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1Equivalent circuit method for static and dynamic analysis of magnetoelectric laminated composites显示文摘Magnetoelectric equivalent circuit analytical method is presented for laminate composites of magneto- strictive Terfenol-D (TbxDy1-xFe2) and piezoelectric Pb(Zr1-xTix)O3 (PZT) operated in longitudinal mag- netized and transverse polarized (or L-T), and transverse magnetized and transverse polarized (or T-T) modes. Magnetoelectric (ME) couplings both at low-frequency and resonance-frequency have been studied, and our analysis predicts that (i) the ME voltage coefficients of both L-T and T-T modes in- crease with increasing the thickness of the piezoelectric phase whereas magnetostrictive phase thickness keeps constant, and then tend to saturation when the thickness ratio of piezoelectric phase to magnetic phases is >3; (ii) there are the optimum thickness ratios that maximize magnetoelectric (ME) voltage coefficients for the two modes, which are dependent on elastic compliances ratio of piezoelec- tric phase and magnetostrictive phase; and (iii) the ME voltage coefficients are dramatically increased by a factor of ~Qm, when operated at resonance frequency. A series of Terfenol-D/PZT laminates were fabricated, and the results were compared with the theoretical ones. Experiments confirmed that equivalent circuit method is a useful tool for optimum designs of ME laminates.DONG ShuXiang ZHAI JunYi 2008Chinese Science Bulletin2008,53,14:13
2A phase I study of different doses and frequencies of pegylated recombinant human granulocyte-colony stimulating factor(PEG rhG-CSF) in patients with standard-dose chemotherapy-induced neutropenia显示文摘Objective: The recommended dose of prophylactic pegylated recombinant human granulocyte-colony stimulating factor(PEG rhG-CSF) is 100 μg/kg once per cycle for patients receiving intense-dose chemotherapy.However, few data are available on the proper dose for patients receiving less-intense chemotherapy. The aim of this phase I study is to explore the proper dose and administration schedule of PEG rhG-CSF for patients receiving standard-dose chemotherapy.Methods:Eligible patients received 3-cycle chemotherapy every 3 weeks.No PEG rhG-CSF was given in the first cycle.Patients experienced grade 3 or 4 neutropenia would then enter the cycle 2 and 3.In cycle 2,patients received a single subcutaneous injection of prophylactic PEG rhG-CSF on d 3,and received half-dose subcutaneous injection in cycle 3 on d 3 and d 5,respectively.Escalating doses(30,60,100 and 200μg/kg)of PEG rhG-CSF were investigated.Results:A total of 26 patients were enrolled and received chemotherapy,in which 24 and 18 patients entered cycle 2 and cycle 3 treatment,respectively.In cycle 2,the incidence of grade 3 or 4 neutropenia for patients receiving single-dose PEG rhG-CSF of 30,60,100 and 200 μg/kg was 66.67%,33.33%,22.22% and 0,respectively,with a median duration less than 1(0–2)d.No grade 3 or higher neutropenia was noted in cycle 3 in all dose cohorts.Conclusions:The pharmacokinetic and pharmacodynamic profiles of PEG rhG-CSF used in cancer patients were similar to those reported,as well as the safety.Double half dose administration model showed better efficacy result than a single dose model in terms of grade 3 neutropenia and above.The single dose of 60 μg/kg,100 μg/kg and double half dose of 30 μg/kg were recommended to the phase Ⅱ study,hoping to find a preferable method for neutropenia treatment.Yan Qin Xiaohong Han Lin Wang Ping Du Jiarui Yao Di Wu Yuanyuan Song Shuxiang Zhang Le Tang Yuankai Shi 2017Chinese Journal of Cancer Research2017,29,5:11
