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| 1 | The PI3K/AKT Pathway and Renal Cell Carcinoma显示文摘The phosphatidylinositol 3 kinase(PI3K)/AKT pathway is genetically targeted in more pathway components and in more tumor types than any other growth factor signaling pathway,and thus is frequently activated as a cancer driver.More importantly,the PI3K/AKT pathway is composed of multiple bifurcating and converging kinase cascades,providing many potential targets for cancer therapy.Renal cell carcinoma(RCC) is a high-risk and high-mortality cancer that is notoriously resistant to traditional chemotherapies or radiotherapies.The PI3K/AKT pathway is modestly mutated but highly activated in RCC,representing a promising drug target.Indeed,PI3 K pathway inhibitors of the rapalog family are approved for use in RCC.Recent large-scale integrated analyses of a large number of patients have provided a molecular basis for RCC,reiterating the critical role of the PI3K/AKT pathway in this cancer.In this review,we summarize the genetic alterations of the PI3K/AKT pathway in RCC as indicated in the latest large-scale genome sequencing data,as well as treatments for RCC that target the aberrant activated PI3K/AKT pathway. | Huifang Guo Peter German Shanshan Bai Sean Barnes Wei Guo Xiangjie Qi Hongxiang Lou Jiyong Liang Eric Jonasch Gordon B.Mills Zhiyong Ding | 2015 | Journal of Genetics and Genomics2015，42，7： | 39 |
| 2 | Suppression of Jasmonic Acid-Mediated Defense by Viral-Inducible MicroRNA319 Facilitates Virus Infection in Rice显示文摘MicroRNAs (miRNAs ) 是植物开发和主人病毒相互作用的枢轴的调节的人。然而,角色和涉及病毒的感染和主人危险性的特定的 miRNAs 的行动模式仍然保持大部分不清楚。在这研究,我们给那瑞斯看引起 miR319 的增加的累积,但是减少的破旧绝技病毒(RRSV ) 感染调整 miR319 的 TCP (TEOSINTE BRANCHED/CYCLOIDEA/PCF ) 的表示基因,特别 TCP21,在米饭植物。转基因的米饭植物 overexpressing miR319 或 downregulating TCP21 展出了像疾病的显型并且与野类型的植物比较显示出显著地更高的危险性到 RRSV。相反,仅仅温和的疾病症状在感染 RRSV 的线 overexpressing TCP21 并且特别在转基因的植物 overexpressing 被观察 miR319 抵抗的 TCP21。miR319 的 RRSV 感染和 overexpression 在米饭与 JA 生合成和信号相关的基因的 downregulated 表示一起引起了减少的内长的 jasmonic 酸(JA ) 层次。然而,有甲基 jasmonate 的米饭植物的治疗减轻了 RRSV 引起并且减少了病毒累积的疾病症状。一起拿,我们的结果建议由在米饭的 RRSV 感染的 miR319 的正式就职压制调停 JA 的防卫便于病毒感染和症状开发。 | Chao Zhang Zuomei Ding Kangcheng Wu Liang Yang Yang Li Zhen Yang Shan Shi Xiaojuan Liu Shanshan Zhao Zhirui Yang Yu Wang Luping Zheng Juan Wei Zhenguo Du Aihong Zhang Hongqin Miao Yi Li Zujian Wu Jianguo Wu | 2016 | Molecular Plant2016，9，9： | 27 |
| 3 | Update in version 2021 of CSCO guidelines for colorectal cancer from version 2020显示文摘Colorectal cancer(CRC) is one of the major cancers threatening life and health of Chinese residents. According to the latest data released by the National Cancer Center in2015(1), there were 387,000 new cases and 187,100 deaths of CRC in China, accounting for 9.87% and 8.01% of all malignancies. The first version of the Chinese Society of Clinical Oncology(CSCO) guidelines was released in April2017, and has been updated annually based on the latest clinical research data and the availability of new drugs(2-4). Here, we present the main updates of the 2021 version compared to 2020 version. | Caixia Dong Yuwei Ding Shanshan Weng Guichao Li Yanqing Huang Hanguang Hu Zhen Zhang Suzhan Zhang Ying Yuan | 2021 | Chinese Journal of Cancer Research2021，33，3： | 19 |
| 4 | Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation显示文摘化疗经常被知道导致严重的胃肠的道毒性,但是内在的机制仍然保持不清楚。这研究作为一个代表性的代理人认为广泛地应用的细胞毒素的代理人是 irinotecan (CPT-11 ) 并且证明治疗从说明混合物的限制剂量的肠的毒性的肠导致双海滨 DNA 的巨大的版本。明确地,通过 exosome 分泌物释放的 self-DNA 进入天生的有免疫力的房间的 cytosol 并且激活 AIM2 (在黑瘤 2 不在) inflammasome。这导致成熟 IL-1 和 IL-18 分泌物并且导致肠的 mucositis 和迟了发作的腹泻。有趣地,在 AIM2 缺乏的老鼠或由象镇静药那样的一个药理学禁止者,没有影响 CPT-11 的 anticancer 功效, AIM2 发信号的废除显著地减少导致药的腹泻的发生。这些调查结果提供化疗怎么触发引起肠的毒性的天生的有免疫力的回答的机械学的卓见,并且揭示维持反瘤效果,但是围绕联系不利煽动性的反应的新化疗政体。 | Lian, Qiaoshi Xu, Jun Yan, Shanshan Huang, Min Ding, Honghua Sun, Xiaoyu Bi, Aiwei Ding, Jian Sun, Bing Geng, Meiyu | 2017 | Cell Research2017，27，6： | 18 |
