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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | Emer- ging role of advanced glyeation-end products (AGEs) in the pathobiology of eye diseases 显示文摘 | Kandarakis SA Piperi C Topouzis F Papavassiliou AG | 2014 | Prog Retin Eye Res2014，42，1： | 1 |
| 4 | Development of Effervescent Tablets Containing Benznidazole Complexed with Cyclodextrin显示文摘 | MAXIMIANO F P COSTA G H Y DE SA BARRETO L C L | 2011 | Journal of Pharmacy and Pharmacology2011，63，6： | 1 |
| 5 | Soil organic matterpools and carbon-protection mechanisms in aggregateclasses influenced by surface liming in a no-till system显示文摘 | Briedis C Sa JCdM Caires E F | 2012 | Geoderma2012，170，： | 1 |
| 6 | Soil organic matter pools and carbon-protection mechanisms in aggregate classes influenced by surface liming in a notall system显示文摘 | Briedis C Caires E F de Moraes Sa J C | 2012 | Geoderma2012，170，： | 1 |
| 7 | Clinical characteristics and evolution of syphilis in 24 HIV+ individuals in Rio de Janeiro,Brazil显示文摘 | Gutierrez-Galhardo M C do Valle G F Sa F C | 2005 | Rev Inst Med Trop Sao Paulo2005，47，： | 1 |
| 8 | Exercise and brain neurotrophins 显示文摘 | Gomez-Pinilla F Choi J Cotman C | 1995 | Nature1995，373，6510： | 1 |
| 9 | Influence of breed and ageing time on the sensory meat quality and consumer acceptability in intensively reared beef显示文摘 | Monson F Sa(n)udo C Sierra I | | 0，，3： | 1 |
| 10 | Role of allelic variants Gly 972Arg of IRS-1 and Gly1057Asp of IRS-2 in moderate-to-severe insulin resistance of women with polyeysfic ovary syndrome显示文摘 | El Mkadem SA Lautier C Macari F | 2001 | Diabetes2001，50，9： | 1 |
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| 12 | Loealisation of enzymes in the digestive system during early development of the grouper ( Epinephelus coioides) 显示文摘 | Quinitio G F Sa - an A C Toledo J D | 2004 | Advances in grouper aquaculture2004，1，： | 1 |
| 13 | Introduction of digestive a-amylase in larvae of Zabrotes subfasciatus (Coleoptera: Bruchidae) in response to ingestion of common bean a-amylase inhibitor 显示文摘 | Silva C P Terra W R de Sa M F G Samuels R I | 2001 | Journal of Insect Physiology2001，47，： | 1 |
| 14 | Removal of ammonium via simultaneous nitrification-denitrification nitrite-shortcut in a single packed-bed batch reactor显示文摘 | Leonidia M C D Eloísa P Eugenio F | 2009 | Bioresource Technology2009，100，3： | 1 |
| 15 | Thermodynamical properties of the transverse lsing model显示文摘 | BARRETO SA F C | 1985 | Phys A1985，129，： | 1 |
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| 17 | Identification of mesenchymal stem cells in perinodular fat and skin in Dupuytren's disease:a potential source of myofibroblasts with implications for pathogene- sis and therapy 显示文摘 | Iqbal SA Manning C Syed F | 2012 | Stem cells and development2012，21，4： | 1 |
| 18 | Myeloid sarcoma:clinico-pathologic,phenotypic and cytogenetic analysis of 92 adult patients显示文摘 | Pileri SA Ascani S Cox MC Campidelli C Bacci F Piccioli M | | 0，，： | 1 |
| 19 | Role of allelic variants Gly972Arg of IRS-1 and Gly1057Asp Of IRS-2 in moderate-to- severe insulin resistance of women with polyeystic ovary syndrome显示文摘 | EI Mkadem SA Lautier C Maeari F | 2006 | Diabetes2006，50，9： | 1 |
| 20 | 'Dopam independent' side effects of selective serotonin reuptake inhibitors:a clinical review显示文摘 | BIANCHI-DEMICHELI F VIDAIHET P | 2004 | J Clin Psychiatry2004，65，8： | 1 |
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