3CAS9 is a genome mutator by directly disrupting DNA-PK dependent DNA repair pathway显示文摘With its high efficiency for site-specific genome editing and easy manipulation,the clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR associated protein 9(CAS9)system has become the most widely used gene editing technology in biomedical research.In addition,significant progress has been made for the clinical development of CRISPR/CAS9 based gene therapies of human diseases,several of which are entering clinical trials.Here we report that CAS9 protein can function as a genome mutator independent of any exogenous guide RNA(gRNA)in human cells,promoting genomic DNA double-stranded break(DSB)damage and genomic instability.CAS9 interacts with the KU86 subunit of the DNA-dependent protein kinase(DNA-PK)complex and disrupts the interaction between KU86 and its kinase subunit,leading to defective DNA-PK-dependent repair of DNA DSB damage via non-homologous end-joining(NHEJ)pathway.XCAS9 is a CAS9 variant with potentially higher fidelity and broader compatibility,and dCAS9 is a CAS9 variant without nuclease activity.We show that XCAS9 and dCAS9 also interact with KU86 and disrupt DNA DSB repair.Considering the critical roles of DNA-PK in maintaining genomic stability and the pleiotropic impact of DNA DSB damage responses on cellular proliferation and survival,our findings caution the interpretation of data involving CRISPR/CAS9-based gene editing and raise serious safety concerns of CRISPR/CAS9 system in clinical application.Shuxiang Xu Jinchul Kim Qingshuang Tang Qu Chen Jingfeng Liu Yang Xu Xuemei Fu 2020Protein & Cell2020,11,5:8
4Development of an Amphibious Turtle-Inspired Spherical Mother Robot显示文摘Liwei Shi Shuxiang Guo Shilian Mao Chunfeng Yue Maoxun Li Kinji Asaka 2013Journal of Bionic Engineering2013,10,4:7
5Recent advances in emerging techniques for non-destructive detection of seed viability: A review显示文摘Over the past decades,imaging and spectroscopy techniques have been developed rapidly with widespread applications in non-destructive agro-food quality determination.Seeds are one of themost fundamental elements of agriculture and forestry.Seed viability is of great significance in seed quality characteristics reflecting potential seed germination,and there is a great need for a quick and effective method to determine the germination condition and viability of seeds prior to cultivate,sale and plant.Some researches based on spectra and/or image processing and analysis have been explored in terms of the external and internal quality of a variety of seeds.Many attempts have been made in image segmentation and spectra correction methods to predict seed quality using various traditional and novel methods.This review focuses on the comparative introduction,development and applications of emerging techniques in the analysis of seed viability,in particular,near infrared spectroscopy,hyperspectral and multispectral imaging,Raman spectroscopy,infrared thermography,and soft X-ray imaging methods.The basic theories,principle components,relative chemometric processing,analytical methods and prediction accuracies are reported and compared.Additionally,on the foundation of the observed applications,the technical challenges and future outlook for these emerging techniques are also discussed.Yu Xia Yunfei Xu Jiangbo Li Chi Zhang Shuxiang Fan 2019Artificial Intelligence in Agriculture2019,,1:7
6Robust RGB-D Camera and IMU Fusion-based Cooperative and Relative Close-range Localization for Multiple Turtle-inspired Amphibious Spherical Robots显示文摘In the narrow, submarine, unstructured environment, the present localization approaches, such as GPS measurement, dead?rcckoning, acoustic positioning, artificial landmarks-based method, are hard to be used for multiple small-scale underwater robots. Therefore, this paper proposes a novel RGB-D camera and Inertial Measurement Unit (IMU) fusion-based cooperative and relative close-range localization approach for special environments, such as underwater caves. Owing to the rotation movement with zero-radius, the cooperative localization of Multiple Turtle-inspired Amphibious Spherical Robot (MTASRs) is realized. Firstly, we present an efficient Histogram of Oriented Gradient (HOG) and Color Names (CNs) fusion feature extracted from color images ofTASRs. Then, by training Support Vector Machine (SVM) classifier with this fusion feature, an automatic recognition method of TASRs is developed. Secondly, RGB-D camerabased measurement model is obtained by the depth map In order to realize the cooperative and relative close-range localization of MTASRs, the MTASRs model is established with RGB-D camera and IMU. Finally, the depth measurement in water is corrected and the efficiency of RGB-D camera for underwater application is validated. Then experiments of our proposed localization method with three robots were conducted and the results verified the feasibility of the proposed method for MTASRs.Huiming Xing Liwei Shi Kun Tang Shuxiang Guo Xihuan Hou Yu Liu Huikang Liu Yao Hu 2019Journal of Bionic Engineering2019,16,3:6
