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| 1 | Metastatic type 1 gastric carcinoid:A real threat or just a myth?显示文摘AIM:To describe disease characteristics and treatment modalities in a group of rare patients with metastatic gastric carcinoid type 1(GCA1).METHODS:Information on clinical,biochemical,radiological,histopathological findings,the extent of the disease,as well as the use of different therapeutic modalities and the long-term outcome were recorded.Patients’data were assessed at presentation,and thereafter at 6 to 12 monthly intervals both clinically and biochemically,but also endoscopically and histopathologically.Patients were evaluated for the presence of specific symptoms;the presence of autoimmune disorders and the presence of other gastrointestinal malignancies in other family members were also recorded.The evaluation of response to treatment was defined using established WHO criteria.RESULTS:We studied twenty consecutive patients with a mean age of 55.1 years.The mean follow-up period was 83 mo.Twelve patients had regional lymph node metastases and 8 patients had liver metastases.The primary tumor mean diameter was 20.13±10.83mm(mean±SD).The mean Ki-67 index was 6.8%±11.2%.All but one patient underwent endoscopic or surgical excision of the tumor.The disease was stable in all but 3 patients who had progressive liver disease.All patients remained alive during the follow-up period.CONCLUSION:Metastatic GCA1 carries a good overall prognosis,being related to a tumor size of≥1 cm,an elevated Ki-67 index and high serum gastrin levels. | Simona Grozinsky-Glasberg Dimitrios Thomas Jonathan R Strosberg Ulrich-Frank Pape Stephan Felder Apostolos V Tsolakis Krystallenia I Alexandraki Merav Fraenkel Leonard Saiegh Petachia Reissman Gregory Kaltsas David J Gross | 2013 | World Journal of Gastroenterology2013，19，46： | 11 |
| 2 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 3 | Exogenous cytokinin application to Actinidia chinensis var. deliciosa ‘Hayward’ fruit promotes fruit expansion through water uptake显示文摘Exogenous application of a cytokinin-like compound forchlorfenuron(CPPU)can promote fruit growth,although often at the expense of dry matter(DM),an important indicator of fruit quality.Actinidia chinensis var.deliciosa‘Hayward’fruit are very responsive to CPPU treatments,but the mechanism underlying the significant fruit weight increase and associated decrease in DM is unclear.In this study,we hypothesised that CPPU-enhanced growth increases fruit carbohydrate demand,but limited carbohydrate supply resulted in decreased fruit DM.During fruit development,CPPU effects on physical parameters,metabolites,osmotic pressure and transcriptional changes were assessed under conditions of both standard and a high carbohydrate supply.We showed that CPPU increased fruit fresh weight but the dramatic DM decrease was not carbohydrate limited.Enhanced glucose and fructose concentrations contributed to an increase in soluble carbohydrate osmotic pressure,which was correlated with increased water accumulation in CPPU-treated fruit and up-regulation of water channel aquaporin gene PIP2.4 at 49 days after anthesis.Transcipt analysis suggested that the molecular mechanism contributing to increased glucose and fructose concentrations was altered by carbohydrate supply.At standard carbohydrate supply,the early glucose increase in CPPU fruit was associated with reduced starch synthesis and increased starch degradation.When carbohydrate supply was high,the early glucose increase in CPPU fruit was associated with a general decrease in starch synthesis but up-regulation of vacuolar invertase and fructokinase genes.We conclude that CPPU affected fruit expansion by increasing the osmotically-driven water uptake and its effect was not carbohydrate supply-limited. | Simona Nardozza Helen L Boldingh Mark W Wohlers Andrew P Gleave Zhiwei Luo Guglielmo Costa Elspeth A MacRae Michael J Clearwater Annette C Richardson | 2017 | Horticulture Research2017，4，1： | 2 |
