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| 1 | Predictive factors for early aspiration in liver abscess显示文摘AIM: To determine the predictive factors for early aspiration in liver abscess. METHODS: A retrospective analysis of all patients with liver abscess from 1995 to 2004 was performed. Abscess was diagnosed as amebic in 661 (68%) patients, pyogenic in 200 (21%), indeterminate in 73 (8%) and mixed in 32 (3%). Multiple logistic regression analysis was performed to determine predictive factors for aspiration of liver abscess. RESULTS: A total of 966 patients, 738 (76%) male, mean age 43 ± 17 years, were evaluated: 540 patients responded to medical therapy while adjunctive percutaneous aspiration was performed in 426 patients. Predictive factors for aspiration of liver abscess were: age ≥ 55 years, size of abscess ≥ 5 cm, involvement of both lobes of the liver and duration of symptoms ≥ 7 d. Hospital stay in the aspiration group was relatively longer than in the non aspiration group. Twelve patients died in the aspiration group and this mortality was not statistically significant when compared to the non aspiration group. CONCLUSION: Patients with advanced age, abscess size > 5 cm, both lobes of the liver involvement and duration of symptoms > 7 d were likely to undergo aspiration of the liver abscess, regardless of etiology. | Rustam Khan Saeed Hamid Shahab Abid Wasim Jafri Zaigham Abbas Mohammed Islam Hasnain Shan Shaalan Beg | 2008 | World Journal of Gastroenterology2008，14，13： | 8 |
| 2 | 863 genomes reveal the origin and domestication of chicken显示文摘Despite the substantial role that chickens have played in human societies across the world,both the geographic and temporal origins of their domestication remain controversial.To address this issue,we analyzed 863 genomes from a worldwide sampling of chickens and representatives of all four species of wild jungle fowl and each of the five subspecies of red jungle fowl(RJF).Our study suggests that domestic chickens were initially derived from the RJF subspecies Gallus gallus spadiceus whose present-day distribution is predominantly in southwestern China,northern Thailand and Myanmar.Following their domestication,chickens were translocated across Southeast and South Asia where they interbred locally with both RJF subspecies and other jungle fowl species.In addition,our results show that the White Leghorn chicken breed possesses a mosaic of divergent ancestries inherited from other subspecies of RJF.Despite the strong episodic gene flow from geographically divergent lineages of jungle fowls,our analyses show that domestic chickens undergo genetic adaptations that underlie their unique behavioral,morphological and reproductive traits.Our study provides novel insights into the evolutionary history of domestic chickens and a valuable resource to facilitate ongoing genetic and functional investigations of the world's most numerous domestic animal. | Ming-Shan Wang Mukesh Thakur Min-Sheng Peng Yu Jiang Laurent Alain Francois Frantz Ming Li Jin-Jin Zhang Sheng Wang Joris Peters Newton Otieno Otecko Chatmongkon Suwannapoom Xing Guo Zhu-Qing Zheng Ali Esmailizadeh Nalini Yasoda Hirimuthugoda Hidayat Ashari Sri Suladari Moch Syamsul Arifin Zein Szilvia Kusza Saeed Sohrabi Hamed Kharrati-Koopaee Quan-Kuan Shen Lin Zeng Min-Min Yang Ya-Jiang Wu Xing-Yan Yang Xue-Mei Lu Xin-Zheng Jia Qing-Hua Nie Susan Joy Lamont Emiliano Lasagna Simone Ceccobelli Humpita Gamaralalage Thilini Nisanka Gunwardana Thilina Madusanka Senasige Shao-Hong Feng Jing-Fang Si Hao Zhang Jie-Qiong Jin Ming-Li Li Yan-Hu Liu Hong-Man Chen Cheng Ma Shan-Shan Dai Abul Kashem Fazlul Haque Bhuiyan Muhammad Sajjad Khan Gamamada Liyanage Lalanie Pradeepa Silva Thi-Thuy Le Okeyo Ally Mwai Mohamed Nawaz Mohamed Ibrahim Megan Supple Beth Shapiro Olivier Hanotte Guojie Zhang Greger Larson Jian-Lin Han Dong-Dong Wu Ya-Ping Zhang | 2020 | Cell Research2020，30，8： | 7 |
| 3 | Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)显示文摘 | Shiv Kumar Sarin Ashish Kumar John A. Almeida Yogesh Kumar Chawla Sheung Tat Fan Hitendra Garg H. Janaka Silva Saeed Sadiq Hamid Rajiv Jalan Piyawat Komolmit George K. Lau Qing Liu Kaushal Madan Rosmawati Mohamed Qin Ning Salimur Rahman Archana Rastogi St | 2009 | Hepatology International2009，，1： | 4 |
