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Gastric mucin expression in Helicobacter pylori-related, nonsteroidal anti-inflammatory drug-related and idiopathic ulcers

查看全文 作　　者：Doron [1]Boltin;Marisa [2]Halpern;Zohar [1]Levi;Alex [1]Vilkin;Sara [3]Morgenstern;Samuel B [4]Ho;Yaron [1]Niv 高影响力作者 机构地区：[1]Department of Gastroenterology, Rabin Medical Center, Tel Aviv University, Petah Tikva 49100, Israel;[2]Department of Pathology, Rabin Medical Center, Hasharon Hospital, Petah Tikva 49100, Israel;[3]Department of Pathology, Rabin Medical Center, Beilinson Hospital, Petah Tikva 49100, Israel;[4]Department of Medicine, University of California, and VA San Diego Healthcare System, San Diego, CA 92161, United States高影响力机构 出　　处：《World Journal of Gastroenterology》索引2012年第18卷第33期,共7页高影响力期刊 基　　金：Beilinson Hospital Gastroenterology Department Trust Fund 摘　　要：AIM: To determine the pattern of secreted mucin expression in Helicobacter pylori (H. pylori)-related, nonsteroidal anti-inflammatory drug (NSAID)-related and idiopathic gastric ulcers. METHODS: We randomly selected 92 patients with H. pylori-associated (n = 30), NSAID-associated (n = 18), combined H. pylori and NSAID-associated gastric ulcers (n = 24), and patients with idiopathic gastric ulcers (n = 20). Immunohistochemistry for T-cell CD4/CD8, andfor mucin 5AC (MUC5AC) and mucin 6 (MUC6), was performed on sections of the mucosa from the ulcer margin. Inflammation score was assessed according to the Sydney system. RESULTS: MUC5AC was expressed on the surface epithelium (98.9%) and neck glands (98.9%) with minimal expression in the deep glands (6.5%). MUC6 was strongly expressed in the deep glands (97.8%), variable in the neck glands (19.6%) and absent in the surface epithelium (0%). The pattern of mucin expression in idiopathic ulcer margins was not different from the expression in ulcers associated with H. pylori, NSAIDs, or combined H. pylori and NSAIDs. CD4/CD8 ratio was higher in H. pylori-positive patients (P = 0.009). Idiopathic ulcers are associated with hospitalized patients and have higher bleeding and mortality rates. CONCLUSION: Idiopathic ulcers have a unique clinical profile. Gastric mucin expression in idiopathic gastric ulcers is unchanged compared with H. pylori and/or NSAID-associated ulcers. 关 键 词：幽门螺旋杆菌 非甾体抗炎药 胃溃疡 粘蛋白 菌相 螺杆 物相 免疫组织化学
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