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| 1 | Gastric mucin expression in Helicobacter pylori-related, nonsteroidal anti-inflammatory drug-related and idiopathic ulcers显示文摘AIM: To determine the pattern of secreted mucin expression in Helicobacter pylori (H. pylori)-related, nonsteroidal anti-inflammatory drug (NSAID)-related and idiopathic gastric ulcers. METHODS: We randomly selected 92 patients with H. pylori-associated (n = 30), NSAID-associated (n = 18), combined H. pylori and NSAID-associated gastric ulcers (n = 24), and patients with idiopathic gastric ulcers (n = 20). Immunohistochemistry for T-cell CD4/CD8, andfor mucin 5AC (MUC5AC) and mucin 6 (MUC6), was performed on sections of the mucosa from the ulcer margin. Inflammation score was assessed according to the Sydney system. RESULTS: MUC5AC was expressed on the surface epithelium (98.9%) and neck glands (98.9%) with minimal expression in the deep glands (6.5%). MUC6 was strongly expressed in the deep glands (97.8%), variable in the neck glands (19.6%) and absent in the surface epithelium (0%). The pattern of mucin expression in idiopathic ulcer margins was not different from the expression in ulcers associated with H. pylori, NSAIDs, or combined H. pylori and NSAIDs. CD4/CD8 ratio was higher in H. pylori-positive patients (P = 0.009). Idiopathic ulcers are associated with hospitalized patients and have higher bleeding and mortality rates. CONCLUSION: Idiopathic ulcers have a unique clinical profile. Gastric mucin expression in idiopathic gastric ulcers is unchanged compared with H. pylori and/or NSAID-associated ulcers. | Doron Boltin Marisa Halpern Zohar Levi Alex Vilkin Sara Morgenstern Samuel B Ho Yaron Niv | 2012 | World Journal of Gastroenterology2012，18，33： | 5 |
| 2 | Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers显示文摘AIM:To determine the expression of membrane-bound mucins and glycan side chain sialic acids in Helicobacter pylori(H.pylori)-associated,non-steroidal inflammatory drug(NSAID)-associated and idiopathic-gastric ulcers.METHODS:We studied a cohort of randomly selected patients with H.pylori(group 1,n=30),NSAID(group 2,n=18),combined H.pylori and NSAID associated gastric ulcers(group 3,n=24),and patients with idiopathic gastric ulcers(group 4,n=20).Immunohistochemistry for MUC1,MUC4,MUC17,and staining for Erythrina cristagalli agglutinin and Sambucus nigra agglutinin(SNA)lectins was performed on sections from the ulcer margins.RESULTS:Staining intensity of MUC17 was higher in H.pylori ulcers(group 1)than in idiopathic ulcers(group4),11.05±3.67 vs 6.93±4.00 for foveola cells,and10.29±4.67 vs 8.00±3.48 for gland cells,respectively(P<0.0001).In contrast,MUC1 expression was higher in group 4 compared group 1,9.89±4.17 vs 2.93±5.13 in foveola cells and 7.63±4.60 vs 2.57±4.50 for glands,respectively(P<0.0001).SNA lectin staining was increased in group 4,in parallel to elevated MUC1expression,indicating more abundantα2-6 sialylation in that group.CONCLUSION:Cytoplasmic MUC17 staining was sig-nificantly decreased in the cases with idiopathic ulcer.The opposite was observed for both MUC1 and SNA lectin.This observation may reflect important pathogenic mechanisms,since different mucins with altered sialylation patterns may differ in their protection efficiency against acid and pepsin. | Yaron Niv Doron Boltin Marisa Halpern Miriam Cohen Zohar Levi Alex Vilkin Sara Morgenstern Vahig Manugian Erica St Lawrence Pascal Gagneux Sukhwinder Kaur Poonam Sharma Surinder K Batra Samuel B Ho | 2014 | World Journal of Gastroenterology2014，20，40： | 5 |
| 3 | Outcomes After Minimally Invasive Esophagectomy: Review of Over 1000 Patients显示文摘 | James D. Luketich Arjun Pennathur Omar Awais Ryan M. Levy Samuel Keeley Manisha Shende Neil A. Christie Benny Weksler Rodney J. Landreneau Ghulam Abbas Matthew J. Schuchert Katie S. Nason | 2012 | Annals of Surgery2012，，1： | 3 |
