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| 1 | Helper T cell differentiation显示文摘CD4^(+)T helper cells are key regulators of host health and disease.In the original model,specialized subsets of T helper cells are generated following activation through lineage-specifying cytokines and transcriptional programs,but recent studies have revealed increasing complexities for CD4^(+)T-cell differentiation.Here,we first discuss CD4^(+)T-cell differentiation from a historical perspective by highlighting the major studies that defined the distinct subsets of T helper cells.We next describe the mechanisms underlying CD4^(+)T-cell differentiation,including cytokine-induced signaling and transcriptional networks.We then review current and emerging topics of differentiation,including the plasticity and heterogeneity of T cells,the tissue-specific effects,and the influence of cellular metabolism on cell fate decisions.Importantly,recent advances in cutting-edge approaches,especially systems biology tools,have contributed to new concepts and mechanisms underlying T-cell differentiation and will likely continue to advance this important research area of adaptive immunity. | Jordy Saravia Nicole M.Chapman Hongbo Chi | 2019 | Cellular & Molecular Immunology2019，16，7： | 25 |
| 2 | Signaling networks in immunometabolism显示文摘Adaptive immunity is essential for pathogen and tumor eradication,but may also trigger uncontrolled or pathological inflammation.T cell receptor,co-stimulatory and cytokine signals coordinately dictate specific signaling networks that trigger the activation and functional programming of T cells.In addition,cellular metabolism promotes T cell responses and is dynamically regulated through the interplay of serine/threonine kinases,immunological cues and nutrient signaling networks.In this review,we summarize the upstream regulators and signaling effectors of key serine/threonine kinase-mediated signaling networks,including PI3K-AGC kinases,mTOR and LKB1-AMPK pathways that regulate metabolism,especially in T cells.We also provide our perspectives about the pending questions and clinical applicability of immunometabolic signaling.Understanding the regulators and effectors of immunometabolic signaling networks may uncover therapeutic targets to modulate metabolic programming and T cell responses in human disease. | Jordy Saravia Jana L.Raynor Nicole M.Chapman Seon Ah Lim Hongbo Chi | 2020 | Cell Research2020，30，4： | 9 |
| 3 | Sunflower seed shells:A novel and effective low-cost adsorbent for the removal of the diazo dye Reactive Black 5 from aqueous solutions显示文摘 | Osma J F Saravia V José L | 2007 | Journal of Hazardous Materials2007，147，： | 1 |
| 4 | Conservative management of an impacted incisor显示文摘 | Bullen C Saravia ME Steinberg B | 1986 | Oral Surg Oral Med Oral Pathol1986，61，6： | 1 |
| 5 | Deep freezing of concentrated boar semen for intrauterine insemination : effects on sperm viability 显示文摘 | Saravia F Wallgren M Nagy S | 2005 | Theriogenology2005，63，5： | 1 |
| 6 | Thrombogenic potential of nonionic contrast media? 显示文摘 | FAREED J WALENGA J M SARAVIA G E | 1990 | Radiology1990，174，2： | 1 |
| 7 | Differences in sperm migration through cervical mucus in vitro relates to sperm colonization of the oviduct and fertilizing ability in goats显示文摘 | Cox J F Zavala A Saravia F | 2002 | Theriogenology2002，58，1： | 1 |
| 8 | Vertical arrangements, market Structure, and competition: An analysis of restructured us electricity markets显示文摘 | Bushnell J Mansur E Saravia C | 2008 | American Economic Review2008，98，1： | 1 |
| 9 | Role of NOM in the performance of adsorption membrane hybrid systems applied for the removal of pharmaceuticals显示文摘 | F Saravia F H Frimmel | 2008 | Desalination2008，224，13： | 1 |
| 10 | Environmentally persistent free radicals induce airway hyperresponsiveness in neonatal rat lungs显示文摘 | Balakrishna S Saravia J Thevenot P | | 0，，： | 1 |
| 11 | Boar spermatozoa in the oviduct显示文摘 | Rodriguez-Martinez H Saravia F Wallgren M | 2005 | Theriogenology2005，63，： | 1 |
| 12 | Cognitive dysfunction and hippocampal changes in experimental type 1 diabetes显示文摘 | Edgardo O. Alvarez Juan Beauquis Yanina Revsin Arturo M. Banzan Paulina Roig Alejandro F. De Nicola Flavia Saravia | 2008 | Behavioural Brain Research2008，，1： | 1 |
| 13 | Evaluation of polymerase chain reaction,adenosine deaminase,and interferon-γ gamma in pleural fluid for the differential diagnosis of pleural tuberculosis显示文摘 | VILLEGAS M V LABRADA L A SARAVIA N G | 2000 | Chest2000，118，5： | 1 |
| 14 | Particulate matter containing environmentally persistent free radicals and adverse infant respiratory health effects: a review 显示文摘 | SARAVIA J LEE GI LOMNICKI S | 2013 | J Biochem Mol Toxicol2013，27，1： | 1 |
| 15 | An innovative method for preventing biocorrosion through microbial adhesion inhibition显示文摘 | Patricia S Guiamet Sandra G Gomez de Saravia Hector A Videla | 1999 | International Bioddeterioration & Biodegradeation1999，43，： | 1 |
| 16 | Deep freezing of concentrated boar semen for intra-uterine insemination: effects on sperm viability 显示文摘 | Saravia F Wallgren M Nagy S | 2005 | Theriogenology2005，63，5： | 1 |
| 17 | Sovereign Defaulters:Do International Capital Markets Punish Them? 显示文摘 | Fuentesl M and Saravia D | 2010 | Journal of Development Economics2010，91，2： | 1 |
| 18 | Anaerobic treatment of municipal solid waste显示文摘 | Plaza G P R Pacheco O Saravia Toledo A | 1996 | Water Science Technology1996，33，3： | 1 |
| 19 | Prominenfly decreased hippoeampal neurogenesis in a spontaneous model of type 1 diabetes, the non obese?diabetic mouse 显示文摘 | Beauquis J Saravia F Coulaud J | 2008 | Exp Neurol2008，210，2： | 1 |
| 20 | Deep freezing of con- centrated boar semen for intra-uterine insemination: effects on sperm viability显示文摘 | Saravia F Wallgren M Nagy S | 2005 | Theriogenology2005，63，5： | 1 |
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