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| 1 | Intraductal neoplasm of the intrahepatic bile duct: Clinicopathological study of 24 cases显示文摘AIM: To investigate the clinicopathological features of intraductal neoplasm of the intrahepatic bile duct (INihB). METHODS: Clinicopathological features of 24 cases of INihB, which were previously diagnosed as biliary papillomatosis or intraductal growth of intrahepatic biliary neoplasm, were reviewed. Mucin immunohistochemistry was performed for mucin (MUC)1, MUC2, MUC5AC and MUC6. Ki-67, P53 and β-catenin immunoreactivity were also examined. We categorized each tumor as adenoma (low grade), borderline (intermediate grade), and malignant (carcinoma in situ , high grade including tumors with microinvasion). RESULTS: Among 24 cases of INihB, we identified 24 tumors. Twenty of 24 tumors (83%) were composed of a papillary structure; the same feature observed in intraductal papillary neoplasm of the bile duct (IPNB). In contrast, the remaining four tumors (17%) showed both tubular and papillary structures. In three of the four tumors (75%), macroscopic mucin secretion was limited but microscopic intracellular mucin was evident. Histologically, 16 tumors (67%) were malignant, three (12%) were borderline, and five (21%) were adenoma. Microinvasion was found in four cases (17%). Immunohistochemical analysis revealed that MUC1 was not expressed in the borderline/adenoma group but was expressed only in malignant lesions (P = 0.0095). Ki-67 labeling index (LI) was significantly higher in the malignant group than in the borderline/adenoma group (22.2 ± 15.5 vs 7.5 ± 6.3, P < 0.01). In the 16 malignant cases, expression of MUC5AC showed borderline significant association with high Ki-67 LI (P = 0.0622). Nuclear expression of β-catenin was observed in two (8%) of the 24 tumors, and these two tumors also showed MUC1 expression. P53 was negative in all tumors. CONCLUSION: Some cases of INihB have a tubular structure, and are subcategorized as IPNB with tubular structure. MUC1 expression in INihB correlates positively with degree of malignancy. | Yoshiki Naito Hironori Kusano Osamu Nakashima Eiji Sadashima Satoshi Hattori Tomoki Taira Akihiko Kawahara Yoshinobu Okabe Kazuhide Shimamatsu Jun Taguchi Seiya Momosaki Koji Irie Rin Yamaguchi Hiroshi Yokomizo Michiko Nagamine Seiji Fukuda Shinichi Sugiyama Naoyo Nishida Koichi Higaki Munehiro Yoshitomi Masafumi Yasunaga Koji Okuda Hisafumi Kinoshita Masayoshi Kage Masamichi Nakayama Makiko Yasumoto Jun Akiba Hirohisa Yano | 2012 | World Journal of Gastroenterology2012，18，28： | 16 |
| 2 | Role of targeted therapy in metastatic colorectal cancer显示文摘Colorectal cancer(CRC) is a significant cause of cancer-related morbidity and mortality all over the world.Improvements of cytotoxic and biologic agents have prolonged the survival in metastatic CRC(mC RC),with a median overall survival of approximately 2 years and more in the past two decades.The biologic agents that have proven clinical benefits in m CRC mainly target vascular endothelial growth factor(VEGF) and epidermal growth factor receptor(EGFR).In particular,bevacizumab targeting VEGF and cetuximab and panitumumab targeting