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| 1 | Phytotoxicity of cadmium on protein, proline and antioxidant enzyme activities in growing Arachis hypogaea L. seedlings显示文摘种 Arachis hypogaea L 上的镉的植物毒性。幼苗被学习。种子暴露于 25, 50,和 100 μ m ol/L CdCl2 集中,为 10, 15, 20 和 25 d 的一个时期。叶绿素,蛋白质,脯氨酸,硝酸盐和亚硝酸根 reductase 的损坏的程度,在叶子和根的抗氧化剂酶活动在镉应力的 10 d 以后被评估。镉(100 μ m ol/L ) 的更高的集中结果(叶子和根) 总计叶绿素 91.01% ,蛋白质 79.51% , 83.61% ,硝酸盐还原酶 79.39% , 80.72% 并且亚硝酸根 reductase 77.07% , 75.88% 活动随镉集中和暴露时期的增加减少了。镉在抗氧化的酶的活动引起了重要变化。 Contrastingly , Cd 对待显示出的植物组织脯氨酸159.87%的增加,239.6%, gluthion reductase ( GR )337.72%,306.14%,超级氧化物 disumutase (草皮)688.56%,381.72%, ascorbate 过氧化物酶( APX )226.47%,252.14%,过氧化物酶(邮政部门)72.19%,60.29%并且过氧化氢酶(猫)228.96%,214.74%同样与控制相比。镉应力在植物种类的叶子和根处于草皮活动的率引起了重要增加。结果显示出庄稼 A。hypogaea 甚至在很低的镉集中是高度敏感的。 | N Dinakar P C Nagajyothi S Suresh Y Udaykiran T Damodharam | 2008 | Journal of Environmental Sciences2008，20，2： | 20 |
| 2 | Use of antibiotics in broiler production:Global impacts and alternatives显示文摘Antibiotics are used to fight bacterial infections.However, a selective pressure gave rise to bacteria resistant to antibiotics.This leaves scientists worried about the danger to human and animal health.Some strategies can be borrowed to reduce the use of antibiotics in chicken farms.Much research has been carried out to look for natural agents with similar beneficial effects of growth promoters.The aim of these alternatives is to maintain a low mortality rate, a good level of animal yield while preserving environment and consumer health.Among these, the most popular are probiotics, prebiotics, enzymes,organic acids, immunostimulants, bacteriocins, bacteriophages, phytogenic feed additives, phytoncides,nanoparticles and essential oils. | Youcef Mehdi Marie-Pierre Létourneau-Montminy Marie-Lou Gaucher Younes Chorfi Gayatri Suresh Tarek Rouissi Satinder Kaur Brar Caroline Cté Antonio Avalos Ramirez Stéphane Godbout | 2018 | Animal Nutrition2018，，2： | 19 |
| 3 | Systemic treatment strategies for triple-negative breast cancer显示文摘Triple-negative breast cancer(TNBC) is defined by the lack of immunohistochemical expression of the estrogen and progesterone receptors and human epidermal growth factor receptor 2(EGFR2). Most TNBC has a basal-like molecular phenotype by gene expression profiling and shares clinical and pathological features with hereditary BRCA1 related breast cancers. This review evaluates the activity of available chemotherapy and targeted agents in TNBC. A systematic review of PubM ed and conference databases was carried out to identify randomised clinical trials reporting outcomes in women with TNBC treated with chemotherapy and targeted agents. Our review identified TNBC studies of chemotherapy and targeted agents with different mechanisms of action, including induction of synthetic lethality and inhibition of angiogenesis, growth and survival pathways. TNBC is sensitive to taxanes and anthracyclins. Platinum agents are effective in TNBC patients with BRCA1 mutation, either alone or in combination with poly adenosine diphosphate polymerase 1 inhibitors. Combinations of ixabepilone and capecitabine have added to progression-free survival(PFS) without survival benefit in metastatic TNBC. Antiangiogenic agents, tyrosine kinase inhibitors and EGFR inhibitorsin combination with chemotherapy produced only modest gains in PFS and had little impact on survival. TNBC subgroups respond differentially to specific targeted agents. In future, the treatment needs to be tailored for a specific patient, depending on the molecular characteristics of their malignancy. TNBC being a chemosensitive entity, combination with targeted agents have not produced substantial improvements in outcomes. Appropriate patient selection with rationale combinations of targeted agents is needed for success. | Budhi Singh Yadav Suresh C Sharma Priyanka Chanana Swaty Jhamb | 2014 | World Journal of Clinical Oncology2014，5，2： | 18 |
