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| 1 | Cis-stilbene glucoside in Polygonum multiflorum induces immunological idiosyncratic hepatotoxicity in LPS-treated rats by suppressing PPAR-γ显示文摘蓼 multiflorum Thunb (下午) 的根在中国被使用了治疗许多疾病,例如便秘,头发和 hyperlipemia 的早 graying。最近的证据证明那位首相在人引起特质的导致药的肝损害(IDILI ) 。在这研究,我们基于 LPS 的非肝毒素的剂量在 IDILI 的一个老鼠模型调查了导致下午的肝损害的分子的基础。SD 老鼠口头上地被管理下午的 3 潜在地肝毒素的混合物:cis 芪配糖物(cis-SG, 50 mg/kg ) , trans-SG (50 mg/kg ) 或 emodin (5 mg/kg ) ,由 LPS 的注射列在后面(2.8 mg/kg, iv ) 。浆液和肝组织学被评估在 LPS 以后的 7 h 注射。在测试的 3 混合物之中, cis-SG,然而并非 emodin 或 trans-SG,当与 LPS 结合了时,在老鼠导致了严重的肝损害。在血浆的著名计算机生产厂商和在血浆和肝纸巾的煽动性的 cytokines 的层次显著地被提高。肝纸巾显示出增加的损害, hepatocyte apoptosis,和巨噬细胞渗入,并且减少房间增长。Microarray 分析揭示了在 peroxisome 之间的否定关联激活 proliferator 的受体 --(PPAR-) 并且 LPS/cis-SG-induced 肝损害。Immunohistochemical 染色和 RT-PCR 结果进一步证实 cis-SG 显著地在 LPS/cis-SG-treated 老鼠的肝纸巾禁止了 PPAR- 小径的激活。有 PPAR- 收缩筋 pioglitazone 的预告的处理(500 g/kg, ig ) 颠倒的 LPS/cis-SG-induced 肝损害,它与禁止原子因素 kappa B (NF-B ) 被联系小径。这些数据证明 cis 芪配糖物导致免疫学的通过在 IDILI 的一个老鼠模型压制 PPAR- 的特质的 hepatotoxicity。 | Ya-kun MENG Chun-yu LI Rui-yu LI Lan-zhi HE He-rong CUI Ping YIN Cong-en ZHANG Peng-yan LI Xiu-xiu SANG Ya WANG Ming NIU Ya-ming ZHANG Yu-ming GUO Rong SUN Jia-bo WANG Zhao-fang BAI Xiao-he XIAO | 2017 | Acta Pharmacologica Sinica2017，38，10： | 30 |
| 2 | Chinese Trauma Surgeon Association for management guidelines of vacuum sealing drainage application in abdominal surgeries-Update and systematic review显示文摘Vacuum sealing drainage (VSD) is frequently used in abdominal surgeries. However, relevant guidelines are rare. Chin ese Trauma Surge on Associati on orga nized a committee composed of 28 experts across China in July 2017, aiming to provide an evidence-based recommendation for the application of VSD in abdominal surgeries.Eleven questions regarding the use of VSD in abdominal surgeries were addressed:(1) which type of materials should be respectively chosen for the intraperitoneal cavity, retroperitoneal cavity and superficial incisions?(2) Can VSD be preventively used for a high-risk abdominal incision w让h primary suture?(3) Can VSD be used in severely contaminated/infected abdominal surgical sites?(4) Can VSD be used for temporary abdominal cavity closure under some special conditions such as severe abdominal trauma, infection, liver transplantation and intra-abdominal volume increment in abdominal compartment syndrome?(5) Can VSD be used in abdominal organ inflammation, injury, or postoperative drainage?(6) Can VSD be used in the treatment of intestinal fistula and pancreatic fistula?(7) Can VSD be used in the treatment of intra-abdominal and extra-peritoneal abscess?(8) Can VSD be used in the treatment of abdominal wall wounds, wound cavity, and defects?(9) Does VSD in crease the risk of bleeding?(10) Does VSD increase the risk of intestinal wail injury?(11) Does VSD increase the risk of peritoneal adhesion? Focusing on these questions, evidence-based recommendations were given accordingly. VSD was strongly recommended regarding the questions 2-4. Weak recommendations were made regarding questions 1 and 5-11. Proper use of VSD in abdominal surgeries can lower the risk of infection in abdominal incisions with primary suture, treat severely contaminated/infected surgical sites and facilitate temporary abdominal cavity closure. | Yang Li Pei-Yuan Li Shi-Jing Sun Yuan-Zhang Yao Zhan-Fei Li Tao Liu Fan Yang Lian-Yang Zhang Xiang-Jun Bai Jing-Shan Huo Wu-Bing He Jun Ouyang Lei Peng Ping Hu Yan-An Zhu Ping Jin Qi-Feng Shao Yan-Feng Wang Rui-Wu Dai Pei-Yang Hu Hai-Ming Chen Ge-Fei Wang Yong-Gao Wang Hong-Xu Jin Chang-Ju Zhu Qi-Yong Zhang Biao Shao Xi-Guang Sang Chang-Lin Yin | 2019 | Chinese Journal of Traumatology2019，22，1： | 26 |