EGFR have demonstrated sig-nificant survival benefits in combination with cytotoxic chemotherapy in the first-line,second-line,or salvage setting.Aflibercept,ramucirumab,and regorafenib are also used in second-line or salvage therapy.Recent retrospective analyses have shown that KRAS or NRAS mutations were negative predictive markers for anti-EGFR therapy.Based on the evidence from large rand-omized clinical trials,personalized therapy is necessary for patients with m CRC according to their tumor biology and characteristics.The aim of this paper was to summarize the results of the major randomized clinical trials and highlight the benefits of the molecular targeted agents in patients with mC RC. | Yoshihito Ohhara Naoki Fukuda Satoshi Takeuchi Rio Honma Yasushi Shimizu Ichiro Kinoshita Hirotoshi Dosaka-Akita | 2016 | World Journal of Gastrointestinal Oncology2016，8，9： | 8 |
| 3 | Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia–reperfusion injury显示文摘 | Kentaro Hayashida Motoaki Sano Ikuroh Ohsawa Ken Shinmura Kayoko Tamaki Kensuke Kimura Jin Endo Takaharu Katayama Akio Kawamura Shun Kohsaka Shinji Makino Shigeo Ohta Satoshi Ogawa Keiichi Fukuda | 2008 | Biochemical and Biophysical Research Communications2008，，1： | 2 |
| 4 | Early and Long-Term Outcome of Total Arch Replacement Using Selective Cerebral Perfusion显示文摘 | Masahito Minakawa Ikuo Fukuda Sanae Yamauchi Kenichi Watanabe Tomonori Kawamura Satoshi Taniguchi Kazuyuki Daitoku Yasuyuki Suzuki Kozo Fukui | 2010 | The Annals of Thoracic Surgery2010，，1： | 2 |
| 5 | Longitudinal associations between anaerobic threshold and distance running performance显示文摘 | Kiyoji Tanaka Hitoshi Watanabe Yotaro Konishi Ryoichi Mitsuzono Satoshi Sumida Shinsuke Tanaka Takashi Fukuda Fumio Nakadomo | 1986 | European Journal of Applied Physiology and Occupational Physiology1986，，： | 2 |
| 6 | Longitudinal associations between anaerobic threshold and distance running performance显示文摘 | Kiyoji Tanaka Hitoshi Watanabe Yotaro Konishi Ryoichi Mitsuzono Satoshi Sumida Shinsuke Tanaka Takashi Fukuda Fumio Nakadomo | 1986 | European Journal of Applied Physiology and Occupational Physiology1986，，3： | 2 |
| 7 | Increased inhibitory ability of conjugated RNA aptamers against the HCV IRES显示文摘 | Kunio Kikuchi Takuya Umehara Fumiko Nishikawa Kotaro Fukuda Tsunemi Hasegawa Satoshi Nishikawa | 2009 | Biochemical and Biophysical Research Communications2009，，1： | 1 |
| 8 | Roles and regulation of cytokinins in tomato fruit development显示文摘 | Satoshi Matsuo Kaori Kikuchi Machiko Fukuda Ichiro Honda Shunsuke Imanishi | 2012 | Journal of Experimental Botany2012，，15： | 1 |
| 9 | Adsorptive granulocyte and monocyte apheresis for refractory Crohn’s disease: an open multicenter prospective study显示文摘 | Yoshihiro Fukuda Toshiyuki Matsui Yasuo Suzuki Kazunari Kanke Takayuki Matsumoto Masakazu Takazoe Takayuki Matsumoto Satoshi Motoya Terasu Honma Koji Sawada Tsuneyoshi Yao Takashi Shimoyama Toshifumi Hibi | 2004 | Journal of Gastroenterology2004，，12： | 1 |
| 10 | Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia–reperfusion injury显示文摘 | Kentaro Hayashida Motoaki Sano Ikuroh Ohsawa Ken Shinmura Kayoko Tamaki Kensuke Kimura Jin Endo Takaharu Katayama Akio Kawamura Shun Kohsaka Shinji Makino Shigeo Ohta Satoshi Ogawa Keiichi Fukuda | 2008 | Biochemical and Biophysical Research Communications2008，，1： | 1 |
