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| 1 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 2 | 宽带高频电磁场数据反演方法研究显示文摘采用非线性最小二乘法结合蒙特卡罗法,实现宽带高频电磁场椭圆极化率数据的精确反演,确定地下层状介质的真实电阻率和介电常数.反演结果表明,对于均匀半空间和二层介质模型,最小二乘法能够很好地实现反演,而对于三层或更多层的介质,首先利用蒙特卡罗法确定拟合初始模型,再进行最小二乘反演,能够避免收敛到局部极小值,提高了反演的稳定性.为了加速正演响应函数的计算和迭代的速度,采用高密度采样的线性滤波算法,大大加快了该精确反演方法的速度.针对如覆盖区地质填图和土壤调查等大面积确定地质体性质的应用,本文还给出了一种近似反演方法(相位矢量图法),能够快速获取视电阻率和视介电常数,不仅可以为应用提供有用的基础信息,而且可作为精确反演方法的初始模型. | 郑圣谈 曾昭发 刘四新 张代国 FengShan Liu | 2008 | 地球物理学报2008，51，1： | 11 |
| 3 | he adaptive chirplet transform and its application in GPR target detection显示文摘探地雷达不仅能够探测金属目标体,而且能够探测非金属目标体,而成为UX0和地雷探测的一种重要的浅部地球物理方法。但是在地雷和UX0探测中,目标体埋藏深度浅,在探地雷达数据信噪比较低情况下,地表和土壤层的反射严重干扰对目标体的拾取。本文采用自适用Chirplet变换来消除地表层和土壤层变化的干扰,并在Radon—Wigner分布的基础上,采用自适用Chirplet变换来拾取目标体的信号。通过对实际探测实验数据应用证明,本方法处理结果比传统的偏移方法具有较高的信噪比,并能清晰地提取目标体信号。 | Zeng Zhaofa Wu Fengshou Huang Ling Liu Fengshan Sun Jiguang | 2009 | Applied Geophysics2009，6，2： | 8 |
| 4 | A comparative study of the osteogenic performance between the hierarchical micro/submicro-textured 3D-printed Ti6Al4V surface and the SLA surface显示文摘Three-dimensional(3D)printed titanium and its alloys have broad application prospect in the field of biomedical implant materials,although the biological performance of the original surface should be improved.Learning from the development experience of conventional titanium implants,to construct a hierarchical hybrid topological surface is the future direction of efforts.Since the original 3D-printed(3D hereafter)Ti6Al4V surface inherently has micron-scale features,in the present study,we introduced submicron-scale pits on the original surface by acid etching to obtain a hierarchical micro/submicro-textured surface.The characteristic and biological performance of the 3D-printed and acid-etched(3DA hereafter)surface were evaluated in vitro and in vivo,compared with the conventional sandblasted,large-grit,acid-etched(SLA hereafter)surface.Our results suggested the adhesion,proliferation and osteogenic differentiation of bone marrow derived mesenchymal stromal cells(BMSCs),as well as the in vivo osseointegration on 3DA surfaces were significantly improved.However,the overall osteogenic performance of the 3DA surface was not as good as the conventional SLA surface. | Jinkai Zhanga Jiaqiang Liu Chengtao Wang Fengshan Chen Xudong Wang Kaili Lin | 2020 | Bioactive Materials2020，5，1： | 8 |
| 5 | Contributions of climate, varieties, and agronomic management to rice yield change in the past three decades in China显示文摘和一个庄稼模拟模型,在四个代表性的 agro 气象学的车站的长期的地实验数据被用来在过去的三十年解开大米收益变化的气候变化,变化更新,和授精管理的贡献。我们发现在 1981-2009 变化期间,更新由 16%-52% 增加了米饭产量,管理改进由产量从 16% ~ 10% 改变了的米饭的气候变化的 0-16% ,和贡献增加了产量。变化更新和气候的否定影响在米饭生产上改变的管理改进偏移量。在主要气候变量之中,在太阳的放射的减少到 0.1%per 年平均减少了米饭产量。温度变化的影响有一个明确的空间模式。它在 Tongcheng 车站在 Xinbin 和 Ganyu 车站并且为迟了的米饭为单个米饭每年由 0.04%-0.4% 增加了产量,由在 Tongcheng 在 Mianyang 车站和早米饭为单个米饭每年由 0.2%-0.4% 对比减少的产量车站。在 1981-2009 期间,米饭变化更新被热要求的增加描绘,谷物数字每尖铁和收获索引。新变化比旧的对气候变化不太敏感。高热的要求,高收益潜力和热的发展和农学的管理的改进,容忍的米饭变化应该被鼓励在未来遇见气候变化和增加的食物需求的挑战。 | He ZHANG Fulu TAO Dengpan XIAO Wenjiao SHI Fengshan LIU Shuai ZHANG Yujie LIU Meng WANG Huizi BAI | 2016 | Frontiers of Earth Science2016，10，2： | 5 |
| 6 | Enhancing phytolith carbon sequestration in rice ecosystems through basalt powder amendment显示文摘由于大气的公司的快速的增加的全球温暖 < 潜水艇 class= “ a-plus-plus ” > 2 排放显著地正在影响世界经济和人的活动。在 phytoliths 的碳隐遁在陆上的生态系统被认为是高度稳定的碳水池机制减轻气候变化。然而,植物的反应到外部硅修正案的堵塞 phytolith 的碳(PhytOC ) 仍然保持不清楚。在这研究,我们调查了暗岩粉末(BP ) 的效果在米饭(Oryza sativa ) 的 phytolith 碳隐遁上的改正,一个 high-PhytOC 蓄电池。结果证明在米饭的 phytolith 和 PhytOC 的内容与 BP 改正增加了。在不同米饭植物部分的 PhytOC 生产流动更加变化了(0.0050.041 ? Mg 公司 < 潜水艇 class= “ a-plus-plus ” > 2 哈 < 啜 class= “ a-plus-plus ” > 1 一 < 啜 class= “ a-plus-plus ” > 有在鞘的最高的流动的 1 ), 。BP 改正能显著地在 150 在农田提高 phytolith 碳隐遁的流动 ?% 。如果 1.55 的全球米饭耕作 ?? 慣敲? | Fengshan Guo Zhaoliang Song Leigh Sullivan Hailong Wang Xueyan Liu Xudong Wang Zimin Li Yuying Zhao | 2015 | Science Bulletin2015，60，6： | 4 |
