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| 1 | Analytical validation of GMEX rapid point- of care CYP2C19 genotyping system for the CHANCE-2 trial显示文摘Background and purpose Rapid genotyping is useful for guiding early antiplatelet therapy in patients with high-risk nondisabling ischaemic cerebrovascular events(HR-NICE).Conventional genetic testing methods used in CYP2C19 genotype-guided antiplatelet therapy for patients with HR-NICE did not satisfy the needs of the Clopidogrel in High-Risk Patients with Acute Nondisabling Cerebrovascular Events(CHANCE)-2 trial.Therefore,we developed the rapid-genotyping GMEX(point-of care)system to meet the needs of the CHANCE-2 trial.Methods Healthy individuals and patients with history of cardiovascular diseases(n=408)were enrolled from six centres of the CHANCE-2 trial.We compared the laboratory-based genomic test results with Sanger sequencing test results for accuracy verification.Next,we demonstrated the accuracy,timeliness and clinical operability of the GMEX system compared with laboratory-based technology(YZY Kit)to verify whether the GMEX system satisfies the needs of the CHANCE-2 trial.Results Genotypes reported by the GMEX system showed 100%agreement with those determined by using the YZY Kit and Sanger sequencing for all three CYP2C19 alleles(*2,*3 and*17)tested.The average result’s turnaround times for the GMEX and YZY Kit methods were 85.0(IQR:85.0-86.0)and 1630.0(IQR:354.0-7594.0)min(p<0.001),respectively.Conclusions Our data suggest that the GMEX system is a reliable and feasible point-of care system for rapid CYP2C19 genotyping for the CHANCE-2 trial or related clinical and research applications. | Xia Meng Anxin Wang Guojun Zhang Siying Niu Wei Li Sifei Han Fang Fang Xingquan Zhao Kehui Dong Zening Jin Huaguang Zheng Kelin Chen Hao Li Chengyuan Yang Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 7 |
| 2 | Clinical and radiological features of medullary infarction caused by spontaneous vertebral artery dissection显示文摘Background and purpose Medullary infarction(MI)caused by spontaneous vertebral artery dissection(sVAD)is an important type of stroke.It is important to distinguish sVAD from other causes of stroke since the treatment strategies and prognosis were different between them.In this study,we aimed to explore the clinical and radiological features of MI in patients with acute MI caused by sVAD.Methods Patients with acute MI caused by sVAD and non-sVAD in a single tertiary hospital were enrolled from 2010 to 2020.Epidemiologic,clinical and image features were collected and analysed.MI lesions were categorised into three levels rostrocaudally and four arterial groups:anteromedial,anterolateral,lateral and posterior.Results A total of 128 patients with MI were enrolled with 47 cases of sVAD and 81 cases of non-sVAD.Patients with sVAD were younger than those with non-sVAD(med 44 years old vs 58 years old).The sVAD group was less likely to have hypertension(44.68%vs 67.90%;p=0.010)and diabetes(19.15%vs 45.69%;p=0.003),but more likely to have non-sudden onset(27.66%vs 9.87%,p=0.009),minor neck injury(19.15%vs 1.23%;p=0.001)and headache(46.81%vs 7.41%;p=0.000).Vertically,sVAD became more common in caudal medulla than in rostral medulla.Horizontally,the sVAD group was more likely to have lateral MI(91.48%vs 2.96%,p=0.000).In multivariable logistic regression analysis,age,non-sudden onset and headache were independently associated with sVAD with ORs of 0.935(95%CI 0.892 to 0.981,p=0.006),3.507(95%CI 1.060 to 11.599,p=0.040)and 5.426(95%CI 1.673 to 17.599,p=0.005).Conclusion sVAD was not uncommon in patients with MI,especially in patients with lateral MI.Young patients with headache and non-sudden onset should remind clinician the possibility of sVAD. | Chun Yu Zhu Zhu Siying Li Yi Xu Wei Yan Xiaocui Kang Yao Li Qiang Dong Weijun Tang Xiang Han | 2022 | Stroke & Vascular Neurology2022，7，3： | 3 |
