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| 1 | Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19:a phase 1 clinical trial显示文摘No effective drug treatments are available for coronavirus disease 2019(COVID-19).Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage,death,or long-term functional disability in survivors require clinical evaluation.We performed a parallel assigned controlled,non-randomized,phase 1 clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells(UC-MSCs)infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease.The study enrolled 18 hospitalized patients with COVID-19(n=9 for each group).The treatment group received three cycles of intravenous infusion of UC-MSCs(3×107 cells per infusion)on days 0,3,and 6.Both groups received standard COVID-treatment regimens.Adverse events,duration of clinical symptoms,laboratory parameters,length of hospitalization,serial chest computed tomography(CT)images,the PaO2/FiO2 ratio,dynamics of cytokines,and IgG and IgM anti-SARS-CoV-2 antibodies were analyzed.No serious UC-MSCs infusion-associated adverse events were observed.Two patients receiving UC-MSCs developed transient facial flushing and fever,and one patient developed transient hypoxia at 12 h post UC-MSCs transfusion.Mechanical ventilation was required in one patient in the treatment group compared with four in the control group.All patients recovered and were discharged.Our data show that intravenous UC-MSCs infusion in patients with moderate and severe COVID-19 is safe and well tolerated.Phase 2/3 randomized,controlled,double-blinded trials with long-term follow-up are needed to evaluate the therapeutic use of UC-MSCs to reduce deaths and improve long-term treatment outcomes in patients with serious COVID-19. | Fanping Meng Ruonan Xu Siyu Wang Zhe Xu Chao Zhang Yuanyuan Li Tao Yang Lei Shi Junliang Fu Tianjun Jiang Lei Huang Peng Zhao Xin Yuan Xing Fan Ji-Yuan Zhang Jinwen Song Dawei Zhang Yanmei Jiao Limin Liu Chunbao Zhou Markus Maeurer Alimuddin Zumla Ming Shi Fu-Sheng Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 16 |
| 2 | Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial显示文摘Tocilizumab has been reported to attenuate the“cytokine storm”in COVID-19 patients.We attempted to verify the effectiveness and safety of tocilizumab therapy in COVID-19 and identify patients most likely to benefit from this treatment.We conducted a randomized,controlled,open-label multicenter trial among COVID-19 patients.The patients were randomly assigned in a 1:1 ratio to receive either tocilizumab in addition to standard care or standard care alone.The cure rate,changes of oxygen saturation and interference,and inflammation biomarkers were observed.Thirty-three patients were randomized to the tocilizumab group,and 32 patients to the control group.The cure rate in the tocilizumab group was higher than that in the control group,but the difference was not statistically significant(94.12%vs.87.10%,rate difference 95%CI−7.19%–21.23%,P=0.4133).The improvement in hypoxia for the tocilizumab group was higher from day 4 onward and statistically significant from day 12(P=0.0359).In moderate disease patients with bilateral pulmonary lesions,the hypoxia ameliorated earlier after tocilizumab treatment,and less patients(1/12,8.33%)needed an increase of inhaled oxygen concentration compared with the controls(4/6,66.67%;rate difference 95%CI−99.17%to−17.50%,P=0.0217).No severe adverse events occurred.More mild temporary adverse events were recorded in tocilizumab recipients(20/34,58.82%)than the controls(4/31,12.90%).Tocilizumab can improve hypoxia without unacceptable side effect profile and significant influences on the time virus load becomes negative.For patients with bilateral pulmonary lesions and elevated IL-6 levels,tocilizumab could be recommended to improve outcome. | Dongsheng Wang Binqing Fu Zhen Peng Dongliang Yang Mingfeng Han Min Li Yun Yang Tianjun Yang Liangye Sun Wei Li Wei Shi Xin Yao Yan Ma Fei Xu Xiaojing Wang Jun Chen Daqing Xia Yubei Sun Lin Dong Jumei Wang Xiaoyu Zhu Min Zhang Yonggang Zhou Aijun Pan Xiaowen Hu Xiaodong Mei Haiming Wei Xiaoling Xu | 2021 | Frontiers of Medicine2021，15，3： | 2 |
| 3 | Mesomechanics Finite-element Method for Determining the Shear Strength of Mudded Intercalation Materials显示文摘A new method regarding mesomechanics finite-element research is proposed to predict the peak shear strength of mudded intercalation materials on a mesoscopic scale. Based on geometric and mechanical parameters, along with the strain failure criteria obtained by sample's deformation characteristics, uniaxial compression tests on the sample were simulated through a finite-element model, which yielded values consistent with the data from the laboratory uniaxial compression tests, implying that the method is reasonable. Based on this model, a shear test was performed to calculate the peak shear strength of the mudded intercalation, consistent with values reported in the literature, thereby providing a new approach for investigating the mechanical properties of mudded intercalation materials. | 胡启军 SHI Rendan YANG Xiaoqiang CAI Qijie HE Tianjun HE Leping | 2017 | Journal of Wuhan University of Technology(Materials Science)2017，32，2： | 2 |
