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| 1 | Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival显示文摘BACKGROUND: In a multidisciplinary conference patients with advanced non-resectable hepatocellular carcinoma (HCC) were stratified according to their clinical status and tumor extent to different regional modalities or to best supportive care. The present study evaluated all patients who were stratified to repeated transarterial chemoembolization (TACE) from 1999 until 2003 in terms of tumor response, toxicity, and survival. A moderate embolizing approach was chosen using a combination of degradable starch microspheres (DSM) and iodized oil (Lipiodol) in order to combine anti-tumoral efficiency and low toxicity. METHODS: Fourty-seven patients were followed up prospectively. TACE treatment consisted of cisplatin (50 mg/m2), doxorubicin (50 mg/m2), 450-900 mg DSM, and 5-30 ml Lipiodol. DSM and Lipiodol were administered according to tumor vascularization. Patient characteristics,toxicity, and complications were outlined. In multivariate regression analyses of pre-treatment variables from a prospective database, predictors for tumor response and survival after TACE were determined. RESULTS: 112 TACE courses were performed (2.4±1.5 courses per patient). Mean maximum tumor size was 75 (± 43) mm, in 68% there was bilobar disease. Best response to TACE treatment was: progressive disease (PD) 9%, stable disease (SD) 55%, partial remission (PR) 36%, and complete remission (CR) 0%. Multivariate regression analyses identified tumor size ≤75 mm, tumor number ≤5, and tumor hypervascularization as predictors for PR. The overall 1-, 2-, and 3-year-survival rates were 75%, 59%, and 41%, respectively, and the median survival was 26 months. Low α-fetoprotein levels (<400 ng/ml) (Odds ratio=3.3) and PR as best response to TACE (Odds ratio=6.7) were significantly associated with long term survival (>30 months, R2=36%). Grade 3 toxicity occurred in 7.1% (n=8), and grade 4 toxicity in 3.6% (n=4) of all courses in terms of reversible leukopenia and thrombocytopenia. The incidence of major complications was 5.4% (n=6). All complications were managed conservatively. The mortality within 6 weeks after TACE was 2.1% (one patient). CONCLUSIONS: DSM and Lipiodol were combined successfully in the palliative TACE treatment of advanced HCC resulting in high rates of tumor response and survival at limited toxicity. Favourable tumor response was associated with tumor extent and vascularization. TACE using DSM and Lipiodol can be considered a suitable palliative measure in patients who might not tolerate long acting embolizing agents. | Timm D Kirchhoff Joerg S Bleck Arne Dettmer Ajay Chavan Herbert Rosenthal Sonja Merkesdal Bernd Frericks Lars Zender Nisar P Malek Tim F Greten Stefan Kubicka Michael P Manns Michael Galanski | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 15 |
| 2 | Regulation of the mesenchymal stem cell fate by interleukin-17: Implications in osteogenic differentiation显示文摘Bone regeneration is a tightly regulated process that ensures proper repair and functionality after injury.The delicate balance between bone formation and resorption is governed by cytokines and signaling molecules released during the inflammatory response.Interleukin(IL)-17A,produced in the early phase of inflammation,influences the fate of osteoprogenitors.Due to their inherent capacity to differentiate into osteoblasts,mesenchymal stem/stromal cells(MSCs)contribute to bone healing and regeneration.This review presents an overview of IL-17A signaling and the leading cellular and molecular mechanisms by which it regulates the osteogenic differentiation of MSCs.The main findings demonstrating IL-17A’s influence on osteoblastogenesis are described.To this end,divergent information exists about the capacity of IL-17A to regulate MSCs’osteogenic fate,depending on the tissue context and target cell type,along with contradictory findings in the same cell types.Therefore,we summarize the data showing both the pro-osteogenic and anti-osteogenic roles of IL-17,which may help in the understanding of IL-17A function in bone repair and regeneration. | Jelena Krstić Slavko Mojsilović Sonja S Mojsilović Juan F Santibanez | 2021 | World Journal of Stem Cells2021，13，11： | 2 |
