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| 1 | Clinical features and outcomes of diffuse large B-cell lymphoma based on nodal or extranodal primary sites of origin:Analysis of 1,085 WHO classified cases in a single institution in China显示文摘Objective: To explore the clinicobiologic features and outcomes of diffuse large B-cell lymphoma(DLBCL)patients in China according to the primary site.Methods: A total of 1,085 patients diagnosed with DLBCL in National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College during a 6-year period were enrolled. Their clinical characteristics and outcomes were analyzed according to the primary site.Results: In the 1,085 patients, 679(62.6%) cases were nodal DLBCL(N-DLBCL) and 406 cases(37.4%) were extranodal DLBCL(EN-DLBCL). The most common sites of N-DLBCL were lymphonodus(64.8%), Waldeyer's ring(19.7%), mediastinum(12.8%) and spleen(2.7%), while in EN-DLBCL, stomach(22.4%), intestine(16.0%),nose and sinuses(8.9%), testis(8.4%), skin(7.9%), thyroid(6.9%), central nervous system(CNS)(6.4%), breast(5.7%), bone(3.4%), and salivary gland(2.7%) were most common. N-DLBCL patients tend to present B symptoms, bulky disease, and elevated LDH more often, while age >60 years, extranodal sites >1, Ann Arbor stage I or II, bone marrow involvement, and Ki-67 index >90% were usually seen in EN-DLBCL. The 5-year overall survival(OS) rate and progression-free survival(PFS) rate for all patients were 62.5% and 54.2%. The 5-year OS rate for patients with N-DLBCL and EN-DLBCL were 65.5% and 56.9%(P=0.008), and the 5-year PFS were57.0% and 49.0%(P=0.020). Waldeyer's ring originated DLBCL possessed the highest 5-year OS rate(83.6%) and PFS rate(76.9%) in N-DLBCL. The top five EN-DLBCL subtypes with favorable prognosis were stomach,breast, nose and sinuses, lung, salivary gland, with 5-year OS rate: 70.3%, 69.6%, 69.4%, 66.7% and 63.6%,respectively. While CNS, testis, oral cavity and kidney originated EN-DLBCL faced miserable prognosis, with 5-year OS rate of 26.9%, 38.2%, and 42.9%.Conclusions: In our study, primary sites were associated with clinical characteristics and outcomes. Compared with EN-DLBCL, N-DLBCL had better prognosis. | Yuankai Shi Ying Han Jianliang Yang Peng Liu Xiaohui He Changgong Zhang Shengyu Zhou Liqiang Zhou Yan Qin Yongwen Song Yueping Liu Shulian Wang Jing Jin Lin Gui Yan Sun | 2019 | Chinese Journal of Cancer Research2019，31，1： | 19 |
| 2 | Degradation of organic pollutants by a Co_3O_4 -graphite composite electrode in an electro-Fenton-like system显示文摘A novel composite electrode was constructed by pressing together Co3O4 and graphite and it was used as the cathode in an electro-Fenton-like (EFL) system. The poor electron transport characteristic of Co3O4 was overcome by incorporating graphite. In situ electro-catalytic generation of hydroxyl radicals (·OH) occurred at high current efficiencies from pH 2-10, extending the traditional Fenton reaction pH range. Cyclic voltammetry and AC impedance spectrometry were used to characterize the composite electrode. The ability of the EFL system to degrade organic compounds was investigated using sulforhodamine B (SRB) and 2,4-dichlorophenol (2,4-DCP) as probes. Decoloration of SRB (1.0×10-5 mol/L) was complete (100%) in 150 min and SRB was effectively degraded from pH 2-10. The decomposition of SRB was studied using Fourier transform infrared spectroscopy (FT-IR) and total organic carbon (TOC) analysis and results indicated that the final degradation products were carbon dioxide, carboxylic acids and amines. The EFL system also decomposed 2,4-DCP and the degradation was 98.6% in 240 min. Electro-catalytic degradation of SRB occurs by a ·OH mechanism. After 5 times reused, the degradation rate of SRB did not significantly slow down. The electrode shows excellent potential for use in advanced oxidation processes (AOPs) used to treat persistent organic pollutants (POPs) in wastewater. | LIU Shuan GU Yan WANG ShuLian ZHANG Yu FANG YanFen JOHNSON David M HUANG YingPing | 2013 | Chinese Science Bulletin2013，58，19： | 18 |
