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| 1 | Levels of synthetic musk fragrances in human milk from three cities in the Yangtze River Delta in Eastern China显示文摘Synthetic musks are used as additives in many household products.After absorption into the human body,they accumulate and their concentrations in human milk reflect both the mother and her infant's exposure level.Concentrations of four synthetic musks,musk xylene(1-tert-butyl-2,6-dimethyl-2,4,6-trinitrobenzene,MX),musk ketone(4-tert-butyl-2,6-dimethyl-3,5-dinitroacetophenone,MK),1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[γ]-2-benzopyran(HHCB) and 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4tetrahydronaphthalene(AHTN),were determined in human milk samples collected from Shanghai,Wuxi,and Shaoxing in Eastern China.The four synthetic musks were found in most samples analyzed,with HHCB the dominant component followed by MX.The median(mean) values for HHCB,AHTN,MX and MK concentrations were 63(82),5(12),17(24) and 4(9) ng/g lipid weight,respectively.These data suggested the total synthetic musk contamination was low,and the distribution percentage was HHCB > MX > AHTN ≈ MK.The relative high ratio of nitro to polycylic musk indicated that nitro musks were still widely used.The musk concentrations in these cities were not significantly different from each other(p > 0.05).Principal components score plots were obtained,which showed similar exposure sources.The amount of total synthetic musks in human milk were not associated with mother's age,although HHCB was significantly correlated with AHTN(p < 0.05).Daily ingestion of HHCB,AHTN,MX and MK for infants from human milk were estimated as(2526 ± 2926),(370 ± 524),(7391 ± 832),and(277 ± 462) ng/day,respectively.Those doses were 1-2 orders of magnitude below the provisional tolerable daily intakes. | Xiaolan Zhang Gaofeng Liang Xiangying Zeng Jing Zhou Guoying Sheng Jiamo Fu | 2011 | Journal of Environmental Sciences2011，23，6： | 8 |
| 2 | Interleukin-5 promotes ATP-binding cassette transporter A1 expression through miR-211/JAK2/STAT3 pathways in THP-1-dervied macrophages显示文摘Interleukin-5 (IL-5) is manifested as its involvement in the process of atherosclerosis, but the mechanism is still unknown. In this study, we explored the effect of IL-5 on lipid metabolism and its underlying mechanisms in THP-1-derived macrophages. The quantitative polymerase chain reaction (qPCR) and western blot analysis results showed that IL-5 significantly up-regulated ATP-binding cassette transporter A1 (ABCA1) expression in a dose-dependent and time-dependent manner. [3H]-labeled cholesterol was used to assess the levels of cholesterol efflux, and the results showed that IL-5 increased ABCA1-mediated cholesterol efflux. A high-performance liquid chromatography assay indicated that cellular cholesterol content was decreased by IL-5 treatment in THP-1-derived macrophages. The selective inhibitor and small interfering RNA were used to block the Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) pathway. The results of the qPCR and western blot analysis showed that IL-5 activated JAK2/STAT3 pathway to up-regulate ABCA1 expression. Meanwhile, IL-5 reduced the expression level of miR-211. Furthermore, we found that JAK2 is a target gene of miR-211 and miR-211 mimic inhibited the expression of JAK2 and reduced the levels of p-STAT3 and ABCA1 as revealed by luciferase reporter assay, qPCR and western blot analysis. In summary, these findings indicated that IL-5 promotes ABCA1 expression and cholesterol efflux through the miR-211/JAK2/STAT3 signaling pathway in THP-1-derived macrophages. | Kong Chen Zhenwang Zhao Gang Wang Jin Zou Xiaohua Yu Dawei Zhang Gaofeng Zeng Chaoke Tang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，8： | 3 |
| 3 | Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine(5hmC)显示文摘As a dioxygenase, Ten-Eleven Translocation 2(TET2) catalyzes subsequent steps of 5-methylcytosine(5 mC) oxidation. TET2 plays a critical role in the self-renewal, proliferation,and differentiation of hematopoietic stem cells, but its impact on mature hematopoietic cells is not well-characterized. Here we show that Tet2 plays an essential role in osteoclastogenesis. Deletion of Tet2 impairs the differentiation of osteoclast precursor cells(macrophages) and their maturation into bone-resorbing osteoclasts in vitro. Furthermore, Tet2^(-/-) mice exhibit mild osteopetrosis, accompanied by decreased number of osteoclasts in vivo. Tet2 loss in macrophages results in the altered expression