7Phase I study of chimeric anti-CD20 monoclonal antibody in Chinese patients with CD20-positive non-Hodgkin's lymphoma显示文摘Objective: This study was designed to determine the safety, pharmacokinetics and biologic effects of a humanmouse chimeric anti-CD20 monoclonal antibody(SCT400) in Chinese patients with CD20-positive B-cell nonHodgkin's lymphoma(CD20+ B-cell NHL). SCT400 has an identical amino acid sequence as rituximab, with the exception of one amino acid in the CH1 domain of the heavy chain, which is common in Asians.Methods: Fifteen patients with CD20+ B-cell NHL received dose-escalating SCT400 infusions(250 mg/m^2: n=3; 375 mg/m^2: n=9; 500 mg/m^2: n=3) once weekly for 4 consecutive weeks with a 24-week follow-up period. The data of all patients were collected for pharmacokinetics and pharmacodynamics analyses.Results: No dose-limiting toxicities were observed. Most drug-related adverse events were grade 1 or 2. Two patients had grade 3 or 4 neutropenia. Under premedication, the drug-related infusion reaction was mild. A rapid, profound and durable depletion of circulating B cells was observed in all dose groups without significant effects on T cell count, natural killer(NK) cell count or immunoglobulin levels. No patient developed antiSCT400 antibodies during the course of the study. SCT400 serum half-life(T1/2), maximum concentration(Cmax) and area under the curve(AUC) generally increased between the first and fourth infusions(P<0.05). At the 375 mg/m^2 dose, the T1/2 was 122.5±46.7 h vs. 197.0±75.0 h, respectively, and the Cmax was 200.6±20.2 μg/m L vs. 339.1±71.0 μg/m L, respectively. From 250 mg/m^2 to 500 mg/m^2, the Cmax and AUC increased significantly in a dose-dependent manner(P<0.05). Patients with a high tumor burden had markedly lower serum SCT400 concentrations compared with those without or with a low tumor burden. Of the 9 assessable patients, 1 achieved complete response and 2 achieved partial responses.Conclusions: SCT400 is well-tolerated and has encouraging preliminary efficacy in Chinese patients with CD20+ B-cell NHL.Lin Gui Xiaohong Han Xiaohui He Yuanyuan Song Jiarui Yao Jianliang Yang Peng Liu Yan Qin Shuxiang Zhang Weijing Zhang Wenlin Gai Liangzhi Xie Yuankai Shi 2016Chinese Journal of Cancer Research2016,28,2:5
8Design of a Surface Plasmon Resonance Sensor Based on Grating Connection显示文摘Nowdays,生物领域的测量的学习集中于在集成和察觉敏感的领域里改进表面电浆子回声 SPR 的研究。我们设计了一种栅栏连接表面电浆子回声传感器。理论上,我们与衍射栅栏结构分析了波浪向量和有效折射索引关系。然后,我们与比传统的 SPR 传感器的高 10 倍的分辨率获得了 nanoparticles 改进 SPR 结构。另外,我们使用了证明它与由 nanoparticles 改进 SPR 结构联合效果是明显的有限差别的时间域 FDTD 分析和模拟反射光谱带宽结果显著地验证了结构它改进了敏感。试验性的结果证明设计传感器的动态反应到达了 10 < 啜 class= “ a-plus-plus ” > 6 RIU 折射索引单位。这研究有某些意义到长途、特殊的察觉到的应用。Jun ZHU Liuli QIN Shuxiang SONG Junwen ZHONG Siyuan LIN 2015Photonic Sensors2015,5,2:5
9Stability analysis and design of time-delay uncertain systems using robust reliability method显示文摘A robust reliability method for stability analysis and reliability-based stabilization of time-delay dynamic systems with uncertain but bounded parameters is presented by treating the uncertain parameters as interval variables.The performance function used for robust reliability analysis is defined by a delayindependent stability criterion.The design of robust controllers is carried out by solving a reliability-based optimization problem in which the control cost satisfying design requirements is minimized.This kind of treatment makes it possible to achieve a balance between the reliability and control cost in the design of controller when uncertainties must be taken into account.By the method,a robust reliability measure of the degree of stability of a time-delay uncertain system can be provided,and the maximum robustness bounds of uncertain parameters such that the time-delay system to be stable can be obtained.All the procedures are based on the linear matrix inequality approach and therefore can be carried out conveniently.The effectiveness and feasibility of the proposed method are demonstrated with two practical examples.It is shown by numerical simulations and comparison that it is meaningful to take the robust reliability into account in the control design of uncertain systems.Shuxiang Guo 2011Journal of Systems Engineering and Electronics2011,22,3:4