| 4 | Exploitation of Gene Expression and Cancer Biomarkers in Paving the Path to Era of Personalized Medicine显示文摘Cancer therapy agents have been used extensively as cytotoxic drugs against tissue or organ of a specific type of cancer. With the better understanding of molecular mechanisms underlying carcinogenesis and cellular events during cancer progression and metastasis, it is now possible to use targeted therapy for these molecular events. Targeted therapy is able to identify cancer patients with dissimilar genetic defects at cellular level for the same cancer type and consequently requires individualized approach for treatment. Cancer therapy begins to shift steadily from the traditional approach of ‘‘one regimen for all patients' to a more individualized approach, through which each patient will be treated specifically according to their specific genetic defects. Personalized medicine accordingly requires identification of indicators or markers that guide in the decision making of such therapy to the chosen patients for more effective therapy. Cancer biomarkers are frequently used in clinical practice for diagnosis and prognosis, as well as identification of responsive patients and prediction of treatment response of cancer patient. The rapid breakthrough and development of microarray and sequencing technologies is probably the main tool for paving the way toward ‘‘individualized biomarker-driven cancer therapy' or ‘‘personalized medicine'. In this review, we aim to provide an updated knowledge and overview of the current landscape of cancer biomarkers and their role in personalized medicine, emphasizing the impact of genomics on the implementation of new potential targeted therapies and development of novel cancer biomarkers in improving the outcome of cancer therapy. | Hala Fawzy Mohamed Kamel Hiba Saeed A.Bagader Al-Amodi | 2017 | Genomics, Proteomics & Bioinformatics2017，15，4： | 3 |
| 5 | Drainage vs. non-drainage after cholecystectomy for acute cholecystitis:a retrospective study显示文摘Many surgeons practice prophylactic drainage after cholecystectomy without reliable evidence,this study was conducted to answer the question whether to drain or not to drain after cholecystectomy for acute calculous cholecystitis.A retrospective review of all patients who had cholecystectomy for acute cholecystitis in Aseer Central Hospital,Abha,Saudi Arabia,was conducted from April 2010 to April 2012.Data were extracted from hospital case files.Preoperative data included clinical presentation,routine investigations and liver function tests.Operative data included excessive adhesions,bleeding,bile leak,and drain insertion.Complicated cases such as pericholecystic collections,mucocele and empyema were also reported.Patients who needed therapeutic drainage were excluded.Postoperative data included hospital stay,volume of drained fluid,time of drain removal,and drain site problems.The study included 103 patients allocated into two groups;group A(n = 38) for patients with operative drain insertion and group B(n = 65) for patients without drain insertion.The number of patients with preoperative diagnosis of acute non-complicated cholecystitis was significantly greater in group B(80%) than group A(36.8%)(P < 0.001).Operative time was significantly longer in group A.All patients who were converted from laparoscopic to open cholecystectomy were in group A.Multivariate analysis revealed that hospital stay was significantly(P < 0.001) longer in patients with preoperative complications.There was no added benefit for prophylactic drain insertion after cholecystectomy for acute calculous cholecystitis in non-complicated or in complicated cases. | Mohammed A Bawahab Walid M Abd El Maksoud Saeed A Alsareii Fahad S Al Amri Hala F Ali Abdul Rahman Nimeri Abdul Rahman M Al Amri Adel A Assiri Mohammed I Abdul Aziz | 2014 | The Journal of Biomedical Research2014，28，3： | 3 |