| 4 | Homocysteine mediates transcriptional changes of the inflammatory pathway signature genes in human retinal pigment epithelial cells显示文摘AIM:To test whether homocysteine(Hcy) can influence the transcriptional profile, we hypothesized that Hcy can lead to the induction of proinflammatory molecules in the retinal cells of aging people.METHODS:An unbiased in vitro inflammatory pathway focused study was designed employing retinal pigment epithelial(RPE) cell line, ARPE-19. Cells were cultured in the presence or absence of Hcy to capture target genes' expression profile. Three different concentrations of Hcy were added in the culture medium of confluent monolayers. c RNAs were made from the isolated total RNAs and the labeled c RNA probes were hybridized to microarrays specific for human disease pathway inflammatory cytokines, chemokines and their receptor gene micro-array panels as per manufacture's recommendations. Two Hcy up-regulated molecules:IL6 and CEBPB were further validated via Western blot analysis. Hcy's effect on ARPE-19 cellular morphology and genomic DNA integrity were also evaluated.RESULTS:Gene microarray analyses of RPE cells in response to Hcy treatment revealed alterations in the expressions of several inflammatory gene transcripts such as CCL5, CEBPB, IL13RA2, IL15 RA, IL6, IL8 and CXCL3 that were up-regulated. The transcripts for C3, CCL2, IL11 RA and IL18 genes exhibited down-regulation. The IL6 and CEBPB expressions were subsequently validated at the protein levels. Treatment of the retinal cells with increasing Hcy concentration influenced their density in culture however their morphology and DNA integrity remained unaffected. CONCLUSION:These findings suggest that Hcy can potentially mediate the expression of chemokines,cytokines and interleukins receptors in the retinal cells without having any debilitating effects on their morphology and the genomic DNA integrity. | Mahavir Singh Suresh C Tyagi | 2017 | International Journal of Ophthalmology(English edition)2017，10，5： | 10 |
| 5 | Current updates on laboratory techniques for the diagnosis of male reproductive failure显示文摘导致不孕的男繁殖失败的发生,是否由于推迟的做家长,环境问题,基因因素,药,等等,在全世界正在增加。男 subfertility 的诊断和预后成为了挑战。当基本精液评价被执行许多年了时,很多研究询问传统的精液特征的价值。这是部分由于不适当的方法和标准化,为优秀保证的技术要求的有限知识,和一个精液评价能提供临床的信息的不完全的理解。当前执行精液和内分泌的评价表演伟人可变性的实验室。世界健康组织() 精液的评估的手册是在许多年在这个领域的进一步的开发帮助了的 andrology 和生育力评估的核心。这些包括精液,对精子计数的评价,活动性,活力,形态学,和精子和精液样品的功能的方面的物理外观。这些测试也由于氧化应力包括男内分泌的侧面,精液的生物化学的评估,在浆液的 antisperm 抗体的察觉,电脑辅助的精子分析(房屋) 的使用,精子 DNA 正直,和它的损坏。帮助繁殖技术(例如, IVF, ICSI ) 显示出大成功,但是是太昂贵的。与更新的技术在这块地里推进开发,广泛的火车 / 说明能改进精确性和还原剂可变性,因此维持如此的评估的质量和标准。有迫切需要标准化了训练中心并且为繁殖成功在 mens 健康的这个区域增加了了解。 | Suresh C Sikka Wayne JG Hellstrom | 2016 | Asian Journal of Andrology2016，18，3： | 9 |
| 6 | Mixed epithelial endocrine neoplasms of the colon and rectum–An evolution over time:A systematic review显示文摘BACKGROUND Mixed tumors of the colon and rectum,composed of a combination of epithelial and endocrine elements of benign and malignant potential are rare neoplasms.These can occur anywhere in the gastrointestinal tract and are often diagnosed incidentally.Though they have been a well-documented entity in the pancreas,where the exocrine-endocrine mixed tumors have been known for a while,recognition and accurate diagnosis of these tumors in the colon and rectum,to date,remains a challenge.This is further compounded by the different terminologies that have been attributed to these lesions over the years adding to increased confusion and misclassification.Therefore,dedicated literature reviews of these lesions in the colon and rectum are inconsistent and are predominantly limited to case reports and case series of limited case numbers.Though,most of these tumors are high grade and of advanced stage,intermediate and low grade lesions of these mixed tumors are also increasingly been reported.There are no established independent consensus based guidelines for the therapeutic patient management of these unique lesions.AIM To provide a comprehensive targeted literature review of these complex mixed tumors in the colon and rectum that chronicles the evolution over time with summarization of historical perspectives of terminology and to further our understanding regarding their pathogenesis including genomic landscape,clinicoradiological features,pathology,treatment,prognosis,the current status of the management of the primary lesions,their recurrences and metastases.METHODS A comprehensive review of the published English literature was conducted using the search engines PubMed,MEDLINE and GOOGLE scholar.The following search terms[“mixed tumors colon”OR mixed endocrine/neuroendocrine tumor/neoplasm/lesion colon OR adenocarcinoma and endocrine/neuroendocrine tumor colon OR mixed adenocarcinoma and endocrine/neuroendocrine carcinoma colon OR Amphicrine tumors OR Collision tumors]were used.Eligibility criteria were defined and all potential relevant