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| 1 | Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth显示文摘AIM: Standard immunosuppression after organ transplantation stimulates tumor growth. Sirolimus has a strong antiproliferative and a tumor inhibiting effect. The purpose is to assess the effect on tumor growth of the immunosuppressive compounds sirolimus and tacrolimus alone and in combination on cells of human hepatocellular carcinoma.METHODS: We used the human cell lines SK-Hep 1 and Hep 3B derived from hepatocellular carcinoma. Proliferation analyses after treatment with sirolimus, tacrolimus, or the combination of both were performed. FACS analyses were done to reveal cell cycle changes and apoptotic cell death. The expression of apoptosis-related proteins was estimated by Western blots.RESULTS: Sirolimus alone or combined with tacrolimus inhibited the growth of both cell lines after 5 d by up to 35% in SK-Hep 1 cells, and by up to 68% in Hep 3B cells at 25 ng/mL. Tacrolimus alone stimulated the growth by 12% after 5 ng/mL and by 25% after 25 ng/mL in Hep 3B cells. We found an increase of apoptotic Hep 3B cells from 6 to 16%, and a G1-arrest in SK-Hep 1 cells with an increase of cells from 61 to 82%, when sirolimus and tacrolimus were combined. Bcl-2 was down-regulated in Hep 3B, but not in SK-Hep 1 cells after combined treatment.CONCLUSION: Sirolimus appears to inhibit the growth of hepatocellular carcinoma cells alone and in combination with tacrolimus. Sirolimus seems to inhibit the growth stimulation of tacrolimus. | Guido Schumacher Marijke Oidtmann Anne Rueggeberg Dietmar Jacob Sven Jonas Jan M. Langrehr Ruth Neuhaus Marcus Bahra Peter Neuhaus | 2005 | World Journal of Gastroenterology2005，11，10： | 14 |
| 2 | Increasing applicability of liver transplantation for patients with hepatitis B–related liver disease显示文摘 | Thomas Steinmüller Daniel Seehofer Nada Rayes Andrea R. Müller Utz Settmacher Sven Jonas Ruth Neuhaus Thomas Berg Uwe Hopf Peter Neuhaus | 2002 | Hepatology2002，，6： | 2 |
| 3 | Increasing applicability of liver transplantation for patients with hepatitis B–related liver disease显示文摘 | Thomas Steinmüller Daniel Seehofer Nada Rayes Andrea R. Müller Utz Settmacher Sven Jonas Ruth Neuhaus Thomas Berg Uwe Hopf Peter Neuhaus | 2002 | Hepatology2002，，6： | 2 |
| 4 | Health-related quality of life and psychosocial adjustment in steroid-sensitive nephrotic syndrome 显示文摘 | RUTH E M LANDOLT M A NEUHAUS T J el al | 2004 | J Pediatr2004，145，6： | 1 |
| 5 | Outcome after liver re‐transplantation in patients with recurrent chronic hepatitis C显示文摘 | Marcus Bahra Ulf Peter Neumann Dietmar Jacob Thomas Berg Ruth Neuhaus Jan Michael Langrehr Peter Neuhaus | 2007 | Transplant International2007，，9： | 1 |
| 6 | Donor evaluation, donor risks, donor outcome, and donor quality of life in adult-to-adult living donor liver transplantation显示文摘 | Andreas Pascher Igor M. Sauer Marc Walter Enrique Lopez-Haeninnen Tom Theruvath Antonino Spinelli Ruth Neuhaus Utz Settmacher Andrea R. Mueller Thomas Steinmueller Peter Neuhaus | 2002 | Liver Transplantation2002，，9： | 1 |
| 7 | Health - related quali- ty of life and psychosocial adjustment in steroid - sensitive ne- phrotic syndrome显示文摘 | Ruth EM Landoi TMA Neuhaus TJ | 2004 | J Pediatr2004，145，6： | 1 |
| 8 | Health-related quality of life and psychosocial adjustment in steroid-sensitive nephrotic syndrome显示文摘 | Ruth E Landolt MA Neuhaus TJ | 2004 | Pediatr2004，145，6： | 1 |
| 9 | Health - related qual- ity of Life and psychosocial adjustment in steroid - sensitive ne- phrotic syndrome 显示文摘 | Ruth EM Landolt MA Neuhaus TJ | 2004 | J pediatrics2004，145，6： | 1 |
| 10 | Treatment of Patients with Recurrent Hepatitis C after Liver Transplantation with Peginterferon Alfa-2B Plus Ribavirin显示文摘 | Ulf Neumann Gero Puhl Marcus Bahra Thomas Berg Jan Michael Langrehr Ruth Neuhaus Peter Neuhaus | 2006 | Transplantation2006，，1： | 1 |
| 11 | Mycophenolate Mofetil Monotherapy in Liver Transplantation: 5-Year Follow-Up of a Prospective Randomized Trial显示文摘 | Maximilian Schmeding Anja Kiessling Ruth Neuhaus Christoph Heidenhain Marcus Bahra Peter Neuhaus Ulf P. Neumann | 2011 | Transplantation2011，，8： | 1 |
| 12 | Role of IL28B Polymorphism in the Development of Hepatitis C Virus-Induced Hepatocellular Carcinoma, Graft Fibrosis, and Posttransplant Antiviral Therapy显示文摘 | Dennis Eurich Sabine Boas-Knoop Marcus Bahra Ruth Neuhaus Rajan Somasundaram Peter Neuhaus Ulf Neumann Daniel Seehofer | 2012 | Transplantation2012，，6： | 1 |
| 13 | Fibrosis progression after liver transplantation in patients with recurrent hepatitis C显示文摘 | Ulf P. Neumann Thomas Berg Marcus Bahra Daniel Seehofer Jan M. Langrehr Ruth Neuhaus Cornelia Radke Peter Neuhaus | 2004 | Journal of Hepatology2004，，5： | 1 |
| 14 | Health- related quality of life and psychosocial adjustment in steroid - sensitive nephrotic syndrome 显示文摘 | Ruth EM Landoi TM A Neuhaus TJ | | J Pediatrics0，145，6： | 1 |
| 15 | PREOPERATIVE ANTIVIRAL TREATMENT AND POSTOPERATIVE PROPHYLAXIS IN HBV-DNA POSITIVE PATIENTS UNDERGOING LIVER TRANSPLANTATION显示文摘 | Daniel Seehofer Nada Rayes Uta Naumann Ruth Neuhaus Andrea R. Müller Stefan G. Tullius Thomas Berg Thomas Steinmüller Wolf Otto Bechstein Peter Neuhaus | 2001 | Transplantation2001，，8： | 1 |
| 16 | Fibrosis Progression in Hepatitis C Positive Liver Recipients After Sustained Virologic Response to Antiviral Combination Therapy (Interferon–Ribavirin Therapy)显示文摘 | Marcus Bahra Ulf P. Neumann Dietmar Jacob Jan M. Langrehr Thomas Berg Ruth Neuhaus Peter Neuhaus | 2007 | Transplantation2007，，3： | 1 |
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