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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | 2012 ACCF/AHA Focused Update Incorporated Into the ACCF/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction显示文摘 | Jeffrey L. Anderson Cynthia D. Adams Elliott M. Antman Charles R. Bridges Robert M. Califf Donald E. Casey William E. Chavey Francis M. Fesmire Judith S. Hochman Thomas N. Levin A. Michael Lincoff Eric D. Peterson Pierre Theroux Nanette K. Wenger R. Scott | 2013 | Journal of the American College of Cardiology2013，，23： | 2 |
| 3 | Metabolic control during exercise with and without medium-chain triglycerides (MCT) in children with long-chain 3-hydroxy acyl-CoA dehydrogenase (LCHAD) or trifunctional protein (TFP) deficiency 显示文摘 | GILLINGHAM MB SCOTt B ELLIOTT D | 2006 | Mol Genet Metab2006，89，12： | 1 |
| 4 | Global eddy permitting simulations of surface ocean nitrogen, iron, sulfur cycling显示文摘 | CHU Shao ping ELLIOTT Scott MALTRUD Mathew E | 2003 | Chemosphere2003，20，2： | 1 |
| 5 | Understanding Stigma: Dimensions of Deviance and Coping显示文摘 | Elliott G C Zieglcr H L Altman B M Scott D R | 1982 | Deviant Behav- ior1982，，3： | 1 |
| 6 | Contours of simulated marine dimethyl sulfide distributions under variation in a Gabric mechanism 显示文摘 | Scott Elliott Shaoping Chu David Erickson | 2007 | Environmental Modelling & Software2007，22，3： | 1 |
| 7 | Soil textural control on decomposition and soil organic matter dynamies显示文摘 | Scott N A Cole C V Elliott E T | 1996 | Soil Science Society of America Journal1996，60，4： | 1 |
| 8 | Neural Antecedents of the Endowment Effect显示文摘 | Brian Knutson G. Elliott Wimmer Scott Rick Nick G. Hollon Drazen Prelec George Loewenstein | 2008 | Neuron2008，，5： | 1 |
| 9 | Energy and material flow through the urban ecosystem 显示文摘 | Ethan H Decker Scott Elliott Felisa A | 2000 | Ann Rev Energy Environ2000，，25： | 1 |
| 10 | Serum lactate and base deficit as predictors of mortality and morbidity显示文摘 | Farah A Husain Matthew J Martin Philip S Mullenix Scott R Steele David C Elliott | 2003 | The American Journal of Surgery2003，，5： | 1 |
| 11 | Neural Predictors of Purchases显示文摘 | Brian Knutson Scott Rick G. Elliott Wimmer Drazen Prelec George Loewenstein | 2007 | Neuron2007，，1： | 1 |
| 12 | Down regulation of trk but not p75<sup>NTR</sup> gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer’s disease显示文摘 | Stephen D.Ginsberg ShaoliChe JoanneWuu Scott E.Counts Elliott J.Mufson | 2006 | Journal of Neurochemistry2006，，2： | 1 |
| 13 | Reduction of cortical TrkA but not p75<sup>NTR</sup> protein in early‐stage Alzheimer’s disease显示文摘 | Scott E.Counts MuhammadNadeem JoanneWuu Stephen D.Ginsberg H. UriSaragovi Elliott J.Mufson | 2004 | Ann Neurol2004，，4： | 1 |
| 14 | Are Patients with Esophageal Cancer Who Become PET Negative after Neoadjuvant Chemoradiation Free of Cancer?显示文摘 | James M. McLoughlin Marcovalerio Melis Erin M. Siegel E. Michelle Dean Jill M. Weber Jeannie Chern Melanie Elliott Scott T. Kelley Richard C. Karl | 2008 | Journal of the American College of Surgeons2008，，5： | 1 |
| 15 | Indicators and assessment methods for measuring the ecological integrity of semi - aquatic terrestrial environments 显示文摘 | Stephanie A Innis Robert J Naiman Scott R Elliott | 2000 | Hydrobiologia2000，，422423： | 1 |
| 16 | ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise th显示文摘 | Jeffrey L. Anderson Cynthia D. Adams Elliott M. Antman Charles R. Bridges Robert M. Califf Donald E. Casey William E. Chavey Francis M. Fesmire Judith S. Hochman Thomas N. Levin A Michael Lincoff Eric D. Peterson Pierre Theroux Nanette Kass Wenger R Scott | 2007 | Circulation2007，，7： | 1 |
| 17 | Risk of recurrent stroke in patients with sickle cell disease treated with erythrocyte transfusions显示文摘 | Charles H. Pegelow Robert J. Adams Virgil McKie Miguel Abboud Brian Berman Scott T. Miller Nancy Olivieri Elliott Vichinsky Winfred Wang Donald Brambilla | 1995 | The Journal of Pediatrics1995，，6： | 1 |
| 18 | Evaluation of Neuropsychological Domain Scores and Postural Stability Following Cerebral Concussion in Sports显示文摘 | Connie L. Peterson Michael S. Ferrara Marty Mrazik Scott Piland Ronald Elliott | 2003 | Clinical Journal of Sport Medicine2003，，4： | 1 |
| 19 | Soil textural control on decomposition and soil organic matter dynamics显示文摘 | Scott N A Cole C V Elliott E T Huffman S A | 1996 | Soil Science Society of America Journal1996，60，4： | 1 |
| 20 | Serum lactate and base deficit as predictors of mortality and morbidity显示文摘 | Farah A Husain Matthew J Martin Philip S Mullenix Scott R Steele David C Elliott | 2003 | The American Journal of Surgery2003，，5： | 1 |
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