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| 1 | Fiber-shaped organic electrochemical transistors for biochemical detections with high sensitivity and stability显示文摘Precise and continuous monitoring of biochemicals by biosensors assists to understand physiological functions for various diagnostics and therapeutic applications.For implanted biosensors,small size and flexibility are essential for minimizing tissue damage and achieving accurate detection.However,the active surface area of sensor decreases as the sensor becomes smaller,which will increase the impedance and decrease the signal to noise ratio,resulting in a poor detection limit.Taking advantages of local amplification effect,organic electrochemical transistors(OECTs)constitute promising candidates for high-sensitive monitoring.However,their detections in deep tissues are rarely reported.Herein,we report a family of implantable,fiber-shaped all-in-one OECTs based on carbon nanotube fibers for versatile biochemical detection including H2O2,glucose,dopamine and glutamate.These fiber-shaped OECTs demonstrated high sensitivity,dynamical stability in physiological environment and antiinterference capability.After implantation in mouse brain,7-day dopamine monitoring in vivo was realized for the first time.These fiber-shaped OECTs could be great additions to the'life science'tool box and represent promising avenue for biomedical monitoring. | Xiaoying Wu Jianyou Feng Jue Deng Zhichang Cui Liyuan Wang Songlin Xie Chuanrui Chen Chengqiang Tang Zhengqi Han Hongbo Yu Xuemei Sun Huisheng Peng | 2020 | Science China Chemistry2020，63，9： | 3 |
| 2 | Isolation of femalespecific AFLP markers and molecular identification of genetic sex in half-smooth tongue sole (Cynoglossus semilaevis) 显示文摘 | Chen Songlin Li Jing Deng Siping | 2007 | Mar Biotechnol2007，9，2： | 1 |
| 3 | Hierarchically wood-derived integrated electrode with tunable superhydrophilic/superaerophobic surface for efficient urea electrolysis显示文摘Conferring surfaces with superhydrophilic/superaerophobic characteristics is desirable for synthesizing efficient gas reaction catalysts.However,complicated procedures,high costs,and poor interfaces hinder commercialization.Here,an integrated electrode with tunable wettability derived from a hierarchically porous wood scaffold was well designed for urea oxidation reaction(UOR).Interestingly,the outer surface of the wood lumen was optimized to the preferred wettability via stoichiometry to promote electrolyte permeation and gas escape.This catalyst exhibits outstanding activity and durability for UOR in alkaline media,requiring only a potential of 1.36 V(vs.RHE)to deliver 10 m A cm^(-2)and maintain its activity without significant decay for 60 h.These experiments and theoretical calculations demonstrate that the nickel(oxy)hydroxide layer formed through surface reconstruction of nickel nanoparticles improves the active sites and intrinsic activity.Moreover,the superwetting properties of the electrode promote mass transfer by guaranteeing substantial contact with the electrolyte and accelerating the separation of gaseous products during electrocatalysis.These findings provide the understanding needed to manipulate the surface wettability through rational design and fabrication of efficient electrocatalysts for gas-evolving processes. | Yu Liao Songlin Deng Yan Qing Han Xu Cuihua Tian Yiqiang Wu | 2023 | Journal of Energy Chemistry2023，，1： | 1 |
| 4 | Solid-phase photocatalytic degradation of polystyrene with modified nano-TiO 2 catalyst显示文摘 | Ling Zan Songlin Wang Wenjun Fa Yanhe Hu Lihong Tian Kejian Deng | 2006 | Polymer2006，，24： | 1 |