| 6 | Productive performance, egg quality, hematological parameters and serum chemistry of laying hens fed diets supplemented with certain fat-soluble vitamins, individually or combined, during summer season显示文摘This present study aimed to determine the efficacy of supplementing layer diets with vitamin A(0, 8,000 and16,000 IU/kg diet) and vitamin E(0, 250 and 500 mg/kg diet) either individually or in combination on egg production and quality, and blood hematology and chemistry of birds reared under summer conditions. A total of 135 Bovans Brown laying hens were distributed to 9 treatment groups with 5 replicates of 3 hens/pen in a 3 × 3 factorial design. A significant improvement in feed conversion ratio(FCR) was observed as supplementary vitamin A or E increased(P 0.01). Hens fed diets supplemented with 16,000 IU vitamin A plus 500 mg vitamin E/kg diet had the best FCR among all groups. Egg quality traits were not significantly affected by the interaction of vitamin A and vitamin E levels. There was a significant increase in monocytes(P ≤ 0.01)and a decrease in basophils counts(P ≤ 0.05) in response to vitamin E. Significant decreases were observed in packed cell volume(PCV), thyroxine(T_4), alanine transferase(ALT), albumin, total cholesterol and total lipids((P ≤ 0.05 or P ≤ 0.01) P 0.01), and increases were observed in serum concentrations of globulin(P ≤ 0.05)and calcium(P ≤ 0.01) due to vitamin A. The combination of 0 IU vitamin A and 500 mg vitamin E/kg diet had the highest values of PCV(40.09%) and hemoglobin(Hb)(10.33 mg/100 mL) among all groups. Vitamin E raised serum values of total protein, total cholesterol and total lipids(P ≤ 0.05 or P≤ 0.01). Feed intake, FCR,PCV, Hb, lymphocytes, monocytes, eosinophils, T_4, ALT and total protein were significantly affected by the interaction of vitamins A and E(P ≤ 0.05 or P ≤ 0.01). The interaction of vitamins A and E was only significant with respect to serum total protein(P ≤ 0.05). It can be concluded that layer diets supplemented with vitamins A and E had good results in alleviating the harmful impacts of high ambient temperature. The combination of 16,000 IU vitamin A and 500 mg vitamin E per kilogram diet is preferable for obtaining better production of laying hens reared under hot summer conditions. | Mohamed E.Abd El-Hack Mahmoud Alagawany Khalid M.Mahrose Muhammad Arif Muhammad Saeed Muhammad A.Arain Rab N.Soomro Farman A.Siyal Sarfraz A.Fazlani Justin Fowler | 2019 | Animal Nutrition2019，，1： | 3 |
| 7 | Play therapy in children with autism:Its role,implications,and limitations显示文摘Play is a pleasurable physical or mental activity that enhances the child’s skills involving negotiation abilities,problem-solving,manual dexterity,sharing,decision-making,and working in a group.Play affects all the brain's areas,structures,and functions.Children with autism have adaptive behavior,adaptive response,and social interaction limitations.This review explores the different applications of play therapy in helping children with autism disorder.Play is usually significantly impaired in children with autism.Play therapy is mainly intended to help children to honor their unique mental abilities and developmental levels.The main aim of play therapy is to prevent or solve psychosocial difficulties and achieve optimal child-healthy growth and development.Play therapy helps children with autism to engage in play activities of their interest and choice to express themselves in the most comfortable ways.It changes their way of self-expression from unwanted behaviors to more non-injurious expressive behavior using toys or activities of their choice as their words.Play therapy also helps those children to experience feeling out various interaction styles.Every child with autism is unique and responds differently.Therefore,different types of intervention,like play therapy,could fit the differences in children with autism.Proper evaluation of the child is mandatory to evaluate which type fits the child more than the others.This narrative review revised the different types of play therapy that could fit children with autism in an evidence-based way.Despite weak evidence,play therapy still has potential benefits for patients and their families. | Reem Elbeltagi Mohammed Al-Beltagi Nermin Kamal Saeed Rawan Alhawamdeh | 2023 | World Journal of Clinical Pediatrics2023，12，1： | 3 |
