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| 1 | Differences in lithospheric structures between two sides of Taihang Mountain obtained from the Zhucheng-Yichuan deep seismic sounding profile显示文摘A 2-D model of lithospheric velocity structures in the southern part of the North China Craton was obtained using data from the Zhucheng-Yichuan deep seismic sounding profile.Results show that there are great differences in lithospheric structures between two sides of Taihang Mountain.In the eastern region,the lithosphere is thinner,with a thickness of about 70-80 km,while in the western region,the thickness is 85-120 km.There is a jump of the lithospheric thickness across Taihang Mountain gravity anomaly belt with a magnitude of about 30 km.P wave velocities of the lithospheric mantle and lower crust are lower in the eastern region and higher in the western region.In the eastern region,there are low velocity bodies in the middle and lower crust,while none were found in the western region.These differences indicate that the Taihang Mountain gravity anomaly belt is a belt with a abrupt change of lithospheric thickness and lithological composition.According to the Pm waveform,it can be deduced that the Moho in the eastern region is not a sharp discontinuity,but a complex transitional zone.From a preliminary analysis,it is found that the geothermal mechanical-chemical erosion could be the main mechanism causing the thinning and destruction of the lithosphere beneath the eastern side of Taihang Mountain.In addition,subduction of the Pacific Plate is an important factor which changes the properties of the lithospheric mantle of the North China Craton. | LI SongLin LAI XiaoLing LIU BaoFeng WANG ZhiSuo HE JiaYong SUN Yi | 2011 | Science China Earth Sciences2011，54，6： | 27 |
| 2 | Circular RNA circStag1 promotes bone regeneration by interacting with HuR显示文摘Postmenopausal osteoporosis is a common bone metabolic disorder characterized by deterioration of the bone microarchitecture,leading to an increased risk of fractures.Recently,circular RNAs(circ RNAs)have been demonstrated to play pivotal roles in regulating bone metabolism.However,the underlying functions of circ RNAs in bone metabolism in postmenopausal osteoporosis remain obscure.Here,we report that circ Stag1 is a critical osteoporosis-related circ RNA that shows significantly downregulated expression in osteoporotic bone marrow mesenchymal stem cells(BMSCs)and clinical bone tissue samples from patients with osteoporosis.Overexpression of circ Stag1 significantly promoted the osteogenic capability of BMSCs.Mechanistically,we found that circ Stag1 interacts with human antigen R(Hu R),an RNA-binding protein,and promotes the translocation of Hu R into the cytoplasm.A high cytoplasmic level of Hu R led to the activation of the Wnt signaling pathway by stabilizing and enhancing low-density lipoprotein receptor-related protein 5/6(Lrp5/6)andβ-catenin expression,thereby stimulating the osteogenic differentiation of BMSCs.Furthermore,overexpression of circ Stag1 in vivo by circ Stag1-loaded adeno-associated virus(circ Stag1-AAV)promoted new bone formation,thereby preventing bone loss in ovariectomized rats.Collectively,we show that circ Stag1 plays a pivotal role in promoting the regeneration of bone tissue via Hu R/Wnt signaling,which may provide new strategies to prevent bone metabolic disorders such as postmenopausal osteoporosis. | Gaoyang Chen Canling Long Shang Wang Zhenmin Wang Xin Chen Wanze Tang Xiaoqin He Zhiteng Bao Baoyu Tan Jin Zhao Yongheng Xie Zhizhong Li Dazhi Yang Guozhi Xiao Songlin Peng | 2022 | Bone Research2022，10，3： | 7 |
| 3 | Elastic Scattering of 7Be on Pb Target显示文摘 | Yang Yanyun Wang Jiansong Wang Qi Huang Meirong Ma Junbing Ma Peng Cao Xiguang Han Jianlong Bai Zhen Jin Shilong Hu Qiang Jin Lei Chen Jiangbo Zhang Xueying Chen Ruofu Hu Zhengguo Xu Shiwei Zhen Chuan Xu Zhiguo Xu Hushan Duan Liming Sun Zhiyu Chen Zhiqiang He Jianjun Li Songlin Lei Xiangguo Fu Fen Zhang Xueheng Yuan Xiaohua Du Chengming Yan Xinshuang Hu Jun Tang Shuwen Ye Ruiping Yang Kun Shi Fudong Zhang Wei Chen Ze Li Long Xu Xing Liu Longxiang Zhang Liyong Lin Qingyun Gou Boxing Xu Ge Zhou Xionghong Zhang Yuhu Xiao Guoqing | 2011 | IMP & HIRFL Annual Report2011，，1： | 4 |