| 7 | A revised species population estimate for the Bar-headed Goose(Anser indicus)显示文摘Background: The Bar-headed Goose(Anser indicus) is a species that relies heavily on the plateau wetlands of Asia and whose population was thought to be declining. Over the past decade, south-central Tibet, one of the most important wintering grounds, supported large numbers of Bar-headed Geese, but the population had not been regularly monitored in this area.Methods: We surveyed wintering Bar-headed Geese along the Yarlung Zangbo, Lhasa and Nyang Qu rivers, the three major river valleys and their tributaries in south-central Tibet in January 2014 and recorded their location, flock size and habitat utilization. Based on these data and the latest wintering counts elsewhere, we revised the population estimate for this species.Results: We recorded more than 67,000 Bar-headed Geese in south-central Tibet during January 2014. By geographic area, the geese were most abundant in the Lhasa River valley(38.5%) and the Nyang Qu River valley(31.0%), and by administrative division in Lhunzhub(27.2%) and Shigatse(26.7%). Bar-headed Geese were most often observed feeding in winter wheat fields and ploughed fields, resting on pastureland and marshes. The approximate number of 67,000 geese recorded in Tibet is more than four times the estimate of 1993 for the same region and exceeds the most recent world population estimate of 52,000–60,000. Based on our work in Tibet and the latest wintering counts available from other areas, we revised the estimated population size of this species to 97,000–118,000.Conclusions: Our result reveals a remarkable increase in the number of Bar-headed Geese wintering in south-central Tibet. This population increase most likely stems from a proliferation of cropland and especially winter wheat fields in south-central Tibet. This habitat improvement may also cause short-stopping of the Bar-headed Goose and thus reduce mortality of the geese that would otherwise undertake a somewhat daunting trans-Himalayan migration. | Dongping Liu Guogang Zhang Fengshan Li Tian Ma Jun Lu Fawen Qian | 2017 | Chinese Birds2017，，1： | 4 |
| 8 | Chromosome doubling of Sedum alfredii Hance: A novel approach for improving phytoremediation efficiency显示文摘Sedum alfredii Hance is a cadmium(Cd)/zinc(Zn)hyperaccumulator native to China.However,its relatively low biomass restricted the large-scale application for heavy metal contamination remediation.The chromosome set doubling of S.alfredii in vitro was achieved by 0.1%–0.2%(W/V)colchicine treatment.The plant DNA ploidy was analyzed by flow cytometry and chromosome set doubling plants(CSD)were identified based on the obvious different sharp peak.A tissue culture experiment with different Cd treated levels and a field trial with natural polluted mined soil were conducted to study the effects of chromosome doubling on plant biomass and Cd accumulation in shoots.The results suggested that S.alfredii is a mixoploid.Compared with the wild type plants(WT),CSD exhibited typical'gigas'characteristics in morphology including stem thickness,root hair production,number of leaves and size of stoma guard cell.Fresh weight and dry weight of CSD were increased to 1.62–2.03-fold and 2.26–3.25-fold of WT.And Cd content of CSD showed a17.49%–42.82%increase and 59%increase under tissue culture and field condition,accordingly.In addition,the TF and in BCF of CSD were 2.37-and 1.59-fold of WT,respectively.These results proved that it is feasible to promote phytoextraction efficiency of S.alfredii in Cd contaminated soils through chromosomal engineering,which provides a novel approach for hyperaccumulator application in phytoremediation. | Ying Feng Qiong Wang Qian Meng Yongjun Liu Fengshan Pan Sha Luo Yingjie Wu Luyao Ma Xiaoe Yang | 2019 | Journal of Environmental Sciences2019，31，12： | 4 |