| 3 | Cationic nanocarriers induce cell necrosis through impairment of Na^+/K^+-ATPase and cause subsequent inflammatory response显示文摘有积极表面费用的 Nanocarriers 以他们限制了他们的临床的应用的毒性著名。位于他们的毒性下面的机制例如煽动性的反应的正式就职,仍然保持大部分未知。在我们发现了 cationic nanocarriers 的那注射的现在的学习,包括 cationic liposomes, PEI,和 chitosan,导致了坏死的房间的快速的外观。cationic nanocarriers 导致的房间坏死依赖于他们的积极表面费用,但是不要求 RIP1 和 Mlkl。相反,细胞内部的 Na + 超载被发现伴随房间死亡。在文化媒介或有 Na +/K+-ATPase 阳离子绑定地点禁止者 ouabain 的房间的预告的处理的 Na + 的弄空,从房间坏死的保护的房间。而且,有 cationic nanocarriers 的处理在 vitro 并且在 vivo 禁止了 Na +/K+-ATPase 活动。计算模拟证明 cationic 搬运人能与 Na +/K+-ATPase 的阳离子绑定地点交往。有 ouabain 的小剂量的老鼠 pretreated 在 cationic nanocarriers 的致命的剂量的注射以后显示出改进幸存。进一步的分析建议 cationic nanocarriers 和 mitochondrial DNA 的产生的漏导致的那房间坏死能在 vivo 触发严重发炎,它被包含 TLR9 并且 MyD88 发信号的一条小径调停。一起拿,我们的结果揭示由此的新奇机制 cationic nanocarriers 通过和 mitochondrial 的随后的暴露的和 Na +/K+-ATPase, 的相互作用导致尖锐房间坏死是的联系损坏的分子的模式调停的一个关键事件煽动性的回答。我们的学习为评估 nanocarriers 的 biocompatibility 并且为药交货设计更好、更安全的有重要含意。 | Xiawei Wei Bin Shao Zhiyao He Tinghong Ye Min Luo Yaxiong Sang Xiao Liang Wei Wang Shuntao Luo Shengyong Yang Shuang Zhang Changyang Gong Maling Gou Hongxing Deng Yinglan Zhao Hanshuo Yang Senyi Deng Chengjian Zhao Li Yang Zhiyong Qian Jiong Li Xun Sun Jiahuai Han Chengyu Jiang Min Wu Zhirong Zhang | 2015 | Cell Research2015，25，2： | 21 |
| 4 | Genetic analysis and gene mapping of a dominant presenescing leaf gene PSL3 in rice (Oryza sativa L.)显示文摘Leaf senescence as an active process is essential for plant survival and reproduction.However,premature senility is harmful to agricultural production.In this study,a rice mutant,named as psl3 (presescing leaf 3) isolated from EMS-treated Jinhui 10,displays obvious premature senility features both in morphological and physiological level.Genetic analysis showed that mutant trait was controlled by a single dominant gene (PSL3),which was located on rice chromosome 7 between SSR marker c7sr1 and InDel marker ID10 with an interval of 53.5 kb.The result may be useful for the isolation of the PSL3 gene. | FANG LiKui LI YunFeng GONG XiaoPing SANG XianChun LING YingHua WANG XiaoWen CONG YunFei HE GuangHua | 2010 | Chinese Science Bulletin2010，55，23： | 20 |
| 5 | Intraductal papillary neoplasm of the bile duct显示文摘Intraductal papillary neoplasm of the bile duct(IPNB)is a variant of bile duct carcinoma that is characterized by intraductal growth and better outcomes compared with common cholangiocarcinoma.IPNBs are mainly found in patients from Far Eastern areas,where hepatolithiasis and clonorchiasis are endemic.According to the immunohistochemical profiles of the mucin core proteins,IPNBs are classified into four types:pancreaticobiliary,intestinal,gastric,and oncocytic.Approximately 40%-80%of IPNBs contain a component of invasive carcinoma or tubular or mucinous adenocarcinoma,suggesting that IPNB is a disease with high potential for malignancy.It is difficult to make an accurate preoperative diagnosis because of IPNB’s low incidence and the lack of specificity in its clinical manifestation.The most common abnormal preoperative imaging findings of IPNB are intraductal masses and the involvement of bile duct dilation.Simultaneous proximal and distal bile duct dilation can be detected in some cases,which has diagnostic significance.Cholangiography and cholangioscopy are needed to confirm the pathology and