| 4 | Nitrate increases cisplatin chemosensitivity of oral squamous cell carcinoma via REDD1/AKT signaling pathway显示文摘Although cisplatin is one of the chemotherapeutics most frequently used in oral squamous cell carcinoma(OSCC)treatment,it exerts multiple side effects and poor chemosensitivity.Nitrate reportedly demonstrates several beneficial biological functions,and synthesized nitrates enhance the therapeutic efficacy of chemotherapy.However,the role of inorganic nitrate in cisplatin chemotherapy remains unclear.We therefore investigated the effect of inorganic nitrate exerted on cisplatin sensitivity in OSCC.We found that nitrate did not affect OSCC cell growth and apoptosis in OSCC cells and OSCC xenograft tumor animal studies.Cisplatin induced REDD1 expression and AKT activation in OSCC.However,nitrate could increase cisplatin chemosensitivity,reduce its REDD1 expression,and attenuate AKT signaling activation in OSCC cells.Dysregulation of high levels of REDD1,which could enhance AKT activation,was positively associated with poor prognosis in OSCC patients.Thus,reduced REDD1 expression and retarded AKT activation induced by inorganic nitrate might be a new potential approach to the sensitization of oral cancer to cisplatin treatment in the future. | Yuanyong Feng Xuedi Cao Bin Zhao Chunyan Song Baoxing Pang Liang Hu Chunmei Zhang Jinsong Wang Junqi He Songlin Wang | 2021 | Science China(Life Sciences)2021，64，11： | 2 |
| 5 | Influence of hierarchical ZSM-5 catalysts with various acidity on the dehydration of glycerol to acrolein显示文摘The main challenge in the dehydration of glycerol to acrolein lies in overcoming catalystdeactivation and improving the selectivity to acrolein. The relationship between theacidity in the mesoporous channels and catalytic performance of glycerol dehydration israrely reported. In this work, to investigate the influence of acidity in the mesoporouschannels of hierarchical ZSM-5 catalysts on the dehydration of glycerol to acrolein, a seriesof hierarchical ZSM-5 zeolites with comparable mesoporous volume and mesoporous sizebut different acid properties in mesopores have been successfully prepared via alkalinetreatment. The sample with the abundant mesoporosity and highest acidity display thebest performance. | Shufang Zhao Songlin He Kyung Du Kim Lizhuo Wang Ryong Ryoo Zichun Wang Jun Huang | 2021 | Magnetic Resonance Letters2021，1，1： | 1 |
| 6 | WWP2 ameliorates oxidative stress and inflammation in atherosclerotic mice through regulation of PDCD4/HO-1 pathway显示文摘WWP2 is a HECT-type E3 ubiquitin ligase that regulates various physiological and pathological activities by binding to different substrates,but its role in atherosclerosis(AS)remains largely unknown.The objective of the present study is to investigate the role and underlying molecular mechanisms of WWP2 in endothelial injury.We found that WWP2 expression is significantly decreased in Apolipoprotein E(ApoE)-/-mice.Overexpression of WWP2 attenuates oxidative stress and inflammation in AS mice,while knockdown of WWP2 has opposite effects.WWP2 overexpression alleviates oxidized low-density lipoprotein(ox-LDL)-induced human umbilical vein endothelial cell(HUVEC)injury,evidenced by the decreased oxidative stress levels and the secretion of inflammatory cytokines.Programmed cell death 4(PDCD4)is identified as a potential substrate of WWP2.Co-immunoprecipitation(Co-IP)further demonstrates that WWP2 interacts with PDCD4,which is enhanced by ox-LDL treatment.Furthermore,the level of PDCD4 ubiquitination is significantly increased by WWP2 overexpression under the condition of MG132 treatment,while WWP2 knockdown shows opposite results.Subsequently,rescue experiments demonstrate that WWP2 knockdown further aggravates oxidative stress and inflammation in ox-LDL-treated HUVECs,while knockdown of PDCD4 alleviates this effect.Moreover,the use of sn-protoporphyrin(SnPP),an inhibitor of HO-1 pathway,confirms that PDCD4 enhances endothelial injury induced by ox-LDL through inhibiting HO-1 pathway.In conclusion,our results suggest that WWP2 protects against atherosclerosis progression via the PDCD4/HO-1 pathway,which may provide a novel treatment strategy for atherosclerosis. | Xingye Wang Lu Ma Songlin Zhang Qiang Song Xumei He Jun Wang | 2022 | Acta Biochimica et Biophysica Sinica2022，54，8： | 0 |