| 4 | Atrial fibrillation, the arrhythmia of the elderly, causes and associated conditions显示文摘 | Samuel Levy | 2002 | Ana Kar Der2002，10，： | 1 |
| 5 | Results of lis2t,a multicenter,randomized study comparing cyclosporine microemulsion with C2 monitoring and tacrolimus with C0 monitoring in de novo liver transplantation显示文摘 | Levy G Villamil F Samuel D | 2004 | Transplantation2004，77，11： | 1 |
| 6 | Colon carcinoma in patients undergoing liver transplantation显示文摘 | Renata Fabia Marlon F Levy Giuliano Testa Samuel Obiekwe Robert M Goldstein Bo S Husberg Thomas A Gonwa Goran B Klintmalm | 1998 | The American Journal of Surgery1998，，3： | 1 |
| 7 | ACC/AHA/ESC Guidelines for the Management of Patients With Atrial Fibrillation: Executive Summary A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee 显示文摘 | Valentin Fuster Lars E. Ryden Richard W. Asinger David S. Cannom Harry J. Crijns Robert L. Frye Jonathan L. Halperin G. Neal Kay Werner W. Klein Samuel Levy Robert L. McNamara Eric N. Prystowsky L. Samuel Wann D. George Wyse Raymond J. Gibbons Elliott M. | 2001 | Circulation: Journal of the American Heart Association2001，，17： | 1 |
| 8 | Coronary microvasculature alteration in hypertensive rats:effect of treatment with a diuretic and an ACE inhibitor显示文摘 | Levy BI Duriez M Samuel J L | 2001 | Am J Hypertens2001，14，： | 1 |
| 9 | Results of lis2t, a multicenter, ran- domized study comparing cyclosporine microemulsion with C2 monito- ring and tacrolimus with CO monitoring in de novo liver transplantation 显示文摘 | Levy G Villamil F Samuel D | 2004 | Transplantation2004，77，11： | 1 |
| 10 | Management of cancer pain 显示文摘 | Levy MH Samuel TA | | Semi- nars in Oncology0，32，1： | 1 |
| 11 | Results of lis2t,a multieenter, randomized study eomaring eyelosorine mieroemulsion with C2 monitoring and taerolimus wih Co monitoring in de nove liver transplatation显示文摘 | Levy G Villamil F Samuel D | 2004 | Transplantation2004，77，： | 1 |
| 12 | Three-dimensional analytical simulation of self-and cross-responsivities of photovoltaic detector arrays 显示文摘 | David Levy Samuel E Schacham I Kidron | 1987 | IEEE Transactions on Electron Devices1987，34，10： | 1 |
| 13 | Coronary microvasculature alteration in hypertensive rats: effect of treatment with a diuretic and an ACE inhibitor 显示文摘 | Levy BI Duriez M Samuel JL | 2001 | AMJ Hypertens2001，，14： | 1 |
| 14 | Coronary microvasculature alteration in hypertensive rats:effect of treatment with a diuretic and an ACE inhibitor显示文摘 | Levy BI Duriez M Samuel JL | 2001 | Am J Hypertens2001，14，1： | 1 |
| 15 | Balancing risk and reward: a critical review of the intragastric balloon for weight loss显示文摘 | Shantanu Gaur Samuel Levy Lisbeth Mathus-Vliegen Ram Chuttani | 2015 | Gastrointestinal Endoscopy2015，，6： | 1 |
| 16 | Coronary microvasculature alteration in hypertensive rats: effect of treatment with a diuretic and an ACE inhibitor 显示文摘 | Levy BI Duriez M Samuel JL | 2001 | Am J Hypertens2001，14，： | 1 |
| 17 | Management of cancer pain 显示文摘 | Levy MH Samuel TA | 2005 | Sere inars in Oncology2005，32，1： | 1 |
| 18 | Management of cancer pain显示文摘 | Levy MH Samuel TA | 2005 | Seminars in Oncology2005，32，1： | 1 |
| 19 | Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma显示文摘 | Ma Xiao-Hong Piao Sheng-Fu Dey Souvik Mcafee Quentin Karakousis Giorgos Villanueva Jessie Hart Lori S Levi Samuel Hu Janice Zhang Gao Lazova Rossitza Klump Vincent Pawelek John M Xu Xiaowei Xu Wei Schuchter Lynn M Davies Michael A Herlyn | 2014 | Journal of Clinical Investigation2014，，3： | 1 |
| 20 | Coronary microvasculature alteration in hypertensive rats:effect of treatment with a diuretic and an ACE inhibitor显示文摘 | Levy BI Duriez M Samuel JL | 2001 | Am J Hypertens2001，14，： | 1 |
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