demonstrate the extent of the lesions.However,pathologic diagnosis by biopsy cannot reflect the actual stage in many cases because different foci may be of different stages and because mixed pathologic findings may exist in the same lesion.Surgical resection is the major treatment.Systematic cholangioscopy with staged biopsies and frozen sections is recommended during resection to ensure that no minor tumors are left and that curative resection is achieved.Staging,histologic subtype,curative resection and lymph node metastasis are factors affecting long-term survival. | Xue-Shuai Wan Yi-Yao Xu Jun-Yan Qian Xiao-Bo Yang An-Qiang Wang Lian He Hai-Tao Zhao Xin-Ting Sang | 2013 | World Journal of Gastroenterology2013，19，46： | 14 |
| 6 | Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development显示文摘Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely underestimated.In recent years,'missing'Men delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated. | Lin Zhao Songguo Xue Zhongyuan Yao Juanzi Shi Biaobang Chen Ling Wu Lihua Sun Yao Xu Zheng Yan Bin Li Xiaoyan Mao Jing Fu Zhihua Zhang Jian Mu Wenjing Wang Jing Du Shuai Liu Jie Dong Weijie Wang Qiaoli Li Lin He Li Jin Xiaozhen Liang Yanping Kuang Xiaoxi Sun Lei Wang Qing Sang | 2020 | Protein & Cell2020，11，12： | 10 |
| 7 | Prognostic impact of the red cell distribution width in esophageal cancer patients: A systematic review and meta-analysis显示文摘AIM To clarify the previous discrepant conclusions, we performed a meta-analysis to evaluate the prognostic value of red cell distribution width(RDW) in esophageal cancer(EC). METHODS We searched the PubM ed, EMBASE, Web of Science and Cochrane Library databases to identify clinical studies, followed by using STATA version 12.0 for statistical analysis. Studies that met the following criteria were considered eligible:(1) Studies including EC patients who underwent radical esophagectomy;(2) studies including patients with localized disease without distant metastasis;(3) studies including patients without preoperative neoadjuvant therapy;(4) studies including patients without previous antiinflammatory therapies and with available preoperative laboratory outcomes;(5) studies reporting association between the preoperative RDW and overall survival(OS)/disease-free survival(DFS)/cancer-specific survival(CSS); and(6) studies published in English.RESULTS A total of six articles, published between 2015 and 2017, fulfilled the selection criteria in the end. Statistical analysis showed that RDW was not associated with the prognosis of EC patients, irrespective of OS/CSS [hazard ratio(HR) = 1.27, 95% confidence interval(CI): 0.97-1.57, P = 0.000] or DFS(HR = 1.42, 95%CI: 0.96-1.88, P = 0.000). Subgroup analysis indicated that elevated RDW was significantly associated with worse OS/CSS of EC patients when RDW > 13%(HR = 1.45, 95%CI: 1.13-1.76, P = 0.000), when the patient number ≤ 400(HR = 1.45, 95%CI: 1.13-1.76, P = 0.000) and when the study type was retrospective(HR = 1.42, 95%CI : 1.16-1.69, P = 0.000).CONCLUSION Contrary to our general understanding, this meta-analysis revealed that RDW cannot serve as an indicator of poor prognosis in patients with EC. However, it may still be a useful predictor of unfavorable prognosis using an appropriate cut-off value. | Wei-Yu Xu Xiao-Bo Yang Wen-Qin Wang Yi Bai Jun-Yu Long Jian-Zhen Lin Jian-Ping Xiong Yong-Chang Zheng Xiao-Dong He Hai-Tao Zhao Xin-Ting Sang | 2018 | World Journal of Gastroenterology2018，24，19： | 9 |