| 7 | Improved phase field model of dislocation intersections显示文摘Revealing the long-range elastic interaction and short-range core reaction between intersecting dislocations is crucial to the understanding of dislocation-based strain hardening mechanisms in crystalline solids.Phase field model has shown great potential in modeling dislocation dynamics by both employing the continuum microelasticity theory to describe the elastic interactions and incorporating theγ-surface into the crystalline energy to enable the core reactions.Since the crystalline energy is approximately formulated by linear superposition of interplanar potential of each slip plane in the previous phase field model,it does not fully account for the reactions between dislocations gliding in intersecting slip planes.In this study,an improved phase field model of dislocation intersections is proposed through updating the crystalline energy by coupling the potential of two intersecting planes,and then applied to study the collinear interaction followed by comparison with the previous simulation result using discrete dislocation dynamics.Collinear annihilation captured only in the improved phase field model is found to strongly affect the junction formation and plastic flow in multislip systems.The results indicate that the improvement is essential for phase field model of dislocation intersections. | Songlin Zheng Dongchang Zheng Yong Ni Linghui He | 2018 | npj Computational Materials2018，，1： | 0 |
| 8 | Advancing drug delivery to articular cartilage:From single to multiple strategies显示文摘Articular cartilage(AC) injuries often lead to cartilage degeneration and may ultimately result in osteoarthritis(OA) due to the limited self-repair ability. To date, numerous intra-articular delivery systems carrying various therapeutic agents have been developed to improve therapeutic localization and retention, optimize controlled drug release profiles and target different pathological processes. Due to the complex and multifactorial characteristics of cartilage injury pathology and heterogeneity of the cartilage structure deposited within a dense matrix, delivery systems loaded with a single therapeutic agent are hindered from reaching multiple targets in a spatiotemporal matched manner and thus fail to mimic the natural processes of biosynthesis, compromising the goal of full cartilage regeneration. Emerging evidence highlights the importance of sequential delivery strategies targeting multiple pathological processes. In this review, we first summarize the current status and progress achieved in single-drug delivery strategies for the treatment of AC diseases. Subsequently, we focus mainly on advances in multiple drug delivery applications, including sequential release formulations targeting various pathological processes, synergistic targeting of the same pathological process, the spatial distribution in multiple tissues, and heterogeneous regeneration. We hope that this review will inspire the rational design of intraarticular drug delivery systems(DDSs) in the future. | Tianyuan Zhao Xu Li Hao Li Haoyuan Deng Jianwei Li Zhen Yang Songlin He Shuangpeng Jiang Xiang Sui Quanyi Guo Shuyun Liu | 2023 | Acta Pharmaceutica Sinica B2023，13，10： | 0 |
| 9 | Transcriptome Analysis and Genes Function Verification of Root Development of Paeonia suffruticosa under Sandy Loam Cultivation显示文摘Relatively poor in vitro rooting has limited the large-scale commercial production of tree peony.In this study,on the basis of transcriptome sequencing,differentially expressed genes and the associated metabolic pathways were identified in tree peony roots at different stages of root formation under sandy loam cultivation.A total of 31.63 Gb raw data were generated and 120,188 unigenes(mean length of 911.98 bp)were annotated according to six databases(NR,NT,GO,KEGG,COG,and Swiss-Prot).Analyses of the ungerminated root primordium period,induced root primordium period,and root formation period detected 8,232,6,907,and 10,687 differentially expressed genes related to 133,132,and 133 metabolic pathways,respectively.Two significantly differentially expressed genes(Unigene13430_All and CL10096.Contig1_All)were associated with the auxin pathway.The full-length Unigene13430_All coding sequence(843 bp)encoded 280 amino acids,whereas the full-length CL10096.Contig1_All coding sequence(1,470 bp)encoded 489 amino acids.Unigene13430_All and CL10096.Contig1_All were identified as IAA gene family members and were respectively named PsIAA27 and PsARF19.The qRT-PCR analysis and functional verification indicated that the expressions of PsARF19 and PsIAA27 in tree peony seedlings,cuttings and grafted seedlings were significant different.PsARF19 promoted root development,it might be a regulatory gene related to the formation of tree peony roots,while PsIAA27 inhibited lateral root development,and it might be involved in controlling auxin sensitivity during root formation.The results of this study may form the basis of future investigations on the mechanism mediating peony root formation.The transcriptome data will be an excellent resource for researchers interested in characterizing the rooting-related tree peony genes. | Yinglong Song Wenqian Shang Zheng Wang Songlin He Xinya Meng Liyun Shi Yuxiao Shen Dan He Xueyuan Lou Yuke Sun | 2022 | Phyton-International Journal of Experimental Botany2022，91，12： | 0 |