| 8 | Gut microbiota in various childhood disorders:Implication and indications显示文摘Gut microbiota has a significant role in gut development,maturation,and immune system differentiation.It exerts considerable effects on the child's physical and mental development.The gut microbiota composition and structure depend on many host and microbial factors.The host factors include age,genetic pool,general health,dietary factors,medication use,the intestine's pH,peristalsis,and transit time,mucus secretions,mucous immunoglobulin,and tissue oxidation-reduction potentials.The microbial factors include nutrient availability,bacterial cooperation or antagonism,and bacterial adhesion.Each part of the gut has its microbiota due to its specific characteristics.The gut microbiota interacts with different body parts,affecting the pathogenesis of many local and systemic diseases.Dysbiosis is a common finding in many childhood disorders such as autism,failure to thrive,nutritional disorders,coeliac disease,Necrotizing Enterocolitis,helicobacter pylori infection,functional gastrointestinal disorders of childhood,inflammatory bowel diseases,and many other gastrointestinal disorders.Dysbiosis is also observed in allergic conditions like atopic dermatitis,allergic rhinitis,and asthma.Dysbiosis can also impact the development and the progression of immune disorders and cardiac disorders,including heart failure.Probiotic supplements could provide some help in managing these disorders.However,we are still in need of more studies.In this narrative review,we will shed some light on the role of microbiota in the development and management of common childhood disorders. | Nermin Kamal Saeed Mohammed Al-Beltagi Adel Salah Bediwy Yasser El-Sawaf Osama Toema | 2022 | World Journal of Gastroenterology2022，28，18： | 3 |
| 9 | Insulin-resistance in paediatric age:Its magnitude and implications显示文摘Insulin resistance(IR)is insulin failure in normal plasma levels to adequately stimulate glucose uptake by the peripheral tissues.IR is becoming more common in children and adolescents than before.There is a strong association between obesity in children and adolescents,IR,and the metabolic syndrome components.IR shows marked variation among different races,crucial to understanding the possible cardiovascular risk,specifically in high-risk races or ethnic groups.Genetic causes of IR include insulin receptor mutations,mutations that stimulate autoantibody production against insulin receptors,or mutations that induce the formation of abnormal glucose transporter 4 molecules or plasma cell membrane glycoprotein-1 molecules;all induce abnormal energy pathways and end with the development of IR.The parallel increase of IR syndrome with the dramatic increase in the rate of obesity among children in the last few decades indicates the importance of environmental factors in increasing the rate of IR.Most patients with IR do not develop diabetes mellitus(DM)type-II.However,IR is a crucial risk factor to develop DM type-II in children.Diagnostic standards for IR in children are not yet established due to various causes.Direct measures of insulin sensitivity include the hyperinsulinemia euglycemic glucose clamp and the insulin-suppression test.Minimal model analysis of frequently sampled intravenous glucose tolerance test and oral glucose tolerance test provide an indirect estimate of metabolic insulin sensitivity/resistance.The main aim of the treatment of IR in children is to prevent the progression of compensated IR to decompensated IR,enhance insulin sensitivity,and treat possible complications.There are three main lines for treatment:Lifestyle and behavior modification,pharmacotherapy,and surgery.This review will discuss the magnitude,implications,diagnosis,and treatment of IR in children。 | Mohammed Al-Beltagi Adel Salah Bediwy Nermin Kamal Saeed | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 10 | Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)显示文摘 | Shiv Kumar Sarin Ashish Kumar John A. Almeida Yogesh Kumar Chawla Sheung Tat Fan Hitendra Garg H. Janaka Silva Saeed Sadiq Hamid Rajiv Jalan Piyawat Komolmit George K. Lau Qing Liu Kaushal Madan Rosmawati Mohamed Qin Ning Salimur Rahman Archana Rastogi St | 2009 | Hepatology International2009，，1： | 2 |