| 8 | Lipid layer thickness and tear meniscus height measurements for the differential diagnosis of evaporative dry eye subtypes显示文摘AIM: To explore a new diagnostic index for differentiating the evaporative dry eye(EDE) subtypes by analysis of their respective clinical characteristics. METHODS: A cross-sectional study of 139 patients(139 eyes) with EDE who were enrolled and classified as obstructive meibomian gland dysfunction(MGD)(n=81) and non-obstructive MGD(n=58) EDE. All patients completed a Standard Patient Evaluation of Eye Dryness(SPEED) questionnaire and were evaluated for average lipid layer thickness(LLT), tear meniscus height measurements(TMH), tear break-up time(TBUT), ocular surface staining score, Schirmer I test(SIT), lid margin abnormalities, and meibomian gland function and morphology. RESULTS: Age, average LLT, TMH, scores of lid margin abnormalities, meibum quality, meibomian gland loss(MGL)(all P≤0.001), and TBUT(P=0.03) were all significantly different between obstructive MGD EDE patients and nonobstructive MGD EDE patients. Average LLT in obstructive MGD EDE was correlated with meibomian expressibility(r=-0.541, P≤0.001), lid margin abnormalities were marginally not significant(r=0.197, P=0.077), and TMH was correlated with MGL(total MGL: r=0.552, P≤0.001; upper MGL: r=0.438, P≤0.001; lower MGL: r=0.407, P≤0.001). Average LLT in non-obstructive MGD EDE, was correlated with meibomian expressibility and Oxford staining(r=-0.396, P=0.002; r=-0.461, P≤0.001). The efficiency of combining average LLT and TMH was optimal, with a sensitivity of 80.2% and a specificity of 74.1%. Obstructive MGD EDE patients had an average LLT≥69 nm and TMH≥0.25 mm, while non-obstructive MGD EDE patients had an average LLT<69 nm and TMH<0.25 mm.CONCLUSION: Obstructive MGD EDE and nonobstructive MGD EDE have significantly different clinical characteristics. Combining average LLT and TMH measurements enhanced their reliability for differentiating these two subtypes and provided guidance for offering more precise treatments for EDE subtypes. | Xuan Sang Yan Li Liu Yang Jia-Hui Liu Xiao-Ran Wang Chao-Yang Li Ying Liu Chen-Jie Wang Xiong-Jun He Shou-Bi Wang Zhi-Chong Wang | 2018 | International Journal of Ophthalmology(English edition)2018，11，9： | 9 |
| 9 | Catalytic performance of hierarchical H-ZSM-5/MCM-41 for methanol dehydration to dimethyl ether显示文摘Micro-mesoporous composite molecular sieves H-ZSM-5/MCM-41 were prepared by the hydrothermal technique with alkali-treated H-ZSM-5zeolite as the source and characterized by scanning electron microscopy,transmission electron microscopy,energy dispersive spectroscopy,X-ray diffraction,N2 adsorption-desorption measurement and NH3 temperature-programmed desorption.The catalytic performances for the methanol dehydration to dimethyl ether over H-ZSM-5/MCM-41 were evaluated.Among these catalysts,H-ZSM-5/MCM-41 prepared with NaOH dosage (nNa/nSi) varying from 0.4 to 0.47 presented excellent catalytic activity with more than 80%methanol conversion and 100%dimethyl ether selectivity in a wide temperature range of 170—300℃,and H-ZSM-5/MCM-41 prepared with nNa/nSi=0.47 showed constant methanol conversion of about 88.7%,100% dimethyl ether selectivity and excellent lifetime at 220℃.The excellent catalytic performances were due to the highly active and uniform acidic sites and the hierarchical porosity in the micro-mesoporous composite molecular sieves.The catalytic mechanism of H-ZSM-5/MCM-41 for the methanol dehydration to dimethyl ether process was also discussed. | Yu Sang Hongxiao Liu Shichao He Hansheng Li Qingze Jiao Qin Wu Kening Sun | 2013 | Journal of Energy Chemistry2013，22，5： | 7 |
