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| 1 | Comparison of PPIs and H_2-receptor antagonists plus prokinetics for dysmotility-like dyspepsia显示文摘AIM:To compare efficacy of proton pump inhibitors(PPIs)with H2-receptor antagonists(H2RAs)plus prokinetics(Proks)for dysmotility-like symptoms in functional dyspepsia(FD).METHODS:Subjects were randomized to receive openlabel treatment with either rabeprazole 10 mg od(n= 57)or famotidine 10 mg bid plus mosapride 5 mg tid(n=57)for 4 wk.The primary efficacy endpoint was change(%)from baseline in total dysmotility-like dyspepsia symptom score.The secondary efficacy endpoint was patient satisfaction with treatment.RESULTS:The improvement in dysmotility-like dyspep-sia symptom score on day 28 was significantly greater in the rabeprazole group(22.5%±29.2%of baseline) than the famotidine+mosapride group(53.2%± 58.6%of baseline,P<0.0001).The superior benefit of rabeprazole treatment after 28 d was consistent regardless of Helicobacter pylori status.Significantly more subjects in the rabeprazole group were satisfied or very satisfied with treatment on day 28 than in the famotidine+mosapride group(87.7%vs 59.6%,P= 0.0012).Rabeprazole therapy was the only significant predictor of treatment response(P<0.0001),defined as a total symptom score improvement≥50%.CONCLUSION:PPI monotherapy improves dysmotility-like symptoms significantly better than H2RAs plus Proks,and should be the treatment of first choice for Japanese FD. | Masahiro Sakaguchi Miyuki Takao Yasuo Ohyama Hiroshi Oka Hiroshi Yamashita Takumi Fukuchi Kiyoshi Ashida Masahiro Murotani Masuyo Murotani Kazuo Majima Hiroshi Morikawa Takashi Hashimoto Keisuke Kiyota Hirohiko Esaki Kanji Amemoto Gouhei Isowa Fumiyuki Takao | 2012 | World Journal of Gastroenterology2012，18，13： | 8 |
| 2 | 基于模糊语言变量的动态目标无线网络选择技术(英文)显示文摘Even though various wireless Network Access Technologies(NATs)with different specifications and applications have been developed in the recent years,no single wireless technology alone can satisfy the anytime,anywhere,and any service wireless-access needs of mobile users.A real seamless wireless mobile environment is only realized by considering vertical and horizontal handoffs together.One of the major design issues in heterogeneous wireless networks is the support of Vertical Handoff(VHO).VHO occurs when a multi-interface enabled mobile terminal changes its Point of Attachment(PoA)from one type of wireless access technology to another,while maintaining an active session.In this paper we present a novel multi-criteria VHO algorithm,which chooses the target NAT based on several factors such as user preferences,system parameters,and traffic-types with varying Quality of Service(QoS)requirements.Two modules i.e.,VHO Necessity Estimation(VHONE)module and target NAT selection module,are designed.Both modules utilize several'weighted'users’and system’s parameters.To improve the robustness of the proposed algorithm,the weighting system is designed based on the concept of fuzzy linguistic variables. | Faisal Kaleem Abolfazl Mehbodniya Arif Islam Kang K.Yen Fumiyuki Adachi | 2013 | China Communications2013，10，1： | 6 |
| 3 | Molecular Mechanisms Contributing to Resistance to Tyrosine Kinase-Targeted Therapy for Non-Small Cell Lung Cancer显示文摘One of the most important pathways in non-small cell lung cancer(NSCLC) is the epidermal growth factor receptor(EGFR) pathway. This pathway affects several crucial processes in tumor development and progression,including tumor cell proliferation,apoptosis regulation,angiogenesis,and metastatic invasion.Targeting EGFR is currently being intensely explored.We are witnessing the development of a number of potential molecular-inhibiting treatments for application in clinical oncology.In the last decade,the tyrosine kinase(TK) domain of the EGFR was identified in NSCLC patients,and it has responded very well with a dramatic clinical