraductal growth of intrahepatic biliary neoplasm, were reviewed. Mucin immunohistochemistry was performed for mucin (MUC)1, MUC2, MUC5AC and MUC6. Ki-67, P53 and β-catenin immunoreactivity were also examined. We categorized each tumor as adenoma (low grade), borderline (intermediate grade), and malignant (carcinoma in situ , high grade including tumors with microinvasion). RESULTS: Among 24 cases of INihB, we identified 24 tumors. Twenty of 24 tumors (83%) were composed of a papillary structure; the same feature observed in intraductal papillary neoplasm of the bile duct (IPNB). In contrast, the remaining four tumors (17%) showed both tubular and papillary structures. In three of the four tumors (75%), macroscopic mucin secretion was limited but microscopic intracellular mucin was evident. Histologically, 16 tumors (67%) were malignant, three (12%) were borderline, and five (21%) were adenoma. Microinvasion was found in four cases (17%). Immunohistochemical analysis revealed that MUC1 was not expressed in the borderline/adenoma group but was expressed only in malignant lesions (P = 0.0095). Ki-67 labeling index (LI) was significantly higher in the malignant group than in the borderline/adenoma group (22.2 ± 15.5 vs 7.5 ± 6.3, P < 0.01). In the 16 malignant cases, expression of MUC5AC showed borderline significant association with high Ki-67 LI (P = 0.0622). Nuclear expression of β-catenin was observed in two (8%) of the 24 tumors, and these two tumors also showed MUC1 expression. P53 was negative in all tumors. CONCLUSION: Some cases of INihB have a tubular structure, and are subcategorized as IPNB with tubular structure. MUC1 expression in INihB correlates positively with degree of malignancy. | Yoshiki Naito Hironori Kusano Osamu Nakashima Eiji Sadashima Satoshi Hattori Tomoki Taira Akihiko Kawahara Yoshinobu Okabe Kazuhide Shimamatsu Jun Taguchi Seiya Momosaki Koji Irie Rin Yamaguchi Hiroshi Yokomizo Michiko Nagamine Seiji Fukuda Shinichi Sugiyama Naoyo Nishida Koichi Higaki Munehiro Yoshitomi Masafumi Yasunaga Koji Okuda Hisafumi Kinoshita Masayoshi Kage Masamichi Nakayama Makiko Yasumoto Jun Akiba Hirohisa Yano | 2012 | World Journal of Gastroenterology2012，18，28： | 16 |
| 2 | Mortalin imaging in normal and cancer cells with quantum dot immuno conjugates显示文摘Quantum dots are the nanoparticles that are recently emerging as an alternative to organic fluorescence probes in cell biology and biomedicine,and have several predictive advantages.These include their i)broad absorption spectra allowing visualization with single light source,ii)exceptional photo-stability allowing long term studies and iii)narrow and symmetrical emission spectrum that is controlled by their size and material composition.These unique properties allow simultaneous excitation of different size of quantum dots with a single excitation light source,their simultaneous resolution and visualization as different colors.At present there are only a few studies that have tested quantum dots in cellular imaging.We describe here the use of quantum dots in mortalin imaging of normal and cancer cells.Mortalin staining pattern with quantum dots in both normal and cancer cells mimicked those obtained with organic florescence probes and were considerably stable. | ZEENIA KAUL TOMOKO YAGUCHI SUNIL C KAUL TAKASHI HIRANO RENU WADHWA KAZUNARI TAIRA | 2003 | Cell Research2003，13，6： | 14 |