10Autologous peripheral blood stem cell mobilization following dose-adjusted cyclophosphamide, doxorubicin, vincristine and prednisolone chemotherapy alone or in combination with rituximab in treating high-risk non-Hodgkin's lymphoma显示文摘Background: The regimen of cyclophosphamide, doxorubicin, vincristine, and prednisolone(CHOP) is an eicient treatment of non-Hodgkin's lymphoma(NHL). This study aimed to assess the eicacy and toxicity of dose-adjusted CHOP alone or in combination with rituximab(R-CHOP) by examining the stem cell mobilization in NHL patients. Factors afecting the collection of CD34+ cells were also explored.Methods: Our retrospective study included 39 patients eligible for autologous stem cell transplantation: 14 patients who expressed CD20 and were inancially eligible received R-CHOP for autologous peripheral blood stem cell(APBSC) mobilization; the remaining 25 patients received CHOP.Results: The median CD34+ cell yield was 7.01 × 106 cells/kg body weight(range 1.49–28.39 × 106 cells/kg body weight), with only two patients failing to meet the target CD34+ cell harvest of ber of apheresis procedures per patient was 1(range 1–3). The≥2.0 APBS× 106 cells/kg body weight. The median numC mobilization yield of the CHOP group appeared to be higher than that of the R-CHOP group(P response(CR) rate in = 0.005), whereas the success rate was similar between groups. R-CHOP elevated the completeB cell lymphoma patients as compared with CHOP(P = 0.01). No signiicant diferences in toxicity or engraftment were observed between the two groups.Conclusion: The present study demonstrated that dose-adjusted CHOP chemotherapy efectively mobilized APBSCs in NHL patients and that the addition of rituximab to dose-adjusted CHOP chemotherapy elevated the CR rate for patients with B-cell lymphoma.Yuankai Shi Ping Zhou Xiaohong Han Xiaohui He Shengyu Zhou Peng Liu Jianliang Yang Changgong Zhang Lin Gui Yan Qin Sheng Yang Liya Zhao Jiarui Yao Shuxiang Zhang 2015Chinese Journal of Cancer2015,34,11:4
11A Fuzzy PID Algorithm for a Novel Miniature Spherical Robots with Three-dimensional Underwater Motion Control显示文摘We proposed and developed a small bionic amphibious spherical robot system for tasks such as coastal environment monitoring and offshore autonomous search and rescue.Our third-generation bionic small amphibious spherical robots have many disadvantages,such as the lack of maneuverability and a small operating range.It is difficult to accomplish underwater autonomous motion control with these robots.Therefore,we proposed a fourth-generation amphibious spherical robot.However,the amphibious spherical robot developed in this project has a small and compact design,with limited sensors and external sensing options.This means that the robot has weak external information collection capabilities.We need to make the real time operation of the robot's underwater motion control system more reliable.In this paper,we mainly used a fuzzy Proportional-Integral-Derivative(PID)control algorithm to design an underwater motion control system for a novel robot.Moreover,we compared PID with fuzzy PID control methods by carrying out experiments on heading and turning bow motions to verify that the fuzzy PID is more robust and exhibits good dynamic performance.We also carried out experiments on the three-dimensional(3D)motion control to validate the design of the underwater motion control system.Liwei Shi Yao Hu Shuxiang Su Shuxiang Guo Huiming Xing Xihuan Hou Yu Liu Zhan Chen Zan Li Debin Xia 2020Journal of Bionic Engineering2020,17,5:4
