|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer’s disease: randomised, double-blind, placebo-controlled, first-in-human study显示文摘 | Bengt Winblad Niels Andreasen Lennart Minthon Annette Floesser Georges Imbert Thomas Dumortier R Paul Maguire Kaj Blennow Joens Lundmark Matthias Staufenbiel Jean-Marc Orgogozo Ana Graf | 2012 | Lancet Neurology2012，，7： | 3 |
| 2 | Schizophrenia 显示文摘 | Schultz S Andreasen N | 1999 | Lancet1999，353，： | 2 |
| 3 | Clinical trials and late‐stage drug development for A lzheimer’s disease: an appraisal from 1984 to 2014显示文摘 | L. S. Schneider F. Mangialasche N. Andreasen H. Feldman E. Giacobini R. Jones V. Mantua P. Mecocci L. Pani B. Winblad M. Kivipelto | 2014 | J Intern Med2014，，： | 2 |
| 4 | Pit-and trench-forming osteoclasts:a distinction that matters显示文摘Osteoclasts(OCs)seeded on bone slices either drill round pits or dig long trenches.Whereas pits correspond to intermittent resorption,trenches correspond to continuous and faster resorption and require a distinct assembly of the resorption apparatus.It is unknown whether the distinction between pits and trenches has any biological relevance.Using OCs prepared from different blood donors,we found that female OCs achieved increased resorption mainly through pit formation,whereas male OCs did so through trench formation.Trench formation went along with high collagenolytic activity and high cathepsin K(CatK)expression,thereby allowing deeper demineralization.A specific CatK inhibitor abrogated the generation of trenches,while still allowing the generation of pits.OCs obtained from bone marrow were more prone to generate trenches than those obtained from blood.Scanning electron microscopy of bone surfaces eroded in vivo showed trenches and pits of similar size as those made by OCs in culture.We conclude that the distinction between trench-and pit-forming OCs is relevant to the differences among OCs from different skeletal sites,different individuals,including gender,and results from differences in colIagenolytic power.This indicates a biological relevance and highlights the importance of discriminating between pits and trenches when assessing resorption. | Ditte MH Merrild Dinisha C Pirapaharan Christina M Andreasen Per Kjxrsgaard-Andersen Anas MJ Mùller Ming Ding Jean-Marie Delaissé Kent Sùe | 2015 | Bone Research2015，3，4： | 2 |
| 5 | Long-term calcium hydroxide as a root canal dressing may increase risk of root fracture 显示文摘 | Andreasen JO Farik B Munksgaard EC | 2002 | Dent Traumatol2002，18，3： | 1 |
| 6 | The urokinase-type plasminogen activator system in cancer metastasis:a review显示文摘 | Kjoller L Christensen L | 1997 | Int J Cancer1997，72，1： | 1 |
| 7 | Human endotoxemia as a model of systemic inflammation显示文摘 | ANDREASEN AS KRABBE KS KROGH-MADSEN R | 2008 | Curr Med Chem2008，15，17： | 1 |
| 8 | Aquaporin-1 is not Expressed in Descending Thin Limbs of Short Loop Nephrons 显示文摘 | Zhai XY Fenton RA Andreasen A | 2007 | Am Soc Nephrol2007，18，11： | 1 |
| 9 | Increased cerebrospinal fluid levels of transforming growth factor- betal in Alzheimer~s disease 显示文摘 | Zetterberg I-I Andreasen N Blennow K | | Neurosci Lett0，367，2： | 1 |
| 10 | CD1 lb expression as a marker to distinguish between recently activated effector CD8+ T cells and memory cells 显示文摘 | Christensen JE Andreasen SO Christensen JP | 2001 | Int Immunol2001，13，4： | 1 |
| 11 | Negative vs positive schizophrenia:definition and validation显示文摘 | Andreasen NC Olsen S | 1982 | Arch Gen Psychiatry1982，39，： | 1 |
| 12 | Zur Kenntnis des mahlgutes 显示文摘 | H M Andreasen | 1928 | Kolloidchemische Beihefte1928，27，6： | 1 |
| 13 | Pulp and perio- dontal healing, root development and root resorption subsequent to transplantation anc显示文摘 | Paulsen HU Andreasen JO Schwartz O | 1995 | Am J Orthod Dentofacial Orthop1995，108，6： | 1 |
| 14 | Comparison of fractureresistance in root canals of immature sheep teeth after filling withcalcium hydroxide or MTA 显示文摘 | Andreasen JO Munksgaard EC Bakland LK | 2006 | Dent Traumatol2006，22，3： | 1 |
| 15 | CSF biomarkers for mild cognitive impairment and early Alzheimer’s disease显示文摘 | Niels Andreasen Kaj Blennow | 2004 | Clinical Neurology and Neurosurgery2004，，3： | 1 |
| 16 | Reduction of nutrient emission by sludge hydrolysis 显示文摘 | Andreasen K Petersen G Thomsen H | 1997 | Water Science and Technology1997，35，： | 1 |
| 17 | Improvement of sludge settleability in activated sludge plants treating effluent from pulp and paper industries 显示文摘 | Andreasen K Agertved J Petersen J O | 1999 | War Sci Tech1999，40，1112： | 1 |
| 18 | Aquaporin-1 is not expressed in desending thin limbs of short-loop nephrons显示文摘 | Zhai X Y Fenton R A Andreasen A | 2007 | J Am Soc Nephrol2007，18，11： | 1 |
| 19 | Tezosentan reduces the microvascular filtration coefficient in isolated lungs from rats subjected to cecum ligation and puncture 显示文摘 | Kuklin V Sovershaev M Andreasen T | 2005 | Crit Care2005，9，6： | 1 |
| 20 | Sensitivity,specificity,and stability of CSF-tau in AD in a community-based patient sample显示文摘 | Andreasen N Minthon L Clarberg A | 1999 | Neurology1999，22，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员