| 3 | GhHyPRP4, a cotton gene encoding putative hybrid proline-rich protein, is preferentially expressed in leaves and involved in plant response to cold stress显示文摘植物混血儿充满脯氨酸的蛋白质(HyPRPs ) 通常由 N 终端信号肽,中央充满脯氨酸的域,和保存八半胱氨酸的主题 C 终端域组成。在这研究,一基因(指定了为 GhHyPRP4 ) 编码通常认为的 HyPRP 从棉花 cDNA 图书馆被孤立。北污点和量的反向的 transcriptasepolymerase 链反应分析表明 GhHyPRP4 优先地在叶子被表示。在冷应力下面, GhHyPRP4 表示在棉花幼苗的叶子是显著地起来调整的。用走途径的染色体, GhHyPRP4 基因的倡导者碎片从棉花染色体被孤立。GUS (GhHyPRP4 倡导者驾驶的 -glucuronidase) 基因明确地在转基因的 Arabidopsis thaliana 的叶子和子叶被表示。而且,在叶子的 GUS 表示被冷应力显著地导致。在酵母(Schizosaccharomyces pombe ) 的 GhHyPRP4 的 Overexpression 显著地没有乙醇在食物上在 20d 消费下面在处理之上提高了房间幸存率;当食物包含了 0.01, 0.3,或 0.5% 时,他们没改变消费乙醇;但是显著地?? | Gengqing Huang Siying Gong Wenliang Xu Peng Li Dejing Zhang Lixia Qin Wen Li Xuebao Li | 2011 | Acta Biochimica et Biophysica Sinica2011，43，7： | 3 |
| 4 | Clinical characteristics of 19 neonates born to mothers with COVID-19显示文摘The aim of this study was to investigate the clinical characteristics of neonates born to SARS-CoV-2 infected mothers and increase the current knowledge on the perinatal consequences of COVID-19.Nineteen neonates were admitted to Tongji Hospital from January 31 to February 29,2020.Their mothers were clinically diagnosed or laboratory-confirmed with COVID-19.We prospectively collected and analyzed data of mothers and infants.There are 19 neonates included in the research.Among them,10 mothers were confirmed COVID-19 by positive SARS-CoV-2 RT-PCR in throat swab,and 9 mothers were clinically diagnosed with COVID-19.Delivery occurred in an isolation room and neonates were immediately separated from the mothers and isolated for at least 14 days.No fetal distress was found.Gestational age of the neonates was 38.61.5 weeks,and average birth weight was 3293425 g.SARS-CoV-2 RT-PCR in throat swab,urine,and feces of all neonates were negative.SARS-CoV-2 RT-PCR in breast milk and amniotic fluid was negative too.None of the neonates developed clinical,radiologic,hematologic,or biochemical evidence of COVID-19.No vertical transmission of SARS-CoV-2 and no perinatal complications in the third trimester were found in our study.The delivery should occur in isolation and neonates should be separated from the infected mothers and care givers. | Wei Liu Jing Wang Wenbin Li Zhaoxian Zhou Siying Liu Zhihui Rong | 2020 | Frontiers of Medicine2020，14，2： | 3 |
| 5 | Engineered neutrophil apoptotic bodies ameliorate myocardial infarction by promoting macrophage efferocytosis and inflammation resolution显示文摘Inflammatory response plays a critical role in myocardial infarction(MI)repair.The neutrophil apoptosis and subsequent macrophage ingestion can result in inflammation resolution and initiate regeneration,while the therapeutic strategy that simulates and enhances this natural process has not been established.Here,we constructed engineered neutrophil apoptotic bodies(eNABs)to simulate natural neutrophil apoptosis,which regulated inflammation response and enhanced MI repair.The eNABs were fabricated by combining natural neutrophil apoptotic body membrane which has excellent inflammation-tropism and immunoregulatory properties,and mesoporous silica nanoparticles loaded with hexyl 5-aminolevulinate hydrochloride(HAL).The eNABs actively targeted to macrophages and the encapsulated HAL simultaneously initiated the biosynthesis pathway of heme to produce anti-inflammatory bilirubin after intracellular release,thereby further enhancing the anti-inflammation effects.In in vivo studies,the eNABs efficiently modulated inflammation responses in the infarcted region to ameliorate cardiac function.This study demonstrates an effective biomimetic construction strategy to regulate macrophage functions for MI repair. | Lili Bao Geng Dou Ran Tian Yajie Lv Feng Ding Siying Liu Ruifeng Zhao Lu Zhao Jun Zhou Lin Weng Yan Dong Bei Li Shiyu Liu Xin Chen Yan Jin | 2022 | Bioactive Materials2022，7，3： | 3 |
