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| 1 | Ginsenoside Rg3 inhibits colon cancer cell migration by suppressing nuclear factor kappa B activity显示文摘OBJECTIVE: To study the mechanism of the inhibitory effect of ginsenoside Rg3 on colon cancer cell migration.METHODS: Transwell migration assays were performed to investigate the inhibitory effect of ginsenoside Rg3 on SW480 cell migration. Electrophoretic mobility shift assays(EMSAs) and dual luciferase reporter assays were used to study the suppression capability of Rg3 on nuclear factor kappa B(NF-κB) activity. Western blotting was adopted to determine protein levels.RESULTS: Two-hundred micromolar ginsenoside Rg3 significantly inhibited SW480 cell migration(P < 0.05). EMSA showed that Rg3 suppressed the DNA binding ability of NF-κB. Dual luciferase reporter assay showed that Rg3 decreased NF-κB-regulated gene transcription(P < 0.01). Western blots indicated that Rg3 down-regulated expression of the NF-κB-regulated matrix metalloproteinase 9,cyclooxygenase-2 and C-Myc. An NF-κB inhibitor,pyrrolidine dithiocarbamate,enhanced the inhibitory effect of Rg3 on SW480 cell migration.CONCLUSION: Ginsenoside Rg3 has a strong antitumor migration capability by suppressing NF-κB activity and expression of NF-κB-regulated gene products. It could be a good adjuvant for colon cancer patients during the course of chemotherapy. | Song Junmin Liu Hongxiang Li Zhen Yang Chao Wang Chaojie | 2015 | Journal of Traditional Chinese Medicine2015，35，4： | 13 |
| 2 | On generation source sites of internal waves in the Luzon Strait显示文摘This effort aims to determine the generation source sites in the Luzon Strait for energetic,long-crest,transbasin internal waves(IW)observed in the northern South China Sea(NSCS).The roles of islands distributed on eastern side of the strait,Kuroshio,submarine ridges,shoaling thermocline,and strait configuration played in the IW generation are examined using the cruise data analysis,satellite data interpretation,and dynamical analysis.The islands and channels on eastern side of the strait are excluded from a list of possible IW source sites owing to their unmatched horizontal dimensions to the scale of IW crest line length,and the relative low Reynolds number.The Kuroshio has a potential to be a radiator for the long-crest IW disturbances,meanwhile,the Kuroshio west(east)wing absorbs the eastward(westward)propagating IW disturbance.Namely,the Kuroshio blockades the outside west-east propagating IW disturbances.The 3-D configuration of the Luzon Strait is characterized by a sudden,more than one order widening of the cross-section areas at the outlets on both sides,providing a favorable condition for IW type initial disturbance formation.In the Luzon Strait,the thermocline is featured by a westward shoaling all the year around,providing the dynamical conditions for the amplitude growth(declination)to the westward(eastward)propagating IW type disturbance.Thus,the west slope of western submarine ridge at the western outlet of the Luzon Strait is a high possibility source sites for energetic,long-crest,transbasin IWs in the NSCS.The interpretation results of satellite SAR images during a 13 a period from 1995 to 2007 provide the convincing evidence for the conclusions. | ZHENG Quanan SONG Y Tony LIN Hui HU Xiaomin MENG Junmin WANG Dan | 2008 | Acta Oceanologica Sinica2008，27，3： | 5 |
| 3 | Effects of cytokine?induced killer cell treatment combined with FOLFOX4on the recurrence and survival rates for gastric cancer following surgery显示文摘 | Hongxiang Liu Junmin Song Zhen Yang Xiefu Zhang | 2013 | Experimental and Therapeutic Medicine2013，，4： | 2 |
| 4 | Ultrasmall Fe<sub>3</sub>O<sub>4</sub> Nanoparticle/MoS<sub>2</sub> Nanosheet Composites with Superior Performances for Lithium Ion Batteries显示文摘 | Yu Chen Bohang Song Xiaosheng Tang Li Lu Junmin Xue | 2014 | Small2014，，8： | 1 |
| 5 | 显示文摘 | Yan Junmin Zhang Xinbo Han Song | 2009 | Journal of Power Sources2009，194，1： | 1 |
| 6 | Role and relationship of nitric oxide and hydrogen peroxide in light/dark regulated-stomatal movement in Vicia faba 显示文摘 | She Xiaoping Song Xigui He Junmin | 2004 | Acta Botanica Sinica2004，46，11： | 1 |