of a set of genes implicated in osteoclast differentiation, such as Cebpa, Mafb, and Nfkbiz. Tet2 deletion also leads to a genome-wide alteration in the level of 5-hydroxymethylcytosine(5 hmC) and altered expression of a specific subset of macrophage genes associated with osteoclast differentiation. Furthermore, Tet2 interacts with Runx1 and negatively modulates its transcriptional activity. Our studies demonstrate a novel molecular mechanism controlling osteoclast differentiation and function by Tet2, that is, through interactions with Runx1 and the maintenance of genomic 5 hmC. Targeting Tet2 and its pathway could be a potential therapeutic strategy for the prevention and treatment of abnormal bone mass caused by the deregulation of osteoclast activities. | Yajing Chu Zhigang Zhao David Wayne Sant Ganqian Zhu Sarah M. Greenblatt Lin Liu Jinhuan Wang Zeng Cao Jeanette Cheng Tho Shi Chen Xiaochen Liu Peng Zhang Jaroslaw P. Maciejewski Stephen Nimer Gaofeng Wang Weiping Yuan Feng-Chun Yang Mingjiang Xu | 2018 | Genomics, Proteomics & Bioinformatics2018，16，3： | 2 |
| 4 | De- fect sealing in Pd membranes via point-ptating显示文摘 | Zeng Gaofeng Goldbach Andreas Xu Hengyong | 2009 | J Membr Sci2009，328，： | 1 |
| 5 | Highly Flexible and Broad‑Range Mechanically Tunable All‑Wood Hydrogels with Nanoscale Channels via the Hofmeister Effect for Human Motion Monitoring显示文摘Wood-based hydrogel with a unique anisotropic structure is an attractive soft material,but the presence of rigid crystalline cellulose in natural wood makes the hydrogel less flexible.In this study,an all-wood hydrogel was constructed by cross-linking cellulose fibers,polyvinyl alcohol(PVA)chains,and lignin molecules through the Hofmeister effect.The all-wood hydrogel shows a high tensile strength of 36.5 MPa and a strain up to~438%in the longitudinal direction,which is much higher than its tensile strength(~2.6 MPa)and strain(~198%)in the radial direction,respectively.The high mechanical strength of all-wood hydrogels is mainly attributed to the strong hydrogen bonding,physical entanglement,and van der Waals forces between lignin molecules,cellulose nanofibers,and PVA chains.Thanks to its excellent flexibility,good conductivity,and sensitivity,the all-wood hydrogel can accurately distinguish diverse macroscale or subtle human movements,including finger flexion,pulse,and swallowing behavior.In particular,when“An Qi”was called four times within 15 s,two variations of the pronunciation could be identified.With recyclable,biodegradable,and adjustable mechanical properties,the all-wood hydrogel is a multifunctional soft material with promising applications,such as human motion monitoring,tissue engineering,and robotics materials. | Guihua Yan Shuaiming He Gaofeng Chen Sen Ma Anqi Zeng Binglin Chen Shuliang Yang Xing Tang Yong Sun Feng Xu Lu Lin Xianhai Zeng | 2022 | Nano-Micro Letters2022，14，5： | 0 |
| 6 | Changes in the gut microbiota of osteoporosis patients based on 16S rRNA gene sequencing:a systematic review and meta-analysis显示文摘Background:Osteoporosis(OP)has become a major public health issue,threatening the bone health of middle-aged and elderly people from all around the world.Changes in the gut microbiota(GM)are correlated with the maintenance of bone mass and bone quality.However,research results in this field remain highly controversial,and no systematic review or meta-analysis of the relationship between GM and OP has been conducted.This paper addresses this shortcoming,focusing on the difference in the GM abundance between OP patients and healthy controls based on previous 16S ribosomal RNA(rRNA)gene sequencing results,in order to provide new clinical reference information for future customized prevention and treatment options of OP.Methods:According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA),we comprehensively searched the databases of Pub Med,Web of Science,Embase,Cochrane Library,and China National Knowledge Infrastructure(CNKI).In addition,we applied the R programming language version 4.0.3 and Stata 15.1 software for data analysis.We also implemented the Newcastle-Ottawa Scale(NOS),funnel plot analysis,sensitivity analysis,Egger’s test,and Begg’s test to assess the risk of bias.Results:This research ultimately considered 12 studies,which included the fecal GM data of 2033 people(604 with OP and 1429 healthy controls).In the included research papers,it was observed that the relative abundance of Lactobacillus and Ruminococcus increased in the OP group,while the relative abundance for Bacteroides of Bacteroidetes increased(except for Ireland).Meanwhile,Firmicutes,Blautia,Alistipes,Megamonas,and Anaerostipes showed reduced relative abundance in Chinese studies.In the linear discriminant analysis Effect Size(LEfSe)analysis,certain bacteria showed statistically significant results consistently across different studies.Conclusions:This observational meta-analysis revealed that changes in the GM were correlated with OP,and variations in some advantageous GM might involve regional differences. | Rui HUANG Pan LIU Yiguang BAI Jieqiong HUANG Rui PAN Huihua LI Yeping SU Quan ZHOU Ruixin MA Shaohui ZONG Gaofeng ZENG | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，12： | 0 |