| 3 | Orthogonal linear polarized lasers (Ⅲ)——Applications in self-sensing显示文摘In this paper, the applications of orthogonal linear polarized lasers in self-sensing are reviewed. The properties for such a laser include the production of a new frequency in one longitudinal mode spacing, the tuning of frequency difference, the change of polarization states as cavity tuning, the control of mode competition intensity, the optical feedback, and so on. The orthogonal polarized lasers have been used as a laser nanometer ruler based on competition between two polarized lights in a HeNe laser and as a displacement measurement tool based on the optical feedback in the orthogonal polarized lasers. They are also used in the phase retardation measurement of a waveplate, the angle measurement, the vibration measurement, the pressure/force measurement, the weak magnetic field measurement,and so on. The structures of these new devices are simple and compact with the great advantages of high resolution and high accuracy.Some of these devices can trace to the source of the laser wavelength. The nanometer laser ruler is an example whose measurement range is 12 mm, resolution is 79 nm and linearity is less than 5×10- 5. The repeatability of the phase retardation measuring system of waveplate can reach 3'. | ZHANG Shulian DU Wenhua LIU Gang | 2005 | Progress in Natural Science:Materials International2005，15，11： | 4 |
| 4 | Orthogonal linear polarized lasers (II)——Study on the physical phenomena显示文摘The physical phenomena and corresponding theoretical analysis of orthogonal polarized laser are reviewed. Four lasers (or systems) with orthogonal polarized beams are involved. For the birefringence dual frequency laser, its physical phenomena discussed include the alternation between strong mode competition and medium mode competition in cavity tuning; the range of frequency difference of strong mode competition (about 0-40 MHz); four polarization statuses (o-light oscillating but e-light extinguishing, both o-light and elight oscillating, e-light oscillating but o-light extinguishing, both o-light and e-light extinguishing) in cavity tuning; the tuning curves of frequency difference; the influence of optical activity of quartz crystal on polarization direction; and the aberrance of frequency splitting.For the Birefringence-Zeeman dual frequency laser, we focus on its intensity tuning and frequency difference tuning. For the feedback system of orthogonally polarized laser, we discuss the mutual suppression between two orthogonal frequencies, intensity exchange between two orthogonal frequencies and double of intensity fringe frequency. For orthogonally polarized LD-pumped Nd: YAG microchip laser, its property of the dependence of intensity sensitivity on frequency difference is described. | ZHANG Shulian LIU Gang | 2005 | Progress in Natural Science:Materials International2005，15，10： | 3 |
| 5 | Single-cell transcriptomic landscape of human blood cells显示文摘High throughput single-cell RNA-seq has been successfully implemented to dissect the cellular and molecular features underlying hematopoiesis.However,an elaborate and comprehensive transcriptome reference of the whole blood system is lacking.Here,we profiled the transcriptomes of 7551 human blood cells representing 32 immunophenotypic cell types,including hematopoietic stem cells,progenitors and mature blood cells derived from 21 healthy donors.With high sequencing depth and coverage,we constructed a single-cell transcriptional atlas of blood cells(ABC) on the basis of both protein-coding genes and long noncoding RNAs(lncRNAs),and showed a high consistence between