| 5 | Factors Associated with Thrombolysis Outcome in Ischemic Stroke Patients with Atrial Fibrillation显示文摘The outcome of early intravenous thrombolysis for ischemic stroke in patients with atrial fibrillation(AF)is worse than that without thrombosis. How to increase the efficacy of intravenous thrombolysis for AF-related ischemic stroke remains largely unknown. In this study, we investigated factors that influence the effect of intravenous thrombolysis in these patients. Our results showed that thrombolysis was independently associated with a favorable outcome(P \ 0.001) and did not influence the mortality of AF-related ischemic stroke, although it increased the risk of hemorrhage within 24 h after treatment. Risk factors for a poor outcome at admission were:heart failure(P = 0.045); high systolic pressure(P = 0.039); high blood glucose(P = 0.030); and a high National Institutes of Health Stroke Scale(NIHSS) score(P \ 0.001). Moreover, high systolic pressure at admission(P = 0.007), high blood glucose(P = 0.027), and a high NIHSS score(P \ 0.001) were independent risk factors for mortality at 3 months. Besides thrombolysis, a high NIHSS score(P = 0.006) and warfarin taken within 48 h before stroke onset(P = 0.032) were also independent risk factors for symptomatic hemorrhage within 24 h after treatment. Ischemic stroke patients with AF benefited from intravenous thrombolysis with recombinant tissue plasminogen activator within 4.5 h after stroke. | Qiuyun Zhao Xiaobo Li Wanli Dong Min Ye Yongjun Cao Meijuan Zhang Qiantao Cheng Junshan Zhou Guofang Chen Ming Yu Shanshan Hong Xiue Wei Bei Wang Guiyun Cui Peng Zhang Hong Ding Rongzhen Xu Yan Chen Yun Xu | 2016 | Neuroscience Bulletin2016，32，2： | 13 |
| 6 | Metallogenic Epoch of Nonferrous Metallic and Silver Deposits in the Jiaodong Peninsula, China and its Geological Significance显示文摘As China's most important gold-producing district,the Jiaodong Peninsula also contains copper,lead-zinc,molybdenum(tungsten),and other nonferrous metal ore deposits,but the space-time and genetic relationships with gold deposits remain uncertain.To investigate the temporal relationship between these nonferrous metal and gold ore deposits,We collected the samples from a number of nonferrous metallic and silver deposits and metallogenetic rock bodies in the eastern Jiaodong Peninsula for isotopic dating.The results show that the Re-Os isotopic model ages of the Lengjia molybdenum deposit in Rongcheng range from 114.5± 1.8 Ma to 112.6± 1.5 Ma,with an average age of 113.6± 1.6Ma;the LA-ICP-MS ^(206)Pb/^(238)U ages of 33 zircons in the sericitization porphyritic monzogranite that hosts the Tongjiazhuang silver deposit in Rongcheng range between 122 Ma and 109 Ma,with a weighted mean age of 116.04± 0.95 Ma;the LA-ICP-MS ^(206)Pb/^(238)U ages of 31 zircons in the copper metallogenic pyroxene monzodiorite that hosts the Kuangbei copper deposit in Rongcheng range from126 Ma to 106 Ma,with a weighted mean age of 116.6± 1.7 Ma;and the LA-ICP-MS ^(206)Pb/^(238)U ages of19 zircons in the pyroxene monzodiorite surrounding the Dadengge gold and multimetal deposit in Weihai range from 113 Ma to 110 Ma,with a weighted mean age of 111.7± 0.6 Ma.All these results indicate that the metallogenic ages of the silver and nonferrous metallic deposits in the Jiaodong Peninsula are in a limited range from 118 Ma to 111 Ma.Previous studies have demonstrated that the isotopic ages of gold deposits in the Jiaodong Peninsula range from 123 Ma to 110 Ma,while Weideshanian magmatism occurred between 126 Ma to 108 Ma.Both these ranges are grossly consistent with the metallogenic ages of silver and nonferrous metallic deposits in this study,suggesting that the large-scale mineralization occurred in the Early Cretaceous when magmatic activities were strong.This epoch may be linked to the lithosphere thinning and the