| 4 | A practical construction of G^1 smooth biquintic B-spline surfaces over arbitrary topology显示文摘 | Shi Xiquan Wang Tianjun Yu Piqiang | 2004 | Computer-Aided Design2004，36，4： | 1 |
| 5 | G^1 continuous conditions of biquartic B-spline surfaces显示文摘 | Shi Xiquan Yu Piqiang Wang Tianjun | 2004 | Journal of Computational and Applied Mathematics2004，144，12： | 1 |
| 6 | Reconstruction of convergent G1 smooth B-Spline surfaces显示文摘 | Shi Xiquan Wang Tianjun PeiruWuc Liu Fengshan | 2004 | Computer Aided Geometric Design2004，，21： | 1 |
| 7 | G1 continuous conditions of biquartic B-spline surfaces显示文摘 | Shi Xiquan Yu Piqiang Wang Tianjun | 2002 | Journal of Computational and applied Mathematics2002，144，12： | 1 |
| 8 | G1 continuous conditions of biquartic B-spline surfaces 显示文摘 | Shi Xiquan Yu Piqiang Wang Tianjun | 2002 | Journal of Computational and Applied Mathematics2002，144，6： | 1 |
| 9 | Formally analyzing software architectural specifications using SAM显示文摘 | He Xudong Yu Huiqun Shi Tianjun | 2004 | Journal of Systems and Software2004，71，12： | 1 |
| 10 | Reconstruction of convergent G1 smooth B-Spline surfaces显示文摘 | Xiquan Shi Tianjun Wang Peiru Wu Fengshan Liu | 2004 | Computer Aided Geometric Design2004，21，： | 1 |
| 11 | Formally analyzing software architectural specifications using SAM显示文摘 | He Xudong Yu Huiqun Shi Tianjun | 2002 | The Journal of Systems and Software2002，71，： | 1 |
| 12 | G1 continuous conditions of biquartic B-spline surfaces显示文摘 | Shi Xiquan Yu Piqiang Wang Tianjun | 2002 | Journal of Computational and Applied Mathematics2002，144，12： | 1 |
| 13 | Reconstruction of convergent G 1 smooth B-spline surfaces显示文摘 | Xiquan Shi Tianjun Wang Peiru Wu Fengshan Liu | 2004 | Computer Aided Geometric Design2004，，9： | 1 |
| 14 | Effects of Thirty Days Isolation on Attention Networks: A Behavioral and Event-related Potential Study显示文摘Kear Editor,Individuals in isolated,confined,and extreme environments,such as astronauts,researchers wintering over Antarctica,submarine soldiers,and participants in simulated isolation environment experiments,commonly report difficulty in focusing their attention[1,2].However,current experimental findings from studies conducted in such environments are insufficient to fully support these self-reports of reduced attention.Certain attention-demanding tasks such as simple reaction time(RT)tasks and dual tasks,including primary pursuit tracking and secondary RT,were not affected in space flight experiments[2,3]. | Jingda Feng Bin Wu Ziqing Cao Hailong Chen Tianjun Lan Haibo Qin Yusheng Shi Weifen Huang Yinghui Li | 2024 | Neuroscience Bulletin2024，40，1： | 0 |
| 15 | Cu(Ⅱ)and ammonium adsorption from dairy cattle breeding sewage by phosphorus-modified dairy cow manure hydrochar显示文摘To realize the synergistic treatment of dairy cow manure solids and dairy cattle breeding sewage,this study produced phosphorus-modified hydrochar by dairy cow manure solids impregnated with potassium phosphate(K_(3)PO_(4)).And then,the adsorption characteristics of Cu(Ⅱ)and ammonium(NH_(4)^(+))in dairy cattle breeding sewage under different dosages and adsorption time conditions of modified hydrochar were explored.The results show that the specific surface area and total pore volume of the hydrochar were increased by phosphorus-modified.The adsorption amount of hydrochar per unit-mass decreased with the increase in the dosage.With the increase in the dosage,the adsorption capacity of Cu(Ⅱ)decreased from the initial 26.16 mg/g to 3.38 mg/g.The adsorption of Cu(Ⅱ)and NH_(4)^(+)in sewage by hydrochar was mainly chemical adsorption,which was mainly affected by chelation and ion exchange.This adsorption was more inclined to single-molecular layer adsorption.Both the pH values and the ionic strength influenced the competitive adsorption between Cu(Ⅱ)and NH_(4)^(+).The higher the pH value was,the greater the adsorption amount,and the stronger the adsorption capacity by hydrochar.Moreover,the increase in the ionic strength decreases the adsorption capacity of hydrochar. | Zhendong Yang Min Tong Xueqin He Lujia Han Jianbin Guo Tianjun Jing Guangqun Huang Changming Shi | 2022 | International Journal of Agricultural and Biological Engineering2022，15，5： | 0 |