| 5 | Efficient purification of cell culture-derived classical swine fever virus by ultrafiltration and size-exclusion chromatography显示文摘Large-scale production of cell culture-based classical swine fever virus(CSFV)vaccine is hampered by the adverse reactions caused by contaminants from host cell and culture medium.Hence,we have developed an efficient method for purifying CSFV from cell-culture medium.Pure viral particles were obtained with two steps of tangential-flow filtration(TFF)and size-exclusion chromatography(SEC),and were compared with particles from ultracentrifugation by transmission electron microscopy(TEM),infectivity and recovery test,and real time fluorescent quantitative PCR(FQ-PCR).TFF concentrated the virus particles effectively with a retention rate of 98.5%,and 86.2%of viral particles were obtained from the ultrafiltration retentate through a Sepharose 4 F F column on a biological liquid chromatography system.CSFV purified by TFF-SEC or ultracentrifugation were both biologically active from 1.0×10–4.25 TCID50·mL^(–1) to 3.0×10^(–6.25) TCID50·mL^(–1),but the combination of TFF and SEC produced more pure virus particles than by ultracentrifugation alone.In addition,pure CSFV particles with the expected diameter of 40–60 nm were roughly spherical without any visible contamination.Mice immunized with CSFV purified by TFF-SEC produced higher antibody levels compared with immunization with ultracentrifugation-purified CSFV(P<0.05).The purification procedures in this study are reliable technically and feasible for purification of large volumes of viruses. | Ruining WANG Yubao ZHI Junqing GUO Qingmei LI Li WANG Jifei YANG Qianyue JIN Yinbiao WANG Yanyan YANG Guangxu XING Songlin QIAO Mengmeng ZHAO Ruiguang DENG Gaiping ZHANG | 2015 | Frontiers of Agricultural Science and Engineering2015，2，3： | 1 |
| 6 | Crustal P-and S-Wave Velocity Structure of the North China Craton at 36°N from Active-Source Seismic Data and Its Tectonic Implications显示文摘We present crustal models for seismic P-waves(Vp),S-waves(Vs)and the Vp/Vs ratio across the southern North China Craton along latitude 36°N.Our results are based on inverse and forward modeling of long-range wide-angle reflection/refraction data.The crust of the southern Ordos Block has high lower crustal velocity(7.0 km/s)and a Moho depth of~42 km.In contrast,thick sediments and a lower average velocity(compared with the Ordos block)found underneath the Shanxi Graben are likely to be the products of rifting that has occurred since the Cenozoic.Steep Moho dips,exposed basement rock and higher average crustal velocity beneath the Lüliang Mountain and the Taihang Mountain are characteristic of an orogenic belt.The Tanlu fault and the Liaocheng-Lankao fault show sharp crustal velocity variations and a Moho offset.This seismic profile sampled the entire region of the Eastern North China Craton where the cratonic root has been destroyed and the unique crustal structure is correlated with the substantially modified lithosphere.Our crustal seismic velocity model shows a strong correspondence between surface geology,local tectonics and the deep crustal structure. | Xiaofeng Tian Walter DMooney Xiaoguo Deng Songlin Li Baofeng Liu Hanqi Liu | 2022 | Journal of Earth Science2022，33，3： | 0 |
| 7 | Advancing drug delivery to articular cartilage:From single to multiple strategies显示文摘Articular cartilage(AC) injuries often lead to cartilage degeneration and may ultimately result in osteoarthritis(OA) due to the limited self-repair ability. To date, numerous intra-articular delivery systems carrying various therapeutic agents have been developed to improve therapeutic localization and retention, optimize controlled drug release profiles and target different pathological processes. Due to the complex and multifactorial characteristics of cartilage injury pathology and heterogeneity of the cartilage structure deposited within a dense matrix, delivery systems loaded with a single therapeutic agent are hindered from reaching multiple targets in a spatiotemporal matched manner and thus fail to mimic the natural processes of biosynthesis, compromising the goal of full cartilage regeneration. Emerging evidence highlights the importance of sequential delivery strategies targeting multiple pathological processes. In this review, we first summarize the current status and progress achieved in single-drug delivery strategies for the treatment of AC diseases. Subsequently, we focus mainly on advances in multiple drug delivery applications, including sequential release formulations targeting various pathological processes, synergistic targeting of the same pathological process, the spatial distribution in multiple tissues, and heterogeneous regeneration. We hope that this review will inspire the rational design of intraarticular drug delivery systems(DDSs) in the future. | Tianyuan Zhao Xu Li Hao Li Haoyuan Deng Jianwei Li Zhen Yang Songlin He Shuangpeng Jiang Xiang Sui Quanyi Guo Shuyun Liu | 2023 | Acta Pharmaceutica Sinica B2023，13，10： | 0 |