thermo-upwelling extension in eastern China at that time.In addition,field investigation also shows that gold and nonferrous metallic deposits are distributed nearby the Weideshanian granite,with the nonferrous metallic deposits lying within or surrounding the granite pluton and the gold deposits outside the granite pluton.We propose the following mineralization scenario:In the Early Cretaceous,an intensive lithospheric extension induced partial melting and degassing of the metasomatized lithospheric mantle,which resulted in the formation of mantle-derived fluids enriched in metal elements.During the rapid process of magma ascent and intrusion,crust-derived fluids were activated by the magmatic thermal dome and served to further extract ore-forming materials from the crust.These fluids may have mixed with the mantle-derived fluid to form a crust-mantle mixing-type ore-forming fluid.The high-temperature conditions in the center or in contact with the granitic magmatic thermal dome would have been favorable for the formation of porphyry-type,skarn-type,and hydrothermal-vein-type ores,thus forming a series of Mo(W),Cu,and Pb-Zn deposits in the mid-eastern Jiaodong Peninsula.In contrast,the medium-to low-temperature conditions in the periphery of the magmatic thermal dome would have favored the deposition of gold(silver) ores under the appropriate physiochemical and structural conditions.The metallogenic epoch of the molybdenum,copper,and silver deposits,and their spatio-temporal and genetic relations to the gold deposits,as demonstrated in this study,not only provide important insights to the study of regional metallogeny,our understanding of the metallogenesis of the Jiaodong type gold deposit,and the geodynamic background of the large-scale mineralization in the Jiaodong Peninsula,but also have practical value in guiding the mineral exploration. | SONG Mingchun WANG Shanshan YANG Lixin LI Jie LI Shiyong DING Zhengjiang | 2017 | Acta Geologica Sinica(English Edition)2017，91，4： | 12 |
| 7 | OsRFPH2-10, a RING-H2 Finger E3 Ubiquitin Ligase, Is Involved in Rice Antiviral Defense in the Early Stages of Rice dwarf virus Infection显示文摘 | Lifang Liu Lian Jin Xiahe Huang Yongtao Geng Feng Li Qingqing Qin Rui Wang Shaoyi Ji Shanshan Zhao Qi Xie Chunhong Wei Can Xie Biao Ding Yi Li | 2014 | Molecular Plant2014，7，6： | 11 |
| 8 | Comparative pharmacokinetics of tetramethylpyrazine phosphate in rat plasma and extracellular fluid of brain after intranasal,intragastric and intravenous administration显示文摘The purpose of this study was to compare the pharmacokinetic profiles of tetramethylpyrazine phosphate(TMPP)in plasma and extracellular fluid of the cerebral cortex of rats via three delivery routes:intranasal(i.n.),intragastric(i.g.)and intravenous(i.v.)administration.After i.n.,i.g.and i.v.administration of a single-dose at 10 mg/kg,cerebral cortex dialysates and plasma samples drawn from the carotid artery were collected at timed intervals.The concentration of TMPP in the samples was analyzed by HPLC.The area under the concentration-time curve(AUC)and the ratio of the AUCbrain to the AUCplasma(drug targeting efficiency,DTE)was calculated to evaluate the brain targeting efficiency of the drug via these different routes of administration.After i.n.administration,TMPP was rapidly absorbed to reach its peak plasma concentration within 5 min and showed a delayed uptake into cerebral cortex(t_(max)=15 min).The ratio of the AUCbrain dialysates value between i.n.route and i.v.injection was 0.68,which was greater than that obtained after i.g.administration(0.43).The systemic bioavailability obtained with i.n.administration was greater than that obtained by the i.g.route(86.33%vs.50.39%),whereas the DTE of the nasal route was 78.89%,close to that of oral administration(85.69%).These results indicate that TMPP is rapidly absorbed from the nasal mucosa into the systemic circulation,and then crosses the blood-brain barrier(BBB)to reach the cerebral cortex.Intranasal administration of TMPP could be a promising alternative to intravenous and oral approaches. | Dongmei Meng Haoyang Lu Shanshan Huang Minyan Wei Pingtian Ding Xianglin Xiao Yuehong Xu Chuanbin Wu | 2014 | Acta Pharmaceutica Sinica B2014，4，1： | 5 |
