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| 1 | Potential role of chitinase 3-like-1 in inflammation-associated carcinogenic changes of epithelial cells显示文摘The family of mammalian chitinases includes members both with and without glycohydrolase enzymatic activity against chitin,a polymer of N-acetylglucosamine.Chitin is the structural component of fungi,crustaceans,insects and parasitic nematodes,but is completely absent in mammals.Exposure to antigens containing chitin-or chitin-like structures sometimes induces strong T helper type-I responses in mammals,which may be associated with the induction of mammalian chitinases.Chitinase 3-like-1(CHI3L1) ,a member of the mammalian chitinase family,is induced specifically during the course of inflammation in such disorders as inflammatory bowel disease,hepatitis and asthma.In addition,CHI3L1 is expressed and secreted by several types of solid tumors including glioblastoma,colon cancer,breast cancer and malignant melanoma.Although the exact function of CHI3L1 in inflammation and cancer is still largely unknown,CHI3L1 plays a pivotal role in exacerbating the inflammatory processes and in promoting angiogenesis and remodeling of the extracellular matrix.CHI3L1 may be highly involved in the chronic engagement of inflammation which potentiates development of epithelial tumorigenesis presumably by activating the mitogen-activated protein kinase and the protein kinase B signaling pathways.Anti-CHI3L1 antibodies or pan-chitinase inhibitors may have the potential to suppress CHI3L1-mediated chronic inflammation and the subsequent carcinogenic change in epithelial cells. | Katrin Eurich Mayuko Segawa Satoko Toei-Shimizu Emiko Mizoguchi | 2009 | World Journal of Gastroenterology2009，15，42： | 9 |
| 2 | Biliary Complications After Liver Transplantation: Old Problems and New Challenges显示文摘 | D. Seehofer D. Eurich W. Veltzke‐Schlieker P. Neuhaus | 2013 | American Journal of Transplantation2013，，2： | 5 |
| 3 | Obesity and outcomes in patients hospitalized with pneumonia显示文摘 | S. Kahlon D. T. Eurich R. S. Padwal A. Malhotra J. K. Minhas‐Sandhu T. J. Marrie S. R. Majumdar | 2013 | Clinical Microbiology and Infection2013，，8： | 1 |
| 4 | Improved clinical outcome associated with metformin in patients with diabetes and heart failure显示文摘 | Eurich DT Majumdar SR Mcalister FA | 2005 | Diabetes Care2005，28，10： | 1 |
| 5 | Reduced mortality associated with the use of ACE inhibi- tors in patients with type 2 diabetes 显示文摘 | EURICH DT MAJUMDAR SR TSUYUKI RT | 2004 | Diabetes Care2004，27，6： | 1 |
| 6 | Benefits and harms ofantidiabetic agentsin patients with diabetes and heart failure:system- atic review显示文摘 | Eurich DT M cA lister FA Blackburn DF | 2007 | Bri Med J2007，335，： | 1 |
| 7 | Improved clinical outcomes associated with metformin in patients with diabetes and heart failure显示文摘 | Eurich DT Majumdar SR McAlister FA | 2005 | Diabetes Care2005，28，： | 1 |
| 8 | Macrolides and mortality in critically ill patients with community-acquired pneumonia: a sys- tematic review and meta-analysis 显示文摘 | Sligl WI Asadi L Eurich DT | 2014 | Crit Care Med2014，42，2： | 1 |
| 9 | Risk of acute coronary events associated with glyburide compared with gliclazide use in patients with type 2 diabetes: a nested case- control study显示文摘 | Abdelraoneim AS Eurich DT Gamble J M | 2014 | Diabetes Obes Metab2014，16，1： | 1 |
| 10 | Biliary complications after liver transplantation: old problems and new challenges显示文摘 | Seehofer D Eurich D Vehzke-Schlieker W | 2013 | Am J Transplant2013，13，2： | 1 |
| 11 | The effect of specialist care within the first year on subsequent outcomes in 24, 232 adults with new-onset diabetes mellitus:population-based cohort study显示文摘 | McAlister FA Majumdar SR Eurich DT | 2007 | Qual Saf Health Care2007，16，： | 1 |
| 12 | The risk of heart failure in patients with type 2 diabetes treated with oral agent monotherapy显示文摘 | McAlister FA Eurich DT Majumdar SR | | European Journal of Heart Failure0，，： | 1 |
| 13 | Biliary complications after liver transplantation:old problems and new challenges显示文摘 | Seehofer D Eurich D Veltzke-Schlieker W | | 0，，02： | 1 |
| 14 | Theeffect of specialist care within the first year on subse quent outcomes in 24,232 adults with new-onset diabe- tes mellitus: population-based cohort study显示文摘 | McAlister FA Majumdar SR Eurich DT | 2007 | Quali- ty ~ Safety in Health Care2007，16，1： | 1 |
| 15 | The risk of heart failure in patients with type 2 diabetes treated with oral agent monotherapy 显示文摘 | McAlister FA Eurich DT Majumdar SR | 2008 | Eur J Heart Fail2008，10，： | 1 |
| 16 | Improved clinical outcomes associated with mefformin in patients with diabetes and heart failure 显示文摘 | Eurich DT Majumdar SR McAlister FA | 2005 | Diabetes Care2005，28，： | 1 |
| 17 | First-fill med-ication discontinuations and non adherence to antihyper-tensive therapy : an observational study 显示文摘 | Evans CD Eurich DT Remillard AJ | 2012 | Am J Hyper-tens2012，25，2： | 1 |
| 18 | Successful prevention of hepatitis C virus (HCV) liver graft reinfection by silibinin mono-therapy显示文摘 | U.P. Neumann M. Biermer D. Eurich P. Neuhaus T. Berg | 2010 | Journal of Hepatology2010，，6： | 1 |
| 19 | The risk of heart failure in patients with type 2 diabetes treated with oral agent monotherapy显示文摘 | McAlister FA Eurich DT Majumdar SR | 2008 | Eur J Heart Fail2008，10，7： | 1 |
| 20 | Benefits and harms of antidiabetic agents in patients with diabetes and heart failure systematic review显示文摘 | Eurich DT McAlister FA Blackburn DF | 2007 | BMJ2007，335，7618： | 1 |
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