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| 1 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 2 | Superior electrochemical performance of La-Mg-Ni-based alloys with novel A_(2)B_(7)-A_(7)B_(23) biphase superlattice structure显示文摘Nickel metal hydride(Ni-MH) rechargeable batteries hold an important position in the new-energy vehicle market owing to their key technology advantages. Their negative electrode materials—hydrogen storage alloys(HSAs) are always on the spotlight and are the key to compete with the burgeoning Li-ion batteries. Here, for the first time we report a series of biphase supperlattice HSAs with a(La,Mg)_(2)Ni_7 matrix phase and a novel(La,Mg)_(7)Ni_(23) secondary phase. The biphase alloys show discharge capacities of402–413 m Ahg^(-1) compared with 376–397 mAhg^(-1) of the other multi-or single-phase alloys. These values are among the highest for superlattice HSAs. In addition, the alloy with 15.4 wt.%(La,Mg)_(7)Ni_(23) phase exhibits good high rate dischargeability due to the proper compromise between the amount of crystal boundaries and equilibrium plateau voltage. The cycling stability of the biphase alloys is lower than that of the single-phase alloy but is till higher than the multiphase alloy. The novel superlattice biphase alloys with superior overall electrochemical properties are expected to inspire further design and development of HSAs as advanced electrode materials for power batteries. | Jingjing Liu Shuai Zhu Xiangyu Chen Jie Xu Lu Zhang Kai Yan Wei Chen Honghui Cheng Shumin Han | 2021 | Journal of Materials Science & Technology2021，，21： | 4 |
| 3 | Rabdosia serra alleviates dextran sulfate sodium salt-induced colitis in mice through anti-inflammation,regulating Th17/Treg balance,maintaining intestinal barrier integrity,and modulating gut microbiota显示文摘Rabdosia serra(R.serra),an important component of Chinese herbal tea,has traditionally been used to treat hepatitis,jaundice,cholecystitis,and colitis.However,the chemical composition of R.serra and its effect against colitis remain unclear.In this study,the chemical composition of the water extract of R.serra was analyzed using ultra performance liquid chromatography coupled with a hybrid linear ion trap quadrupole-orbitrap mass spectrometer(UPLC-LTQ-Orbitrap-MS).A total of 46 compounds,comprising ent-kaurane diterpenoids,flavonoids,phenolic acids,and steroids,were identified in the water extract of R.serra,and the extract could significantly alleviate dextran sulfate sodium salt-induced colitis by improving colon length,upregulating anti-inflammatory factors,downregulating proinflammatory factors,and restoring the balance of T helper 17/T regulatory cells.R.serra also preserved intestinal barrier function by increasing the level of tight junction proteins(zonula occludens 1 and occludin)in mouse colonic tissue.In addition,R.serra modulated the gut microbiota composition by increasing bacterial richness and diversity,increasing the abundance of beneficial bacteria(Muribaculaceae,Bacteroides,Lactobacillus,and Prevotellaceae_UCG-001),and decreasing the abundance of pathogenic bacteria(Turicibacter,Eubacterium_fissicatena_group,and Eubacterium_xylanophilum_group).Gut microbiota depletion by antibiotics further confirmed that R.serra alleviated colitis in a microbiota-dependent manner.Overall,our findings provide chemical and biological evidence for the potential application of R.serra in the management of colitis. | Hongyi Li Yi Wang Shumin Shao Hui Yu Deqin Wang Chuyuan Li Qin Yuan Wen Liu Jiliang Cao Xiaojuan Wang Haibiao Guo Xu Wu Shengpeng Wang | 2022 | Journal of Pharmaceutical Analysis2022，12，6： | 4 |
| 4 | Bi Nanoparticles Anchored in N-Doped Porous Carbon as Anode of High Energy Density Lithium Ion Battery显示文摘A novel bismuth–carbon composite, in which bismuth nanoparticles were anchored in a nitrogen-doped carbon matrix(Bi@NC), is proposed as anode for high volumetric energy density lithium ion batteries(LIBs).Bi@NC composite was synthesized via carbonization of Zn-containing zeolitic imidazolate(ZIF-8) and replacement of Zn with Bi, resulting in the N-doped carbon that was hierarchically porous and anchored with Bi nanoparticles. The matrix provides a highly electronic conductive network that facilitates the lithiation/delithiation of Bi.Additionally, it restrains aggregation of Bi nanoparticles and serves as a buffer layer to alleviate the mechanical strain of Bi nanoparticles upon Li insertion/extraction.With these contributions, Bi@NC exhibits excellent cycling stability and rate capacity compared to bare Bi nanoparticles or their simple composites with carbon. This study provides a new approach for fabricating high volumetric energy density LIBs. | Yaotang Zhong Bin Li Shumin Li Shuyuan Xu Zhenghui Pan Qiming Huang Lidan Xing Chunsheng Wang Weishan Li | 2018 | Nano-Micro Letters2018，10，4： | 3 |