| 9 | Formation and evolution of layered structure in dissimilar welded joints between ferritic-martensitic steel and 316L stainless steel with fillers显示文摘Dissimilar high-energy beam(HEB)welding is necessary in many industrial applications.Different composition of heat-affected zone(HAZ)and weld metal(WM)lead to variation in mechanical properties within the dissimilar joint,which determines the performance of the welded structure.In the present study,appropriate filler material was used during electron beam welding(EBW)to obtain a reliable dissimilar joint between reduced-activation ferritic-martensitic(RAFM)steel and 316L austenitic stainless steel.It was observed that the layered structure occurred in the weld metal with 310S filler(310S-WM),which had the inferior resistance to thermal disturbance,leading to severe hardening of 310S-WM after one-step tempering treatment.To further ameliorate the joint inhomogeneity,two-step heat treatment processes were imposed to the joints and optimized.δ-ferrite in the layered structure transformed intoγ-phase in the first-step normalizing and remained stable during cooling.In the second-step of tempering,tempered martensite was obtained in the HAZ of the RAFM steel,while the microstructure of 310S-WM was not affected.Thus,the optimized properties for HAZ and 310S-WM in dissimilar welded joint was both obtained by a two-step heat treatment.The creep failure position of two dissimilar joints both occurred in CLAM-BM. | Guoliang Liu Shanwu Yang Jianwen Ding Wentuo Han Lujun Zhou Mengqi Zhang Shanshan Zhou RDKMisra Farong Wan Chengjia Shang | 2019 | Journal of Materials Science & Technology2019，35，11： | 4 |
| 10 | Metagenome analysis reveals potential microbial functions in topsoil of wheat-maize rotation system with five-year application of fertilizers显示文摘Fertilization mode affects soil quality and ecological health.The effects of four fertilization regimens on lignocellulose content,readily degradable carbohydrate decomposition,and potential microbial functions in the topsoil of a wheat-maize rotation system between 2012 and 2017 were investigated.The fertilization regimens of control(control NFNB),high chemical fertilizer(HCF),high biochar plus low chemical fertilizer(HBLCF),and biochar-based fertilizer(BBF)were compared on soil fundamental properties,microbial structure,and potential function in soil carbohydrate degradation based on metagenome analysis.The diversity of carbohydrate-active enzyme genes in the topsoil microbial consortia in the four trials was primarily distributed within the ten ecologically most dominant phyla.Application of BBF was associated with the lowest decline in total nitrogen and P2O5(2012-2017:6.5%and 28.1%,respectively)and the most effective carbohydrate decomposition(2015-2017:67.0%for cellulose and 59.9%for readily degradable carbohydrate).Carbohydrate transport and metabolism accounted for 6.0%of reads assigned functional classification under the BBF regimen.These findings reveal the ecologically functional diversity of topsoil microorganisms and suggest BBF application as a promising strategy for sustainable agriculture and beneficial to soil health. | Yujun Shen Lixin Zhao Haibo Meng Hongsheng Cheng Jingtao Ding Jiarui Wang Shanshan Dong Xi Zhang Liqiu Song Shengwei Zheng | 2019 | International Journal of Agricultural and Biological Engineering2019，12，6： | 3 |