improvement to TK inhibitors such are gefitinib and erlotinib.Unfortunately,there were primary and/or secondary resistance to these treatments,as shown by clinical trials.Subsequent molecular biology studies provided some explanations for the drug resistance phenomenon.The molecular mechanisms of resistance need to be clarified.An in-depth understanding of these targeted-therapy resistance may help us explore new strategies for overcoming or reversing the resistance to these inhibitors for the future of NSCLC treatment. | Fariz Nurwidya Akiko Murakami Fumiyuki Takahashi Kazuhisa Takahashi | 2012 | Clinical oncology and cancer resexreh2012，9，1： | 6 |
| 4 | 慢性头晕患者的颈肌张力和静态平衡的客观评价显示文摘目的:头晕患者常诉有颈部僵硬的症状。本研究拟探讨颈部症状在头晕患者中的病理机制。方法:26例因单侧前庭病变导致慢性头晕的患者和24例健康对照者参与本次研究,通过客观测量慢性头晕患者双侧斜方肌的肌张力,探讨其与静态姿势干扰的关系。采用颈肌张力仪客观测量双侧斜方肌张力,计算双侧颈肌张力(ANT)和双侧颈肌张力比值(右/左)(RNT)。静态平衡仪测量重心移动轨迹的总长度(LNG)。结果:头晕患者闭眼状态下,ANT和LNG呈负相关(r=-0.44,P<0.05)。头晕患者和健康对照者在闭眼状态时,RNT和LNG呈正相关。结论:ANT平均值升高提示前庭代偿导致的维持静态姿势平衡的颈肌张力增加。颈肌张力的不对称和姿势不平衡有关。 | 张甦琳 孔维佳 YOUJI ASAMA FUMIYUKI GOTO TOMOKO TSUTSUMI KAORU OGAWA | 2013 | 临床耳鼻咽喉头颈外科杂志2013，27，3： | 5 |
| 5 | Challenges for beyond 5G:ultra-densification of radio access network显示文摘Ultra-densification of radio access network(RAN)is a key to efficiently support the exponentially growing mobile data traffic in 5 G era.Furthermore,extremely high frequency band like mm Wave band was utilized to solve the bandwidth shortage problem.However,untra-dense reusing the same radio resource produced severe interference.And the mm Wave link was very harsh due to frequent blockage by obstacles.Therefore a new RAN architecture needed to be introduced to realize ultra-reliable communications in such a severe radio propagation environment.An architecture of distributed MIMO based RAN was presented.Then,enhanced interference coordination(e IC)was described.Finally,the effectiveness of distributed MIMO based RAN with e IC by computer simulation was showed. | Fumiyuki Adachi Ryo Takahashi Hidenori Matsuo | 2020 | 通信学报2020，41，11： | 2 |
| 6 | A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations显示文摘 | Sreenath V. Sharma Diana Y. Lee Bihua Li Margaret P. Quinlan Fumiyuki Takahashi Shyamala Maheswaran Ultan McDermott Nancy Azizian Lee Zou Michael A. Fischbach Kwok-Kin Wong Kathleyn Brandstetter Ben Wittner Sridhar Ramaswamy Marie Classon Jeff Settleman | 2010 | Cell2010，，1： | 2 |
| 7 | Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction显示文摘In vivo genome editing represents a powerful strategy for both understanding basic biology and treating inherited diseases.However,it remains a challenge to develop universal and efficient in vivo genome-editing tools for tissues that comprise diverse cell types in either a dividing or non-dividing state.Here,we describe a versatile in vivo gene knock-in methodology that enables the targeting of a broad range of mutations and cell types through the insertion of a minigene at an intron of the target gene locus using an intracellularly linearized single homology arm donor.As a proof-of-concept,we focused on a mouse model of prematureaging caused by a dominant point mutation,which is difficult to repair using existing in vivo genome-editing tools.Systemic treatment using our new method ameliorated aging-associated phenotypes and extended animal lifespan,thus highlighting the potential of this methodology for a broad range of in vivo genome-editing applications. | Keiichiro Suzuki Mako Yamamoto Reyna Hernandez-Benitez Zhe Li Christopher Wei Rupa Devi Soligalla Emi Aizawa Fumiyuki Hatanaka Masakazu Kurita Pradeep Reddy Alejandro Ocampo Tomoaki Hishida Masahiro Sakurai Amy NNemeth Estrella Nunez Delicado Josep MCampistol Pierre Magistretti Pedro Guillen Concepcion Rodriguez Esteban Jianhui Gong Yilin Yuan Ying Gu Guang-Hui Liu Carlos Lopez-Otin Jun Wu Kun Zhang Juan Carlos Izpisua Belmonte | 2019 | Cell Research2019，29，10： | 2 |