| 5 | Characterization of DNA damage response deficiency in pancreatic cancer patients from China显示文摘To the editor,Pancreatic ductal adenocarcinoma(PDAC)has the worst prognosis among all common malignant solid tumors,with a 5-year overall survival(OS)rate of less than 10%[1].Few effective targets for anticancer ther-apy have been confirmed in pancreatic cancer.Recently,it was substantiated that pancreatic cancer patients carry-ing deleterious mutations of the DNA damage response(DDR)genes are more likely to benefit from platinum-based chemotherapy[2]and poly(adenosine diphosphate-ribose)polymerase(PARP)inhibitor[3]. | Xiaofei Zhang Tiebo Mao Bei Zhang Haiyan Xu Jiujie Cui Feng Jiao Dongqin Chen Yu Wang Jiong Hu Qing Xia Shumin Li Ming Yue Jingyu Ma Jiayu Yao Yongchao Wang Xiao Zhang Shiqing Chen Yuezong Bai Yuexiang Wang Xuebin Zhang Qiang Liu Yongwei Sun Deliang Fu Yingbin Liu Lei Xiong Liwei Wang | 2022 | Cancer Communications2022，42，1： | 2 |
| 6 | Antimicrobial effect and membrane-active mechanism of tea polyphenols against Serratia marcescens显示文摘 | Shumin Yi Wei Wang Fengling Bai Junli Zhu Jianrong Li Xuepeng Li Yongxia Xu Tong Sun Yutang He | 2014 | World Journal of Microbiology and Biotechnology2014，，2： | 2 |
| 7 | A molecular roadmap for induced multi-lineage transdifferentiation of fibroblasts by chemical combinations显示文摘 | Xiaoping Han Hao Yu Daosheng Huang Yang Xu Assieh Saadatpour Xia Li Lengmei Wang Jie Yu Luca Pinello Shujing Lai Mengmeng Jiang Xueying Tian Fen Zhang Yanhong Cen Yuko Fujiwara Wei Zhu Bin Zhou Tianhua Zhou Hongwei Ouyang Jianan Wang Guo-Cheng Yuan Shumin Duan Smart H Orkin Guoji Guo | 2017 | Cell Research2017，27，3： | 2 |
| 8 | Association of PDE4D and IL-1 gene polymorphism with ischemic stroke in a Han Chinese population显示文摘 | Nan Li Zhiyi He Jialiang Xu Fang Liu Shumin Deng Hui Zhang | 2009 | Brain Research Bulletin2009，，1： | 1 |
| 9 | Building confidential and efficient query services in the cloud with RASP data per- turhation 显示文摘 | XU Huiqi Guo Shumin Chen Keke | 2014 | IEEE Transactions on Knowledge and Data Engineering2014，26，2： | 1 |
| 10 | Improvement of Fluorescence Lifetime from Er-Doped Sol-Gel Silica Glass by Dehydration in CCl4显示文摘 | Yigang Li Liying Liu Zian He Hengsheng Tang Shumin Xiao Lei Xu Wencheng Wang | 2004 | Journal of Sol - Gel Science and Technology2004，，1： | 1 |
| 11 | Redox regulation of I10 remodeling in diabetic rat heart 显示文摘 | Xun Li Zhi Xu Shumin Li | 2005 | Am J Physiol Heart Circ Physiol2005，288，3： | 1 |
| 12 | Neural symbolic reasoning with knowledge graphs:Knowledge extraction,relational reasoning,and inconsistency checking显示文摘Knowledge graphs(KGs)express relationships between entity pairs,and many real-life problems can be formulated as knowledge graph reasoning(KGR).Conventional approaches to KGR have achieved promising performance but still have some drawbacks.On the one hand,most KGR methods focus only on one phase of the KG lifecycle,such as KG completion or refinement,while ignoring reasoning over other stages,such as KG extraction.On the other hand,traditional KGR methods,broadly categorized as symbolic and neural,are unable to balance both scalability and interpretability.To resolve these two problems,we take a more comprehensive perspective of KGR with regard to the whole KG lifecycle,including KG extraction,completion,and refinement,which correspond to three subtasks:knowledge extraction,relational reasoning,and inconsistency checking.In addition,we propose the implementation of KGR using a novel neural symbolic framework,with regard to both scalability and interpretability.Experimental results demonstrate that our proposed methods outperform traditional neural symbolic models. | Huajun Chen Shumin Deng Wen Zhang Zezhong Xu Juan Li Evgeny Kharlamov | 2021 | Fundamental Research2021，1，5： | 1 |
| 13 | Modulation instability of femtosecond pulses in dispersion decreasing fibers显示文摘 | Zhang Shumin Luo Aiping | 2001 | Optics Communications2001，199，56： | 1 |
| 14 | Analysis of a diverse global Pisum sp. collection and comparison to a Chinese local P. sativum collection with microsatellite markers显示文摘 | Xuxiao Zong Robert J. Redden Qingchang Liu Shumin Wang Jianping Guan Jin Liu Yanhong Xu Xiuju Liu Jing Gu Long Yan Peter Ades Rebecca Ford | 2009 | Theoretical and Applied Genetics2009，，2： | 1 |
