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| 1 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 2 | Prospective evaluation of small bowel preparation with bisacodyl and sodium phosphate for capsule endoscopy显示文摘AIM: To determine the effect of Prepacol?, a com- bination of sodium phosphate and bisacodyl, on transit and quality of capsule endoscopy (CE). METHODS: Fivety two consecutive patients were included in this prospective study. CE was performed following a 12 h fasting period. Twenty six patients were randomized for additional preparation with Prepacol?. The quality of CE was assessed separately for the proximal and the distal small bowel by 3 experienced endoscopists on the basis of a graduation which was initially developed with 20 previous CE. RESULTS: Preparation with Prepacol? accelerated small bowel transit time (262 ± 55 min vs 287 ± 97 min), but had no effect on the quality of CE. Visibility was significantly reduced in the distal compared to the proximal small bowel. CONCLUSION: The significantly reduced visibility of CE in the distal small bowel allocates the need for a good preparation. Since Prepacol? has no beneficial effect on CE the modality of preparation and the ideal time of application remains unclear. Further standardized examinations are necessary to identify sufficient preparation procedures and to determine the impact of the volume of the preparation solution. | Andreas Franke Frank Hummel Phillip Knebel Christoph Antoni Ulrich Bcker Manfred V Singer Matthias Lhr | 2008 | World Journal of Gastroenterology2008，14，13： | 5 |
| 3 | Nerve Growth Factor and Artemin Are Paracrine Mediators of Pancreatic Neuropathy in Pancreatic Adenocarcinoma显示文摘 | Güralp O. Ceyhan Karl-Herbert Sch?fer Annika G. Kerscher Ulrich Rauch Ihsan Ekin Demir Mustafa Kadihasanoglu Carolin B?hm Michael W. Müller Markus W. Büchler Nathalia A. Giese Mert Erkan Helmut Friess | 2010 | Annals of Surgery2010，，5： | 2 |
| 4 | Two year follow-up after treatment of coronary in-stent restenosis with a paclitaxel-coated balloon catheter显示文摘 | Bruno Scheller Christoph Hehrlein Wolfgang Bocksch Wolfgang Rutsch Dariush Haghi Ulrich Dietz Michael B?hm Ulrich Speck | 2008 | Clinical Research in Cardiology2008，，10： | 2 |
| 5 | CMR Imaging Predicts Death and Other Adverse Events in Suspected Cardiac Sarcoidosis显示文摘 | Simon Greulich Claudia Christina Deluigi Steffen Gloekler Andreas Wahl Christine Zürn Ulrich Kramer Detlev Nothnagel Helmut Bültel Julia Schumm Stefan Grün Peter Ong Anja Wagner Steffen Schneider Kai Nassenstein Meinrad Gawaz Udo Sechtem Oliver Bruder Hei | 2013 | JACC: Cardiovascular Imaging2013，，： | 2 |
| 6 | Chemical changes due to acid precipitation in a loess-derived soil in central Europe显示文摘 | Ulrich B Mayer R R Khanna P K | 1980 | Soil Science1980，130，4： | 1 |
| 7 | Fast-track surgery:the Heidelberg experience显示文摘 | Kremer M Ulrich A Büchler MW | 2005 | Recent Results Cancer Res2005，165，： | 1 |
| 8 | GABA (B) receptors: synaptic functions and mechanisms of diversity 显示文摘 | Ulrich D Bettler B | 2007 | Curr Opin Neurobiol2007，17，3： | 1 |
| 9 | Near-field effects and energy transfer in hybrid metal-oxide nanostructures 显示文摘 | ULRICH H BALATI K CAHIT B | 2013 | Beilstein J Nanotechnol2013，4，： | 1 |
| 10 | Pharmacokinetics of amino acid ester prodrugs of acyclovir after oral administration: Interaction with the transporters on Caco-2 cells显示文摘 | Stephan AM Ulrich FS Stefan B | 2008 | Int J Pharm2008，362，12： | 1 |
| 11 | GABA(B)receptors:synaptic functions and mechanisms of diversity显示文摘 | Ulrich D Bettler B | 2007 | Curr Opin Neurobiol2007，17，： | 1 |
| 12 | Definition and grading of anastomotic leakage following anterior resection of the rectum: A proposal by the International Study Group of Rectal Cancer显示文摘 | Nuh N. Rahbari Jürgen Weitz Werner Hohenberger Richard J. Heald Brendan Moran Alexis Ulrich Torbj?rn Holm W. Douglas Wong Emmanuel Tiret Yoshihiro Moriya S?ren Laurberg Marcel den Dulk Cornelis van de Velde Markus W. Büchler | 2010 | Surgery2010，，3： | 1 |
| 13 | Load transfer analysis of the distal radius fromin-vivo high resolution CT imaging显示文摘 | Ulrich D Van Rietbergen B Laib A | 1999 | J Biomech1999，32，： | 1 |
| 14 | Structure and process quality illustrated by fibreoptic intubation: analysis of 1 612 cases 显示文摘 | Heidegger T Gerig HJ Ulrich B | 2003 | Anaesthesia2003，58，： | 1 |
| 15 | Parameters for describing soil acidi, cation and their relevance to the stability of forest ecosystems显示文摘 | Meiwes K Khanna J Ulrich B | 1986 | Forest Ecology and Management1986，15，： | 1 |
| 16 | Cyoprotectants removal temperature as a factor in the survival of frozen rice and sugarcane cells显示文摘 | Finkle B J Ulrich J M | 1982 | Cryobiology1982，19，： | 1 |
| 17 | Biliary pneumonitis after proximal stent migration显示文摘 | Lutz Liebich-Bartholain Ulrich Kleinau Harry Elsbernd Reinhard Büchsel | 2001 | Gastrointestinal Endoscopy2001，，3： | 1 |
| 18 | Molecular cloning of a functional promoter of the human plakoglobin gene显示文摘 | Eyck P Sabine B Ulrich L | 2001 | Eur J Endocrinol2001，145，： | 1 |
| 19 | Effect of a mixture of cryprotectants in attaining liquid nitrogen survival of callus cultures of a tropical plant显示文摘 | Ulrich J M Finkle B J Moore P H | 1979 | Cryobiology1979，16，6： | 1 |
| 20 | Transdifferentiation of human islet cells in along-term eulture显示文摘 | SCHMIED B M ULRICH A MATSUZAKI H | 2001 | Pancreas2001，23，2： | 1 |
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