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| 1 | Association between Metabolic Dysfunction-associated Fatty Liver Disease and Cognitive Impairment显示文摘Background and Aims:Metabolic dysfunction-associated fatty liver disease(MAFLD)is a newly proposed term based on modified criteria.Although nonalcoholic fatty liver disease(NAFLD)has been well-documented as a multisystem dis-ease,research on the correlation of MAFLD and extra-hepatic diseases is limited.This study aimed to clarify the association of MAFLD,as well as NAFLD status with cognitive function.Methods:A total of 5,662 participants 20-59 years of age who underwent cognitive tests and liver ultrasonography in the Third National Health and Nutrition Examination Survey were included in the analysis.Cognitive function was evalu-ated using three computer-administered tests,the serial dig-it learning test(SDLT),the simple reaction time test(SRTT)and the symbol digit substitution test(SDST).Results:Par-ticipants with MAFLD had significantly poorer performance on the SRTT[odds ratio(OR)1.47,95%confidence interval(CI):1.14-1.89)].MAFLD with moderate-severe liver stea-tosis was associated with higher risks of scoring low in the SDLT(OR 1.37,95%CI:1.04-1.82)and SRTT(OR 1.55,95%CI:1.19-2.02).NAFLD combined with metabolic dys-function,instead of NAFLD without metabolic disorders,was associated an increased risk of a low SRTT score(OR 1.44,95%CI:1.10-1.82).MAFLD patients had a high probability of fibrosis,prediabetes,and diabetes and were also signifi-cantly associated with increased risks based on the SDST or SRTT score.Conclusions:MAFLD was significantly associ-ated with increased risk of cognitive impairment,especially among MAFLD patients with a high degree of liver fibrosis,moderate-severe steatosis,or hyperglycemia. | Qiang Yu Ruixin He Haowen Jiang Ji Wu Zhifeng Xi Kang He Yongbo Liu Tao Zhou Mingxuan Feng Ping Wan Hexin Yan Qiang Xia | 2022 | Journal of Clinical and Translational Hepatology2022，10，6： | 1 |
| 2 | Short-chain fatty acids ameliorate spinal cord injury recovery by regulating the balance of regulatory T cells and effector IL-17^(+) γδ T cells显示文摘Spinal cord injury(SCI)causes motor,sensory,and autonomic dysfunctions.The gut microbiome has an important role in SCI,while short-chain fatty acids(SCFAs)are one of the main bioactive mediators of microbiota.In the present study,we explored the effects of oral administration of exogenous SCFAs on the recovery of locomotor function and tissue repair in SCI.Allen’s method was utilized to establish an SCI model in Sprague-Dawley(SD)rats.The animals received water containing a mixture of 150 mmol/L SCFAs after SCI.After 21 d of treatment,the Basso,Beattie,and Bresnahan(BBB)score increased,the regularity index improved,and the base of support(BOS)value declined.Spinal cord tissue inflammatory infiltration was alleviated,the spinal cord necrosis cavity was reduced,and the numbers of motor neurons and Nissl bodies were elevated.Enzyme-linked immunosorbent assay(ELISA),real-time quantitative polymerase chain reaction(qPCR),and immunohistochemistry assay revealed that the expression of interleukin(IL)-10 increased and that of IL-17 decreased in the spinal cord.SCFAs promoted gut homeostasis,induced intestinal T cells to shift toward an anti-inflammatory phenotype,and promoted regulatory T(Treg)cells to secrete IL-10,affecting Treg cells and IL-17^(+)γδT cells in the spinal cord.Furthermore,we observed that Treg cells migrated from the gut to the spinal cord region after SCI.The above findings confirm that SCFAs can regulate Treg cells in the gut and affect the balance of Treg and IL-17^(+)γδT cells in the spinal cord,which inhibits the inflammatory response and promotes the motor function in SCI rats.Our findings suggest that there is a relationship among gut,spinal cord,and immune cells,and the“gut-spinal cord-immune”axis may be one of the mechanisms regulating neural repair after SCI. | Pan LIU Mingfu LIU Deshuang XI Yiguang BAI Ruixin MA Yaomin MO Gaofeng ZENG Shaohui ZONG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，4： | 0 |
| 3 | DFT study on the selective oxidation of vinyl chloride on different metal surfaces显示文摘Selective epoxidation of vinyl chloride on Ag(111), Pt(111) and Rh(111) with pre-adsorbed atomic oxygen has been studied by density functional theory (DFT) calculation with the periodic slab model. The reaction energies and activation energies of the epoxidation reaction are determined. Because of the asymmetry of vinyl chloride, three competitive reaction pathways are investigated. The results indicate that the most possible reaction pathway is pathway III. Compared the activation energies of the epoxidation reaction on Ag(111), Pt(111) and Rh(111), it is obvious that the reaction via OMMC(3) on Ag(111) is the most possible process. However, the selectivity to the target product over Ag(111) is the lowest among the three metals. The results also indicate that the formation of chloroacetaldehyde is more favorable than that of chloroepoxide. | Ruipeng Ren Ruixin Xi Xianyong Pang Yongkang Lu | 2011 | Journal of Natural Gas Chemistry2011，20，2： | 0 |
| 4 | Involvement of sulfur assimilation in the low β subunit content of soybean seed storage protein revealed by comparative transcriptome analysis显示文摘The β subunit of soybean [Glycine max (L.) Merr.] seed storage protein is of great significance in sulfur-containing amino acid balance and soybean processing properties. The objective of this study was to elucidate the relationship between the β subunit and sulfur-containing amino acid composition, and the potential regulatory mechanism. The β subunit was independently accumulated in comparison with other major subunits (α/α′, acidic, basic, and A3) during seed filling, and a low level of β subunit content (BSC) was formed during the accumulation process. In low-BSC mature seeds, crude protein, oil content, and fatty acid composition were not changed, but sulfur-containing amino acids (Cys + Met) in the low- BSC seeds increased significantly (by 31.5%), suggesting that an internal regulatory mechanism within seed might be responsible for the rebalance of seed protein composition and that sulfur assimilation might be deeply involved in β subunit accumulation. Transcriptomic analysis revealed that genes involved in anabolism of cysteine, methionine, and glutathione were up-regulated but those involved in the catabolism of these compounds were down-regulated, suggesting a relationship between the elevation of methionine and glutathione and low BSC. Our study sheds light on seed composition in low BSC lines and on the potential molecular regulatory mechanism of β subunit accumulation, broadening our understanding of soybean seed protein synthesis and its regulation. | Xi Zhang Ruixin Xu Wei Hu Wan Wang Dezhi Han Fan Zhang Yongzhe Gu Yong Guo Jun Wang Lijuan Qiu | 2019 | The Crop Journal2019，7，4： | 0 |
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