| 7 | Chromatographic separation and physicochemical properties of collagen species in the skin of deep-sea redfish ( Sebastes mentella )显示文摘 | Lin Wang Yufeng Zou Song Jiang Junmin Xu Shenhua Jiang Qiuhui Hu | 2010 | Food Hydrocolloids2010，，5： | 1 |
| 8 | Role and rela- tionship of nitric oxide and hydrogen peroxide in light / dark regulated stomatal movement in Vicia faba显示文摘 | She Xiaoping Song Xigui He Junmin | 2004 | Acta Botanica Sinica2004，46，： | 1 |
| 9 | Role and relationship of nitric oxide and hydrogen peroxide in light/dark-regulated stomatal movement in Vicia faba 显示文摘 | SHE Xiaoping SONG Xigui HE Junmin | 2004 | Acta Botanica Sinica2004，46，11： | 1 |
| 10 | Identification of in-vivo induced genes of Streptococcus suis serotype 2 specially expressed in infected human显示文摘 | Shu Li Jie Song Hui Huang Wei Chen Ming Li Yan Zhao Yanguang Cong Junmin Zhu Xiancai Rao Xiaomei Hu Fuquan Hu | 2013 | Microbial Pathogenesis2013，，： | 1 |
| 11 | Role and relationship of nitric oxide and hydrogen peroxide in light/dark-regulated stomatal movement in Vicia faba 显示文摘 | SHE Xiaoping SONG Xigui HE Junmin | 2004 | Acta Botanica Sinica2004，，： | 1 |
| 12 | Efficacy and safety of obinutuzumab for the first-line treatment of follicular lymphoma:a subgroup analysis of Chinese patients enrolled in the phase III GALLIUM study显示文摘Backgrounds:GALLIUM is a global phase Ⅲ study that demonstrated significant improvements in progression-free survival(PFS)for obinutuzumab plus chemotherapy(G-chemo)vs.rituximab plus chemotherapy(R-chemo)in previously untreated patients with follicular lymphoma(FL).This study aimed to report the results of a subgroup of patients in China.Methods:Patients were randomized to G-chemo or R-chemo.Responders received maintenance therapy for 2 years or until disease progression.The primary endpoint was investigator(INV)-assessed PFS.Secondary endpoints included the overall response rate(ORR)and complete response rate(CRR)at the end of induction chemotherapy,overall survival(OS),and safety.Results:Overall,58 patients with FL were randomized to the G-chemo(n=25)and R-chemo arms(n=33).The INV-assessed PFS rate at 3 years was 81.8%in the G-chemo arm,vs.70.2%in the R-chemo arm(hazard ratio 0.35;95%confidence interval:0.09-1.34;P=0.1120).The INV-assessed CRRs(without positron emission tomography[PET])in these arms were 24.0%and 21.2%,respectively,whereas the ORRs were 80.0%and 90.9%,respectively.INV-assessed CRR-PET was 52.6%in the G-chemo,vs.60.9%in the R-chemo.Median OS was not reached in either arm.Grade 3 to 5 adverse events were more frequent in the R-chemo arm(97.0%vs.88.0%).Conclusions:The results of this subgroup analysis were consistent with those of the global population,and they suggest that G-chemo has a positive benefit-risk profile in patients from China with FL.Trial registration:ClinicalTrials.gov,No.NCT01332968. | Xiaonan Hong Yuqin Song Yuankai Shi Qingyuan Zhang Wei Guo Gang Wu Junmin Li Jifeng Feng Anastasiia Kinkolykh Andrea Knapp Tongyu Lin | 2022 | Chinese Medical Journal2022，，4： | 1 |
| 13 | A Real-time Relaxed Garbage Collection in DSM显示文摘 | WU Junmin SONG Zhenhua | 2007 | Chinese Journal of Electronics2007，16，1： | 0 |
| 14 | Etoposide,dexamethasone,and pegaspargase with sandwiched radiotherapy in early-stage natural killer/T-cell lymphoma:A randomized phase III study显示文摘Methotrexate,etoposide,dexamethasone,and pegaspargase(MESA)with sandwiched radiotherapy is known to be effective for early-stage extranodal natural killer/T-cell lymphoma,nasal type(NKTCL).We explored the efficacy and safety of reduced-intensity,non-intravenous etoposide,dexamethasone,and pegaspargase(ESA)with sandwiched radiotherapy.This multicenter,randomized,phase III trial enrolled patients aged between 14 and 70 years with newly diagnosed early-stage nasal NKTCL from 27 centers in China.Patients were randomly assigned(1:1)to receive ESA(pegaspargase 2,500 IU/m^(2)intramuscularly on day 1,etoposide 200 mg orally,and dexamethasone 40 mg orally on days 2–4)or MESA(methotrexate 1 g/m^(2)intravenously on day 1,etoposide 200 mg orally,and dexamethasone 40 mg orally on days 2–4,and pegaspargase 2,500 IU/m^(2)intramuscularly on day 5)regimen(four cycles),combined with sandwiched radiotherapy. | Huijuan Zhong Shu Cheng Xi Zhang Bing Xu Jiayi Chen Xufeng Jiang Jie Xiong Yu Hu Guohui Cui Juying Wei Wenbin Qian Xiaobing Huang Ming Hou Feng Yan Xin Wang Yongping Song Jianda Hu Yuanhua Liu Xuejun Ma Fei Li Chongyang Wu Junmin Chen Li Yu Ou Bai Jingyan Xu Zunmin Zhu Li Liu Xin Zhou Li Huang Yin Tong Ting Niu Depei Wu Hao Zhang Chaofu Wang Binshen Ouyang Hongmei Yi Qi Song Gang Cai Biao Li Jia Liu Zhifeng Li Rong Xiao Luqun Wang Yujie Jiang Yanyan Liu Xiaoyun Zheng Pengpeng Xu Hengye Huang Li Wang Saijuan Chen Weili Zhao | 2023 | The Innovation2023，4，3： | 0 |