| 10 | A phosphatidic acid-binding lncRNA SNHG9 facilitates LATS1 liquid–liquid phase separation to promote oncogenic YAP signaling显示文摘Long noncoding RNAs(lncRNAs)are emerging as a new class of important regulators of signal transduction in tissue homeostasis and cancer development.Liquid–liquid phase separation(LLPS)occurs in a wide range of biological processes,while its role in signal transduction remains largely undeciphered.In this study,we uncovered a lipid-associated lncRNA,small nucleolar RNA host gene 9(SNHG9)as a tumor-promoting lncRNA driving liquid droplet formation of Large Tumor Suppressor Kinase 1(LATS1)and inhibiting the Hippo pathway.Mechanistically,SNHG9 and its associated phosphatidic acids(PA)interact with the C-terminal domain of LATS1,promoting LATS1 phase separation and inhibiting LATS1-mediated YAP phosphorylation.Loss of SNHG9 suppresses xenograft breast tumor growth.Clinically,expression of SNHG9 positively correlates with YAP activity and breast cancer progression.Taken together,our results uncover a novel regulatory role of a tumor-promoting lncRNA(i.e.,SNHG9)in signal transduction and cancer development by facilitating the LLPS of a signaling kinase(i.e.,LATS1). | Rui-Hua Li Tian Tian Qi-Wei Ge Xin-Yu He Cheng-Yu Shi Jun-Hong Li Zhen Zhang Fang-Zhou Liu Ling-Jie Sang Zuo-Zhen Yang Ya-Zhuo Liu Yan Xiong Qingfeng Yan Xu Li Huai-Qiang Ju Jian Liu Liang-Jing Wang Jian-Zhong Shao Wenqi Wang Tianhua Zhou Aifu Lin | 2021 | Cell Research2021，31，10： | 6 |
| 11 | Endoscopy-assisted cerebral falx incision via unilateral approach for treatment of dissymmetric bilateral frontal contusion显示文摘ObjectiveTo 调查临床的特征和不对称的双边的正面的殴打的治疗策略,并且在由最低限度地侵略的 surgery.MethodsOver 对待这些病人总结我们的经验过去的 3 年,我们用帮助内视镜检查法的单方的服的 falx 切口与不对称的双边的正面的殴打对待 31 个病人的一个总数。一样的时期在单方的手术组作为 control.ResultsSeventeen 案例(54.8%)被采取的在内的平淡的双边的途径对待的另外的 30 个病人幸存并且处于好状况,(25.8%) 8 有中等残疾,(12.9%) 4 有严重残疾,(3.2%) 1 处于植物的状态,并且(3.2%) 1 死了。与控制组相比,格拉斯哥结果规模分数不在单方的操作组,而是操作时间是显著地不同的,输血体积,医院停留的长度,心理混乱和嗅觉的神经损害的发生极大地在单方的操作被减少 帮助group.ConclusionsEndoscopy 的单方的服的 falx 切口能弄短操作时间,与不对称的 bil 在病人的治疗减少外科的损伤和复杂并发症它能显然减少推迟的 intracerebral hematoma 并且随后的机会最小化 subfalcial 和 centrencephalic 形成疝的发生。 | DONG Ji-rong XU Qin-yi CAI Xue-jian WANG Biao WANG Yu-hai SHI Zhong-hua LIU Bing CAI Sang HE Jian-qing HU Xu | 2012 | Chinese Journal of Traumatology2012，15，2： | 6 |
| 12 | Intercalibration of international and domestic ^(40)Ar/^(39)Ar dating standards显示文摘Four international standards, Ga1550, MMhb-1, Lp-6, Bern 4M, and one domestic standard BT-1 have been intercalibrated. The repeated measurements on MMhb-1 with different mass demonstrate that MMhb-1 is inhomogeneous in age and its average age is 519.8 Ma. The results of Bern 4M and Lp-6 reflect that they have an invariable value of 40Ar*/39Ark (F) and the ages we obtained are consensus with their K-Ar age: Lp-6=127.7Ma; Bern 4M=18.2 Ma. Analyses of BT-1 age spectra, Ca/K and Cl/K spectra as well as inverse isochrons indicate that the sample is homogeneous and invariable and keeps close chemically, with its trapped argon isotope composition close to the at- mosphere. The dating results show that age values are reproducible and steady, total fusion age, step-heating age, plateau age and isochron age are in accord with each other within the error range (2σ). Therefore, we recommend 28.7 Ma as the calibrated age of BT-1. We also discuss the variation in neutron flux