| 9 | Influences of agricultural phenology dynamic on land surface biophysical process and climate feedback显示文摘到气候变化的土地表面过程的反应和反馈是地球科学的领域里的研究优先级之一。学习在陆地表面过程上对全球变化的影响给予了更多的注意的水流,而是到气候变化的陆地表面过程的反馈是糟糕理解。系统地理解在农业物候学之间的关系在地球系统科学的框架下面正在变得越来越有意义气候上的动态、生物物理的过程,以及反馈。在这篇论文,我们在这个领域里总结了研究进步,包括农业物候学变化,在土地表面进步模型动态的物候学的 parameterization,对气候的在生物物理的过程上动态的农业物候学的影响,以及它的反馈的事实。结果证明农业 phenophase,由象播种, flowering 和成熟那样的关键 phenological 阶段代表了,由于气候变化和农学的管理的影响显著地变了。土地的数字表情出现动态过程和大气的过程,被联合在土地动态的物候学改进表面模型。农业物候学动态影响了网放射,潜伏的热,理智的热,反照率,温度,降水,循环,在划分的表面精力和气候反馈起一个重要作用。认为在陆地表面动态的农业物候学的重要性是生物物理的过程和气候反馈,下列研究优先级应该被强调:(1 ) 在气候之间的相互作用变化并且登陆表面物候学动态;(2 ) 在动态的农业物候学和土地之间的关系出现在不同系列的反射率;(3 ) 土地的庄稼生理学特征变化的贡献出现生物物理的过程;(4 ) 从在不同气候地区动态的物候学的气候反馈的地区性的差别。这评论是有用的加速在陆地表面过程和气候反馈动态的农业物候学的角色的理解。 | LIU Fengshan CHEN Ying SHI Wenjiao ZHANG Shuai TAO Fulu GE Quansheng | 2017 | Journal of Geographical Sciences2017，27，9： | 3 |
| 10 | Nanoscale monitoring of mitochondria and lysosome interactions for drug screening and discover显示文摘Technology advances in genomics,proteomics,and metabolomics largely expanded the pool of potential therapeutic targets.Compared with the in vitro setting,cell-based screening assays have been playing a key role in the processes of drug discovery and development.Besides the commonly used strategies based on colorimetric and cell viability,we reason that methods that capture the dynamic cellular events will facilitate optimal hit identification with high sensitivity and specificity.Herein,we propose a live-cell screening strategy using structured illumination microscopy (SIM) combined with an automated cell colocalization analysis software,CellprofilerTM,to screen and discover drugs for mitochondria and lysosomes interaction at a nanoscale resolution in living cells.This strategy quantitatively benchmarks the mitochondria-lysosome interactions such as mitochondria and lysosomes contact (MLC) and mitophagy.The automatic quantitative analysis also resolves fine changes of the mitochondria-lysosome interaction in response to genetic and pharmacological interventions.Super-resolution live-cell imaging on the basis of quantitative analysis opens up new avenues for drug screening and development by targeting dynamic organelle interactions at the nanoscale resolution,which could facilitate optimal hit identification and potentially shorten the cycle of drug discovery. | Qixin Chen Xintian Shao Zhiqi Tian Yang Chen Payel Mondal Fei Liu Fengshan Wang Peixue Ling Weijiang He Kai Zhang Zijian Guo Jiajie Diao | 2019 | Nano Research2019，12，5： | 2 |
| 11 | Impact of thermal time shift on wheat phenology and yield under warming climate in the Huang-Huai-Hai Plain, China显示文摘 | Dengpan XIAO Yongqing QI Zhiqiang LI Rende WANG Juana P. MOIWO Fengshan LIU | 2017 | Frontiers of Earth Science2017，11，1： | 2 |
| 12 | Three-dimensional non-grey gas radiative transfer analyses using the statistical narrow-band model 显示文摘 | Fengshan Liu Omer L Giiilder Gregory J Smallwood | 1998 | International Journal of Heat and Mass Transfer(S0017-9310)1998，37，： | 1 |
| 13 | Numerical modelling of soot formation and oxidation in laminar coflow non-smoking and smoking ethylene diffusion flames显示文摘 | Fengshan Liu Hongsheng Guo Gregory J. Smallwood omer L. Gulder | 2003 | Combustion Theory and Modelling2003，，2： | 1 |
| 14 | Regularization of Nonlinear Ill-Posed Variational Inequalities and Convergence Rates显示文摘 | Fengshan Liu M. Zuhair Nashed | 1998 | Set - Valued Analysis1998，，4： | 1 |