| 11 | Cough as a neurological sign:What a clinician should know显示文摘Cough is a common respiratory complaint driving patients to seek medical advice.Besides being a fundamental respiratory sign,it is also a crucial neurological sign.There are three main types of coughs:Reflex cough(typeⅠ),voluntary cough(typeⅡ),and evoked cough(typeⅢ).Cough is a reflex predominantly mediated by control centers in the respiratory areas of the brainstem,modulated by the cerebral cortex.Cough reflex sensitivity could be increased in many neurological disorders such as brainstem space-occupying lesions,medullary lesions secondary to Chiari typeⅠmalformations,tics disorders such as Tourette's syndrome,somatic cough,cerebellar neurodegenerative diseases,and chronic vagal neuropathy due to allergic and non-allergic conditions.Meanwhile,cough sensitivity decreases in multiple sclerosis,brain hypoxia,cerebral hemispheric stroke with a brainstem shock,Parkinson's disease,dementia due to Lewy body disease,amyotrophic lateral sclerosis,and peripheral neuropathy as diabetic neuropathy,hereditary sensory and autonomic neuropathy typeⅣ,vitamin B12,and folate deficiency.Arnold's nerve ear-cough reflex,syncopal cough,cough headache,opioids-associated cough,and cough-anal reflex are signs that could help diagnose underlying neurological conditions.Cough reflex testing is a quick,easy,and cheap test performed during the cranial nerve examination.In this article,we reviewed the role of cough in various neurological disorders that increase or decrease cough sensitivity. | Mohammed Al-Biltagi Adel Salah Bediwy Nermin Kamal Saeed | 2022 | World Journal of Critical Care Medicine2022，11，3： | 2 |
| 12 | 传统溶剂提取法和超临界流体萃取法对钟花蒲桃次生代谢产物的回收率的比较研究(英文)显示文摘目的:寻求一种最佳的钟花蒲桃次生代谢产物的萃取方法,以实现在工业上的应用。创新点:全面深入地比较传统溶剂提取法和超临界流体萃取法对钟花蒲桃的主要次生代谢产物的回收率。方法:在超临界流体萃取法中,应用Box-Behnken设计,以压力、温度和萃取粒径大小为自变量,以粗提取物、个别的和总的次生代谢产物的百分比产量为因变量。另外,还研究了调节剂乙醇对产量的影响。在传统溶剂提取中,结合十种不同的溶剂和三不同的技术(浸提、索氏和回流)产生二十种不同的提取产物。通过高效液相色谱法检测不同的提取方法对钟花蒲桃的主要次生代谢产物的回收率。结论:超临界流体萃取法优于传统溶剂提取法,省成本又省时。因此在工业使用上,超临界流体萃取法可替代传统溶剂提取法。 | Abdul Hakeem MEMON Mohammad Shahrul Ridzuan HAMIL Madeeha LAGHARI Fahim RITHWAN Salman ZHARI Mohammed Ali Ahmed SAEED Zhari ISMAIL Amin Malik Shah Abdul MAJID | 2016 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2016，17，9： | 2 |
| 13 | An Ensemble Learning Based Approach for Detecting and Tracking COVID19 Rumors显示文摘Rumors regarding epidemic diseases such as COVID 19,medicines and treatments,diagnostic methods and public emergencies can have harmful impacts on health and political,social and other aspects of people’s lives,especially during emergency situations and health crises.With huge amounts of content being posted to social media every second during these situations,it becomes very difficult to detect fake news(rumors)that poses threats to the stability and sustainability of the healthcare sector.A rumor is defined as a statement for which truthfulness has not been verified.During COVID 19,people found difficulty in obtaining the most truthful news easily because of the huge amount of unverified information on social media.Several methods have been applied for detecting rumors and tracking their sources for COVID 19-related information.However,very few studies have been conducted for this purpose for the Arabic language,which has unique characteristics.Therefore,this paper proposes a comprehensive approach which includes two phases:detection and tracking.In the detection phase of the study carried out,several standalone and ensemble machine learning methods were applied on the Arcov-19 dataset.A new detection model was used which combined two models:The Genetic Algorithm Based Support Vector Machine(that works on users’and tweets’features)and the stacking ensemble method(that works on tweets’texts).In the tracking phase,several similarity-based techniques were used to obtain the top 1%of similar tweets to a target tweet/post,which helped to find the source of the rumors.The experiments showed interesting results in terms of accuracy,precision,recall and F1-Score for rumor detection(the accuracy reached 92.63%),and showed interesting findings in the tracking phase,in terms of ROUGE L precision,recall and F1-Score for similarity techniques. | Sultan Noman Qasem Mohammed Al-Sarem Faisal Saeed | 2022 | Computers, Materials & Continua2022，，1： | 2 |