gradients of Beijing 49-2 reactor. It was found that the neutron flux gradient varies considerably, and more monitors (standard samples) are needed to fix the trend of variation. The coefficient of the 49-2 reactor that transfers the ratio of production rate of 37ArCa/39ArK into Ca/K ratio is 1.78. This is different from that reported earlier, 2.0, which may be caused by the reconstruction of the reactor. | WANG Fei HE Huaiyu ZHU Rixiang SANG Haiqing WANG Yinglan YANG Liekun | 2006 | Science China Earth Sciences2006，49，5： | 6 |
| 13 | Genetic analysis and molecular mapping of a novel gene for zebra mutation in rice (Oryza sativa L.)显示文摘A novel zebra mutant,zebra-15,derived from the restorer line Jinhui10(Oryza sativa L. ssp. indica) treated by EMS,displayed a distinctive zebra leaf from seedling stage to jointing stage. Its chlorophyll content decreased(55.4%) and the ratio of Chla/Chlb increased(90.2%) significantly in the yellow part of the zebra-15,compared with the wild type. Net photosynthetic rate and fluorescence kinetic parameters showed that the decrease of chlorophyll content significantly influenced the photosynthetic efficiency of the mutant. Genetic analysis of F2 segregation populations derived from the cross of Xinong1A and zebra-15 indicated that the zebra leaf trait is controlled by a single recessive nuclear gene. Ninety-eight out of four hundred and eighty pairs of SSR markers showed the diversity between the Xinong1A and the zebra-15,their F2 population was then used for gene mapping. Zebra-15(Z-15) gene was primarily restricted on the short arm of chromosome 5 by 150 F2 recessive individuals,19.6 cM from marker RM3322 and 6.0 cM from marker RM6082. Thirty-six SSR markers were newly designed in the restricted location,and the Z-15 was finally located between markers nSSR516 and nSSR502 with the physical region 258 kb by using 1,054 F2 recessive individuals. | Qiushi Wang,Xianchun Sang,Yinghua Ling,Fangming Zhao,Zhenglin Yang,Yunfeng Li,Guanghua He Key Laboratory of Biotechnology and Crop Quality Improvement,Ministry of Agriculture Rice Research Institute,Southwest University,Chongqing 400716,China | 2009 | Journal of Genetics and Genomics2009，36，11： | 5 |
| 14 | Online Unsupervised Learning Classification of Pedestrian and Vehicle for Video Surveillance显示文摘This paper presents an online unsupervised learning classification of pedestrians and vehicles for video surveillance. Different from traditional methods depending on offline training, our method adopts the online label strategy based on temporal and morphological features,which saves time and labor to a large extent. It extract the moving objects with their features from the original video.An online filtering procedure is adopted to label the moving objects according to certain threshold of speed and area feature. The labeled objects are sent into a SVM classifier to generate the pedestrian & vehicle classifier. Experimental results illustrate that our unsupervised learning algorithm is adapted to polymorphism of the pedestrians and diversity of the vehicles with high classification accuracy. | HE Yi SANG Nong GAO Changxin HAN Jun | 2017 | Chinese Journal of Electronics2017，26，1： | 5 |