| 11 | A Knowledge-Enriched and Span-Based Network for Joint Entity and Relation Extraction显示文摘The joint extraction of entities and their relations from certain texts plays a significant role in most natural language processes.For entity and relation extraction in a specific domain,we propose a hybrid neural framework consisting of two parts:a span-based model and a graph-based model.The span-based model can tackle overlapping problems compared with BILOU methods,whereas the graph-based model treats relation prediction as graph classification.Our main contribution is to incorporate external lexical and syntactic knowledge of a specific domain,such as domain dictionaries and dependency structures from texts,into end-to-end neural models.We conducted extensive experiments on a Chinese military entity and relation extraction corpus.The results show that the proposed framework outperforms the baselines with better performance in terms of entity and relation prediction.The proposed method provides insight into problems with the joint extraction of entities and their relations. | Kun Ding Shanshan Liu Yuhao Zhang Hui Zhang Xiaoxiong Zhang Tongtong Wu Xiaolei Zhou | 2021 | Computers, Materials & Continua2021，，7： | 3 |
| 12 | Review of Rapid Transformation of Floodplain Wetlands in Northeast China: Roles of Human Development and Global Environmental Change显示文摘Northeast China is the region with the largest area of wetlands in China. The Sanjiang Plain and the Songnen Plain are large freshwater marsh distribution regions that are affected by climate warming and by the increasing frequency and density of extreme weather and are the regions most subject to disturbances by human activities in Northeast China. The wetlands of the Sanjiang Plain and the Songnen Plain have shrunk severely in the past 60 years, and wetland functions have been reduced substantially because of climate change, unreasonable land use, fire episodes, engineering and construction works and urbanization. Large-scale agricultural development started in the 1950 s has been the most important driving factor for wetland loss and degradation in the Sanjiang Plain. Water shortage has been the most important factor for degradation and fragmentation of wetlands in the Songnen Plain. To mitigate wetland degradation and better protect wetlands, special regulations, long-term mechanisms and technical support of wetland protection should be established. A wetland compensation program should be implemented, and technologies for increasing the adaptive capacity of wetlands should be developed. Moreover, it is most important to find the balanced threshold between agricultural development and wetland protection. | YU Xiaofei DING Shanshan ZOU Yuanchun XUE Zhenshan LYU Xianguo WANG Guoping | 2018 | Chinese Geographical Science2018，28，4： | 2 |
| 13 | Investigation and analysis of the linkage mechanism and whole process cost of livestock manure organic fertilizer显示文摘In recent years,the utilization of manure resources for livestock and poultry farming has attracted a widespread attention,and manure resources utilization models suitable for different regional characteristics have formed gradually.Among them,the production of organic fertilizer from animal manure is a vital utilization method.However,there are still some problems such as high production costs,difficult sales,and the unwillingness of farmers to use organic fertilizers which have affected the breeding cycle and the sustainability of manure treatment in livestock and poultry breeding.This article selected 371 organic fertilizer plants,related farms and farmers in China,focusing on the main links of the entire process of livestock manure-organic fertilizer-farm application,and studied the mode of animal manure collection by organic fertilizer plants.The costs of organic fertilizer production and farmland application were discussed.Moreover,suggestions were made for the promotion and implementation of large-scale organic fertilizers to make good utilization of manure resources in livestock and poultry farming. | Shanshan Dong Bin Sui Yujun Shen Haibo Meng Lixin Zhao Jingtao Ding Haibin Zhou Xi Zhang Hongsheng Cheng Jian Wang Ran Li Liqiu Song Pengxiang Xu Ji Li | 2020 | International Journal of Agricultural and Biological Engineering2020，13，2： | 2 |