| 11 | Quantitative Analysis of Right Ventricular Function in Patients With Pulmonary Hypertension Using Three-Dimensional Echocardiography and a Two-Dimensional Summation Method Compared to Magnetic Resonance Imaging显示文摘 | Tomoko Morikawa Mitsushige Murata Shigeo Okuda Hikaru Tsuruta Shiro Iwanaga Mitsuru Murata Toru Satoh Satoshi Ogawa Keiichi Fukuda | 2011 | The American Journal of Cardiology2011，，3： | 1 |
| 12 | Synchronous or Metachronous Double Cancers of the Pancreas and Other Organs: Report on 12 Cases显示文摘 | Naofumi Eriguchi Shigeaki Aoyagi Masao Hara Koji Okuda Tsuyoshi Tamae Shuichi Fukuda Kotaro Hashino Shinji Sato Kei Fujiki Satoshi Furukawa Atsuo Jimi | 2000 | Surgery Today2000，，8： | 1 |
| 13 | Computer image-guided surgery for total maxillectomy显示文摘 | Akihiro Homma Masahiko Saheki Fumiyuki Suzuki Satoshi Fukuda | 2008 | European Archives of Oto - Rhino - Laryngology2008，，12： | 1 |
| 14 | Structural dynamics of dendritic spines in memory and cognition显示文摘 | HARUO KASAI MASAHIRO FUKUDA SATOSHI WATANABE | 2010 | Trends in Neurosciences2010，，33： | 1 |
| 15 | GABAergic Excitation Promotes Neuronal Differentiation in Adult Hippocampal Progenitor Cells显示文摘 | Yusuke Tozuka Satoshi Fukuda Takashi Namba Tatsunori Seki Tatsuhiro Hisatsune | 2005 | Neuron2005，，6： | 1 |
| 16 | Phase II Study of Chemoradiotherapy With 5-Fluorouracil and Cisplatin for Stage II–III Esophageal Squamous Cell Carcinoma: JCOG Trial (JCOG 9906)显示文摘 | Ken Kato Kei Muro Keiko Minashi Atsushi Ohtsu Satoshi Ishikura Narikazu Boku Hiroya Takiuchi Yoshito Komatsu Yoshinori Miyata Haruhiko Fukuda | 2011 | International Journal of Radiation Oncology Biology Physics2011，，3： | 1 |
| 17 | Thoracic radiotherapy with or without daily low-dose carboplatin in elderly patients with non-small-cell lung cancer: a randomised, controlled, phase 3 trial by the Japan Clinical Oncology Group (JCOG0301)显示文摘 | Shinji Atagi Masaaki Kawahara Akira Yokoyama Hiroaki Okamoto Nobuyuki Yamamoto Yuichiro Ohe Toshiyuki Sawa Satoshi Ishikura Taro Shibata Haruhiko Fukuda Nagahiro Saijo Tomohide Tamura | 2012 | Lancet Oncology2012，，7： | 1 |
| 18 | Preparation of hydroperoxides by N-hydroxyphthalimide catalyzed aerobic oxidation of alkylbenzenes and hydroaromatic compounds and its application显示文摘 | Fukuda Osamu Sakaguchi Satoshi Ishii Yasutaka | 2001 | Advanced Synthesis & Catalysis2001，343，8： | 1 |
| 19 | Longitudinal associations between anaerobic threshold and distance running performance显示文摘 | Kiyoji Tanaka Hitoshi Watanabe Yotaro Konishi Ryoichi Mitsuzono Satoshi Sumida Shinsuke Tanaka Takashi Fukuda Fumio Nakadomo | | 0，，： | 1 |
| 20 | Radiologic Variations in Gastrorenal Shunts and Collateral Veins from Gastric Varices in Images Obtained Before Balloon-Occluded Retrograde Transvenous Obliteration显示文摘 | Hiroaki Maeda Shozo Hirota Satoshi Yamamoto Kaoru Kobayashi Keisuke Arai Yoshiya Miyamoto Tetsuya Fukuda Koji Sugimoto Norio Nakao | 2007 | CardioVascular and Interventional Radiology2007，，3： | 1 |
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