items,including full articles and/or abstracts were independently reviewed,assessed and agreed upon items were selected for in-depth analysis.RESULTS In total 237 full articles/abstracts documents were considered for eligibility of which 45 articles were illegible resulting in a total of 192 articles that were assessed for eligibility of which 139 have been selected for reference in this current review.This seminal manuscript is a one stop article that provides a detailed outlook on the evolution over time with summarization of historical perspectives,nomenclature,clinicoradiological features,pathology,treatment,prognosis and the current status of the management of both the primary lesions,their recurrences and metastases.Gaps in knowledge have also been identified and discussed.An important outcome of this manuscript is the justified proposal for a new,simple,clinically relevant,non-ambiguous terminology for these lesions to be referred to as mixed epithelial endocrine neoplasms(MEENs).CONCLUSION MEEN of the colon and rectum are poorly understood rare entities that encompass an extensive range of heterogeneous tumors with a wide variety of combinations leading to tumors of high,intermediate or low grade malignant potential.This proposed new revised terminology of MEEN will solve the biggest hurdle of confusion and misclassification that plagues these rare unique colorectal neoplasms thus facilitating the future design of multi institutional prospective randomized controlled clinical trials to develop and evaluate newer therapeutic strategies that are recommended for continued improved understanding and personal optimization of clinical management of these unique colorectal neoplasms. | Rani Kanthan Suresh Tharmaradinam Tehmina Asif Shahid Ahmed Selliah C Kanthan | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 7 | Carcinogenic Helicobacter pylori in gastric pre-cancer and cancer lesions: Association with tobacco-chewing显示文摘AIM:To investigate the low gastric cancer incidence rate relative to the highly prevalent Helicobacter pylori(H.pylori)infection;data relevant to H.pylori infection during gastric carcinogenesis in Indian patients is currently lacking.METHODS:The present study examines the prevalence of H.pylori infection in DNA derived from 156endoscopic gastric biopsies of different disease groups that represent gastric pre-cancer[intestinal metaplasia(n=15),dysplasia(n=15)],cancer[diffuse adenocarcinoma(n=44),intestinal adenocarcinoma(n=21)],and symptomatic but histopathologically-normal controls(n=61).This was done by generic ureC polymerase chain reaction(PCR)and cagA-specific PCR that could specifically identify the carcinogenic H.pylori strain.RESULTS:Our analysis showed the presence of H.pylori infection in 61%of symptomatic histopathologically-normal individuals,however only 34%of control tissues were harboring the cagA+H.pylori strain.A similar proportion of H.pylori infection(52%)and cagA(26%)positivity was observed in the tumor tissue of the gastric cancer group.In comparison,H.pylori infection(90%)and cagA positivity(73%)were the highest in gastric pre-cancer lesions.In relation to tobacco and alcohol abuse,H.pylori infection showed an association with tobacco chewing,whereas we did not observe any association between tobacco smoking or alcohol abuse with prevalence of H.pylori infection in the tissue of any of the patient groups studied.CONCLUSION:High incidence of H.pylori infection and carcinogenic cagA positive strain in pre-cancer lesions during gastric carcinogenesis may be | Arvind Pandey Satyendra Chandra Tripathi Sutapa Mahata Kanchan Vishnoi Shirish Shukla Sri Prakash Misra Vatsala Misra Suresh Hedau Ravi Mehrotra Manisha DwivediZ Alok C Bharti | 2014 | World Journal of Gastroenterology2014，20，22： | 4 |