| 15 | Constrained fitting for 2D profile-based reverse modeling 显示文摘 | KE Yinglin ZHU Weidong LIU Fengshan | 2006 | Computer-Aided Design2006，38，2： | 1 |
| 16 | Three-dimensional non-grey gas radiative transfer analyses using the statistical narrow-band model 显示文摘 | Liu Fengshan GiiilderO L Smallwood G J | 1998 | International Journal of Heat Mass Transfer1998，37，： | 1 |
| 17 | Isolation and characterization of a β-glucosidase from Penicillium decumbens and improving hydrolysis of corncob residue by using it as cellulase supplementation显示文摘 | Mei Chen Yuqi Qin Ziyong Liu Kai Liu Fengshan Wang Yinbo Qu | 2010 | Enzyme and Microbial Technology2010，，6： | 1 |
| 18 | Constrained fitting for 2D profile-based reverse modeling显示文摘 | KE Yinglin ZHU Weidong LIU Fengshan | 2006 | Computer-Aided Design2006，38，2： | 1 |
| 19 | Effects of anisotropic scattering on radiative heat lransfer using the P1-approximation显示文摘 | Liu Fengshan Garbett E S Swithenbank J | 1992 | International Journal of Heat and Mass Transfer1992，35，10： | 1 |
| 20 | Astrocytic effect of low molecular weight heparin-superoxide dismutase conjugate in interleukin-6 overexpressing mice following local cerebral ischemia显示文摘BACKGROUND:Studies have shown that low molecular weight heparin-superoxide dismutase conjugate exhibits a remarkable neuroprotective effect. OBJECTIVE:To investigate the effect of low molecular weight heparin-superoxide dismutase conjugate on astrocytes in an interleukin-6(IL-6) overexpressing mice following local cerebral ischemia. DESIGN,TIME AND SETTING:Randomized,cytological,controlled,animal study was performed in the Department of Physiology and Neuroscience,Neurology and Biochemistry and Molecular Biology,Medical University of South Carolina from January 2005 to March 2005. MATERIALS:Nine IL-6 transgenic mice,irrespective of gender,were randomly divided into three groups:sham-operated,model,and treatment,with three mice in each group.With exception of the sham-operated group,right middle cerebral artery occlusion was induced in the mice. Expression of glial fibrillary acidic protein,an astrocyte marker,was determined by immunohistochemistry.Low molecular weight heparin-superoxide dismutase conjugate was purchased from Biochemistry and Biotechnique Institute,Shandong University. METHODS:Two minutes prior to ischemia induction,0.5 mL/kg saline or 20 000 U/kg low molecular weight heparin-superoxide dismutase conjugate were administrated via the femoral artery in the model group and treatment group,respectively.The sham-operated group underwent the same protocols,with the exception of occlusion and treatment. MAIN OUTCOME MEASURES:The number of glial fibrillary acidic protein-positive cells was quantified under light microscopy(x200). RESULTS:In the sham-operated group,there were a large number of astrocytes in the IL-6 transgenic mice.However,the cell bodies were small,and the branches were few and thin.The number of astrocytes in the model group was remarkably less than the sham-operated group. Compared to the model and sham-operated groups,the number of astrocytes significantly increased,and the cell body became larger,following treatment with low molecular weight heparin-superoxide dismutase conjugate.Astrocytes exhibited hypertrophy and hyperplasia,and the processes became longer and thicker. CONCLUSION:The low molecular weight heparin-superoxide dismutase conjugate may provide neuroprotection through astrocytic activation at the super-early stage of cerebral ischemia and reperfusion. | Yizhao Li Guixiang Cui Qingde Wang Hongxia Liu Xiaoxia Zhang Fengshan Wang Keqin Xie | 2009 | Neural Regeneration Research2009，4，2： | 1 |
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