them.Notably,putative lncRNAs and transcription factors regulating hematopoietic cell differentiation were identified.While common transcription factor regulatory networks were activated in neutrophils and monocytes,lymphoid cells dramatically changed their regulatory networks during differentiation.Furthermore,we showed a subset of nucleated erythrocytes actively expressing immune signals,suggesting the existence of erythroid precursors with immune functions.Finally,a web portal offering transcriptome browsing and blood cell type prediction has been established.Thus,our work provides a transcriptional map of human blood cells at single-cell resolution,thereby offering a comprehensive reference for the exploration of physiological and pathological hematopoiesis. | Xiaowei Xie Mengyao Liu Yawen Zhang Bingrui Wang Caiying Zhu Chenchen Wang Qing Li Yingying Huo Jiaojiao Guo Changlu Xu Linping Hu Aiming Pang Shihui Ma Una Wang Wenbin Cao Shulian Chen Qiuling Li Sudong Zhang Xueying Zhao Wen Zhou Hongbo Luo Guoguang Zheng Erlie Jiang Sizhou Feng Lixiang Chen Lihong Shi Hui Cheng Sha Hao Ping Zhu Tao Cheng | 2021 | National Science Review2021，8，3： | 3 |
| 6 | Acupuncture stimulation of Yamen(GV 15), Fengfu(GV 16), Baihui(GV 20), Shuigou(GV 26) and Hegu(LI 4) reduces brain microglia activation in a traumatic brain injury rat model显示文摘OBJECTIVE: To evaluate the effect of acupuncture on neuroinflammation in traumatic brain injury(TBI) rats by stimulating Yamen(GV 15), Fengfu(GV16), Baihui(GV 20), Shuigou(GV 26) and Hegu(LI 4)acupoints and to investigate the mechanism underpinning this effect.METHODS: A TBI model was induced in SpragueDawley rats using Feeney's freefall impact method.Acupuncture to stimulate the Yamen(GV 15), Fengfu(GV 16), Baihui(GV 20), Shuigou(GV 26) and Hegu(LI 4) acupoints was performed on the TBI rats. After 3 consecutive days of acupuncture treatment, we investigated signal molecules, receptors and microglia related to neuroinflammation in brain tissue of the TBI rats and analyzed the possi-ble mechanism underlying the effect of acupuncture on neuroinflammation.RESULTS: After the acupuncture treatment, ionized calcium binding adaptor molecule 1(Iba1), a protein specific to microglia, was investigated. In the cortical layer of damaged brain tissue in TBI rats,the Iba1-positive area was 3.3% ± 0.9% in the rats that received acupuncture compared with 5.2% ±1.4% in the TBI rats that did not receive acupuncture, and the microglia were smaller with more slender protrusions in the acupuncture-treated rats.This result indicates that acupuncture can significantly reduce microglia activation in TBI rats. A possible mechanism for this effect is that acupuncture reduces the expression of autotaxin and lysophosphatidic acid. Together, these constitute the autotaxin-lysophosphatidic acid axis, which induces microglial activation in the brains of TBI rats. Acupuncture treatment may downregulate the expression of Lysophosphatidic acid(LPA) receptor(LPAR) 1 and LPAR2 on the microglial cytomembrane, which affects the microglia activation process.CONCLUSION: Acupuncture stimulating the Yamen(GV 15), Fengfu(GV 16), Baihui(GV 20),Shuigou(GV 26) and Hegu(LI 4) acupoints can effectively inhibit the development of neuroinflammation after TBI. One possible mechanism for this effect is that acupuncture downregulates LPA synthesis and affects the LPA-LPAR pathway by inhibiting LPAR1 and LPAR2, thereby inhibiting microglial activation and reducing neuroinflammation. | Lin Shujun Zhu Mingmin Chen Weihao Zhang Yujuan Lin Jihuan Pu Liu Chen Shulian Zhang Yimin Liu Xin | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 3 |