| 8 | Polypyrrole reinforced ZIF-67 with modulated facet exposure and billion-fold electrical conductivity enhancement towards robust photocatalytic CO_(2) reduction显示文摘The implementation of metal organic frameworks(MOFs) as the co-catalysts in hybrid photocatalytic systems puts requirements on both their charge-carrying capability and solvent stability. In the current study, in order to simultaneously promote the electrical conductivity and water stability of ZIF-67, an insitu monomer trapping strategy is deployed to synthesize polypyrrole(PPy)-reinforced ZIF-67 ensembles.Through coordination modulation, the incremental addition of pyrrole monomers enables to alter the crystal morphology of ZIF-67 from rhombic dodecahedra to truncated rhombic dodecahedra, and further to cubes. Upon polymerization, the resulted composite, in comparison to ZIF-67, demonstrates a billionfold conductivity enhancement, much improved chemical stability in pronated solvents, as well as largely retained specific surface area and porosity, enabling it functioning as an outstanding co-catalyst for catalyzing robust photocatalytic CO_(2) reduction. Furthermore, a PPy-mediated electron harvest and relay mechanism is proposed for rationalizing the enhanced photocatalytic performance. | Xuzhou Yuan Qiaoqiao Mu Songlin Xue Yanhui Su Yanlei Zhu Hao Sun Zhao Deng Yang Peng | 2021 | Journal of Energy Chemistry2021，30，9： | 0 |
| 9 | In Vitro Antibacterial Effect of Effective Microorganisms( EM) on Aeromonas hydrophila显示文摘In order to understand in vitro antibacterial effect of antibiotics and EM on Aeromonas hydrophila,14 isolates of A. hydrophila were isolated from diseased fish and aquaculture in the study. PCR amplification results of aerolysin gene( Aero gene) of isolates indicated that 7 out of 14 isolates were pathogenic A.hydrophila. In vitro antibacterial test indicated that 14 isolates were resistance to penicillin G,ampicillin,cephradine,cefazolin,tetracycline,terimethoprim,lincomycin and cephalexin,but showed high sensitivity to cefotaxime and furazolidone. In vitro antibacterial effect of EM on 14 isolates of A. hydrophila was positively correlated with concentration,and EM with the concentration greater than 60% had antibacterial effect on 14 isolates. | Zhu Zhixiu He Houjun Zhang Wenbo Wu Xiangdong Wan Gen Deng Shunzhou Liu Songlin | 2014 | Animal Husbandry and Feed Science2014，6，2： | 0 |
| 10 | Effects of seagrass leaf litter decomposition on sediment organic carbon composition and the key transformation processes显示文摘Seagrass leaf litters are an important source of sediment organic carbon(SOC). However, the mechanisms of seagrass leaf litter decomposition influencing SOC composition and the key transformation processes remain unknown. We performed a laboratory chamber experiment to compare the labile organic carbon(OC) composition and the enzyme activities governing SOC transformation between the seagrass group(seagrass leaf litter addition) and the control group. The results showed that the seagrass leaf litter decomposition significantly elevated the salt-extractable carbon(SEC) content and the SEC/SOC. Additionally,the levels of invertase, polyphenol oxidase, and cellulase in the seagrass leaf litters addition group were generally higher than in the control group, which could elevate recalcitrant OC decomposition. Following 24 days incubation, addition of seagrass leaf litter increased the amount of CO_2 released, but decreased the SOC content. Therefore, seagrass leaf litter decomposition leached abundant dissolved OC, which enhanced the activity and transformation of SOC. | LIU SongLin JIANG ZhiJian DENG YiQin WU YunChao ZHAO ChunYu ZHANG JingPing SHEN Yuan HUANG XiaoPing | 2017 | Science China Earth Sciences2017，60，12： | 0 |
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