| 14 | Stable and unique graphitic Raman internal standard nanocapsules for surface-enhanced Raman spectroscopy quantitative analysis显示文摘Graphitic nanomaterials 有的独特、强壮、稳定的拉曼颤动广泛地在化学和 biomedicine 被使用了。然而,作为内部标准(ISs ) 利用他们改进提高表面的拉曼的精确性光谱学(重量的单位) 分析没被尝试。此处,我们报导设计一唯一是由很多金牌组成的 nanostructure nanoparticles (AuNPs ) 在 multilayered graphitic 上装饰了磁性的 nanocapsules (AGN ) 确定 analyte 并且消除与传统的 ISs 联系的问题。AGN 从 graphitic 部件表明了一个独特拉曼乐队,它在拉曼是局部性的 biomolecules 的沉默区域,没有任何背景干扰,使他们成为理想为量的拉曼分析。是从也显示的 AGN 的信号优异稳定性,甚至在严厉条件下面。与装饰 AuNPs 的改进, AGN nanostructures 极大地改进了重量的单位,特别地量的错误源于收集损失的排除和 analytes 的不一致的分发的量的精确性。AGN 进一步为房间染色和拉曼成像被利用,并且他们在 biomedicine 为应用显示出大诺言。 | Yuxiu Zou Long Chen Zhiling Song Ding Ding Yiqin Chen Yiting Xu Shanshan Wang Xiaofang Lai Yin Zhang Yang Sun Zhuo Chen Weihong Tan | 2016 | Nano Research2016，9，5： | 2 |
| 15 | Novel human H7N9 influenza virus in China显示文摘Outbreaks of H7N9 avian influenza in humans in 5 provinces and 2 municipalities of China have reawakened concern that avian influenza viruses may again cross species barriers to infect the human population and thereby initiate a new influenza pandemic.Evolutionary analysis shows that human H7N9 influenza viruses originated from the H9N2,H7N3 and H11N9 avian viruses,and that it is as a novel reassortment influenza virus.This article reviews current knowledge on 11 subtypes of influenza A virus from human which can cause human infections. | Chengmin WANG Jing LUO Jing WANG Wen SU Shanshan GAO Min ZHANG Li XIE Hua DING Shelan LIU Xiaodong LIU Yu CHEN Yaxiong JIA Hongxuan HE | 2014 | Integrative Zoology2014，9，3： | 2 |
| 16 | Comparative analysis of habitation behavioral patterns in spatial configuration of traditional houses in Anhui;Jiangsu;and Zhejiang provinces of China显示文摘This study investigated the categories of spatial characteristics of traditional houses in Anhui,Jiangsu,and Zhejiang provinces of China by applying syntactic theories and conducting a comparative analysis of their different layout configurations.Six houses in the three provinces were selected as measurement samples,and statistical analysis of their spatial variables was conducted through SPSS 22.Results showed that the correlation of depth and integration in the Zhejiang and Jiangsu samples are negative,whereas the samples in Anhui show no correlation.These results further indicated that spaces with high rates of utilization in Zhejiang and Jiangsu dwellings are located at low depths in the spatial configurations,whereas the samples from Anhui show opposite findings.Different housing spatial structures reflect various habitation behavioral patterns in this area.Zhejiang and Jiangsu residents interact more closely with outside spaces in their daily lives,whereas Anhui residents have very limited interaction with outside spaces,thereby reflecting two different modes of living behavior,namely,extroversion and introversion. | Jie Ding Shanshan Ma | 2020 | Frontiers of Architectural Research2020，9，1： | 2 |
| 17 | Lipocalin-2-induced proliferative endoplasmic reticulum stress participates in Kawasaki disease-related pulmonary arterial abnormalities显示文摘Clinical cases have reported pulmonary arterial structural and functional abnormalities in patients with Kawasaki disease(KD);however,the underlying mechanisms are unclear.In this study,a KD rat model was established via the intraperitoneal injection of Lactobacillus casei cell wall extract(LCWE).The results showed that pulmonary arterial functional and structural abnormalities were observed in KD rats.Furthermore,proliferative endoplasmic reticulum stress(ER stress)was observed in the pulmonary