| 15 | Cartilage-targeting peptide-modified dual-drug delivery nanoplatform with NIR laser response for osteoarthritis therapy显示文摘Cartilage-targeting delivery of therapeutic agents is still an effective strategy for osteoarthritis(OA)therapy.Recently,scavenging for reactive oxygen species(ROS)and activating autophagy have been increasingly reported to treat OA effectively.In this study,we designed,for the first time,a dual-drug delivery system based on metal organic framework(MOF)-decorated mesoporous polydopamine(MPDA)which composed of rapamycin(Rap)loaded into the mesopores and bilirubin(Br)loaded onto the shell of MOF.The collagen II-targeting peptide(WYRGRL)was then conjugated on the surface of above nanocarrier to develop a cartilage-targeting dual-drug delivery nanoplatform(RB@MPMW).Our results indicated the sequential release of two agents from RB@MPMW could be achieved via near-infrared(NIR)laser irritation.Briefly,the rapid release of Br from the MOF shell exhibited excellent ROS scavenging ability and anti-apoptosis effects,however responsively reduced autophagy activity,to a certain extent.Meanwhile,following the NIR irradiation,Rap was rapidly released from MPDA core and further enhanced autophagy activation and chondrocyte protection.RB@MPMW continuously phosphorylated AMPK and further rescued mitochondrial energy metabolism of chondrocytes following IL-1βstimulation via activating SIRT1-PGC-1αsignaling pathway.Additionally,the cartilage-targeting property of peptide-modified nanocarrier could be monitored via Magnetic Resonance(MR)and IVIS imaging.More significantly,RB@MPMW effectively delayed cartilage degeneration in ACLT rat model.Overall,our findings indicated that the as-prepared dual-drug delivery nanoplatform exerted potent anti-inflammation and anti-apoptotic effects,rescued energy metabolism of chondrocytes in vitro and prevented cartilage degeneration in vivo,which thereby showed positive performance for OA therapy. | Song Xue Xiaojun Zhou Weilin Sang Cong Wang Haiming Lu Yiming Xu Yiming Zhong Libo Zhu Chuanglong He Jinzhong Ma | 2021 | Bioactive Materials2021，6，8： | 5 |
| 16 | Impact of the origin of sinus node artery on recurrence after pulmonary vein isolation in patients with paroxysmal atrial fibrillation显示文摘 | ZHANG Zhi-jun CHEN Ke TANG Ri-bo SANG Cai-hua Edmundo Patricio Lopes Lao YAN Qian HE Xiao-nan DU Xin LONG De-yong YU Rong-hui DONG Jian-zeng MA Chang-sheng | 2013 | Chinese Medical Journal2013，，9： | 5 |
| 17 | Low concentration of sodium hyaluronate temporarily elevates the tear film lipid layer thickness in dry eye patients with lipid deficiency显示文摘AIM: To investigate the effects of different concentrations of artificial tears on lipid layer thickness(LLT) and blink rate(BR) in dry eye patients.METHODS: This study included 106 eyes of 58 patients with dry eye. The lipid deficiency type was defined as the LLT baseline <75 nm. The LLT and BR were measured at baseline and 1, 5 and 15 min after the instillation of 0.1% or 0.3% sodium hyaluronate(SH) eye drops by using the LipiV iew ocular surface interferometer. RESULTS: In the lipid deficiency group, the LLT increased from baseline at 1 min post instillation. The LLT after the instillation of 0.1% SH was significantly higher than that after the instillation of 0.3% SH(P<0.001). The LLT returned to baseline at 15 min post instillation of 0.1% SH and at 5 min post instillation of 0.3% SH. In the non-lipid deficiency group, the LLT decreased from baseline at 1 min and returned to baseline at 5 min for both treatments. The BRs were not significantly different at different time points for both treatments.CONCLUSION: SH eye drops induce a short-term increase in LLT of patients with lipid deficiency. A low concentration of artificial tears have a stronger effect than a high concentration of artificial tears on the increase in LLT. In comparison, SH eye drops induce a transient and slight decrease in LLT of patients without lipid deficiency. A low concentration of artificial tears might be better for patients with lipid deficiency. | Yan Li Xuan Sang Liu Yang Xiao-Ran Wang Jia-Hui Liu Xiong-Jun He Ying Liu Xiao-He Lu Zhi-Chong Wang | 2018 | International Journal of Ophthalmology(English edition)2018，11，3： | 5 |