| 8 | A hypothesis for treating inflammation and oxidative stress with hydrogen sulfide during age-related macular degeneration显示文摘Age-related macular degeneration(AMD) is a leading cause of blindness and is becoming a global crisis since affected people will increase to 288 million by 2040.Genetics,age,diabetes,gender,obesity,hypertension,race,hyperopia,iris-color,smoking,sun-light and pyroptosis have varying roles in AMD,but oxidative stress-induced inflammation remains a significant driver of pathobiology.Eye is a unique organ as it contains a remarkable oxygengradient that generates reactive oxygen species(ROS) which upregulates inflammatory pathways.ROS becomes a source of functional and morphological impairments in retinal pigment epithelium(RPE),endothelial cells and retinal ganglion cells.Reports demonstrated that hydrogen sulfide(H_2S) acts as a signaling molecule and that it may treat ailments.Therefore,we propose a novel hypothesis that H_2S may restore homeostasis in the eyes thereby reducing damage caused by oxidative injury and inflammation.Since H_2S has been shown to be a powerful antioxidant because of its free-radicals' inhibition properties in addition to its beneficial effects in age-relatedconditions,therefore,patients may benefit from H_2S salubrious effects not only by minimizing their oxidant and inflammatory injuries to retina but also by lowering retinal glutamate excitotoxicity. | Akash K George Mahavir Singh Rubens Petit Homme Avisek Majumder Harpal S SANDhu Suresh C Tyagi | 2018 | International Journal of Ophthalmology(English edition)2018，11，5： | 3 |
| 9 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 10 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 11 | 印度农业推广改革现状:战略重点和政策选择显示文摘独立以来,虽然印度农业推广经历了翻天覆地的变化,但是小农农民和其他弱势群体仍未参与到公共推广体系之中。许多组织性能问题妨碍了公共推广体系的效率和效果。这些问题包括人员的匮乏,较低的合作伙伴关系以及继续自上而下的线性推广方式。本文回顾了印度农业推广改革的现状,并基于比哈尔、喜马偕尔邦、马哈拉施特拉邦和泰米尔纳德邦等4个邦的实地调研,分析并进一步细化了当前的改革进程,在此基础上,提出了促进农业公共推广体系有序发展和运行的优先政策和战略选择。 | Suresh C Babu P K Joshi Claire J.Glendenning Kwadwo Asenso-Okyere Rasheed Sulaiman V 蔡彦虹(翻译) | 2017 | 世界农业2017，，7： | 2 |
| 12 | Genes and genetics in eye diseases: a genomic medicine approach for investigating hereditary and inflammatory ocular disorders显示文摘Past 25 y have witnessed an exponential increase in knowledge and understanding of ocular diseases and their respective genetic underpinnings. As a result, scientists have mapped many genes and their variants that can influence vision and health of our eyes. Based on these findings, it is becoming clear that an early diagnosis employing genetic testing can help evaluate patients' conditions for instituting treatment plan(s) and follow-up care to avoid vision complications later. For example, knowing family history becomes crucial for inherited eye diseases as it can benefit members in family who may have similar eye diseases or predispositions. Therefore, gathering information from an elaborate examination along with complete assessment of past medical illness by ophthalmologists followed by consultation with geneticists can help create a roadmap for making diagnosis and treatment precise and beneficial. In this review, we present an update on ocular genomic medicine that we believe has tremendous potential towards unraveling genetic implications in ocular diseases and patients' susceptibilities. We also discuss translational aspects of genetic ophthalmology and genome engineering that may help advance molecular diagnostics and therapeutics. | Mahavir Singh Suresh C Tyagi | 2018 | International Journal of Ophthalmology(English edition)2018，11，1： | 2 |
| 13 | Collagen network of the myocardium: function ,structural remodeling and regulatory mechanisms显示文摘 | Weber KT Sun Y Suresh C | 1994 | J Mol Cell Cardiol1994，26，3： | 1 |
| 14 | Anatase to rurile transformation in sol-gel titania by modification of precursor 显示文摘 | Suresh C Biju V Mukundan P | 1998 | Polyhedron1998，17，18： | 1 |
| 15 | Protective effect of 17-beta-estradiol in human neurocellular models of lead exposure显示文摘 | Chetty CS Vemuri MC Suresh C | 2007 | Neurotoxicology2007，28，： | 1 |
| 16 | The impact of pricing policy on sales variability in a supermarket retail context 显示文摘 | Hamister J W Suresh N C | 2008 | International Journal of Production Economics2008，111，2： | 1 |
| 17 | Effect of stocking density on water quality and production of red tilapia in a recirculated water system 显示文摘 | Suresh A V Lin C K | 1992 | Aquae Engineering1992，，11： | 1 |
| 18 | Role of monocyte chemoattractant protein-1(MCP-1/CCL2)in migration of neural progenitor cells toward glial tumors显示文摘 | Suresh N M Saafan Z M Nicolas C R | 2009 | J Neuro Res2009，87，7： | 1 |
| 19 | A dynamic lot sizing problem with multiple customers: customer-specific shipping and backlogging costs 显示文摘 | Suresh C Hsu V N Sethi S Deshpande V | 2007 | IIE Transactions2007，39，： | 1 |
| 20 | Phase transformation in sol-gel titania containing silica显示文摘 | Kumar S R Suresh C Vasudevan A K | 1999 | Materials Letters1999，38，3： | 1 |
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