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| 1 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 2 | Improving the Local Sheep in Gansu via Crossing with Introduced Sheep Breeds Dorset and Borderdale显示文摘In order to improve the meat performance of local sheep in Gansu Province,Dorset and Borderdale were introduced to crossbreed with local sheep which were Tan sheep,Small-tail Han sheep and Mongolia sheep. The offspring under different crossbreeding combinations were sampled randomly at the different growing stage to measure their growth traits so as to select optimize the crossbreeding mode. The results indicated that,for the same crossbreeding mode,the growth rate of progeny was in order F3> F2> F1; for the F3 progeny,the combinations Dorset- Borderdale- Small tail Han sheep and Dorset- Borderdale- Mongolia sheep gave a higher growth rate,with a body weight of 1. 57%,3. 17%,8. 23%,1. 15% higher in male and female individuals than the counterparts of Dorset and Tan sheep and Small tail Han sheep; for the F2 progeny,the combinations Dorset- Borderdale- Small tail Han sheep and Dorset- Borderdale- Mongolia sheep also gave a higher growth rate,with a body weight of 2. 15%,4. 53%,9. 21% and 2. 75% higher in male and female individuals than the counterparts of Dorset and Tan sheep and Small tail Han sheep; for the F1 progeny,the combination Borderdale and Small tail Han sheep assumed a higher growth rate,with a body weight of 3. 23%,6. 07%,7. 42% and 8. 66% higher in male and female individuals than the counterparts of Borderdale- Mongolia sheep and Tan sheep- Small tail Han sheep,respectively. Therefore,in the Small-tail Han sheep and Mongolia sheep producing regions,the F2 or F3progeny bred by using Dorset or Borderdale sheep as male parent to cross with local breeds,or the hybrid lambs of Small-tail Han sheep and Borderdale sheep as highly qualified commodity,would produce significant economic benefit. Moreover,the novel breeds obtained by crossing were the valuable genetic resource for breeding meat sheep. | Sun Xiaoping Liu Jianbin Zhang Wanlong Lang Xia Yang Bohui Guo Jian Feng Ruilin | 2014 | Animal Husbandry and Feed Science2014，6，5： | 3 |
| 3 | Solvent effects on Pt-Ru/C catalyst for methanol electro-oxidation显示文摘Alloying degree,particle size and the level of dispersion are the key structural parameters of Pt-Ru/C catalyst in fuel cells.Solvent(s) used in the preparation process can affect the particle size and alloying degree of the object substance,which lead to a great positive impact on its properties.In this work,three types of solvents and their mixtures were used in preparation of the Pt-Ru/C catalysts by chemical reduction of metal precursors with sodium borohydride at room temperature.The structure of the catalysts was characterized by X-ray diffraction(XRD) and Transmission electron microscopy(TEM).The catalytic activity and stability for methanol electro-oxidation were studied by Cyclic Voltammetry(CV) and Chronoamperometry(CA).Pt-Ru/C catalyst prepared in H2O or binary solvents of H2O and isopropanol had large particle size and low alloying degree leading to low catalytic activity and less stability in methanol electro-oxidation.When tetrahydrofuran was added to the above solvent systems,Pt-Ru/C catalyst prepared had smaller particle size and higher alloying degree which resulted in better catalytic activity,lower onset and peak potentials,compared with the above catalysts.Moreover,the catalyst prepared in ternary solvents of isopropanol,water and tetrahydrofuran had the smallest particle size,and the high alloying degree and the dispersion kept unchanged.Therefore,this kind of catalyst showed the highest catalytic activity and good stability for methanol electro-oxidation. | Jinwei Chen Chunping Jiang Hui Lu Lan Feng Xin Yang Liangqiong Li Ruilin Wang | 2009 | Journal of Natural Gas Chemistry2009，18，3： | 2 |