| 7 | Highly controlled structured catalysts for on-board methanol reforming显示文摘The on-board methanol steam reforming(MSR) has long been considered as an effective approach to insitu produce hydrogen for fuel cell vehicles(FCVs). However, the conventional MSR catalyst pellets suffer from easy breakage during the vehicle movement, leading to increased pressure drop and reduced system stability. Herein, we introduce an integrated method to prepare the highly controlled structured catalysts based on coupled processes: direct prototyping the structured substrate using digital light processing(DLP) 3D printing technology, in-situ dynamic crystallization of active components assisted by magnetic resonance imaging(MRI) and calcination. The synthesized catalyst owns a gradient layer of active component, and exhibits better MSR performance, higher mechanical strength, reduced pressure drop, higher Cu dispersion and better adhesion of active compounds when compared with the conventional powder and pellet catalysts. The demonstrated successful application proves the feasibility of developed method,which has great potential to be used for preparing precisely other monolithic catalysts with customized structures. | Zhuangdian Liang Gang Wang Gaofeng Zeng Jie Zhang Zhiyong Tang | 2022 | Journal of Energy Chemistry2022，31，5： | 0 |
| 8 | Mechanically durable biomimetic fibrous membrane with superhydrophobicity and superoleophilicity for aqueous oil separation显示文摘Developing an effective and mechanically durable biomimetic membrane for the separation of highly emulsified aqueous oil is significant but challenging owing to its low water flux and serious membrane fouling.In this work,a biomimetic membrane with superhydrophobicity and superoleophilicity was rationally developed via co-electrospinning of polysulfonamide/polyacrylonitrile(PSA/PAN)emulsion solution,followed by decorating of a-Fe2 O_(3) nanowire onto the membrane surface to create membrane roughness,and grafting of 1 H,1 H,2 H,2 H-perfluorododecyltrichlorosilane(FTCS)to lower membrane surface free energy.Benefiting from the nanowire-wrapped rough membrane structure and the low surface free energy FTCS,the resultant membrane showed superhydrophobicity with a high water contact angle(WCA)of 156°,superoleophilicity with a low oil contact angle(OCA)of 0°,which can separate the highly emulsified aqueous oil with an ultrahigh permeation flux over 7000 L m2 h-1 and high separation efficiency of about 99%.Significantly,the biomimetic membrane also displayed robust stability for long-te rm separation owing to its adva ntage of antifouling property,showing great potential applications in large-scale aqueous oil treatment. | Zhigao Zhu Lingling Zhong Yu Wang Gaofeng Zeng Wei Wang | 2020 | Chinese Chemical Letters2020，31，10： | 0 |
| 9 | Metal organic polymers with dual catalytic sites for oxygen reduction and oxygen evolution reactions显示文摘Metal-organic frameworks and covalent organic frameworks have been widely employed in electrochemical catalysis owing to their designable skeletons,controllable porosities,and well-defined catalytic centers.However,the poor chemical stability and low electron conductivity limited their activity,and single-functional sites in these frameworks hindered them to show multifunctional roles in catalytic systems.Herein,we have constructed novel metal organic polymers(Co-HAT-CN and Ni-HAT-CN)with dual catalytic centers(metal-N_(4) and metal-N_(2))to catalyze oxygen reduction reaction(ORR)and oxygen evolution reaction(OER).By using different metal centers,the catalytic activity and selectivity were well-tuned.Among them,Co-HAT-CN catalyzed the ORR in a 4e^(-)pathway,with a half-wave potential of 0.8 V versus RHE,while the Ni-HAT-CN catalyze ORR in a 2e^(-)pathway with H_(2)O_(2) selectivity over 90%.Moreover,the Co-HAT-CN delivered an overpotential of 350 mV at 10 mA cm^(-2) with a corresponding Tafel slope of 24 mV dec^(-1) for OER in a 1.0 M KOH aqueous solution.The experimental results revealed that the activities toward ORR were due to the M-N_(4) sites in the frameworks,and both M-N_(4) and M-N_(2) sites contributed to the OER.This work gives us a new platform to construct bifunctional catalysts. | Sijia Liu Minghao Liu Xuewen Li Shuai Yang Qiyang Miao Qing Xu Gaofeng Zeng | 2023 | Carbon Energy2023，5，5： | 0 |