| 4 | Role of rumination in the relationship between metacognition and shyness显示文摘AIM To explore the association between metacognitive beliefs, rumination and shyness in a non-clinical sample of adults. METHODS One hundred and three healthy subjects from the general population were enrolled in the study. Shyness was evaluated using the Revised Cheek and Buss Shyness Scale, rumination was assessed using the Ruminative Response Scale, metacognition was evaluated using the MetaCognitions Questionnaire 30, and anxiety levels were measured using the State Trait Anxiety Inventory form Y. Correlation analyses, mediation models and 95% bias-corrected and accelerated(BCaCI) bootstrapped analyses were performed. Mediation analyses were adjusted for sex and anxiety. RESULTS Shyness, rumination and metacognition were significantly correlated(P < 0.05). The relationship between metacognition and shyness was fully mediated by rumination(Indirect effect: 0.20; 95% BCaCI: 0.08-0.33).CONCLUSION These findings suggest an association between metacognition and shyness. Rumination mediated the relationship between metacognition and shyness, suggesting that rumination could be a cognitive strategy for shy people. Future research should explore the relationship between these constructs in more depth. | Sara Palmieri Giovanni Mansueto Simona Scaini Francesca Fiore Sandra Sassaroli Giovanni M Ruggiero Rosita Borlimi Bernardo J Carducci | 2018 | World Journal of Psychiatry2018，8，4： | 2 |
| 5 | Impact of Age on the Importance of Systolic and Diastolic Blood Pressures for Stroke Risk: The MOnica, Risk, Genetics, Archiving, and Monograph (MORGAM) Project显示文摘 | Julie K.K. Vishram Anders Borglykke Anne H. Andreasen J?rgen Jeppesen Hans Ibsen Torben J?rgensen Grazyna Broda Luigi Palmieri Simona Giampaoli Chiara Donfrancesco Frank Kee Giuseppe Mancia Giancarlo Cesana Kari Kuulasmaa Susana Sans Michael H. Olsen | 2012 | Hypertension2012，，5： | 1 |
| 6 | Revealing the structural and mechanical characteristics of ovine teeth显示文摘 | Simona O B Amanda J K Paul C | 2014 | J Mech Behav Biomed Mater2014，33，3： | 1 |
| 7 | Effects of Gene Deletion of the Tissue Inhibitor of the Matrix Metalloproteinase-type 1 (TIMP-1) on Left Ventricular Geometry and Function in Mice显示文摘 | Lisa Roten Shintaro Nemoto Janet Simsic Mytsi L Coker Vijay Rao Simona Baicu Gilberto Defreyte Paul J Soloway Michael R Zile Francis G Spinale | 2000 | Journal of Molecular and Cellular Cardiology2000，，1： | 1 |
| 8 | ComBined Mitomycin C Application and Free Flap Conjunctival Autograft in Pterygium Surgery 显示文摘 | Fani S Simona J Noa G | 2003 | Cornea2003，22，7： | 1 |
| 9 | Early-Life Stress Induces Lung-term Morphologic Changes in Primate Brain显示文摘 | SIMONA S SVETLANA C STEPHEN J | 2009 | Archives of General psychiatry2009，，66： | 1 |
| 10 | Giant piezoelectric effect in GaN self-assembled quantum dots显示文摘 | Simona J Pelekanosa N T | 1999 | Microelectronics Journal1999，30，： | 1 |
| 11 | Drape behaviour of seamed fabrics显示文摘 | SIMONA J DARIA Z L | | 0，，05： | 1 |
| 12 | In-transit shipboard fumigation for pine wood chips to control Bursaphelenthus xylophilus显示文摘 | Leesch J G Davis R Simonaitis R A | 1989 | Bulletin OEPP/EPPO Bulletin1989，19，： | 1 |
| 13 | Drape behaviour of seamed fabrics显示文摘 | SIMONA J DARJA 2 | 2007 | Fibers and Polymers2007，8，5： | 1 |
| 14 | O3 and NOy relationships at a rural site 显示文摘 | Olszyna K J Bailey E M Simonaitis R | 1994 | J Geophys Res1994，99，14： | 1 |
| 15 | Gas chromatographic determination of hydrazoic acid显示文摘 | ZEHNER J M SIMONAITIS R A | 1976 | J Chromatogr Sci1976，14，： | 1 |
| 16 | Carotid Artery Stenosis as a Cause of Stroke显示文摘 | Flaherty Matthew L Kissela Brett Khoury Jane C Alwell Kathleen Moomaw Charles J Woo Daniel Khatri Pooja Ferioli Simona Adeoye Opeolu Broderick Joseph P Kleindorfer Dawn | 2012 | Neuroepidemiology2012，，1： | 1 |
| 17 | Electrochemical oxidation of chlorinated benzenes显示文摘 | Wojciech J Simona G Merica | 1999 | Electrochemistry Communications1999，1，： | 1 |
| 18 | β cells are responsible for CXCR3 mediated T-cell infiltration in insulitis 显示文摘 | Simona F Tobias J Bao L | 2002 | Nat Med2002，8，12： | 1 |
| 19 | Can ki -67 play a role in predietion of breast cancer patients' response to neo- adjuvant chemotherapy? 显示文摘 | INGOLF J B RUSSALINA M SIMONA M | 2014 | Biomed Res Int2014，2014，62： | 1 |
| 20 | O3 and NOy relationships at a rural site显示文摘 | Olszyna K J Bailey E M Simonaitis R | 1994 | Journal of Geophysical Research1994，99，14： | 1 |
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