| 3 | Diagnostic efficacy of gadoxetic acid-enhanced MRI for hepatocellular carcinoma and dysplastic nodule显示文摘AIM:To evaluate the relationship between the signal intensity of hepatobiliary phase images on gadoxetic acid-enhanced magnetic resonance imaging(MRI)and histological grade.METHODS:Fifty-nine patients with 82 hepatocellular lesions were evaluated retrospectively.Hepatobiliary phase images on gadoxetic acid-enhanced MRI were classified into 3 groups:low,iso or high.Angiographyassisted computed tomography(CT)findings were also classified into 3 groups:CT during arterial portography,and CT hepatic arteriography:A:iso,iso or low;B:slightly low,iso or low;;and C:low,high.We correlated angiography-assisted CT,hepatobiliary phase findings during gadoxetic acid-enhanced MRI and histological grades.Furthermore,correlations between MRI findings and histological grade for each hemodynamic pattern were performed.Correlations among radiologicaland pathological findings were statistically evaluated using the chi-square test and Fisher's exact test.RESULTS:There was a significant correlation between histological grade and hemodynamic pattern(P<0.05).There was a significant correlation between histological grade and signal intensity in the hepatobiliary phase(P<0.05)in group A lesions.There was no significant correlation between histological grade and signal intensity in the hepatobiliary phase in group B or C lesions(P>0.05).CONCLUSION:Signal intensity in the hepatobiliary phase correlated with histological grade in the lesions that maintained portal blood flow,but did not correlate in lesions that showed decreased or defective portal blood flow. | Kazuhiro Saito Ryota Nishio Toru Saguchi Soichi Akata Koichi Tokuuye Fuminori Moriyasu Katsutoshi Sugimoto Junichi Taira Toshitaka Nagao | 2011 | World Journal of Gastroenterology2011，17，30： | 12 |
| 4 | Transmission of vector vortex beams in dispersive media显示文摘Scattering phenomena affect light propagation through any kind of medium from free space to biological tissues.Finding appropriate strategies to increase the robustness to scattering is the common requirement in developing both communication protocols and imaging systems.Recently,structured light has attracted attention due to its seeming scattering resistance in terms of transmissivity and spatial behavior.Moreover,correlation between optical polarization and orbital angular momentum(OAM),which characterizes the so-called vector vortex beams(VVBs)states,seems to allow for the preservation of the polarization pattern.We extend the analysis by investigating both the spatial features and the polarization structure of vectorial optical vortexes propagating in scattering media with different concentrations.Among the observed features,we find a sudden swift decrease in contrast ratio for Gaussian,OAM,and VVB modes for concentrations of the adopted scattering media exceeding 0.09%.Our analysis provides a more general and complete study on the propagation of structured light in dispersive and scattering media. | Ilaria Gianani Alessia Suprano Taira Giordani NicolòSpagnolo Fabio Sciarrino Dimitris Gorpas Vasilis Ntziachristos Katja Pinker Netanel Biton Judy Kupferman Shlomi Arnong | 2020 | Advanced Photonics2020，2，3： | 7 |
| 5 | 一种新型网膜对SARS冠状病毒的抑制作用显示文摘利用光触媒钛羟基磷灰石网膜 (PTAF)具有吸附和酶催化的特点 ,研究其对SARS病毒的抑制作用 .实验结果表明在紫外照射条件下 ,PTAF膜对SARS冠状病毒的抑制率为 10 0 % .在没有紫外照射的条件下 ,PTAF膜对SARS冠状病毒的抑制率为 99 99% ,与对照组相比 ,PTAF膜抑制病毒的效率是HAF膜的 10 0 0倍以上 .研究结果提示 ,PTAF在预防SARS冠状病毒及其他病毒性疾病流行方面有潜在的应用价值 . | 韩伟 张泮河 曹务春 杨东玲 SHIGEHARU TAIRA YOSHIO OKAMOTO JUN-ICHIRO ARAI 阎锡蕴 | 2004 | 生物化学与生物物理进展2004，31，11： | 6 |