| 14 | 随钻声波测井新技术显示文摘工程师根据声波测井仪记录的声波资料以更高的安全系数提高钻井效率,优化完井方式。LWD声波测井仪是在上世纪90年代中期问世的,能够记录纵波资料,但不能记录所有地层的横波资料。新型LWD声波测井仪能记录以前无法得到的横渡资料,工程师正在利用横渡资料优化钻井作业,确定最佳钻进方向,识别具有更好完井特征的岩层。 | Jeff Alford Matt Blyth Ed Tollefsen John Crowe Julio Loreto Saeed Mohammed Vivian Pistre Adrian Rodriguez-Herrera | 2013 | 国外测井技术2013，，2： | 2 |
| 15 | Week Ahead Electricity Power and Price Forecasting Using Improved DenseNet-121 Method显示文摘In the Smart Grid(SG)residential environment,consumers change their power consumption routine according to the price and incentives announced by the utility,which causes the prices to deviate from the initial pattern.Thereby,electricity demand and price forecasting play a significant role and can help in terms of reliability and sustainability.Due to the massive amount of data,big data analytics for forecasting becomes a hot topic in the SG domain.In this paper,the changing and non-linearity of consumer consumption pattern complex data is taken as input.To minimize the computational cost and complexity of the data,the average of the feature engineering approaches includes:Recursive Feature Eliminator(RFE),Extreme Gradient Boosting(XGboost),Random Forest(RF),and are upgraded to extract the most relevant and significant features.To this end,we have proposed the DensetNet-121 network and Support Vector Machine(SVM)ensemble with Aquila Optimizer(AO)to ensure adaptability and handle the complexity of data in the classification.Further,the AO method helps to tune the parameters of DensNet(121 layers)and SVM,which achieves less training loss,computational time,minimized overfitting problems and more training/test accuracy.Performance evaluation metrics and statistical analysis validate the proposed model results are better than the benchmark schemes.Our proposed method has achieved a minimal value of the Mean Average Percentage Error(MAPE)rate i.e.,8%by DenseNet-AO and 6%by SVM-AO and the maximum accurateness rate of 92%and 95%,respectively. | Muhammad Irfan Ali Raza Faisal Althobiani Nasir Ayub Muhammad Idrees Zain Ali Kashif Rizwan Abdullah Saeed Alwadie Saleh Mohammed Ghonaim Hesham Abdushkour Saifur Rahman Omar Alshorman Samar Alqhtani | 2022 | Computers, Materials & Continua2022，，9： | 2 |
| 16 | Evaluation of anti-resistant activity of Auklandia(Saussurea lappa) root against some human pathogens显示文摘Objective:The antimicrobial activity of the ethanol extract of the Auklandia(Saussurea lappa)root plant was investigated to verify its medicinal use in the treatment of microbial infections.Methods:The antimicrobial activity of the ethanol extract was tested against clinical isolates ofsome multidrug-resistant bacteria using the agar well diffusion method.Commercial antibioticswere used as positive reference standards to determine the sensitivity of the clinical isolates.Results:The extracts showed significant inhibitory activity against clinical isolates of methicillinresistantStaphylococcus aureus,Pseudomonas aeruginosa,Escherichia coli,Klebsiella pneumonia,Extended Spectrum Beta-Lactemase,Acinetobacter baumannii.The minimum inhibitory concentration values obtained using the agar dilution test ranged from 2.0μg/μL-12.0μg/μL.In the contrary the water extract showed no activity at all against the tested isolates.Furthermore,theresults obtained by examining anti-resistant activity of the plant ethanolic extract showed thatat higher concentration of the plant extract(12μg)all tested bacteria isolates were inhibited with variable inhibition zones similar to those obtained when we applied lower extract concentrationusing the well diffusion assay.Conclusion:The results demonstrated that the crude ethanolicextract of the Auklandia(Saussurea lappa)root plant has a wide spectrum of activity suggestingthat it may be useful in the treatment of infections caused by the above clinical isolates(humanpathogens). | Sidgi Syed Anwer Hasson Mohammed Saeed Al-Balushi KhazinaAlharthy JumaZaidAl-Busaidi MunaSulimanAldaihani Mohammed Shafeeq Othman Elias Antony Said Omar Habal Talal Abdullah Sallam Ali Abdullah Aljabri Mohamed AhmedIdris | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，7： | 2 |