| 15 | Analysis of a diverse global Pisum sp. collection and comparison to a Chinese local P. sativum collection with microsatellite markers显示文摘 | Xuxiao Zong Robert J. Redden Qingchang Liu Shumin Wang Jianping Guan Jin Liu Yanhong Xu Xiuju Liu Jing Gu Long Yan Peter Ades Rebecca Ford | 2009 | Theoretical and Applied Genetics2009，，2： | 1 |
| 16 | Numerical study of the optimum counter-flow mode of air jets in a large utility furnace显示文摘 | HE Boshu CHEN Meiqian YU Qiumei LIU Shumin FAN Lijuan SUN Shouguang XU Jinyuan PAN Wei-Ping | | 0，，： | 1 |
| 17 | Feedback control and adaptive control of the energy resource chaotic system显示文摘 | Mei Sun Lixin Tian Shumin Jiang Jun Xu | 2007 | Chaos Solitions&Fractals2007，32，5： | 1 |
| 18 | Random Lasing in Bone Tissue显示文摘 | Song Qinghai Xiao Shumin Xu Zhengbin | 2010 | Optics Letters2010，35，9： | 1 |
| 19 | Construction of a high-density mutant population of Chinese cabbage facilitates the genetic dissection of agronomic traits显示文摘Chinese cabbage(Brassica rapa ssp.pekinensis)is an economically important vegetable crop throughout the world,especially in Asia.High-quality genome sequences are available for Chinese cabbage,but gene functional studies remain challenging.To promote functional genomic studies of Chinese cabbage,we generated an ethyl methane sulfonate(EMS)mutant population of~8000 M_(2) plants using the double haploid inbred line A03 as the parent.The genome of A03 was sequenced and used as a reference for high-throughput functional characterization of gene mutations at the whole-genome level.A total of 300 M_(2) to M_(5) EMS mutants were phenotypically screened and then sequenced,revealing 750629 SNPs and 46272 InDel mutations that cover 98.27%of all predicted genes in the A03 genome.A forward-genetics approach was successfully used to identify two genes with chloroplast-related functions that are responsible for the yellow leaf mutant trait.A reverse-genetics approach was also used to identify associations between mutations in five genes of the glucosinolate biosynthetic pathway and variations in glucosinolate content of the mutant plants.In addition,we built the Chinese cabbage EMS mutation database(CCEMD,www.bioinformaticslab.cn/EMSmutation/home)to increase the usability of this mutant population resource.In summary,we performed large-scale screening of a heading Chinese cabbage EMS mutant collection at the phenotypic and genotypic levels,which will facilitate gene mining of Chinese cabbage and might also be useful for the study of other Brassica crops. | Xiaoxue Sun Xing Li Yin Lu Shan Wang Xiaomeng Zhang Kang Zhang Xiangjie Su Mengyang Liu Daling Feng Shuangxia Luo Aixia Gu Yu Fu Xueping Chen Shuxin Xuan Yanhua Wang Donghui Xu Shumin Chen Wei Ma Shuxing Shen Feng Cheng Jianjun Zhao | 2022 | Molecular Plant2022，15，5： | 1 |
| 20 | A candy-like photocatalyst by wrapping Co, N-co-doped hollow carbon sphere with ultrathin mesoporous carbon nitride for boosted photocatalytic hydrogen evolution显示文摘Hierarchical carbon material is used as a star cocatalyst in the field of photocatalysis due to its excellent catalytic properties. In this work, mesoporous carbon nitride sheet(MCNS) photocatalyst introduced nitrogen-doped hollow carbon spheres assembled with cobalt nanoparticles(Co@NHC) is synthesized by electrostatic adsorption. A series of characterizations are analyzed to display the structures, morphologies and optical properties of as-prepared materials. The photocatalytic activity of Co@NHC/MCNS material is evaluated with hydrogen evolution under visible light irradiation. The results indicate that 5 wt%Co@NHC/MCNS material reveals higher photocatalytic activity of hydrogen evolution rate of 3675 μmol/g with 4 h reaction time, which is 159 times than that of pure MCNS material. The carbon material with excellent charge transport properties can effectively accelerate the charge transfer from ultrathin MCNS to cobalt nanoparticles. The goal of improving the photocatalytic performance of Co@NHC/MCNS material is achieved. As a result, it provides a feasible and promised approach for doping transition metals to enhance photocatalytic activity. | Jinyuan Liu Shumin Zhu Bin Wang Ruizhe Yang Rong Wang Xingwang Zhu Yanhua Song Junjie Yuan Hui Xu Huaming Li | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
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