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| 1 | 葛根素和大豆甙元抑制^3H-氟硝西泮和体外大鼠脑膜的结合显示文摘目的从中药葛根中提取脑内苯并二氮杂卓(BZ)受体活性化合物。方法用体外的放射配体-受体结合法(RRA)和高压液相法(HPLC)提取、分离、纯化BZ受体活性化合物,用核磁共振和质谱仪确定活性化合物的结构。后用GABA比和Scatchardplot分析确定它们的作用特性。结果从葛根中提取、分离到葛根素和大豆甙元2种活性化合物。它们在体外可抑制3H-氟硝西泮和脑细胞膜的结合,IC50值分别为(18.46±2.34)μmol/L和(15.4±31.89)μmol/L。大豆甙元还可抑制3H-呱唑嗪和α1-肾上腺素受体的结合(IC50值为89μmol/L)。2种化合物的GABA比分别为1.11和1.12,提示2种黄酮化合物是BZ受体的拮抗剂或部分激动剂。Scatchardplot分析显示2种化合物对3H-氟硝西泮和脑膜结合的抑制是通过竞争性与非竞争性混合机制而实现的。结论葛根素和大豆甙元是脑内BZ受体的拮抗剂或部分激动剂。它们的抑制作用是通过竞争性与非竞争性混合机制而实现的。 | 沈行良 Witt MR Nielsen M Sterner O | 2004 | 海南医学院学报2004，10，3： | 3 |
| 2 | Oxygenated Sesquiterpenoids from a Nonpoisonous Sardinian Chemotype of Giant fennel (ferula communis) 显示文摘 | Appendino G Cravotto F Sterner O | 2001 | J Nat Prod2001，64，： | 1 |
| 3 | Comparison of the antimicrobial and cytotoxic activities of twenty unsaturated sesquiterpene dialdehydes from plants and mushrooms 显示文摘 | Anke H Sterner O | 1991 | Planta Med1991，57，4： | 1 |
| 4 | New metabolites with nematicidal and antimicrobial activities from the ascomycete Lachnum papyraceum (KARST) KARST Ⅶ: Structural determination of brominated lachnumon and mycorrhizin显示文摘 | Stadler M Anke H Sterner O | 1995 | Journal of Antibioicst1995，48，： | 1 |
| 5 | Diel mineralization patterns of standing-dead plant litter: implications for CO2 flux from wetlands显示文摘 | KUEHN K A STERNER D GESSNER M O | 2004 | Ecology2004，85，9： | 1 |
| 6 | Furanosesquiterpenes from Commiphora sphaerocarpa and related adulterants of true myrrh显示文摘 | Dekebo A Dagne E Sterner O | 2002 | Fitoterapia2002，73，1： | 1 |
| 7 | Characterisation of the differential interference effects of two arboreal dwarf shrub species显示文摘 | Nilsson M C Zackrosson O Sterner O | 2000 | Oecologia2000，123，： | 1 |
| 8 | Cibaric acid, a new fatty acid derivative formed enzymically in damaged fruit bodies of Cantharellus cibarius (Chanterelle) 显示文摘 | PangZJ Sterner O 1991 | 1991 | J Org Chem1991，56，： | 1 |
| 9 | Inhibition of NF-kappa B activation by panepoxydone显示文摘 | Erkel G Anke T Sterner O | | 0，，01： | 1 |
| 10 | Zopfiellamides A and B,antimicrobial pyrrolidinone derivatives from the marine fungus Zopfiella latipes 显示文摘 | Daferner M Anke T Sterner O | 2002 | Tetrahedron2002，58，： | 1 |
| 11 | Mariannaepyrone-a new inhibitor of thromboxane A2 induced platelet aggregation显示文摘 | Fabian K Anke T Sterner O | 2001 | ZNaturforsch2001，56，12： | 1 |
| 12 | Novel natural vanilloid receptor agonists:new therapeutic targets for drug development显示文摘 | STERNER O SZALLASI A | 1999 | Trends Pharmacol Sci1999，20，11： | 1 |
| 13 | Dermatolactone,a cytotoxic fungal sesquiterpene with a novel skeleton显示文摘 | Mayer A Anke H Sterner O 1996 | 1996 | Phytochemistry1996，43，2： | 1 |
| 14 | Linoleic acid--the nematicidal principle of several nematophagous fungi and its production in trap-forming submerged cultures显示文摘 | Stadler M Anke H Sterner O | 1993 | Arch Microbiol1993，160，： | 1 |
| 15 | Improvement of peritoneal ultrafiltration with peritoneal dialysis solution buffered with bicarbonate/lactate mixture 显示文摘 | Simonsen O Sterner G Carlsson O | 2006 | Petit Dial Int2006，26，3： | 1 |
| 16 | Heptemerones A-G,sevennovel diterp-enoids from Coprinus heptemerus:producing organism,fermentation,isolation and biological activities显示文摘 | Kettering M Valdivia C Sterner O | 2005 | J Antibiot(Tokyo)2005，58，6： | 1 |
| 17 | Secondary metabolites from a Gloeophyllum species显示文摘 | Rasser F Anke T Sterner O | 2000 | Phytochemistry2000，54，5： | 1 |
| 18 | The sesquiterpene of Lactarius vellereus and their role in a proposed chemical defense system 显示文摘 | Sterner O Bergman R Kihlberg J | 1985 | J Nat Prod1985，48，： | 1 |
| 19 | Collinone, a new recombinant angular polyketide antibioticmade by an engineered Streptomyces strain 显示文摘 | Martin R Sterner O Aivarez MA | 2001 | Antibiot2001，54，： | 1 |
| 20 | Collinone, a new re- combinant angular polyketide antibiotic made by an engineered Streptomyces strain显示文摘 | Martin R Sterner O Alvarez MA | 2001 | JAntibiot (Tokyo)2001，54，3： | 1 |
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