| 10 | Discrete element modeling and verification of the simulation parameters for chopped hybrid Broussonetia papyrifera stems显示文摘In this study,the discrete element software EDEM was applied to establish a simulation model of non-uniform-sized particle units for Broussonetia papyrifera stalks,which aimed to address the low utilization rate of existing Broussonetia papyrifera harvesting machinery,the significant variation between the simulated model of Broussonetia papyrifera stalks and their actual appearance,as well as the absence of contact parameter calibration.Through a combination of the free-fall collision method,inclined plane sliding method,and inclined plane rolling method,numerical simulation was conducted to analyze the pattern of variations in contact parameters between Broussonetia papyrifera stalks and the steel material of the machinery.Accordingly,these parameters were calibrated.The results showed that the coefficient of restitution between Broussonetia papyrifera stalks and steel materials was 0.321,the static friction factor was 0.589,and the rolling friction factor was 0.078.With the parameters of contact between Broussonetia papyrifera stalks as variables and the experimentally measured pile angle as the objective of optimization,the steepest ascent experiment and the three-factor five-level rotation combination experiment were conducted.In this way,a second-order response model was constructed to analyze the relationship between the contact parameters and the pile angle.Through the optimization analysis of experimental data,it was determined that the coefficient of restitution between Broussonetia papyrifera stalks was 0.21,the static friction factor was 0.24,and the rolling friction factor was 0.03.Furthermore,the calibration results were validated through experimentation to show that the relative error between the obtained pile angle under the context of optimal parameter combination and the actual one was 4.11%.In addition,the relative error of mass flow rate in spiral transport was within a reasonable range,this study lays a foundation both theoretically and statistically for the simulation of contact parameters for Broussonetia papyrifera stalk harvesting processing,mechanical harvesting,and so on. | Caiwang Peng Junwei Chen Xi He Songlin Sun Yulong Yin Zhong Chen | 2024 | International Journal of Agricultural and Biological Engineering2024，17，1： | 0 |
| 11 | Effects of vibration conditions,spatial confinement and friction on mixing and segregation characteristics of mixed pebble beds for CFETR WCCB blanket显示文摘This paper presents the study of the dynamic characteristics of confined mixed pebble beds with different friction under different vibration conditions using the discrete element method.Theλsegre-gation index is used to quantify the degree of particle mixing or segregation.The percolation,convection and diffusion mechanisms are responsible for the segregation patterns of the mixed pebble.The results show the degree of segregation can be suppressed by decreasing the vibration acceleration or free space height below a threshold.Further simulation reveals the threshold of vibration acceleration or free space height both are related to the bed height increment which determines the strength of the percolation mechanism.In addition,the strength of percolation and convection becomes weaker by decreasing the friction of particles and walls,which makes the pebbled bed remains in a mixed state under vibration.These findings are significant to clarify the main factors behind the three segregation mechanisms and hence provide solutions to retaining the mixed state of the Li2TiO3&Be12Ti mixed pebble bed. | Yong Liu Chongyang He Cong Wang Lei Chen Songlin Liu | 2024 | Particuology2024，85，2： | 0 |
| 12 | MUDAL:a 4л Multi-detector Array in Lanzhou for Charged Particle Detection at HIRFL显示文摘MUDAL:a4лMulti-detectorArrayinLanzhouforChargedParticleDetectionatHIRFL￥ZhuYongtai;LiSonglin;JinGenming;XuHushan;LuJun;LiZuyu... | Zhu Yongtai Li Songlin Jin Genming Xu Hushan Lu Jun Li Zuyul Wang Qi He Zhiyong Cheng Keliang Zhang Baoguo and Wang Xiaoqiu | 1996 | IMP & HIRFL Annual Report1996，，1： | 0 |