| 6 | Neoadjuvant chemotherapy followed by surgery in gastric cancer patients with extensive lymph node metastasis显示文摘Gastric cancer with extensive lymph node metastasis(ELM) is usually considered unresectable and is associated with poor outcomes. Cases with clinical enlargement of the para-aortic lymph nodes and/or bulky lymph node enlargement around the celiac artery and its branches are generally dealt with as ELM. A standard treatment for gastric cancer with ELM has yet to be determined. Two phase Ⅱ studies of neoadjuvant chemotherapy followed by surgery showed that neoadjuvant chemotherapy with S-1 plus cisplatin followed by surgical resection with extended lymph node dissection could represent a treatment option for gastric cancer with ELM. However,many clinical questions remain unresolved,including the criteria for diagnosing ELM,optimal regime,number of courses and extent of lymph node dissection. | Seiji Ito Yuichi Ito Kazunari Misawa Yasuhiro Shimizu Taira Kinoshita | 2015 | World Journal of Clinical Oncology2015，6，6： | 4 |
| 7 | Distal pancreatectomy with resection of the celiac axis and reconstruction of the hepatic artery for carcinoma of the body and tail of the pancreas显示文摘 | Masaru Konishi Taira Kinoshita Toshio Nakagori Kazuto Inoue Tatsuya Oda Takahiro Kimata Hiroyuki Kikuchi Munemasa Ryu | 2000 | Journal of Hepato - Biliary - Pancreatic Surgery2000，，2： | 4 |
| 8 | Survival of geriatric patients after percutaneous endoscopic gastrostomy in Japan显示文摘AIM: To examine the long term survival of geriatric patients treated with percutaneous endoscopic gastrostomy (PEG) in Japan. METHODS: We retrospectively included 46 Japanese community and tertiary hospitals to investigate 931 consecutive geriatric patients (≥ 65 years old) with swallowing difficulty and newly performed PEG between Jan 1st 2005 and Dec 31st 2008. We set death as an outcome and explored the associations among patient’s characteristics at PEG using log-rank tests and Cox proportional hazard models. RESULTS: Nine hundred and thirty one patients were followed up for a median of 468 d. A total of 502 deaths were observed (mortality 53%). However, 99%, 95%, 88%, 75% and 66% of 931 patients survived more than 7, 30, 60 d, a half year and one year, respectively. In addition, 50% and 25% of the patients survived 753 and 1647 d, respectively. Eight deaths were considered as PEG-related, and were associated with lower serum albumin levels (P = 0.002). On the other hand, among 28 surviving patients (6.5%), PEG was removed. In a multivariate hazard model, older age [hazard ratio (HR), 1.02; 95% confidence interval (CI), 1.00-1.03; P = 0.009], higher C-reactive protein (HR, 1.04; 95% CI: 1.01-1.07; P = 0.005), and higher blood urea nitrogen (HR, 1.01; 95% CI: 1.00-1.02; P = 0.003) were significant poor prognostic factors, whereas higher albumin (HR, 0.67; 95% CI: 0.52-0.85; P = 0.001), female gender (HR, 0.60; 95% CI: 0.48-0.75; P < 0.001) and no previous history of ischemic heart disease (HR, 0.69; 95% CI: 0.54-0.88, P = 0.003) were markedly better prognostic factors. CONCLUSION: These results suggest that more than half of geriatric patients with PEG may survive longer than 2 years. The analysis elucidated prognostic factors. | Yutaka Suzuki Seryna Tamez Akihiko Murakami Akihiko Taira Akihiro Mizuhara Akira Horiuchi Chie Mihara Eiji Ako Hirohito Muramatsu Hitoshi Okano Hitoshi Suenaga Kazuaki Jomoto Junya Kobayashi Katsunari Takifuji Kazuhiro Akiyama Koh Tahara Koji Onishi Makoto Shimazaki Masami Matsumoto Masashi Ijima Masato Murakami Masato Nakahori Michiaki Kudo Michio Maruyama Mikako Takahashi Naohiro Washizawa Shigeru Onozawa Satoshi Goshi Satoyoshi Yamashita Shigeki Ono Shin Imazato Shinji Nishiwaki Shuichirou Kitahara Takao Endo Takao Iiri Takeshi Nagahama Takuto Hikichi Tatsuya Mikami Tetsuo Yamamoto Tetsushi Ogawa Tomoko Ogawa Tomoyuki Ohta Toshifumi Matsumoto Toshiroh Kura Tsutomu Kikuchi Tsuyoshi Iwase Tsuyotoshi Tsuji Yukio Nishiguchi Mitsuyoshi Urashima | 2010 | World Journal of Gastroenterology2010，16，40： | 4 |