arteries of KD rats.Notably,the level of lipocalin-2(Lcn 2),a trigger factor of inflammation,was remarkably elevated in the plasma and lung tissues of KD rats;increased Lcn 2 levels following LCWE stimulation may result from polymorphonuclear neutrophils(PMNs).Correspondingly,in cultured pulmonary artery smooth muscle cells(PASMCs),Lcn 2 markedly augmented the cleavage and nuclear localization of activating transcription factor-6(ATF6),upregulated the transcription of glucose regulated protein 78(GRP78)and neurite outgrowth inhibitor(NOGO),and promoted PASMCs proliferation.However,proapoptotic C/EBP homologous protein(CHOP)and caspase 12 levels were not elevated.Treatment with 4-phenyl butyric acid(4-PBA,a specific inhibitor of ER stress)inhibited PASMCs proliferation induced by Lcn 2 and attenuated pulmonary arterial abnormalities and right ventricular hypertrophy and reduced right ventricular systolic pressure in KD rats.In conclusion,Lcn 2 remarkably facilitates proliferative ER stress in PASMCs,which probably accounts for KD-related pulmonary arterial abnormalities. | Zhaoling Shi Yue Yin Chen Li Hui Ding Nan Mu Yishi Wang Shanshan Jin Heng Ma Manling Liu Jie Zhou | 2021 | Science China(Life Sciences)2021，64，6： | 1 |
| 18 | Sim- ultaneous absorption of NOx and SO2 from flue gas with pyrolusite slurry combined with gas-phase oxidation of NO using ozone 显示文摘 | Sun Weiyi Ding Sanglan Zeng Shanshan | 2011 | Journal of Hazardous Materials2011，192，1： | 1 |
| 19 | Evolution and roles of cytokinin genes in angiosperms 1:Do ancient IPTs play housekeeping while non-ancient IPTs play regulatory roles?显示文摘Isopentenyltransferase(IPT)genes,including those encoding ATP/ADP-IPTs and tRNA-IPTs,control the rate-limiting steps of the biosynthesis of N6-(Δ2-isopentenyl)adenine(iP)-type and trans-zeatin(tZ)-type cytokinins and cis-zeatin(cZ)-type cytokinins,respectively.However,the evolution and roles of these IPTs in angiosperms are not well understood.Here,we report comprehensive analyses of the origins,evolution,expression patterns,and possible roles of ATP/ADP-IPTs and tRNA-IPTs in angiosperms.We found that Class I and II tRNA-IPTs likely coexisted in the last common ancestor of eukaryotes,while ATP/ADP-IPTs likely originated from a Class II tRNA-IPT before the divergence of angiosperms.tRNA-IPTs are conservatively retained as 2–3 copies,but ATP/ADP-IPTs exhibit considerable expansion and diversification.Additionally,tRNA-IPTs are constitutively expressed throughout the plant,whereas the expression of ATP/ADP-IPTs is tissue-specific and rapidly downregulated by abiotic stresses.Furthermore,previous studies and our present study indicate that ATP/ADP-IPTs and their products,iPs/tZs,may regulate responses to environmental stresses and organ development in angiosperms.We therefore hypothesize that tRNA-IPTs and the associated cZs play a housekeeping role,whereas ATP/ADP-IPTs and the associated iP/tZ-type cytokinins play regulatory roles in organ development and stress responses in angiosperms,which echoes the conclusions and hypothesis presented in the accompanying study by Wang,X.et al Evolution and roles of cytokinin genes in angiosperms 2:Do ancient CKXs play housekeeping roles while non-ancient CKXs play regulatory roles?Hortic Res http://gffzzd3cc09b8251d45dfs9pxcuxwun9696qv9.ffgz.tsg.suse.edu.cn/10.1038/s41438-020-0246-z. | Xiaojing Wang Shanshan Lin Decai Liu Lijun Gan Richard McAvoy Jing Ding Yi Li | 2020 | Horticulture Research2020，7，1： | 1 |
| 20 | KRAB-type zinc-finger proteins PITA and PISA specifically regulate p53-dependent glycolysis and mitochondrial respiration显示文摘 | Shan Wang Zhiqiang Peng Siying Wang Lihua Yang Yuhan Chen Xue Kong Shanshan Song Pei Pei Chunyan Tian Hui Yan Peipei Ding Weiguo Hu Cui Hua Liu Xin Zhang Fuchu He Lingqiang Zhang | 2018 | Cell Research2018，28，5： | 1 |
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