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| 1 | Gastrointestinal Microbiome Signatures of Pediatric Patients With Irritable Bowel Syndrome显示文摘 | Delphine M. Saulnier Kevin Riehle Toni–Ann Mistretta Maria–Alejandra Diaz Debasmita Mandal Sabeen Raza Erica M. Weidler Xiang Qin Cristian Coarfa Aleksandar Milosavljevic Joseph F. Petrosino Sarah Highlander Richard Gibbs Susan V. Lynch Robert J. Shulman | 2011 | Gastroenterology2011，，5： | 4 |
| 2 | American Gastroenterological Association Institute Guideline on the Prevention and Treatment of Hepatitis B Virus Reactivation During Immunosuppressive Drug Therapy显示文摘 | K. Rajender Reddy Kimberly L. Beavers Sarah P. Hammond Joseph K. Lim Yngve T. Falck-Ytter | 2015 | Gastroenterology2015，，1： | 3 |
| 3 | Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders显示文摘 | Elaine Y. Hsiao Sara W. McBride Sophia Hsien Gil Sharon Embriette R. Hyde Tyler McCue Julian A. Codelli Janet Chow Sarah E. Reisman Joseph F. Petrosino Paul H. Patterson Sarkis K. Mazmanian | 2013 | Cell2013，，7： | 3 |
| 4 | Burden of onchocerciasis-associated epilepsy:first estimates and research priorities显示文摘Background:Since the 1990s,evidence has accumulated of an increased prevalence of epilepsy in onchocerciasisendemic areas in Africa as compared to onchocerciasis-free areas.Although the causal relationship between onchocerciasis and epilepsy has yet to be proven,there is likely an association.Here we discuss the need for disease burden estimates of onchocerciasis-associated epilepsy(OAE),provide them,detail how such estimates should be refined,and discuss the socioeconomic impact of OAE,including a cost-estimate for anti-epileptic drugs.Main body:Providing OAE burden estimates may aid prevention of epilepsy in onchocerciasis-endemic areas by inciting and informing collaboration between onchocerciasis control programmes and mental health services.Epilepsy not only massively impacts the health of those affected,but it also carries a high socioeconomic burden for the households and communities involved.We used previously published geospatial estimates of onchocerciasis in Africa and a separately published logistic regression model quantifying the association between onchocerciasis and epilepsy to estimate the number of OAE cases.We then applied disability weights for epilepsy to quantify the burden in terms of years of life lived with disability(YLD)and estimate the cost of treatment.We estimate that in 2015 roughly 117000 people were affected by OAE across onchocerciasis-endemic areas previously under the African Programme for Onchocerciases control(APOC)mandate where OAE has ever been reported or suspected,and another 264000 persons in onchocerciasis-endemic areas where OAE has never been investigated before.The total number of YLDs due to OAE was 39300 and 88700 in these areas respectively,based on a weighted mean disability weight of 0.336.The burden of OAE is approximately 13%of the total YLDs attributable to onchocerciasis and 10%of total YLDs attributable to epilepsy.We estimated that by 2015 the total costs of treatment with antiepileptic drug for OAE cases would have been a minimum of 12.4 million US$.Conclusions:These estimates suggest a considerable health,social and economic burden of OAE in Africa.The treatment and care for people with epilepsy,especially in hyperendemic onchocerciasis areas with high epilepsy prevalence thus requires more financial and human resources. | Natalie V.S.Vinkeles Melchers Sarah Mollenkopf Robert Colebunders Michael Edlinger Luc E.Coffeng Julia Irani Tresor Zola Joseph N.Siewe Sake Jde Vlas Andrea S.Winkler Wilma A.Stolk | 2018 | Infectious Diseases of Poverty2018，7，1： | 3 |
| 5 | Biodiversity, Nitrogen Deposition, and CO2 Affect Grassland Soil Carbon Cycling but not Storage显示文摘 | Joseph Reid E. Adair Sarah Hobbie Peter Reich | 2012 | Ecosystems2012，，4： | 2 |