| 16 | Clinical Epidemiology,Illness Profiles,and the Implication of COVID-19 Before and After the Nationwide Omicron Outbreak During the Winter of 2022显示文摘China.In this study,we aimed to investigate the clinical characteristics and outcomes of patients with coronavirus disease 2019(COVID-19)in the Beijing region.Methods:In this retrospective study,we enrolled inpatients admitted for COVID-19 in the Fifth Medical Center of Chinese PLA General Hospital in Beijing between November 10,2022,and January 30,2023.Demographic and clinical features and treatment outcomeswere comprehensively analyzed.We used logistic regression and linear regression analyses to explore the risk factors associated with disease severity and time of nucleic acid conversion,respectively.Results:A total of 1010 hospitalized patients with COVID-19 were enrolled.The median age was 43.0 years(interquartile range,28.0–63.0),and patients aged<60 years and≥60 years comprised 71.2%and 28.8%of total included patients,respectively.The clinical classification of mild(74.6%,753/1010),moderate(21.0%,212/1010),severe(2.7%,27/1010),and unidentified(1.8%,18/1010)was separately recorded;1005 patients were discharged,and 5 patients died in the hospital.The outbreak of the emerging epidemic witnessed an evident increase in the proportion of moderate(42.9%vs.16.4%)and severe(10.3%vs.1.1%)cases after December 7,2022.Patients with a moderate/severe classification had higher levels of procalcitonin,IL-6,serum ferritin,C-reactive protein,lactic dehydrogenase,serum urea nitrogen,and D-dimer and lower counts of CD4+T,CD8+T,and B cells(all P<0.001).Multivariable regression analysis revealed that increased odds of disease severity were associated with the following factors:age≥60 years,IL-6>7 pg/mL,lactic dehydrogenase level>245 U/L,cough,and fever at admission.Age≥80 years and chronic lung diseasewere independent risk factors in the nonmild group in elderly patients.In addition,the duration for nucleic acid to turn negativewas approximately 5.0 d(interquartile range,3.0–7.0).Prolonged time of nucleic acid conversion was associated with age≥60 years,serum urea nitrogen level>8.2 mmol/L,neutrophil count>7×10^(9)/L,and the presence of a chronic lung disease or carcinoma.Finally,unvaccinated patients accounted for 37.3%of enrolled patients;children and the elder people accounted for approximately half of that.The univariable analysis found that booster doses reduced disease severity and shortened the time of nucleic acid conversion in elderly patients.Conclusions:The outbreak ofOmicron rapidly increased the number of patientswith COVID-19 in Beijing.In elderly patients,booster doses may reduce disease severity and shorten the time of nucleic acid conversion.Healthcare systems should be optimized before an emerging epidemic outbreak. | Yuming Guo Zhe Xu Wen-Xin Wang Cheng Zhen Jinhua Hu Jinsong Mu Chengcheng Ji Xin Yuan Ruonan Xu Lei Huang Lei Shi Fanping Meng Junliang Fu Shuangnan Zhou Siyu Wang Fengyi Li Bo Tu Dawei Zhang Huihuang Huang Yufeng Mao Wen Xu Chao Zhang Xiuying Mu Jun Zhao Bo Jin Haibin Su Yinying Lu Yongqian Cheng Dong Ji Shaoli You Jinghui Dong Changchun Liu Mengmeng Zhang Yuanyuan Li Tianjun Jiang Yonggang Li Fu-Sheng Wang | 2023 | Infectious Diseases & Immunity2023，3，4： | 0 |
| 17 | Unraveling templated-regulated distribution of isolated SiO_(4) tetrahedra in silicoaluminophosphate zeolites with high-throughput computations显示文摘Silicoaluminophosphate(SAPO)zeolites are well-known catalytic materials because of the mild acidity originating from the isolated SiO_(4) tetrahedra in their frameworks.Regulating the distribution of isolated SiO_(4) tetrahedra in SAPO zeolites is formidably challenging because SiO_(4) tetrahedra tend to agglomerate to form Si islands and the isolated SiO_(4) tetrahedra are difficult to determine using conventional characterization techniques.Here we synthesized Si-island-free SAPO-35 zeolites by using N-methylpiperidine as a new template,which exhibited excellent thermal stability compared to conventional SAPO-35 zeolites and a substantially improved methanol-to-olefins catalytic lifetime even comparable to that of commercial SAPO-34 zeolites.More strikingly,with the aid of high-throughput computations on 44697 structure models combined with various state-of-the-art characterization techniques,for the first time,we reveal that the host–guest interactions between template molecules and SAPO frameworks determine the specific distributions of isolated SiO_(4) tetrahedra,which are responsible for the improvement in the chemical properties of zeolites.Our work provides an insight into the template-based regulation of isolated SiO_(4) tetrahedra in SAPO zeolites,which opens a new avenue in the discovery of promising zeolite catalysts with optimal SiO_(4) distribution. | Yan Li Chao Shi Lin Li Guoju Yang Junyan Li Jun Xu Qinfen Gu Xingxing Wang Ji Han Tianjun Zhang Yi Li Jihong Yu | 2022 | National Science Review2022，9，9： | 0 |
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