12Defect-rich titanium nitride nanoparticle with high microwaveacoustic conversion efficiency for thermoacoustic imaging-guided deep tumor therapy显示文摘Pulse microwave excite thermoacoustic(TA)shockwave to destroy tumor cells in situ.This has promising applications for precise tumor therapy in deep tissue.Nanoparticle(NP)with high microwave-acoustic conversion is the key to enhance the efficiency of therapy.In this study,we firstly developed defect-rich titanium nitride nanoparticles(TiN NPs)for pulse microwave excited thermoacoustic(MTA)therapy.Due to a large number of local structural defects and charge carriers,TiN NPs exhibit excellent electromagnetic absorption through the dual mechanisms of dielectric loss and resistive loss.With pulsed microwave irradiation,it efficiently converts the microwave energy into shockwave via thermocavitation effect,achieving localized mechanical damage of mitochondria in the tumor cell and yielding a precise antitumor effect.In addition to the therapeutic function,the NP-mediated TA process also generates images that provide valuable information,including tumor size,shape,and location for treatment planning and monitoring.The experimental results showed that the TiN NPs could be efficiently accumulated in the tumor via intravenous infusion.With the deep tissue penetration characteristics of microwave,the proposed TiN-mediated MTA therapy effectively and precisely cures tumors in deep tissue without any detectable side effects.The results indicated that defect-rich TiN NPs are promising candidates for tumor therapy.Zhujun Wu Fanchu Zeng Le Zhang Shuxiang Zhao Linghua Wu Huan Qin Da Xing 2021Nano Research2021,14,8:4
13The potent different risk factors for cerebral infarction in young patients with and without type 2 diabetes: Subanalysis of the Young Cerebral Infarction Study (YCIS)显示文摘Bin Zhang Cong Gao Qinghua Hou Jianrui Yin Longchang Xie Shuxiang Pu Yonghong Yi Qingchun Gao 2011Atherosclerosis2011,,1:3
14Polarization microwave-induced thermoacoustic imaging for quantitative characterization of deep biological tissue microstructures显示文摘Polarization optical imaging can be used to characterize anisotropy in biological tissue microstructures and has been demonstrated to be a powerful tool for clinical diagnosis. However, the approach is limited by an inability to image targets deeper than ~1 mm due to strong optical scattering in biological tissues. As such, we propose a novel polarization microwave-induced thermoacoustic imaging(P-MTAI) technique to noninvasively detect variations in deep tissue by exploiting the thermoacoustic signals induced by four pulsed microwaves of varying polarization orientations. The proposed P-MTAI method overcomes the penetration limits of conventional polarization optical imaging and provides submillimeter resolution over depths of several centimeters. As part of the paper, the structural characteristics of tissues were quantified using a new parameter, the degree of microwave absorption anisotropy. P-MTAI was also applied to the noninvasive detection of morphological changes in cardiomyocytes as they transitioned from ordered to disordered states, providing a potential indication of myocardial infarction.YUJING LI SHANXIANG ZHANG LINGHUA WU ZHONGWEN CHENG ZHENHUI ZHANG HAOHAO WANG SHUXIANG ZHAO MINGYANG REN SIHUA YANG DA XING HUAN QIN 2022Photonics Research2022,10,5:2
15Study on antitumor effects of curcumin显示文摘Cui Shuxiang Jin Dongqing Zhou Ling 2002China J Cancer Prev Treat FEB2002,9,1:2
16Discrimination of Chuanminshen violaceum Sheh et Shen from different regions based on fatty acid profiles of roots and leaves显示文摘Objectives:The purpose of this paper was to construct a reliable methodology to discriminate the geographical origins of Chuanminshen violaceum Sheh et Shan planted in different regions in Sichuan,China.Materials and methods:Fatty acid profiles of roots and leaves of C.violaceum planted in various regions of Sichuan Province in China,namely Guangyuan(GY),Langzhong(LZ),Jintang(JT),Bazhong(BZ),and Shuangling(SL),were determined using GC-MS followed by multivariate statistical analyses,including orthogonal partial least-squares discriminant analysis and hierarchical clustering analysis.Results:Leaves of C.violaceum showed the highest contents of hexadecatrienoic acid(3.21 g/kg),linoleic acid(6.62 g/kg),andα-linolenic acid(7.24 g/kg),which were all higher than those contained in roots.Chuanminshen violaceum samples collected from LZ,JT,and GY could be clearly distinguished based on fatty acid profiles of leaves and those collected from LZ,GY,and BZ could be clearly distinguished based on fatty acid profiles of roots.Conclusions:Chemometric method is used as a potential approach for analyses of fatty acid profiles of roots and leaves to control the quality of C.violaceum and their powered products.Qing Zhang Junrui Tian Chong Wan Hongmin Dong Dingtao Wu Shuxiang Liu Wen Qin 2020Food Quality and Safety2020,4,2:2