| 4 | Analysis on Autofrettage of Cylinders显示文摘Autofrettage is an effective technique to improve load-bearing capacity and safety for pressure vessels.For autofrettaged cylinder,the depth of plastic zone,or overstrain is a key factor which affects load-bearing capacity and safety.The previous research on overstrain was not done in terms of the point of view of raising load-bearing capacity as far as possible and simultaneously avoiding compressive yield for cylinders experiencing autofrettage handling,and there were no analytic solutions of autofrettage in the above view point presented,the 3rd and 4th strength theories were not applied synthetically in the research to compare the results from these two theories.In this paper,with the aid of the analytic method,based on summing up the authors' previous research,results from autofrettage of a cylinder based on the 3rd and 4th strength theories are studied and compared,and the laws contained in the results are looked into.Then,the essential cause and reason for the obtained laws are analyzed and the inherent and meaning relations between various parameters in autofrettage theory are revealed.It is shown that the maximum radius ratio for equivalent residual stress at inside surface never exceeds the yield strength even for a cylinder experiencing wholly yielded autofrettage,or the critical radius ratio is kc=2.218 457 489 916 7…,irrespective of the 3rd or 4th strength theories.The equation relating the depth of plastic zone with the thickness of a cylinder is identical for the 3rd and 4th strength theories.In form,the optimum load-bearing capacity of an autofrettaged cylinder is two times the initial yield pressure of the unautofrettaged cylinder irrespective of the 3rd or 4th strength theory.The revealed inherent relations between various parameters and varying laws of the parameters as well as the forms of the relations under the 3rd and 4th strength theories not only have theoretical meanings but also have prospects in engineering application. | ZHU Ruilin ZHU Guolin TANG Feng | 2012 | Chinese Journal of Mechanical Engineering2012，25，3： | 2 |
| 5 | Bearing capacity of surface circular footings on granular material under low gravity fields显示文摘Low gravity fields have been simulated through magnetic acceleration to conduct experimental study on bearing capacity of circular footings on a type of crushable planetary regolith simulant,which has comparable density and particle size distribution of lunar soil.The loadesettlement responses of surface spread footings are obtained by investigating the relative density,footing size and gravity effects.Applying the hyperbolic asymptote method,normalised foundation stiffness and ultimate bearing capacity are obtained by curve fitting and predicted by power functions using multivariate nonlinear regression.The results show that the nonlinear gravity effect is not negligible,related to stress condition,soil dilatancy and mobilised friction angle.A cone penetration test(CPT)-based method for prediction of bearing capacity is proposed with correlations between ultimate bearing capacity of footings and shallow penetration stiffness of CPTs,avoiding the uncertainties of soil property estimations.Analyses of allowable bearing capacity and footing influence zone in consideration of footing size and gravity effects could therefore improve the design of shallow foundations on the Moon and Mars,and provide new understandings and potential implications to the bearing capacity of shallow foundations on crushable granular material in both terrestrial and extraterrestrial geotechnical engineering. | Pin-Qiang Mo Guoqing Zhou Feng Gao Ruilin Li | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，3： | 2 |
| 6 | Application of the triple porosity model in well-log effectiveness estimation of the carbonate reservoir in Tarim Oilfield 显示文摘 | Liu Ruilin Li Ning Feng Qingfu | 2009 | Journal of Petroleum Science Engineering2009，68，12： | 1 |