| 10 | Effect and mechanism of Polygonatum sibiricum polysaccharide on osteogenic differentiation of bone mesenchymal stem cells(BMSCs)显示文摘Objective:To investigate the effects and mechanisms of Polygonatum sibiricum polysaccharide(PSP)on osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs).Methods:The mouse BMSCs were cultured and induced in osteoblast medium(OBM)containing finalconcentrations(0 mg/L,12.5 mg/L,25 mg/L,and 50 mg/L)of PSP.The proliferation and cytotoxicity of BMSCs were detected by MTT assay.Alkaline phosphatase(ALP)and Alizarin red S staining were performed after 7 days' ossification-inducing culture.The mRNA expressions of ALP,Runx2 and osteocalcin(OCN)were determined by fluorescence quantitative PCR(qPCR).The mRNA and protein expressions of Tafazzin(TAZ)(a key effector of Hippo pathway)were measured by qPCR and western blotting,respectively.Results:PSP was non-cytotoxicwithin the dose range of 12.5-50 mg/L and had no impact on the proliferation of BMSCs.The activity of ALP,the intensity of ALP staining,and the formation of mineralized nodules were increased by PSP treatment(25 and50 mg/L)(P<0.01).Moreover,administration of 25 mg/L PSP significantly enhanced the mRNA levels of osteoblastic differentiation makers ALP,Runx2 and OCN as well as the mRNA and protein expressions of TAZ(P<0.01).Conclusion:PSP could promote osteogenic differentiation of BMSCs,and the mechanisms might be related to the activation of TAZ in the Hippo signaling pathway. | Pingping Wu Lei Zhang Shaohui Zong Fangna Yan Yin Xiong Wenwen Fu Bo Li Gaofeng Zeng | 2018 | 广西医科大学学报2018，35，5： | 0 |
| 11 | Short-chain fatty acids ameliorate spinal cord injury recovery by regulating the balance of regulatory T cells and effector IL-17^(+) γδ T cells显示文摘Spinal cord injury(SCI)causes motor,sensory,and autonomic dysfunctions.The gut microbiome has an important role in SCI,while short-chain fatty acids(SCFAs)are one of the main bioactive mediators of microbiota.In the present study,we explored the effects of oral administration of exogenous SCFAs on the recovery of locomotor function and tissue repair in SCI.Allen’s method was utilized to establish an SCI model in Sprague-Dawley(SD)rats.The animals received water containing a mixture of 150 mmol/L SCFAs after SCI.After 21 d of treatment,the Basso,Beattie,and Bresnahan(BBB)score increased,the regularity index improved,and the base of support(BOS)value declined.Spinal cord tissue inflammatory infiltration was alleviated,the spinal cord necrosis cavity was reduced,and the numbers of motor neurons and Nissl bodies were elevated.Enzyme-linked immunosorbent assay(ELISA),real-time quantitative polymerase chain reaction(qPCR),and immunohistochemistry assay revealed that the expression of interleukin(IL)-10 increased and that of IL-17 decreased in the spinal cord.SCFAs promoted gut homeostasis,induced intestinal T cells to shift toward an anti-inflammatory phenotype,and promoted regulatory T(Treg)cells to secrete IL-10,affecting Treg cells and IL-17^(+)γδT cells in the spinal cord.Furthermore,we observed that Treg cells migrated from the gut to the spinal cord region after SCI.The above findings confirm that SCFAs can regulate Treg cells in the gut and affect the balance of Treg and IL-17^(+)γδT cells in the spinal cord,which inhibits the inflammatory response and promotes the motor function in SCI rats.Our findings suggest that there is a relationship among gut,spinal cord,and immune cells,and the“gut-spinal cord-immune”axis may be one of the mechanisms regulating neural repair after SCI. | Pan LIU Mingfu LIU Deshuang XI Yiguang BAI Ruixin MA Yaomin MO Gaofeng ZENG Shaohui ZONG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，4： | 0 |
