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| 1 | Helicobacter pylori eradication to prevent gastric cancer: underlying molecular and cellular mechanisms显示文摘众多的细胞、分子的事件在胃的癌症的开发被描述了。在这篇文章,我们 Helicobacter pylori (H pylori ) 的 overviewed 角色一些在胃的致癌作用的重要事件上的感染并且讨论了这些细胞、分子的事件是否在感染的痊愈以后是可逆的。有几个细菌的部件,影响胃的致癌作用的胃的上皮的动力学和提升。细菌也增加基因不稳定性和变化的风险由于没有并且另外的反应的氧种类。肿瘤的渐成说 silencing 压制或象 RUNX3 那样的基因可以与肠的组织变形改变那些的胃腺的显型变化的频率。象生长因素, cytokines 和 COX-2 的增加的表示那样的主机因素也在 H pylori 积极的题目在非癌的织物被报导了。大多数上述现象在感染的痊愈以后被颠倒,是引人注目的。然而,他们的一些包括在 COX-2 的表示上继续存在并且可以为致癌作用增加风险在甚至在成功的 H pylori 根除以后遇见了无形或发育异常的的粘膜。因此, H pylori 根除不能完全为胃的致癌作用废除风险。胃的癌症取决于预定和目标人口的在压制的感染的痊愈的效率,和保证推进调查。 | Shingo Tsuji Masahiko Tsujii Hiroaki Murata Tsutomu Nishida Masato Komori Masakazu Yasumaru Shuji Ishii Yoshiaki Sasayama Sunao Kawano Norio Hayashi | 2006 | World Journal of Gastroenterology2006，12，11： | 7 |
| 2 | gastrointestinal symptom prevalence depends on disease duration and gastrointestinal region in type 2 diabetes mellitus显示文摘AIM To unravel relationships between gastrointestinal(GI)symptoms impairing quality of life(QOL)and clinical profiles of diabetes mellitus(DM)patients. METHODS We enrolled 134 outpatients with type 2 DM.Mean age was 64.7 years,mean body mass index was 24.7 RESULTS Lower abdominal symptoms were found to be more frequent than those affecting the upper abdomen.Diabetic duration and medications showed associations with GI symptoms.We identified differences in peak prevalences of the five symptoms.Gastralgia(P=0.02vs 10-14 years)and total GI symptoms(P=0.01 and P=0.02 vs 5-9 years and 10-14 years,respectively)peaked at a diabetes duration of 15-19 years.Heartburn(P=0.004)and postprandial fullness(P=0.03)tended to increase with disease duration.Constipation and diarrhea showed bimodal peaks,with the first early and the second late(e.g.,P=0.03 at 15-19 years vs 10-14years for diarrhea)in the disease course.Finally,GI symptoms showed clustering that reflected the region of the GI tract affected,i.e.,constipation and diarrhea had similar frequencies(P<0.0001). CONCLUSION Our study highlights the importance of questioning patients about QOL impairment due to abdominal symptoms,especially in the early and the late periods of diabetes. | Midori Fujishiro Akifumi Kushiyama Hiroki Yamazaki Sunao Kaneko Yuko Koketsu Takeshi Yamamotoya Takako Kikuchi Hideyuki Sakoda Ryo Suzuki Takashi Kadowaki | 2017 | World Journal of Gastroenterology2017，23，36： | 4 |
| 3 | CagA mediates epigenetic regulation to attenuate let-7 expression in Helicobacter pylori-related carcinogenesis显示文摘 | Yoshito Hayashi Masahiko Tsujii Jun Wang Jumpei Kondo Tomofumi Akasaka Ying Jin Wei Li Toru Nakamura Tsutomu Nishida Hideki Iijima Shingo Tsuji Sunao Kawano Norio Hayashi Tetsuo Takehara | 2013 | Gut2013，，11： | 2 |
| 4 | Positive End-Expiratory Pressure Ventilation Decreases Plasma Atrial and Brain Natriuretic Peptide Levels in Humans显示文摘 | Gotaro Shirakami Tatsuo Magaribuchi Koh Shingu Shin-ichi Suga Sunao Tamai Kazuwa Nakao Kenjiro Mori | 1993 | Anesthesia & Analgesia1993，，6： | 1 |