| 13 | Dual-bionic regenerative microenvironment for peripheral nerve repair显示文摘Autologous nerve grafting serves is considered the gold standard treatment for peripheral nerve defects;however,limited availability and donor area destruction restrict its widespread clinical application.Although the performance of allogeneic decellularized nerve implants has been explored,challenges such as insufficient human donors have been a major drawback to its clinical use.Tissue-engineered neural regeneration materials have been developed over the years,and researchers have explored strategies to mimic the peripheral neural microenvironment during the design of nerve catheter grafts,namely the extracellular matrix(ECM),which includes mechanical,physical,and biochemical signals that support nerve regeneration.In this study,polycaprolactone/silk fibroin(PCL/SF)-aligned electrospun material was modified with ECM derived from human umbilical cord mesenchymal stem cells(hUMSCs),and a dual-bionic nerve regeneration material was successfully fabricated.The results indicated that the developed biomimetic material had excellent biological properties,providing sufficient anchorage for Schwann cells and subsequent axon regeneration and angiogenesis processes.Moreover,the dual-bionic material exerted a similar effect to that of autologous nerve transplantation in bridging peripheral nerve defects in rats.In conclusion,this study provides a new concept for designing neural regeneration materials,and the prepared dual-bionic repair materials have excellent auxiliary regenerative ability and further preclinical testing is warranted to evaluate its clinical application potential. | Yanjun Guan Zhiqi Ren Boyao Yang Wenjing Xu Wenjun Wu Xiangling Li Tieyuan Zhang Dongdong Li Shengfeng Chen Jun Bai Xiangyu Song Zhibo Jia Xing Xiong Songlin He Chaochao Li Fanqi Meng Tong Wu Jian Zhang Xiuzhi Liu Haoye Meng Jiang Peng Yu Wang | 2023 | Bioactive Materials2023，，8： | 0 |
| 14 | In Vitro Antibacterial Effect of Effective Microorganisms( EM) on Aeromonas hydrophila显示文摘In order to understand in vitro antibacterial effect of antibiotics and EM on Aeromonas hydrophila,14 isolates of A. hydrophila were isolated from diseased fish and aquaculture in the study. PCR amplification results of aerolysin gene( Aero gene) of isolates indicated that 7 out of 14 isolates were pathogenic A.hydrophila. In vitro antibacterial test indicated that 14 isolates were resistance to penicillin G,ampicillin,cephradine,cefazolin,tetracycline,terimethoprim,lincomycin and cephalexin,but showed high sensitivity to cefotaxime and furazolidone. In vitro antibacterial effect of EM on 14 isolates of A. hydrophila was positively correlated with concentration,and EM with the concentration greater than 60% had antibacterial effect on 14 isolates. | Zhu Zhixiu He Houjun Zhang Wenbo Wu Xiangdong Wan Gen Deng Shunzhou Liu Songlin | 2014 | Animal Husbandry and Feed Science2014，6，2： | 0 |
| 15 | Enhanced thermal isolation in porous thermal barrier coatings by the formation of pore guided thermal-shock cracks显示文摘Pore structure design is an effective strategy to tailor the thermal isolation capability of thermal barrier coatings(TBCs).Pursuing optimal porosity is crucial to balance the requirements of thermal isolation and mechanical reliability since the pore structure shields thermal heat transfer but increases mechanical degradation.In this work,we investigate how thermal heat transfer couples with fracture propagation in porous TBCs by the using thermo-mechanical coupling phase field model for fracture.The simulated results show that cracks induced by thermal shock favor deflection that is sometimes perpendicular to the direction of heat flow.The thermal conductivity degradation by the transverse cracks significantly impedes thermal heat transfer,leads to enhanced reduction of the effective thermal conductivity of TBCs,decreases the average thermal stress of the substrate,and thus decreases the risk of the crack penetrating into the substrate.The numerical results demonstrate that the phase field method fully considering the thermo-mechanical interaction between cracks and pores can be a useful tool to improve the thermal isolation of porous TBCs under extreme thermal shock loadings through pore structure design. | ZHEN Yu WU KaiJin LIU MengQi ZHENG SongLin HE LingHui YU Yin NI Yong | 2023 | Science China(Technological Sciences)2023，66，4： | 0 |
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