| 9 | Cytomegalovirus gastritis显示文摘Cytomegalovirus(CMV)has been increasingly recognized as an important common pathogen in an immunocompromised state.The colon and stomach are the most common sites of its gastrointestinal infection. Symptoms of CMV gastritis are usually nonspecific and include epigastric pain,fever,nausea and bleeding. Endoscopic features are quite variable and include macroscopically normal mucosa,diffuse erythema, nodules,pseudotumors,erosions and ulcers.The bioptic detection of intranuclear inclusions is the hallmark of CMV infection.Most gastrointestinal CMV infection responds well to ganciclovir.We present endoscopic and histopathological features of CMV gastritis in a 71 year old woman receiving long-term prednisolone for pemphigus vulgaris. | Akira Hokama Kiyohito Taira Yu-ichi Yamamoto Nagisa Kinjo Fukunori Kinjo Kenzo Takahashi Jiro Fujita | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，11： | 4 |
| 10 | Lymph Node Metastases of Gastric Cancer: General Pattern in 1931 Patients显示文摘 | KEIICHI MARUYAMA PETER GUNVéN KENZO OKABAYASHI MITSURO SASAKO TAIRA KINOSHITA | 1989 | Annals of Surgery1989，，： | 3 |
| 11 | Phase II trial of S-1 for neoadjuvant chemotherapy against scirrhous gastric cancer (JCOG 0002)显示文摘 | Taira Kinoshita Mitsuru Sasako Takeshi Sano Hitoshi Katai Hiroshi Furukawa Akira Tsuburaya Isao Miyashiro Masahide Kaji Motoki Ninomiya | 2009 | Gastric Cancer2009，，1： | 3 |
| 12 | Left thoracoabdominal approach versus abdominal-transhiatal approach for gastric cancer of the cardia or subcardia: a randomised controlled trial显示文摘 | Mitsuru Sasako Takeshi Sano Seiichiro Yamamoto Motonori Sairenji Kuniyoshi Arai Taira Kinoshita Atsushi Nashimoto Masahiro Hiratsuka | 2006 | Lancet Oncology2006，，8： | 3 |
| 13 | VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development显示文摘 | Kukk E Lymboussaki A Taira S | | 0，，12： | 2 |
| 14 | Survival benefits of portal vein resection for pancreatic cancer显示文摘 | Toshio Nakagohri Taira Kinoshita Masaru Konishi Kazuto Inoue Shinichiro Takahashi | 2003 | The American Journal of Surgery2003，，2： | 2 |
| 15 | The leaf extract of Mallotus japonicus and its major active constituent, rutin,suppressed on melanin production in murine B16F1 melanoma显示文摘Objective: To find anti-melanogenesis materials used in whitening cosmetics.Methods: The ethanolic leaf extract of Mallotus japonicus(M. japonicus) having an anti-melanogenesis activity was separated by a sephadex LH-20 chromatography. Each fraction was measured for its tyrosinase inhibitory activity together with its polyphenol content using the Folin–Ciocalteu method. The anti-melanogenesis activity of the active fractions was determined by the melanin content in the murine B16F1 melanoma. The active fractions were put together due to similar constituents, and then separated by high performance liquid chromatography using a C-18 ODS column. The major antimelanogenesis compound was identified using1 H and13C-NMR and liquid chromatography-mass spectrometry.Results: The ethanolic leaf extract of M. japonicus