| 5 | Development of a Multiplex PCR-based rapid typing method for enterohemorrhagic Escherichia coli O157 Strainss显示文摘 | Tadasuke O Sunao I Tetsuya H | 2009 | Journal of Clinical Microbiology2009，47，9： | 1 |
| 6 | Investigations on Determining Thermal Stress in Massive Concrete Structures显示文摘 | Tohru Kawaguchi and Sunao Nakane | 1996 | ACI1996，，1： | 1 |
| 7 | Association between inst - ability of carotid plaque and coronary plaque assessed by echogenicity using integrated backscatter and virtual histology显示文摘 | Yoko H Seigo S Sunao K | 2010 | Jpn J Med Ultrasonics2010，37，4： | 1 |
| 8 | Helicobacter Pylori Infection Induces Candidate Stem Cell Marker Musashi-1 in the Human Gastric Epithelium显示文摘 | Hiroaki Murata Shingo Tsuji Masahiko Tsujii Toru Nakamura Hai Ying Fu Hiroshi Eguchi Kayoko Asahi Hideyuki Okano Sunao Kawano Norio Hayashi | 2008 | Digestive Diseases and Sciences2008，，2： | 1 |
| 9 | Development and operating status of'1500℃ class' gas turbine显示文摘 | SUNAO U MASAHIKO M YOSHIAKI T | 1998 | Mitsubishi Heavy Industries Technical Review1998，35，3： | 1 |
| 10 | Cyclooxygenase-2 overexpression enhances lymphatic invasion and metastasis in human gastric carcinoma显示文摘 | Hiroaki M Sunao K Shirgo T | 1999 | Gastroenterol1999，94，： | 1 |
| 11 | Plasma adiponectin levels are associated with coronary lesion complexity in men with coronary artery disease 显示文摘 | Fumiyuki Otsuka Seigo Sugiyama Sunao Kojima | 2006 | J Am Coll Cardiol2006，48，6： | 1 |
| 12 | Cyclooxygenase-2 overexpression enhances lymphatic invasion and metastasis in human gastric carcinoma显示文摘 | Hiroaki Murata Sunao Kawano Shingo Tsuji | 1999 | Am J Gastro1999，94，2： | 1 |
| 13 | Responses of Plasma Adrenocorticotropic Hormone, Cortisol, and Cytokines during and after Upper Abdominal Surgery显示文摘 | Yoshiyuki Naito Sunao Tamai Koh Shingu Kazuo Shindo Teruo Matsui Hajime Segawa Yoshikatsu Nakai Kenjiro Mori | 1992 | Anesthesiology1992，，3： | 1 |
| 14 | Treatment of partial sei- zures with gabapentin : Double-blind, placebo-controlled, parallel- group study 显示文摘 | Toshio Y Sunao K Kazuichi Yagi | 2006 | Psychiatry and Clinical Neurosciences2006，60，： | 1 |
| 15 | Beta-catenin mutations are frequent in calcifying odontogenic cysts, but rare in ameloblastomas显示文摘 | Shigeki S Sunao S Takashi T | 2003 | Am J Pathol2003，163，： | 1 |
| 16 | Levels of the adipocyte-derivedplasma protein, adiponectin, have a close relation-ship with theroma显示文摘 | Sunao K Tohru F Hidetomo M | 2005 | Thrombosis Research2005，115，6： | 1 |
| 17 | Investigations on determining thermal stress in massive concrete structures 显示文摘 | TOHRU K SUNAO N | 1996 | ACI1996，93，1： | 1 |
| 18 | Production of nitric monoxide using pulsed arc discharge显示文摘 | Takao Namihira Sunao Katsuki reuben hackam | 2002 | IEEE Trans Plasma Sci2002，30，5： | 1 |
| 19 | Investigation on de- termining thermal stress in massive concrete structures显示文摘 | KAWAGUCHI TOHRU NAKANE SUNAO | 1996 | ACI1996，92，2： | 1 |
| 20 | Responses of plasma adrenocorticotropic hormone,cortisol and cytokines during and after upper abdoninal surgery显示文摘 | Naito Y Sunao T Shingu K | 1992 | Anesthesiology1992，77，： | 1 |
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