| 6 | Dental remineralization via poly(amido amine) and restorative materials containing calcium phosphate nanoparticles显示文摘Tooth decay is prevalent,and secondary caries causes restoration failures,both of which are related to demineralization.There is an urgent need to develop new therapeutic materials with remineralization functions.This article represents the first review on the cutting edge research of poly(amido amine)(PAMAM) in combination with nanoparticles of amorphous calcium phosphate (NACP).PAMAM was excellent nucleation template,and could absorb calcium (Ca) and phosphate (P) ions via its functional groups to activate remineralization.NACP composite and adhesive showed acid-neutralization and Ca and P ion release capabilities.PAMAM +NACP together showed synergistic effects and produced triple benefits: excellent nucleation templates,superior acidneutralization,and ions release.Therefore,the PAMAM+NACP strategy possessed much greater remineralization capacity than using PAMAM or NACP alone.PAMAM+NACP achieved dentin remineralization even in an acidic solution without any initial Ca and P ions.Besides,the long-term remineralization capability of PAMAM+NACP was established.After prolonged fluid challenge,the immersed PAMAM with the recharged NACP still induced effective dentin mineral regeneration.Furthermore,the hardness of predemineralized dentin was increased back to that of healthy dentin,indicating a complete remineralization.Therefore,the novel PAMAM+NACP approach is promising to provide long-term therapeutic effects including tooth remineralization,hardness increase,and caries-inhibition capabilities. | Kunneng Liang Suping Wang Siying Tao Shimeng Xiao Han Zhou Ping Wang Lei Cheng Xuedong Zhou Michael D.Weir Thomas W.Oates Jiyao Li Hockin H.K.Xu | 2019 | International Journal of Oral Science2019，11，3： | 3 |
| 7 | Well-defined coordination environment breaks the bottleneck of organic synthesis:Single-atom palladium catalyzed hydrosilylation of internal alkynes显示文摘Single-atom site(SAS)catalysts have attracted considerable attention due to their excellent performance.However,most of the current research models of SAS catalysts are based on inorganic catalysts,where“metal and coordination atom interaction”cannot simulate the fine-tuning effect of organic ligands on metal catalytic centers in homogeneous catalysts.Therefore,certain chemical transformations in homogeneous catalysis cannot be perfectly replicated.Here,we used porous organic ligand polymers as the carrier,which effectively changes the charge regulation of nanoparticles and monoatomic metal catalysts.Drawing lessons from traditional homogeneous metal/ligand catalysis,we introduced various functional groups into the ligand polymers to adjust the electronic properties,and successfully realized the hydrosilylation of internal alkynes with high catalytic performance.The selectivity and catalytic efficiency under the Pd@POL-1 catalyst system were improved compared with previous studies.The internal alkynes with various structures can complete this reaction,and the ratio of E/Zcan reach up to 100:1. | Shicheng Ren Bochao Ye Siying Li Liping Pang Yingming Pan Haitao Tang | 2022 | Nano Research2022，15，2： | 2 |
