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| 1 | The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming显示文摘新陈代谢对房间功能的每个方面重要,然而,导致的 pluripotent 干细胞(iPSCs ) 的 metabolome 仍然保持大部分未经勘探。这里,我们报导,用一条 untargeted metabolomics 途径,那人的 iPSCs 份额有从他们的父母房间是不同的胚胎的干细胞(转换字符) 的 pluripotent metabolomic 签名,并且那被变化在涉及细胞的呼吸的代谢物描绘。细胞的 bioenergetics 的检查与我们的 metabolomic 分析支持了,并且证明体的房间在 pluripotency 从一个氧化状态变换成一个 glycolytic 状态。有趣地,各种各样的体的房间的 bioenergetics 与他们的 reprogramming 效率相关。我们进一步识别了在 iPSCs 和转换字符之间不同的代谢物,它揭示了在调整体的房间 reprogramming 起一个关键作用的新奇新陈代谢的小径。我们的调查结果是第一全球性分析 iPSCs 的 metabolome,并且提供机械学的卓见进涉及导致 pluripotency,并且在评估 iPSC 和转换字符等价的规定的新层。 | Athanasia D Panopoulos Oscar Yanes Sergio Ruiz Yasuyuki S Kida Dinh Diep Ralf Tautenhahn Aida Herrerias Erika M Batchelder Nongluk Plongthongkum Margaret Lutz W Travis Berggren Kun Zhang Ronald M Evans Gary Siuzdak Juan Carlos Izpisua Belmonte] | 2012 | Cell Research2012，22，1： | 12 |
| 2 | Review of 500 single incision laparoscopic colorectalsurgery cases-Lessons learned显示文摘Single incision laparoscopic surgery(SILS) is a minimally invasive platform with specific benefits over traditional multiport laparoscopic surgery. The safety and feasibility of SILS has been proven, and the applications continue to grow with experience. After 500 cases at a high-volume, single-institution, we were able to standardize instrumentation and operative steps, as well as develop adaptations in technique to help overcome technical and ergonomic challenges. These technical adaptations have allowed the successful application of SILS to technically difficult patient populations, such as pelvic cases, inflammatory bowel disease cases, and high body mass index patients. This review is a frame of reference for the application and wider integration of the single incision laparoscopic platform in colorectal surgery. | Deborah S Keller Juan R Flores-Gonzalez Sergio Ibarra Eric M Haas | 2016 | World Journal of Gastroenterology2016，22，2： | 8 |
| 3 | Six - month echocar- diographic study in patients with submassive pulmonary embolism and right ventricle dysfunction: comparison of thrombolysis with heparin显示文摘 | Sergio F Sebastiano S Giorgio M | 2011 | Am J Med Sci2011，341，1： | 1 |
| 4 | Detailed genetic and physical mapping of tumor suppressor loci on chromosome 3p in ovarian cancer显示文摘 | Paul F Sergio M Janet S | 1999 | Cancer Res1999，59，15： | 1 |
| 5 | A model-based direct power control for three-phase power converters显示文摘 | SERGIO V Juan A S Juan M C | | 0，，04： | 1 |
| 6 | Development and application of a capillary electrophoresis based method for the simultaneous screening of six antibiotics in spiked milk samples显示文摘 | Santos Sergio M Henrique's Marilla Duarte Armando C | 2007 | Talanta2007，71，2： | 1 |
| 7 | Visual Space Perception and Visually Directed Action显示文摘 | Jack M Loomis Naofumi Fujita Josi A Da Silva Sergio S Fukusima | 1992 | Journal of Experimental Psychology:Human Perception and Performance (S0096-1523)1992，18，4： | 1 |