| 7 | Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou,China显示文摘Prolonged viral RNA shedding and recurrence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in coronavirus disease 2019(COVID-19)patients have been reported.However,the clinical outcome and pathogenesis remain unclear.In this study,we recruited 43 laboratory-confirmed COVID-19 patients.We found that prolonged viral RNA shedding or recurrence mainly occurred in severe/critical patients(P<0.05).The average viral shedding time in severe/critical patients was more than 50 days,and up to 100 days in some patients,after symptom onset.However,chest computed tomography gradually improved and complete absorption occurred when SARS-CoV-2 RT-PCR was still positive,but specific antibodies appeared.Furthermore,the viral shedding time significantly decreased when the A1,430G or C12,473T mutation occurred(P<0.01 and FDR<0.01)and increased when G227A occurred(P<0.05 and FDR<0.05).High IL1R1,IL1R2,and TNFRSF21 expression in the host positively correlated with viral shedding time(P<0.05 and false discovery rate<0.05).Prolonged viral RNA shedding often occurs but may not increase disease damage.Prolonged viral RNA shedding is associated with viral mutations and host factors. | Zhengtu Li Yinhu Li Ruilin Sun Shaoqiang Li Lingdan Chen Yangqing Zhan Mingzhou Xie Jiasheng Yang Yanqun Wang Airu Zhu Guoping Gu Le Yu Shuaicheng Li Tingting Liu Zhaoming Chen Wenhua Jian Qian Jiang Xiaofen Su Weili Gu Liyan Chen Jing Cheng Jincun Zhao Wenju Lu Jinping Zheng Shiyue Li Nanshan Zhong Feng Ye | 2021 | Science China(Life Sciences)2021，64，12： | 1 |
| 8 | Effects of Er^3+ concentration on UV/blue upconverted luminescence and a three-photon process in the cubic nanocrystalline Y2O5 : Er^3+ 显示文摘 | Wang Xin Shah Guiye Chao Kefu Zhang Youlin Liu Ruilin Feng Liyun Zeng Qinghui Sun Yajuan Liu Yichun Kong Xianggui | 2006 | Materials Chemistry and Physics2006，99，23： | 1 |
| 9 | A joint call for actions to advance taxonomy in China显示文摘Taxonomy plays an important role in understanding the origin, evolution, and ecological functionality of biodiversity. There are large number of unknown species yet to be described by taxonomists, which together with their ecosystem services cannot be effectively protected prior to description. Despite this, taxonomy has been increasingly underrated insufficient funds and permanent positions to retain young talents. Further, the impact factordriven evaluation systems in China exacerbate this downward trend, so alternative evaluation metrics are urgently necessary. When the current generation of outstanding taxonomists retires,there will be too few remaining taxonomists left to train the next generation. In light of these challenges, all co-authors worked together on this paper to analyze the current situation of taxonomy and put out a joint call for immediate actions to advance taxonomy in China. | Chaodong Zhu Arong Luo Ming Bai Michael COrr Zhonge Hou Siqin Ge Jun Chen Yibo Hu Xuming Zhou Gexia Qiao Hongzhi Kong Limin Lu Xiaohua Jin Lei Cai Xinli Wei Ruilin Zhao Wei Miao Qingfeng Wang Zhongli Sha Qiang Lin Meng Qu Jianping Jiang Jiatang Li Jing Che Xuelong Jiang Xiaoyong Chen Lianming Gao Zongxin Ren Chunlei Xiang Shixiao Luo Donghui Wu Dong Liu Yanqiong Peng Tao Su Chenyang Cai Tianqi Zhu Wanzhi Cai Xingyue Liu Hu Li Huaijun Xue Zhen Ye Xuexin Chen Pu Tang Shujun Wei Hong Pang Qiang Xie Feng Zhang Feng Zhang Xianjin Peng Aibing Zhang Taiping Gao Changfa Zhou Chen Shao Libin Ma Zhaoming Wei Yunxia Luan Ziwei Yin Wu Dai Cong Wei Xiaolei Huang Jingxian Liu Xiangsheng Chen Tianci Yi Zhisheng Zhang Zhulidezi Aishan Qin Li Hongying Hu | 2022 | Zoological Systematics2022，47，3： | 1 |
| 10 | Ephrin-A2 and-A3 are negative regulators of the regenerative potential of Müller cells显示文摘 | Zhu Ruilin Cho Kin-Sang Chen Dong Feng Yang Liu | 2014 | Chinese Medical Journal2014，，19： | 1 |
| 11 | Automated detection on the security of the linked-list operations显示文摘1 Introduction As measures taken by OS(operation system)to mitigate exploit getting more perfect,the stack-related vulnerabilities are reduced gradually and heap-related vulnerabilities have become increasingly prominent in most C/C++memory vulnerabilities.As is known,software program is a fusion of data structures and algorithms.Therefore,if unsafe operations are performed on data,unintended results may occur. | Hongyu KUANG Jian WANG Ruilin LI Chao FENG YunFei SU Xing ZHANG | 2022 | Frontiers of Computer Science2022，16，2： | 0 |