| 7 | Tuning Curves of 70 MHz Frequency Differences for HeNe Standing-Wave Lasers显示文摘Two experiments are reported on measuring the variation of the frequency differences for the st&nding wave lasers with tuning the cavity length.The frequency difference is caused by an intracavity quartz crystal plate(laser mode splitting technology).The relative variation of the frequency difference during the tuning are about 10^(-3) order from the edge to the centre of lasing bandwidth.The diiFerence between the largest and the smallest frequency differences is two orders as large as that of ring lasers. | ZHANG Shulian HAN Yanmei | 1993 | Chinese Physics Letters1993，10，12： | 2 |
| 8 | Screening of Benzoic Acid Biodegradation Strains显示文摘Three strains BQ,BJ,and BS utilizing benzoic acid as the sole carbon source were achieved from Yichang City,Hubei Province,China,through selective enrichment and domestication.Both BQ and BJ were primarily identified as Acinetobacter.spp while BS was Geotrichum.spp.After three domestications,the removal rates of BQ,BJ,and BS to chemical oxygen demand(COD) value of benzoic acid were 62.41%,94.44%,and 43.34%,respectively.The strains were mixed cultured,and the degradation rates of strains to benzoic acid at different temperature,pH and benzoic acid concentration were determined.The results show that the optimum degradation conditions about strains were pH 7.0,temperature 30 ℃,and aerobic with 1 500 mg/L of concentration of benzoic acid.In this condition,the COD removal rate of strains to benzoic acid reached 84.93%. | WANG Shulian,ZHANG Liping,WANG Xiaoxing,CHEN Dengxia,LI Xiaocong,HUANG Yingping Alan G.MacDiarmid Research Institute of Renewable Energy,China Three Gorges University,Yichang 443002,Hubei,China | 2010 | Wuhan University Journal of Natural Sciences2010，15，6： | 2 |
| 9 | The discovery of nanometer fringes in laser self-mixing interference显示文摘 | Ligang Fei Shulian Zhang | 2006 | Optics Communications2006，，1： | 2 |
| 10 | Diode-pumped dual-frequency microchip Nd∶YAG laser with tunable frequency difference显示文摘 | Ren Cheng Zhang Shulian | 2009 | Journal of Physics D: Applied Physics2009，42，15： | 1 |
| 11 | Using a cat's eye cavity to improve displacement self-sensing laser 显示文摘 | DU Wenhua LI Yan ZHANG Shulian | 2005 | Sensors & Actuators A: Physical2005，122，1： | 1 |
| 12 | Method for the measurement of phase retardation of any wave plate with high precision显示文摘 | LIU Weixing LIU Ming ZHANG Shulian | 2008 | Applied Optics2008，47，30： | 1 |
| 13 | Multiple in-fiber Bragg gratings sensor with a grating scale显示文摘 | Fangxie Shulian Zhang | 2002 | Measurement2002，31，： | 1 |
| 14 | Zeeman-birefringence He-Ne dual-frequency lasers based on hole-drilling birefringence in a cavity mirror 显示文摘 | ZHOU Lufei ZHANG Shulian | 2008 | Laser Physics2008，18，12： | 1 |
| 15 | Laser longitudinal mode splitting phenomenon and its application in laser physics and active metrology sensors 显示文摘 | ZHANG Shulian GUO Hong HAN Yanmei | 1995 | Optics and Lasers in Engineering1995，23，1： | 1 |
| 16 | Diode-pumped dual-frequency mieroehip Nd: YAG laser with tunable frequency difference 显示文摘 | Cheng Ren Zhang Shulian | 2009 | J Physics D: Applied Physics2009，42，15： | 1 |
| 17 | Theoretical and experimental study of intensity branch phenomena in self-mixing interference in a He-Ne laser 显示文摘 | Liu G Zhang Shulian Zhu Jun | 2003 | Opt Commun2003，221，46： | 1 |
| 18 | Displacement self-sensing HeNe laser with λ/8 accuracy and selfcalibration 显示文摘 | Li Yan Zhang Shulian Han Yanmei | 2000 | Optical Engineering2000，39，11： | 1 |
| 19 | Laser longitudinal mode splitting phenomenon and its applications in laser physics and active metrologysensors 显示文摘 | Zhang Shulian Guo Hui Li Kelan Han Yanmei | 1995 | Optics and Lasers in Engineering1995，23，： | 1 |
| 20 | The correlation be- tween frequency difference and mode polarization in an intracavity birefi'ig- ent dual-frequency laser显示文摘 | HU Zhaohui ZHANG Shulian LIU Weixin | 2010 | Optics & Laser Tech::ology2010，42，： | 1 |
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