| 8 | 临床怀疑深静脉血栓形成病人的压迫超声诊断:前瞻性队列研究显示文摘目的:评价临床上怀疑为深静脉血栓形成但压迫超声显像所见正常病人不给予肝素治疗的安全性。设计:根据一种简化的程序来做压迫超声显像,超声显像的部位限于3处,即腹股沟部的股总静脉、腘静脉及胭静脉远端小腿静脉的分叉部位。初诊时超声显像为正常的病人1周后再重复检查1次。评价结果的标准:对于临床上怀疑为深静脉血栓形成的病人,凡是间隔1周两次超声显像均正常者则不予以肝素治疗,随访6个月,统计在这段时间内静脉血栓栓塞合并症的发生率。参加单位:四所大学附属医院的研究中心。结果:本研究共包括1702名病人,第一次检查发现400名血栓形成者,第二次检查又发现12名,因此用超声诊断方法在该1702名临床上怀疑为深静脉血栓形成的病人中确诊了412例,占24%。全组病人均获得随访,在两次 B 超检查之间,有1例发生了静脉血栓性栓塞的合并症,在6个月随访期间又有8例,所以累计发生率为0.7%(95%可信限为0.3%~1.2%),登门随访及补做检查的次数为平均每例0.8次。结论:对于临床上怀疑为深静脉血栓形成的病人,若连续两次压迫超声检查均为正常者,不给予肝素治疗是安全的。 | Alberto Cogo Anthonie W A Lensing Maria M W Koopman Franco Piovella Sergio Siragusa Philip S Wells Sabina Villalta Harry R Bller Alexander G G Turpie Paolo Prandoni 冷希圣 | 1998 | 英国医学杂志中文版1998，0，1： | 1 |
| 9 | Performance of Drought Indices for Ecological, Agricultural, and Hydrological Applications显示文摘 | Vicente-Serrano Sergio M Beguería Santiago Lorenzo-Lacruz Jorge Camarero Jesús Julio López-Moreno Juan I Azorin-Molina Cesar Revuelto Jesús Morán-Tejeda Enrique Sanchez-Lorenzo Arturo | 2012 | EN2012，，10： | 1 |
| 10 | Evidence of increasing drought severity caused by temperature rise in southern Europe显示文摘 | Sergio M Vicente-Serrano Juan-I Lopez-Moreno Santiago Beguería Jorge Lorenzo-Lacruz Arturo Sanchez-Lorenzo José M García-Ruiz Cesar Azorin-Molina Enrique Morán-Tejeda Jesús Revuelto Ricardo Trigo Fatima Coelho Francisco Espejo | 2014 | Environmental Research Letters2014，，4： | 1 |
| 11 | Alcohol dehydrogenase activitiesand ethanol tolerance in Anastrepha(Diptera,Tephritidae)fruit-fly species and their hybrids显示文摘 | Eneas C Vera N S Sergio R M | 2009 | Genet Mol Biol2009，32，1： | 1 |
| 12 | Erttomogertous fungi and the conservation of the cultural heritage : A review 显示文摘 | Valme J Sergio S M Cesareo S J | 2008 | Int Biodet Biodegr2008，62，4： | 1 |
| 13 | Control system design on a power-split CVT for high-power agricultural tractors显示文摘 | Sergio M S Francesco L T | 2004 | IEEE/ASME Transactions on Mechatronics2004，9，3： | 1 |
| 14 | Providing Integrity and Authenticity in DICOM Images:A Novel Approach显示文摘 | Luiz S F Sergio S L Paulo M B | 2009 | IEEE Transactions on Information Technology in Biomedicine2009，13，4： | 1 |
| 15 | Design and evaluation of a high hydrostatic pressure combined process for pasteurization of liquid whole egg显示文摘 | Silvia M Sergio R Nicol 6 s M | 2012 | Innovative Food Science&Emerging Technologies2012，14，4： | 1 |
| 16 | Lipid coating on polyelectrolyte surface modified colloidal particles and polyelectrolyre capsules 显示文摘 | Sergio M Edwin D Gleb B S | 2000 | Macromolecules2000，33，12： | 1 |
| 17 | The role of forest structure, fragment size and corridors in maintaining small mammal abundance and diversity in an Atlantic forest landscape 显示文摘 | RENATA P SERGIO M S RICARDO B N | 2005 | Biological Conservation2005，124，2： | 1 |
| 18 | Tunneling and op- ileal control in quantum ring molecules 显示文摘 | LUIS D S JOSE M V SERGIO E U | 2007 | Physical Re-view B2007，，76： | 1 |
| 19 | Microencapsulation of organic solvents in polyelectrolyte multilayer micrometersized shells 显示文摘 | Sergio M Gleb B S Mark A | 1999 | Journal of Colloid and Interface Science1999，216，2： | 1 |
| 20 | Estrogen and antiestrogen regulation of cell cycle progression in breast cancer cells显示文摘 | DOISNEAU-SIXOU S SERGIO C M CARROLL J S | 2003 | Endocrine-related Cancer2003，10，2： | 1 |
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