| 6 | Hemoglobin A1c in early postpartum screening of women with gestational diabetes显示文摘AIM:To assess the utility of hemoglobin A1c(HbA1c) in the early postpartum screening of women with gestational diabetes mellitus(GDM).METHODS:Over a 3 years period,HbA1c estimations were undertaken in addition to and simultaneously with the traditional oral glucose tolerance test(OGTT),in 203 women with GDM as a part of early postpartum screening for dysglycaemia,at 6 wk post-partum.World Health Organization criteria was used for diagnosing diabetes:fasting blood glucose(FBG) ≥ 7.0 mmol/Land/or 2-h postprandial blood glucose(PPBG) ≥ 11.1 mmol/L and/or HbA1c ≥ 48 mmol/mol;and impaired glycaemiastate:impaired fasting glucose 6.1-6.9 mmol/L and/or impaired glucose tolerance 7.8-11.0 mmol/L and/or HbA1c:42-47 mmol/mol.RESULTS:Mean FBG,2-h PPBG and HbA1c were 4.9 ± 0.7 mmol/L,5.6 ± 2.0 mmol/L and 38 ± 5 mmol/mol respectively.FBG,2-h PPBG and HbA1c detected 6(3%),7(3.5%) and 11(5.4%) cases of diabetes respectively,and 11(5.4%),25(12.3%) and 23(11.3%) cases of pre-diabetes state respectively.HbA1c values ≥ 48 mmol/mol(≥ 6.5%) showed a diagnostic sensitivity of 71.4% and specificity of 98.5% for diabetes in comparison to OGTT in receiver operating characteristics curve analysis.At HbA1c cut-off 44 mmol/mol,sensitivity and specificity were 100% and 92.3% respectively [area under the curve:0.98(95%CI:0.96-1.00)].Sensitivity and specificity for detecting high risk 'impaired glycaemia' state [HbA1c 42 mmol/mol(6.0%)] were 28% and 80%,respectively.CONCLUSION:HbA1c level ≥ 48 mmol/mol(≥ 6.5%) has reasonable sensitivity and high specificity in comparison to OGTT for early postpartum screening of diabetes in GDM.At 6 th week postpartum screening,if FBG is normal and HbA1c < 44 mmol/mol OGTT is not recommended. | Mahesh V Katreddy Joseph M Pappachan Sarah E Taylor Radha Indusekhar Ananth U Nayak Alan M Nevill | 2013 | World Journal of Diabetes2013，4，3： | 2 |
| 7 | Laparoscopic Distal Pancreatectomy Offers Shorter Hospital Stays with Fewer Complications显示文摘 | Joseph DiNorcia Beth A. Schrope Minna K. Lee Patrick L. Reavey Sarah J. Rosen James A. Lee John A. Chabot John D. Allendorf | 2010 | Journal of Gastrointestinal Surgery2010，，11： | 2 |
| 8 | Extraction and characterisation of lipids from Antarctic krill ( Euphausia superba )显示文摘 | Joseph C. Gigliotti Matthew P. Davenport Sarah K. Beamer Janet C. Tou J. Jaczynski | 2010 | Food Chemistry2010，，3： | 2 |
| 9 | Arsenic variability and groundwater age in three water supply wells in southeast New Hampshire显示文摘Three wells in New Hampshire were sampled bimonthly over three years to evaluate the temporal variability of arsenic concentrations and groundwater age.All samples had measurable concentrations of arsenic throughout the entire sampling period and concentrations in individual wells had a mean variation of more than 7 μg/L.The time series data from this sampling effort showed that arsenic concentrations ranged from a median of 4 mg/L in a glacial aquifer well (SGW-65) to medians of 19 μg/L and 37 μg/L in wells (SGW-93 and KFW-87) screened in the bedrock aquifer,respectively.These high arsenic concentrations were associated with the consistently high pH (median ≥- 8) and low dissolved oxygen (median <0.1 mg/L) in the bedrock aquifer wells,which is typical of fractured crystalline bedrock aquifers in New Hampshire.Groundwater from the glacial aquifer often has high dissolved oxygen,but in this case was consistently low.The pH also is generally acidic in the glacial aquifer but in this case was slightly alkaline (median =7.5).Also,sorption sites may be more abundant in glacial aquifer deposits than in fractured bedrock which may contribute to lower arsenic concentrations.Mean groundwater ages were less than 50 years old in all three wells and correlated with conservative tracer concentrations,such as chloride;however,mean age was not directly correlated with arsenic concentrations.Arsenic concentrations at KFW-87 did correlate with water levels,in addition,there was a seasonal pattern,which suggests that either the timing of or multiple sampling efforts may be important to define the full range of arsenic concentrations in domestic bedrock wells.Since geochemically reduced conditions and alkaline pHs are common to both bedrock and glacial aquifer wells in this study,groundwater age correlates less strongly with arsenic concentrations than geochemical conditions.There also is evidence of direct hydraulic connection between the glacial and bedrock aquifers,which can influence arsenic concentrations.Correlations between arsenic