| 12 | Lithium Ion Conduction in Covalent Organic Frameworks显示文摘Ion conduction plays key roles in electrochemical systems,including fuel cells,lithium ion batteries,and metal-air batteries.Covalent organic frameworks(COFs),as a new class of porous polymers,constructed by pre-designable building blocks,are ideal hosts to accommodate ionic carries for conduction because of their straightforward pore channels,tunable pore size,controllable pore environment,and good chemical and thermal stability.Different from proton conduction,how to achieve high lithium ion conduction is still a challenge as it is difficult to dissociate ionic bonds of the lithium salts.To facilitate the dissociation of lithium salts,COFs with different pores and skeletons are well designed and constructed.This review focuses on emerging developments of lithium ion conduction in COFs,and discusses the structures of these COFs and conductive performance to elucidate the structure-property correlations.Furthermore,we have concluded the remaining challenge and future direction in these COF-based lithium conductive areas.This review provides deeper insight into COFs for ionic conduction. | Sijia Liu Minghao Liu Qing Xu Gaofeng Zeng | 2022 | Chinese Journal of Structural Chemistry2022，41，11： | 0 |
| 13 | Dual atomic catalysts from COF-derived carbon for CO_(2)RR by suppressing HER through synergistic effects显示文摘The electrochemical carbon dioxide reduction reaction(CO_(2)RR)for highvalue-added products is a promising strategy to tackle excessive CO_(2) emissions.However,the activity of and selectivity for catalysts for CO_(2)RR still need to be improved because of the competing reaction(hydrogen evolution reaction).In this study,for the first time,we have demonstrated dual atomic catalytic sites for CO_(2)RR from a core-shell hybrid of the covalent-organic framework and the metal-organic framework.Due to abundant dual atomic sites(with CoN_(4)O and ZnN_(4) of 2.47 and 11.05 wt.%,respectively)on hollow carbon,the catalyst promoted catalysis of CO_(2)RR,with the highest Faradic efficiency for CO of 92.6%at-0.8 V and a turnover frequency value of 1370.24 h^(-1) at-1.0 V.More importantly,the activity and selectivity of the catalyst were well retained for 30 h.The theoretical calculation further revealed that CoN_(4)O was the main site for CO_(2)RR,and the activity of and selectivity for Zn sites were also improved because of the synergetic roles. | Minghao Liu Sijia Liu Qing Xu Qiyang Miao Shuai Yang Svenja Hanson George Zheng Chen Jun He Zheng Jiang Gaofeng Zeng | 2023 | Carbon Energy2023，5，6： | 0 |
| 14 | Recent advances in the syntheses of pyrroles显示文摘The pyrrole moiety is an important structural motif in functional materials,natural products,and pharmaceuticals.More and more synthetic strategies toward pyrroles have emerged,where various efficient building blocks are developed and these synthons enable the syntheses of pyrroles with different numbers of components.However,no review specifically summarizes the syntheses of pyrroles according to the type and number of employed building blocks.To aid researchers to design appropriate substrates for pyrrole synthesis,herein we summarized the advances in pyrrole syntheses and classified these reactions into four categories according to the number of employed components,which may shed light on developing more efficient synthetic methods toward substituted pyrroles. | Tao Shi Gaofeng Yin Xiaodong Wang Yongxia Xiong Yan Peng Shuang Li Yaofu Zeng Zhen Wang | 2023 | Green Synthesis and Catalysis2023，4，1： | 0 |
| 15 | Construction of Synergistic Co and Cu Diatomic Sites for Enhanced Higher Alcohol Synthesis显示文摘Higher alcohol synthesis(HAS)from syngas could efficiently alleviate the dependence on the traditional fossil resources.However,it is still challenging to construct high-performance HAS catalysts with satisfying selectivity,space–time yield(STY),and stability.Herein,we designed a diatomic catalyst by anchoring Co and Cu sites onto a hierarchical porous N-doped carbon matrix(Co/Cu–N–C).The Co/Cu–N–C is efficient for HAS and is among the best catalysts reported.With a COconversion of 81.7%,C2+OHselectivity could reach 58.5%with an outstanding C2+OH STY of 851.8 mg/g·h.We found that the N4–Co1 and Cu1–N4 showed an excellent synergistic effect.The adsorption of CO occurred on the Co site,and the surrounding nitrogen sites served as a hydrogen reservoir for the CO reduction reactions to form CHxCo.Meanwhile,the Cu sites stabilized a CHOCu species to interact with CHxCo,facilitating a barrier-free formation of C2 species,which is responsible for the high selectivity of higher alcohols. | Gaofeng Chen Olga A.Syzgantseva Maria A.Syzgantseva Shuliang Yang Guihua Yan Li Peng Changyan Cao Wenxing Chen Zhiwei Wang Fengjuan Qin Tingzhou Lei Xianhai Zeng Lu Lin Weiguo Song Buxing Han | 2023 | CCS Chemistry2023，5，4： | 0 |
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