| 17 | Efficacy and safety of treatment of hepatitis C virus infection in renal transplant recipients显示文摘AIM: To assess the efficacy and safety of combinedpegylated interferon and ribavirin therapy in hepatitis C virus (HCV) infection in renal transplant recipients. METHODS: This is a retrospective chart review of post renal transplant patients who were positive for anti-HCV and HCV-RNA, and who have received treatment with combination of pegylated interferon and ribavirin between October 2003 and December 2008. Only patients with stable graft function and absence of evidence of cirrhosis and who received the therapy for continuous 48 wk were included. Nineteen patients (13 male and 6 female) were identified and included. The patient's complete blood count, liver and kidney prof ile, and cal- culated glomerular f iltration rate (GFR) were monitored every 6-8 wk while on treatment. HCV-RNA was tested at 12 wk for early virological response, at 48 wk for end of treatment response (ETR), and then retested at 24, and 48 wk after completion of therapy for sustained virological response (SVR). Liver biopsies were obtained before treatment from all patients and graft kidney biopsies were performed as required. RESULTS: Of the entire cohort, 9 patients (47.4%) showed an ETR and 8 had SVR (42.1%). Of the 8 patients with abnormal alanine aminotransferase (ALT) levels at baseline, 78.9% had their ALT normalized (including the virological non responders). ALT was normal in all responders at the end of therapy and at 24 wk post therapy (100%). Only one patient (5.3%) developed an increase in creatinine and decline in GFR from baseline towards the end of treatment. This patient's kidney biopsy revealed borderline rejection. There was no impact on response by HCV-genotype, initial HCV RNA load, age or sex of the patient or duration post transplant before commencement of therapy. All patients tolerated treatment in the same way as non-transplant with no unusual or increased occurrence of side effects. CONCLUSION: The combination of pegylated interferon and ribavirin is effective in suppressing HCV-RNA,with a low risk of graft rejection or failure in HCV infected renal transplant recipients. | Abdulrahman A Aljumah Mohamed A Saeed Ahmed I Al Flaiw Ibrahim H Al Traif Abduljaleel M Al Alwan Salem H Al Qurashi Ghormallah A Al Ghamdi Fayez F Al Hejaili Mohammed A Al Balwi Abdulla A Al Sayyari | 2012 | World Journal of Gastroenterology2012，18，1： | 2 |
| 18 | Effect of erythromycin before endoscopy in patients presenting with variceal bleeding: a prospective, randomized, double-blind, placebo-controlled trial显示文摘 | Ibrahim Altraif Fayaz A. Handoo Abdulrahman Aljumah Abduljaleel Alalwan Mutasim Dafalla Abdullah Mohamed Saeed Abdulrahman Alkhormi Abdul Karim Albekairy Hani Tamim | 2011 | Gastrointestinal Endoscopy2011，，2： | 1 |
| 19 | Role of chloride ions on expansion and strength reduction in plain and blended cements in sulfate environments显示文摘 | OMAR Saeed Baghabra Al-Amoudi MOHAMMED Masiehuddin YASER A B Abdui-Al | 1995 | Constr Build Mater1995，9，1： | 1 |
| 20 | Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)显示文摘 | Shiv Kumar Sarin Ashish Kumar John A. Almeida Yogesh Kumar Chawla Sheung Tat Fan Hitendra Garg H. Janaka Silva Saeed Sadiq Hamid Rajiv Jalan Piyawat Komolmit George K. Lau Qing Liu Kaushal Madan Rosmawati Mohamed Qin Ning Salimur Rahman Archana Rastogi St | 2009 | Hepatology International2009，，1： | 1 |
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