concentrations and the age of the old fraction of water in SGW-65 and the age of the young fraction of water in SGW-93 suggest that water in the two aquifers may be mixing or at least some of the deeper,older water captured by the glacial aquifer well may be from a similar source as the shallow young groundwater from the bedrock aquifer.The contrast in arsenic concentrations in the two aquifers may be because of increased adsorption capacity of glacio-fluvial sediments,which can limit contaminants more than fractured rock.In addition,this study illustrates that long residence times are not necessary to achieve more geochemically evolved conditions such as high pH and reduced conditions as is typically found with older water in other regions. | Joseph P.Levitt James R.Degnan Sarah M.Flanagan Bryant C.Jurgens | 2019 | Geoscience Frontiers2019，10，5： | 2 |
| 10 | MPTP Susceptibility in the Mouse: Behavioral, Neurochemical, and Histological Analysis of Gender and Strain Differences显示文摘 | Marco Sedelis Katja Hofele Georg W. Auburger Sarah Morgan Joseph P. Huston Rainer K. W. Schwarting | 2000 | Behavior Genetics2000，，3： | 1 |
| 11 | Extraction and characterisation of lipids from Antarctic krill (Euphausia superba)显示文摘 | JOSEPH C G MATTHEW P D SARAH K B | 2010 | Food Chemistry2010，125，3： | 1 |
| 12 | Drivers of food SMEs network success:101 tales from Norway显示文摘 | Sarah Eyaa Joseph M. Ntayi Sheila Namagembe | | 0，，： | 1 |
| 13 | Extraction and characterization of lipids from Antarctic krill(Euphausia superba)显示文摘 | Joseph C G Matthew P D Sarah K B | 2011 | Food Chemistry2011，，125： | 1 |
| 14 | Exercise, APOE, and working memory: MEG and behavioral evidence for benefit of exercise in epsilon4 carriers显示文摘 | Sean P. Deeny David Poeppel Jo B. Zimmerman Stephen M. Roth Josef Brandauer Sarah Witkowski Joseph W. Hearn Andrew T. Ludlow José L. Contreras-Vidal Jason Brandt Bradley D. Hatfield | 2008 | Biological Psychology2008，，2： | 1 |
| 15 | 农业健康研究中阳光暴露、维生素D受体基因变异与乳腺癌风险显示文摘[背景]流行病学证据表明,阳光暴露与乳腺癌风险之间存在负性相关。假设其机制是阳光诱导皮肤合成维生素D。[目的]探讨阳光暴露及其与维生素D受体(VDR)基因变异的交互作用对乳腺癌风险的影响。[方法]在前瞻性农业健康研究队列的入组人群中,研究31 021位持有私人执照的杀虫剂从业人员的妻子受到的阳光暴露与乳腺癌发病率,其中包括578个病例,平均随访8.6年。在一项由293名病例和586名匹配对照组成的巢式病例-对照研究中,评估阳光暴露、VDR变异体与乳腺癌之间的交互作用。有关阳光暴露的信息来自于队列入组时的问卷调查。对队列数据采用Cox比例风险回归估计相对风险,对巢式病例-对照数据采用条件logistic回归估计相对风险。[结果]在所有参与者中,患乳腺癌风险的小幅度下降与随访前10年中平时阳光暴露≥1 h/d相关(与<1 h/d相比)[风险比(HR)=0.8;95%CI:0.6~1.0]。这一相关性在雌激素受体阳性肿瘤(HR=0.7;95%CI:0.5~0.9)中比雌激素受体阴性肿瘤(HR=1.1;95%CI:0.6~2.1)中稍强。阳光暴露≥1 h/d和一个VDR单倍型的联合HR低于预期,因为单一暴露的HR为负值(交互作用,P=0.07)。[结论]上述研究结果提示,阳光暴露可能与乳腺癌风险降低相关,但是研究中并没有发现通过VDR变异体修饰的明确证据。需要进行更大规模的研究,特别是平时阳光暴露水平低的人群中可能能够更精确描述。 | Lawrence S.Engel Jaya Satagopan Camelia S.Sima Irene Orlow Urvi Mujumdar Joseph Coble Pampa Roy Sarah Yoo Dale P.Sandler Michael C.Alavanja | 2014 | 环境与职业医学2014，31，5： | 1 |
| 16 | Chemotherapy for schis tosomiasis in Ugandan Fishermen:treatment can cause a rapid in crease in interleukin 5 levels in plasma but decreased levels of eosin ophilia and worm specific immunoglobulin E显示文摘 | Colin MF Sarah Joseph Frances MJ | 2004 | Infect Immun2004，72，7： | 1 |
| 17 | Neck Circumference as a Nove Measure of Cardiometabolic Risk:The Framingham Heart Study显示文摘 | Sarah RP Joseph MM Udo H | 2009 | The Journal of Clinical Endocrinology & Metabolism2009，95，8： | 1 |
| 18 | Preterm birth and low birth weight among in vitro fertilization singletons: A systematic review and meta-analyses显示文摘 | Sarah D. McDonald Zhen Han Sohail Mulla Kellie E. Murphy Joseph Beyene Arne Ohlsson | 2009 | European Journal of Obstetrics and Gynecology2009，，2： | 1 |
| 19 | An information-motivation-behavioral skills (IMB) model-based HIV prevention intervention for truck drivers in India显示文摘 | Deborah H. Cornman Sarah J. Schmiege Angela Bryan T. Joseph Benziger Jeffrey D. Fisher | 2006 | Social Science & Medicine2006，，8： | 1 |
| 20 | Diffusion imaging quality control via entropy of principal direction distribution显示文摘 | Mahshid Farzinfar Ipek Oguz Rachel G. Smith Audrey R. Verde Cheryl Dietrich Aditya Gupta Maria L. Escolar Joseph Piven Sonia Pujol Clement Vachet Sylvain Gouttard Guido Gerig Stephen Dager Robert C. McKinstry Sarah Paterson Alan C. Evans Martin A. Styner | 2013 | Neuroimage2013，，： | 1 |
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