showed an anti-tyrosinase activity with a high polyphenol content, resulting in suppression of melanin production in the B16F1 melanoma. The extract was separated and the active compound was identical as rutin based on the1 H,13C-NMR and liquid chromatography-mass spectrometry analysis data. In addition, the rutin treatment with cells reduced the melanin content in a concentration dependent manner without any cell toxicity. The leaf extract of M. japonicus containing rutin would be useful in whitening cosmetics for protection from UV-light exposure to be limiting the accumulation of melanin in skin.Conclusions: The leaf extract of M. japonicus and/or rutin isolated from the extract as a key whitening agent would be useful as a whitening cosmetic material for protecting against disorder skin due to melanin accumulation. | Junsei Taira Eito Tsuchida Masatsugu Uehara Natsuko Ohhama Wakana Ohmine Takayuki Ogi | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，10： | 2 |
| 16 | Residual risk of transfusion‐transmitted hepatitis B virus (HBV) infection caused by blood components derived from donors with occult HBV infection in Japan显示文摘 | Rikizo Taira Masahiro Satake Shun’ya Momose Satoru Hino Yoshiharu Suzuki Hiroyuki Murokawa Shigeharu Uchida Kenji Tadokoro | 2013 | Transfusion2013，，7： | 2 |
| 17 | 帕克菲尔德地区圣安德烈斯断层强度变化的远距离影响因素显示文摘 | Taka’aki Taira Paul G.Silver Fenglin Niu Robert M.Nadeau 左玉玲 | 2009 | 国际地震动态2009，，11： | 2 |
| 18 | Cancer-derived VEGF plays no role in malignant ascites formation in the mouse显示文摘AIM: Vascular endothelial growth factor (VEGF) is a potent mediator of peritoneal fluid accumulation following tumor progression. This study investigated the role of VEGF secreted by cancerous cells in the formation of malignant ascites.METHODS: VEGF expression was eliminated byknockdown in the pancreas cancer cell-line PancO2 using vector-based short-hairpin type RNA interference (RNAi).Malignant ascites formation in the mouse was analyzed by intraperitoneal injection of PancO2 cells expressing VEGF or with expression knockdown.RESULTS: The VEGF knockdown PancO2 cell was successfully established. Knockdown of VEGF did not affect cancer cell proliferation in vitro or in vivo. The volume of ascites following peritoneal expansion of the tumor in VEGF knockdown cells and control cells did not differ statistically in this in vivo study. Moreover, the VEGF concentration in the ascites did not differ statistically.CONCLUSION: Malignant ascites formation might be mediated by VEGF production in noncancerous tissues,such as stromal compartments. An anti-VEGF strategy against malignant ascites could be applied to various tumors regardless of whether they secrete VEGF. | Bayasi Guleng Keisuke Tateishi Fumihiko Kanai Amarsanaa Jazag Miki Ohta Yoshinari Asaoka Hideaki Ijichi Yasuo Tanaka Jun Imamura Tsuneo Ikenoue Yasushi Fukushima Keita-Morikane Makoto Miyagishi Kazunari Taira Takao Kawabe Masao Omata | 2005 | World Journal of Gastroenterology2005，11，35： | 2 |
| 19 | Effects of two vitamins, two growth factors and dexamethasone on the proliferation of rat bone marrow stromal cells and osteoblastic MC3T3-E1 cells显示文摘 | Taira M Nakao H Takahashi J | 2003 | J Oral Rehabil2003，30，7： | 2 |
| 20 | Evaluation of HER2-based biology in 1,006 cases of gastric cancer in a Japanese population显示文摘 | Masaki Aizawa Akiko K. Nagatsuma Koji Kitada Takeshi Kuwata Satoshi Fujii Taira Kinoshita Atsushi Ochiai | 2014 | Gastric Cancer2014，，1： | 2 |
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