| 8 | αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model显示文摘Dear Editor,Homeostasis and repair are critical biological processes that allow for tissue and organ preservation and function in multicellular organisms.Their regulation and extension vary drastically across the animal kingdom,and mammals show limited tissue-specific regenerative capacity that declines with age.During aging,articular cartilage is one of the tissues that undergo substantial changes in the matrix structure,molecular composition,metabolic activity,and mechanical properties(Loeser et al.2016). | Paloma Martinez-Redondo Isabel Guillen-Guillen Noah Davidsohn Chao Wang Javier Prieto Masakazu Kurita Fumiyuki Hatanaka Cuiqing Zhong Reyna Hernandez-Benitez Tomoaki Hishida Takashi Lezaki Akihisa Sakamoto Amy NNemeth Yuriko Hishida Concepcion Rodriguez Esteban Kensaku Shojima Ling Huang Maxim Shokhirev Estrella Nunez-Delicado Josep MCampistol Isabel Guillen-Vicente Elena Rodriguez-Inigo Juan Manuel Lopez-Alcorocho Marta Guillen-Vicente George Church Pradeep Reddy Pedro Guillen-Garcia Guang-Hui Liu Juan Carlos Izpisua Belmonte | 2020 | Protein & Cell2020，11，3： | 2 |
| 9 | 显示文摘 | Masahiro Y Kazuya U Fumiyuki N | 1998 | Journal of Polymer Science: Part A: Polymer Chemistry1998，36，： | 1 |
| 10 | Study on Biological Monitioing of Fenpropathtin Exposure in Application by Utilizing Urinary 3-Phenoxybenzoic Acid Level 显示文摘 | CHOI Jin-Ok Fumihiko J Fumiyuki A | 1998 | Environmental Health and Preventive Medicine1998，2，4： | 1 |
| 11 | Impact of Ultrasound Attenuation and Plaque Rupture as Detected by Intravascular Ultrasound on the Incidence of No-Reflow Phenomenon After Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction显示文摘 | Mitsuaki Endo Kiyoshi Hibi Tomoaki Shimizu Naohiro Komura Ikuyoshi Kusama Fumiyuki Otsuka Takayuki Mitsuhashi Noriaki Iwahashi Jun Okuda Kengo Tsukahara Masami Kosuge Toshiaki Ebina Satoshi Umemura Kazuo Kimura | 2010 | JACC: Cardiovascular Interventions2010，，5： | 1 |
| 12 | The sorption of heavy metal species by sediments in soakaways receiving urban road runoff显示文摘 | Michio Murakami Fumiyuki Nakajima Hiroaki Furumai | 2007 | Chemosphere2007，，11： | 1 |
| 13 | The sorption of heavy metal species by sediments in soakaways receiv- ing urban road runoff 显示文摘 | Michio Murakami Fumiyuki Nakajima Hiroaki Furumai | 2008 | Chemosphere2008，70，： | 1 |
| 14 | Recurrence of meningiomas:influence of vascular endothelial growth factor expression显示文摘 | Hiroyuki Y Seiji H | 2000 | Cancer2000，89，： | 1 |
| 15 | Osteopontin overproduced by tumor cells acts as a potent angiogenic factor contributing to tumor growth 显示文摘 | Michihiro Hirana Fumiyuki Takahashi Kazuhisa Takahashi | 2003 | Cancer Lett2003，198，2： | 1 |
| 16 | Plasma adiponectin levels are associated with coronary lesion complexity in men with coronary artery disease 显示文摘 | Fumiyuki Otsuka Seigo Sugiyama Sunao Kojima | 2006 | J Am Coll Cardiol2006，48，6： | 1 |
| 17 | Classification of Coronary Atherosclerotic Plaques Ex Vivo With T1, T2, and Ultrashort Echo Time CMR显示文摘 | Mihály Károlyi Harald Seifarth Gary Liew Christopher L. Schlett Pál Maurovich-Horvat Paul Stolzmann Guangping Dai Shuning Huang Craig J. Goergen Masataka Nakano Fumiyuki Otsuka Renu Virmani Udo Hoffmann David E. Sosnovik | 2013 | JACC: Cardiovascular Imaging2013，，4： | 1 |
| 18 | Identification of sewer pipes to be cleaned for reduction of CSO pollutant load 显示文摘 | Akihiro N Katsushi S Fumiyuki N | 2007 | Water Sci Technol2007，55，4： | 1 |
| 19 | Viscosity and surface tension measurements of RE20rMgO-Si02 (RE = Y, Gd, Nd and La) melts显示文摘 | FUMIYUKI S HlROFUMI T NORITAKA S | 2006 | ISIJ Int2006，46，： | 1 |
| 20 | Analysis of Seasonal and Structural Changes in Microbial Community including Algae in Tsukui Lake by PCR-DGGE显示文摘 | KASUGA LKURO FYRUMAI HIROAKI NAKAJIMA FUMIYUKI | 2001 | Journal of Japan Society on Water Environment2001，24，12： | 1 |
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