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| 1 | Tranexamic acid for acute intracerebral haemorrhage growth based on imaging assessment (TRAIGE): a multicentre, randomised, placebo- controlled trial显示文摘Background Studies show tranexamic acid can reduce the risk of death and early neurological deterioration after intracranial haemorrhage.We aimed to assess whether tranexamic acid reduces haematoma expansion and improves outcome in intracerebral haemorrhage patients susceptible to haemorrhage expansion.Methods We did a prospective,double-blind,randomised,placebo-controlled trial at 10 stroke centres in China.Acute supratentorial intracerebral haemorrhage patients were eligible if they had indication of haemorrhage expansion on admission imaging(eg,spot sign,black hole sign or blend sign),and were treatable within 8 hours of symptom onset.Patients were randomly assigned(1:1)to receive either tranexamic acid or a matching placebo.The primary outcome was intracerebral haematoma growth(>33% relative or>6 mL absolute)at 24 hours.Clinical outcomes were assessed at 90 days.Results Of the 171 included patients,124(72.5%)were male,and the mean age was 55.9±11.6 years.89 patients received tranexamic acid and 82 received placebo.The primary outcome did not differ significantly between the groups:36(40.4%)patients in the tranexamic acid group and 34(41.5%)patients in the placebo group had intracranial haemorrhage growth(OR 0.96,95% CI 0.52 to 1.77,p=0.89).The proportion of death was lower in the tranexamic acid treatment group than placebo group(8.1%vs 10.0%),but there were no significant differences in secondary outcomes including absolute intracranial haemorrhage growth,death and dependency.Conclusions Among patients susceptible to haemorrhage expansion treated within 8 hours of stroke onset,tranexamic acid did not significantly prevent intracerebral haemorrhage growth.Larger studies are needed to assess safety and efficacy of tranexamic acid in intracerebral haemorrhage patients. | Jingyi Liu Ximing Nie Hongqiu Gu Qi Zhou Haixin Sun Ying Tan Dacheng Liu Lina Zheng Jiahui Zhao Yan Wang Yibin Cao Haomeng Zhu Yunpeng Zhang Lijin Yi Yuehua Pu Miao Wen Zhonghua Yang Shengjun Sun Wenzhi Wang Xingquan Zhao Liping Liu Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 3 |
| 2 | Relati4n between the in situ stress field and geological tectonics of a gold mine area in Jiaodong Peninsula, China 显示文摘 | Shengjun Miao Yuan Li Wenhui Tan Fenhua Ren | 2012 | International Journal of Rock Mechanics and Mining Sciences2012，51，4： | 1 |
| 3 | Increased complexity of gene structure and base composition in vertebrates显示文摘结构和基因的基础作文怎么随着脊椎动物的进化变化了,仍然是一个思索的问题。这里,我们分析了 895 orthologous 在六个多细胞的动物的编码蛋白质的基因:人,鸡肉, zebrafish,海喷射,水果苍蝇,和蠕虫。我们的分析表明许多基因区域,特别地 intron 和 3 UTR,逐渐地从他们的无脊椎的祖先在整个脊椎动物的进化膨胀了,并且 exons 的数字每基因增加了。研究基于在每个染色体的所有编码蛋白质的基因提供一致结果。我们也发现那个 GC 内容在温血动物的进化在许多基因区域(特别 5 UTR ) 增加了,除了在 coding-exons。单个染色体的分析比有在所有六种的大 intron 的 5 UTR,和基因表明相对类似的 GC 内容的证明 3 UTR 表明了有 intron 的更强壮的长度和 GC 内容关联。我们的数据在基因和我们建议的脊椎动物在复杂性显示大增加为词法、功能的变化的要求可能在多细胞的动物基因是在结构和基础作文复杂性的进化后面的驱动力。 | Ying Wu Huizhong Yuan Shengjun Tan Jian-Qun Chen Dacheng Tian Haiwang Yang | 2011 | Journal of Genetics and Genomics2011，38，7： | 1 |
| 4 | Decreased expression of micro RNA ‐21 correlates with the imbalance of Th17 and Treg cells in patients with rheumatoid arthritis显示文摘 | Liyang Dong Xuefeng Wang Jun Tan Hao Li Wei Qian Jianguo Chen Qiaoyun Chen Jun Wang Wenlin Xu Caihua Tao Shengjun Wang | 2014 | J. Cell. Mol. Med2014，，： | 1 |
| 5 | Corrigendum to‘The power of“controllers”:Transposon-mediated duplicated genes evolve towards neofunctionalization’[Journal of Genetics and Genomics(2023)50,462–472]显示文摘This corrigendum clarifies information in the review‘The power of“controllers”:Transposon-mediated duplicated genes evolve towards neofunctionalization’by Ma et al.(2023).The word“controllers”throughout the paper should be corrected into“controlling elements”:1.The title‘The power of“controllers”:Transposon-mediated duplicated genes evolve towards neofunctionalization’should be corrected into‘The power of“controlling elements”:Transposon-mediated duplicated genes evolve towards neofunctionalization’. | Huijing Ma Mengxia Wang Yong E.Zhang Shengjun Tan | 2024 | Journal of Genetics and Genomics2024，51，1： | 0 |
| 6 | The power of“controllers”:Transposon-mediated duplicated genes evolve towards neofunctionalization显示文摘Since the discovery of the first transposon by Dr.Barbara McClintock,the prevalence and diversity of transposable elements(TEs)have been gradually recognized.As fundamental genetic components,TEs drive organismal evolution not only by contributing functional sequences(e.g.,regulatory elements or“controllers”as phrased by Dr.McClintock)but also by shuffling genomic sequences.In the latter respect,TE-mediated gene duplications have contributed to the origination of new genes and attracted extensive interest.In response to the development of this field,we herein attempt to provide an overview of TEmediated duplication by focusing on common rules emerging across duplications generated by different TE types.Specifically,despite the huge divergence of transposition machinery across TEs,we identify three common features of various TE-mediated duplication mechanisms,including end bypass,template switching,and recurrent transposition.These three features lead to one common functional outcome,namely,TE-mediated duplicates tend to be subjected to exon shuffling and neofunctionalization.Therefore,the intrinsic properties of the mutational mechanism constrain the evolutionary trajectories of these duplicates.We finally discuss the future of this field including an in-depth characterization of both the duplication mechanisms and functions of TE-mediated duplicates. | Huijing Ma Mengxia Wang Yong E.Zhang Shengjun Tan | 2023 | Journal of Genetics and Genomics2023，50，7： | 0 |
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