| 18 | The Treatment of Mid-shaft Clavicle Fractures显示文摘 | Qing-Hua Sang Zhi-Gang Gou Hua-Yong Zheng Jing-Tao Yua Jian-Wen Zhao Hong-Ying He Chuang Liu Zhi Liu | 2015 | Chinese Medical Journal2015，，21： | 5 |
| 19 | Outcome of catheter ablation of atrial fibrillation in patients with prior ischemic stroke显示文摘 | LI Song-nan KANG Jun-ping DU Xin HE Xiao-nan LONG De-yong YU Rong-hui TANG Ri-bo SANG Cai-hua JIANG Chen-xi NING Man DONG Jian-zeng MA Chang-sheng | 2013 | Chinese Medical Journal2013，，6： | 4 |
| 20 | A simple and easily implemented risk model to predict 1-year ischemic stroke and systemic embolism in Chinese patients with atrial fibrillation显示文摘Background:Accurate prediction of ischemic stroke is required for deciding anticoagulation use in patients with atrial fibrillation(AF).Even though only 6%to 8%of AF patients die from stroke,about 90%are indicated for anticoagulants according to the current AF management guidelines.Therefore,we aimed to develop an accurate and easy-to-use new risk model for 1-year thromboembolic events(TEs)in Chinese AF patients.Methods:From the prospective China Atrial Fibrillation Registry cohort study,we identified 6601 AF patients who were not treated with anticoagulation or ablation at baseline.We selected the most important variables by the extreme gradient boosting(XGBoost)algorithm and developed a simplified risk model for predicting 1-year TEs.The novel risk score was internally validated using bootstrapping with 1000 replicates and compared with the CHA2DS2-VA score(excluding female sex from the CHA2DS2-VASc score).Results:Up to the follow-up of 1 year,163 TEs(ischemic stroke or systemic embolism)occurred.Using the XGBoost algorithm,we selected the three most important variables(congestive heart failure or left ventricular dysfunction,age,and prior stroke,abbreviated as CAS model)to predict 1-year TE risk.We trained a multivariate Cox regression model and assigned point scores proportional to model coefficients.The CAS scheme classified 30.8%(2033/6601)of the patients as low risk for TE(CAS score=0),with a corresponding 1-year TE risk of 0.81%(95%confidence interval[CI]:0.41%–1.19%).In our cohort,the C-statistic of CAS model was 0.69(95%CI:0.65–0.73),higher than that of CHA2DS2-VA score(0.66,95%CI:0.62–0.70,Z=2.01,P=0.045).The overall net reclassification improvement from CHA2DS2-VA categories(low=0/high≥1)to CAS categories(low=0/high≥1)was 12.2%(95%CI:8.7%–15.7%).Conclusion:In Chinese AF patients,a novel and simple CAS risk model better predicted 1-year TEs than the widely-used CHA2DS2-VA risk score and identified a large proportion of patients with low risk of TEs,which could potentially improve anticoagulation decision-making.Trial Registration:www.chictr.org.cn(Unique identifier No.ChiCTR-OCH-13003729). | Chao Jiang Tian-Ge Chen Xin Du Xiang Li Liu He Yi-Wei Lai Shi-Jun Xia Rong Liu Yi-Ying Hu Ying-Xue Li Chen-Xi Jiang Nian Liu Ri-Bo Tang Rong Bai Cai-Hua Sang De-Yong Long Guo-Tong Xie Jian-Zeng Dong Chang-Sheng Ma | 2021 | Chinese Medical Journal2021，，19： | 4 |
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