| 3 | Incidence of FusariumSpecies and Mycotoxins in Silage Maize显示文摘 | Sonja E Felix E W Hans R F | 2011 | Toxins2011，3，8： | 1 |
| 4 | Effect of organic solvents on the yield of solvent-tolerant Pseudomonas putida S12显示文摘 | Derks Aatoine Wolffs Petra F G | 1999 | Applied and Environmental Microbilogy1999，65，： | 1 |
| 5 | In vitro antiplasmodial activity of prenylated chalcone derivatives of hops (Humulus lupulus) and their interaction with haemin显示文摘 | SONJA F CAROLA S ULRICH B | 2005 | Journal of Antimicrobial Chemotherapy2005，55，： | 1 |
| 6 | Onset and spreading patterns of upper and lower motor neuron symptoms in amyo- trophie lateral sclerosis显示文摘 | SONJA K KATJA K MARION F | 2011 | Muscle Nerve2011，43，10： | 1 |
| 7 | Expres- sion of insulin-like growth factor 2 in mesenchymal neoplasms显示文摘 | Steigen Sonja E Schaeffer David F West Robert B | 2009 | Mod Pathol2009，22，7： | 1 |
| 8 | Breast cancer in young women:poor survival despite intensive treatment显示文摘 | Hanna F Sonja E Jan F | 2009 | Plos One2009，4，11： | 1 |
| 9 | Efficacy of chlorine for inactivation ofEscherichia coli on vegetables显示文摘 | JULIA B SONJA W PETER F | 2000 | Postharvest Biology and Technology2000，19，2： | 1 |
| 10 | Impact Fragmentation of Nanoparticle Agglomerates 显示文摘 | Sonja F Stefanie K Alfred P and Gerhard K | 2003 | Journal of Aerosol Science2003，34，： | 1 |
| 11 | Caspase cleavage of the nonstructural protein NS1 mediates replication of Aleutian mink disease parvovirus显示文摘 | Sonja M Best Janie F Shelton Justine M Pompey | 2003 | Journal of Virology2003，77，： | 1 |
| 12 | Measures of fit and discomfort for elementary school children in Serbia 显示文摘 | DAVID F SONJA PV ALAN H | 2013 | Work2013，44，1： | 1 |
| 13 | Plasma membrane H^+-ATPase is involved in auxin-mediated cell elongation during wheat embryo development显示文摘 | NICOLE R K JOLANA T P A SONJA F NORBERT H WOLFGANG M EDGAR W VOLKER S GUNTHER N CHRISTIANE F I | 2003 | Plant Physiol2003，131，3： | 1 |
| 14 | The Influence of industrial laundering of hospital textiles on the properties of cotton fabrics显示文摘 | SABINA F SONJA (S) BRANKO N | | 0，，77： | 1 |
| 15 | Effects of ski piste preparation on alpine vegetation显示文摘 | SONJA W CHRISTIAN R MARKUS F | 2005 | Appl Ecol2005，42，2： | 1 |
| 16 | Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice显示文摘 | Froese Alexander Breher Stephanie S Waldeyer Christoph Schindler Roland F R Nikolaev Viacheslav O Rinné Susanne Wischmeyer Erhard Schlueter Jan Becher Jan Simrick Subreena Vauti Franz Kuhtz Juliane Meister Patrick Kreissl Sonja Torlopp Ange | 2012 | EN2012，，3： | 1 |
| 17 | Report of AAPM TG 135 :Quality assurance for robotic radiosurgery显示文摘 | Sonja D Carlo C Cynthia F C | 2011 | Medical Physics2011，38，6： | 1 |
| 18 | Identification of the plasmid-bome quinolone resistance gene qnrS in Salmonella enterica serovar Infantis显示文摘 | Corinna K Sonja F Annode J | 2006 | Antimicrobial Agents and Chemotherapy2006，58，1： | 1 |
| 19 | Design analysis and realization of tendon-based parallel manipulators显示文摘 | SHIQING F SONJA M | 2005 | Mechanism and Machine Theory2005，40，4： | 1 |
| 20 | Diesel particles are taken up by alveolar type Ⅱ Tumor cells and alter cytokines secretion 显示文摘 | PHILIPPE J THIERRY F SONJA B | 2002 | Archives Environ Health2002，57，1： | 1 |
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