17Development of a Novel Robotic Catheter Manipulating System with Fuzzy PID Control显示文摘Xu Ma Shuxiang Guo Nan Xiao Jian Guo Shunichi Yoshida Takashi Tamiya Masahiko Kawanishi 2012International Journal of Intelligent Mechatronics and Robotics (IJIMR)2012,,2:2
18Preparation of slightly crosslinked monodisperse poly(maleic anhydride-cyclohexyl vinyl ether-divinylbenzene)functional microspheres with anhydride groups via precipitation polymerization显示文摘Slightly crosslinked monodisperse poly(maleic anhydride-cyclohexyl vinyl ether-divinylbenzene)(MA-CHVE-DVB) microspheres were prepared via precipitation polymerization while using 2,2-azobisisobutyronitrile as an initiator in a mixture of methyl ethyl ketone and n-heptane without any stabilizer.The number-average diameter of the resultant poly(MA-CHVE-DVB) microspheres ranged from 0.478 to 1.386 μm with a polydispersity index of 1.00 to 1.02 that depended on the feed ratios of the MA/CHVE/DVB monomers.The introduction of one electron donor monomer cyclohexyl vinyl ether strongly affected the yield,size,and morphology of these slightly crosslinked microspheres.Quinolinetype chelating resins were obtained after combining the poly(MA-CHVE-DVB) with 8-hydroxyquinoline;the adsorption properties of these materials were measured through their ability to remove Cu^(2+) ions from water.The poly(MA-CHVE-DVB) microspheres with low degrees of crosslinldng provided more effective functional groups and therefore better ion removal capabilities.These slightly crosslinked microspheres may have applications in water treatment as well as in sensing and drug delivery.Cen Yin Anhou Xu Li Gong Luqing Zhang Bing Geng Shuxiang Zhang 2015Particuology2015,13,2:2
19A differential magnetoelectric laminated composite for vibration noise suppression显示文摘A magnetoelectric(ME) laminated composite made of one pair of piezoelectric Pb(Zr,Ti)O3(PZT) fiber layers with multiple push–pull polarization units laminated between high-permeability metglas ribbon layers with a differential configuration was proposed for vibration noise suppression. Unlike conventional metglas/PZT fiber/metglas three-layer ME laminated structures, the differential configuration has the capability to reject vibration-induced noise from the magnetic signal. The experiment results showed that the differential ME laminated composite was with up to 30 times enhancement in signal-to-noise ratio.Guoxi Liu Shuxiang Dong 2014Chinese Science Bulletin2014,59,36:2
20Massage treatment of chronic persistent pediatric asthma显示文摘Objective:We observed the clinical effect of massage in treating chronic persistent pediatric asthma and the changes in expression of TLR1,TLR2,and TLR4 on macrophages.Methods:One hundred sixty pediatric patients with persistent chronic asthma were col-lected,and divided into treatment and control groups of 80 each in strict accordance with the principle of random allocation.The patients in the control group received general nebulizer therapy,and the patients in the treatment group received infantile massage.Both groups of patients were observed for 3 months with respect to the following indicators:the frequency of asthmatic attacks;the frequency of respiratory tract infections(RTIs);C-ACT rating;and the PEF%of peripheral blood(PB)before and after treatment to detect macrophage TLR1,TLR2,and TLR4.Results:After treatment,the frequency of asthmatic attacks,frequency of RTIs,C-ACT rat-ing,and the PEF%and macrophage TLR1,TLR2,and TLR4 expression of fluorescence intensity in the treatment group showed a statistically significant increase when compared with the control group(P<0.05).Conclusion:Pediatric massage can improve the clinical symptoms of pediatric asthma by up-regulating the expression of macrophage TLR1,TLR2,and TLR4.Fuling Tian Qi Li Jianmei Cui Shuxiang Ma Hongbin Wang Xueqing Li 2014Family Medicine and Community Health2014,2,2:2
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