| 8 | Stretchable supercapacitor based on a hierarchical PPy/CNT electrode and hybrid hydrogel electrolyte with a wide operating temperature显示文摘Hydrogel is frequently used as a solid electrolyte for all solid-state supercapacitors(SCs)because of its liquid-like ion-transport property and high conformability.However,due to the higher water content,the hydrogel electrolyte undergoes inevitable freezing and/or dehydration with climate change.Herein,polypyrrole/carbon all-solid-state SCs(PCSCs)were developed based on a hierarchical polypyrrole/carbon nanotube electrode and a highly stretchable double-network polymer hydrogel electrolyte with LiCl/ethylene glycol as a mixed solvent.The PCSCs showed excellent electrochemical performance and cycle stability with a wide operating temperature.The specific capacitances could reach 202.2 and 112.3 mF cm^(−2) at current densities of 0.5 and 3.0 mA cm^(−2),respectively.Meanwhile,the PCSCs showed outstanding mechanical properties in maintaining a high areal capacitance under deformations of bending and tension.The excellent water retention of the device also ensured the stable electrochemical performance of PCSCs in a wide temperature range(30–80℃),which could potentially represent a reliable application in various harsh environments. | Yanfang Ren Yunlong Liu Siying Wang Qian Wang Shuhong Li Wenjun Wang Xiaochen Dong | 2022 | Carbon Energy2022，4，4： | 2 |
| 9 | Endothelin antagonism and interleukin-6 inhibition attenuate the proatherogenic effects of C-reactive protein显示文摘 | Verma S Li SII Badiwada MV | 2002 | Circulation2002，105，16： | 1 |
| 10 | Silver nanowire/polymer composite soft conductive film fabricated by large-area compatible coating for flexible pressure sensor array显示文摘Soft conductive films composed of a silver nanowire(AgNW) network, a neutral-pH PEDOT:PSS overcoating layer and a polydimethylsiloxane(PDMS) elastomer substrate are fabricated by large area compatible coating processes. The neutral-pH PEDOT:PSS layer is shown to be able to significantly improve the conductivity,stretchability and air stability of the conductive films. The soft conductive films are patterned using a simple maskless patterning approach to fabricate an 8 x 8 flexible pressure sensor array. It is shown that such soft conductive films can help to improve the sensitivity and reduce the signal crosstalk over the pressure sensor array. | Sujie Chen Siying Li Sai Peng Yukun Huang Jiaqing Zhao Wei Tang Xiaojun Guo | 2018 | Journal of Semiconductors2018，39，1： | 1 |
| 11 | Assessing enter- prise micro -blogging marketing communication effec- tiveness and improvement suggestions 显示文摘 | Bing Wang Siying Li Jingquan Liu | 2014 | Journal of Chemical & Pharmaceutical Research2014，6，6： | 1 |
| 12 | Expression and localization of GhH6L, a putative classical arabinogalactan protein in cotton (Gossypium hirsutum)显示文摘Arabinogalactan 蛋白质(AGP ) 是一个大家庭高度 hydroxyproline 富有的 glycoproteins 的 glycosylated 在植物生长,开发,和信号 transduction 起重要作用。编码通常认为的古典 AGP 说出 GhH6L 的 cDNA 从棉花纤维 cDNA 图书馆被孤立,并且推出的蛋白质包含 XYprolineprolineproline 的重复主题的 17 个拷贝(在 X 是的地方,丝氨酸或丙氨酸和 Y 是 threonine 或丝氨酸) 。北弄污分析和量的 RTPCR 结果证明它优先地在 10 天内被表示开花期以后(dpa ) 纤维并且发展地也被调整。倡导者碎片被走 PCR 的染色体从棉花(Gossypium hirsutum ) 孤立。-glucuronidase (GUS ) 的表示在 GhH6L 倡导者下面的基因在转基因的 Arabidopsis 植物被检验;仅仅叶柄和花梗被染色,没有染色在另外的纸巾被检测。Subcellular 本地化显示 GhH6L 对血浆膜并且在细胞质局部性。这些数据推进我们 GhH6L 的理解以及在棉花使功能的卓见清楚些到 GhH6L。 | Yanfeng Wu Wenliang Xu Gengqing Huang Siying Gong Juan Li Yongfang Qin Xuebao Li | 2009 | Acta Biochimica et Biophysica Sinica2009，41，6： | 1 |
| 13 | Environmental Lead Pollution and Elevated Blood Lead Levels Among Children in a Rural Area of China显示文摘 | Lin Sihao Wang Xiaorong Yu Ignatius Tak Sun Tang Wenjuan Miao Jianying Li Jin Wu Siying Lin Xing | 2011 | American Journal of Public Health2011，，： | 1 |
| 14 | Cholelithiasis and risk of pancreatic cancer: systematic review and meta-analysis of 21 observational studies显示文摘 | Yuanfeng Gong Siying Li Yunqiang Tang Cong Mai Mingchen Ba Peng Jiang Hui Tang | 2014 | Cancer Causes & Control2014，，： | 1 |
| 15 | The mediating and moderating role of personal strain and coping resource in the relationship between work stressor and quality of life among Chinese nurses 显示文摘 | Siying Wu Huangyuan Li Shujuan Yang | 2012 | Int Arch Occup Environ Health2012，85，1： | 1 |