| 15 | Predictive values of plasma TNFαand IL-8 for intracranial hemorrhage in patients with acute promyelocytic leukemia显示文摘In patients with acute promyelocytic leukemia(APL),intracranial hemorrhage(ICH),if not identified promptly,could be fatal.It is the leading cause of failure of induction and early death.Thus,biomarkers that could promptly predict severe complications are critical.Here,cytokine differences between patients with APL with and without ICH were investigated to develop predictive models for this complication.The initial cytokine profiling using plasma samples from 39 patients and 18 healthy donors found a series of cytokines that were remarkedly different between patients with APL and healthy controls.The APL patients were subsequently divided into high and low white blood cell count groups.Results showed that tumor necrosis factor a and interleukin 8(IL-8)were vital in distinguishing patients with APL who did or did not develop ICH.In addition,verification in 81 patients with APL demonstrated that the two cytokines were positively correlated with the cumulative incidence of ICH.Finally,in-vitro and in-vivo experimental evidence were provided to show that IL-8 influenced the migration of APL-derived NB4 cells and impaired the blood-brain barrier in PML/RARαpositive blast-transplanted FVB/NJ mice.These assessments may facilitate the early warning of ICH and reduce future mortality levels in APL. | Fangyi Dong Li Chen Chaoxian Zhao Xiaoyang Li Yun Tan Huan Song Wen Jin Hongming Zhu Yunxiang Zhang Kai Xue Junmin Li Kankan Wang | 2022 | Frontiers of Medicine2022，16，6： | 0 |
| 16 | Tunable hybrid hydrogels with multicellular spheroids for modeling desmoplastic pancreatic cancer显示文摘The tumor microenvironment consists of diverse,complex etiological factors.The matrix component of pancreatic ductal adenocarcinoma(PDAC)plays an important role not only in physical properties such as tissue rigidity but also in cancer progression and therapeutic responsiveness.Although significant efforts have been made to model desmoplastic PDAC,existing models could not fully recapitulate the etiology to mimic and understand the progression of PDAC.Here,two major components in desmoplastic pancreatic matrices,hyaluronic acid-and gelatin-based hydrogels,are engineered to provide matrices for tumor spheroids composed of PDAC and cancer-associated fibroblasts(CAF).Shape analysis profiles reveals that incorporating CAF contributes to a more compact tissue formation.Higher expression levels of markers associated with proliferation,epithelial to mesenchymal transition,mechanotransduction,and progression are observed for cancer-CAF spheroids cultured in hyper desmoplastic matrix-mimicking hydrogels,while the trend can be observed when those are cultured in desmoplastic matrix-mimicking hydrogels with the presence of transforming growth factor-β1(TGF-β1).The proposed multicellular pancreatic tumor model,in combination with proper mechanical properties and TGF-β1 supplement,makes strides in developing advanced pancreatic models for resembling and monitoring the progression of pancreatic tumors,which could be potentially applicable for realizing personalized medicine and drug testing applications. | Menekse Ermis Natashya Falcone Natan Roberto de Barros Marvin Mecwan Reihaneh Haghniaz Auveen Choroomi Mahsa Monirizad Yeji Lee Jihyeon Song Hyun-Jong Cho Yangzhi Zhu Heemin Kang Mehmet R.Dokmeci Ali Khademhosseini Junmin Lee Han-Jun Kim | 2023 | Bioactive Materials2023，，7： | 0 |
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