| 16 | The biogeographical distribution of tree species-abundance and its relation to climatic factors in mass islands显示文摘Tree species-abundance in forests is a function of geographical area and climate, although it is not clear whether such relationships apply to mass islands. We examined the spatial pattern of tree species in mass islands along the coast of Zhejiang, East China Sea using the Preston model, to identify the relationships between tree communities and climatic conditions. The results show that:(1) the biogeographical distribution of tree species-abundance conformes to Preston's log-normal pattern, and is in accordance with the findings in both tropical rainforests and estuarine forests;(2) the climatic factors related to tree communities in mass islands are similar to that of the subtropical zone, including the major species of evergreen needle-leaf, broad-leaf and deciduous broad-leaf forests. We conclude that the Preston model can be applied to the trees of mass islands and thus facilitate the systematic ecological researches of vegetation species' composition in subtropical zone. | LI Xiaoming WU Chengzhen GU Wu YE Ran ZHANG Haibo QI Ping WANG Shengqiang ZHOU Siying WEI Yongjie CAI Yanhong | 2017 | Acta Oceanologica Sinica2017，36，9： | 1 |
| 17 | NF-E2 related factor 2 activation and berne oxygeuase-1 induction by tert-butyl- bydroquinone protect against deltamethrin-mediated oxidative stress in PC12 cells 显示文摘 | Li Huangyuan Zhong Yufang Wu Siying | 2007 | Chem Res Toxicol2007，20，9： | 1 |
| 18 | Transcription factor Nrf2 acti- vation by dehamethrin in PC12 cells: Involvement of ROS 显示文摘 | Li Huangyuan Wu Siying Shi N | 2007 | ToxicolLett2007，171，12： | 1 |
| 19 | Constructing Pd-N interactions in Pd/g-C_(3)N_(4)to improve the charge dynamics for efficient photocatalytic hydrogen evolution显示文摘The formation of chemical bonds between metal ions and their supports is an effective strategy to achieve good catalytic activity.However,both the synthesis of active metal species on a support and control of their coordination environment are still challenging.Here,we show the use of an organic compound to produce tubular carbon nitride(TCN)as a support for Pd nanoparticles(NPs),creating a composite material(NP-Pd-TCN).It was found that Pd ions preferentially bind with the electron-rich N atoms of TCN,leading to strong metal-support interactions that benefit charge transfer from g-C_(3)N_(4)to Pd.X-ray absorption spectroscopy further revealed that the metal-support interactions resulted in the formation of Pd-N bonds,which are responsible for the improvement in the charge dynamics as evidenced by the results from various techniques including photoluminescence(PL)spectroscopy,photocurrent measurements,and electrochemical impedance spectroscopy(EIS).Owing to the good dynamical properties,NP-Pd-TCN was used for photocatalytic hydrogen evolution under visible-light irradiation(λ>420 nm)and an excellent evolution rate of~381μmol·h^(-1)(0.02 g of the photocatalyst)was attained.This work aims to promote a strategy to synthesize efficient photocatalysts for hydrogen production by controllably introducing metal nanoparticles on a support and in the meantime forming chemical bonds to achieve intimate metal-support contact. | Xudong Xiao Siying Lin Liping Zhang Huiyuan Meng Jing Zhou Qi Li Jianan Liu Panzhe Qiao Baojiang Jiang Honggang Fu | 2022 | Nano Research2022，15，4： | 1 |
| 20 | miR-124 Represses ROCK1 Expression to Promote Neurite Elongation Through Activation of the PI3K/Akt Signal Pathway显示文摘 | Xi Gu Siying Meng Shuhu Liu Chunhong Jia Yingying Fang Shuji Li Congcong Fu Qiancheng Song Lifang Lin Xuemin Wang | 2014 | Journal of Molecular Neuroscience2014，，1： | 1 |
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