| 12 | Research on the Impact of Market Concern for Real Estate Policy on Housing Prices: Evidence from Internet Search and Hedonic Price Theory显示文摘To avoid the effects of systemic financial risks caused by extreme fluctuations in housing price,the Chinese government has been exploring the most effective policies for regulating the housing market.Measuring the effect of real estate regulation policies has been a challenge for present studies.This study innovatively employs big data technology to obtain Internet search data(ISD)and construct market concern index(MCI)of policy,and hedonic price theory to construct hedonic price index(HPI)based on building area,age,ring number,and other hedonic variables.Then,the impact of market concerns for restrictive policy,monetary policy,fiscal policy,security policy,and administrative supervision policy on housing prices is evaluated.Moreover,compared with the common housing price index,the hedonic price index considers the heterogeneity of houses and could better reflect the changes in housing prices caused by market supply and demand.The results indicate that(1)a long-term interaction relationship exists between housing prices and market concerns for policy(MCP);(2)market concerns for restrictive policy and administrative supervision policy effectively restrain rising housing prices while those for monetary and fiscal policy have the opposite effect.The results could serve as a useful reference for governments aiming to stabilize their real estate markets. | Wenwen Zhou Mengyao Chen Yang Gao Ruilin Feng | 2022 | Computer Modeling in Engineering & Sciences2022，，6： | 0 |
| 13 | Room-temperature tracking of chiral recognition process at the single-molecule level显示文摘酞毒(Pc ) 的一个 chiral 识别过程的分子水平的鉴定被扫描通道显微镜学(STM ) 在 Cu (100 ) 表面上学习。STM 表明一个 chiral Pc 分子与另外的 Pc 分子形成一系列亚稳的更暗淡的配置。最后, Pc 分子与一样的 chirality 认出另一个 Pc 分子形成一种稳定的更暗淡的配置。Homochiral dimers 在 Cu 表面上被发现,表明 Pc dimerization 的 chiral 特性。为这个 chiral 识别过程的机制被识别,揭示 Cu 表面上的 chiral dimers 的特别吸附几何学的关键角色。 | Ruilin Xu Juan Liu Feng Chen Nianhua Liu Yingxiang Cai Xiaoqing Liu Xin Song Mingdong Dong Li Wang | 2015 | Nano Research2015，8，11： | 0 |
| 14 | Learning discriminative and invariant representation for fingerprint retrieval显示文摘Dear editor,Fingerprints are widely used in civil and forensic recognition systems owing to their uniqueness and immutability.However,the size of a modern gallery database has exceeded billions hitherto.It is challenging to identify a query fingerprint against a large-scale database. | Dehua SONG Ruilin LI Fandong ZHANG Jufu FENG | 2019 | Science China(Information Sciences)2019，62，1： | 0 |
| 15 | Achieving macroscale superlubricity with ultra-short running-in period by using polyethylene glycol-tannic acid complex green lubricant显示文摘Superlubricating materials can greatly reduce the energy consumed and economic losses by unnecessary friction.However,a long pre-running-in period is indispensable for achieving superlubricity;this leads to severe wear on the surface of friction pairs and has become one of the important factors in the wear of superlubricating materials.In this study,a polyethylene glycol-tannic acid complex green liquid lubricant(PEG10000-TA)was designed to achieve macroscale superlubricity with an ultrashort running-in period of 9 s under a contact pressure of up to 410 MPa,and the wear rate was only 1.19×10^(–8)mm^(3)·N^(−1)·m^(−1).This is the shortest running-in time required to achieve superlubricity in Si_(3)N_(4)/glass(SiO_(2)).The results show that the strong hydrogen bonds between PEG and TA molecules can significantly reduce the time required for the tribochemical reaction,allowing the lubricating material to reach the state of superlubrication rapidly.Furthermore,the strong hydrogen bond can share a large load while fixing free water molecules in the contact zone to reduce shear interaction.These findings will help advance the use of liquid superlubricity technology in industrial and biomedical. | Changhe DU Tongtong YU Zishuai WU Liqiang ZHANG Ruilin SHEN Xiaojuan LI Min FENG Yange FENG Daoai WANG | 2023 | Friction2023，11，5： | 0 |
| 16 | Investigation of electrode and hydrogen induced crack in welded joint of dissimilar steel显示文摘The welded joint of dissimilar heat-resisting steels 20Crl2MoV(F12)and 12 Cr2MoWVTiB(102)generally works around 600°C.In this paperthree kinds of ferritic electrodes are used for testing.They are R817 high-strength electrode(CrllMoVNi),R347 low-strength electrode(Cr2MoVWB)and newly-developed R507MoNb medium-strength electrode.The study on theinfluence of those three different electrodes on carbon migration,HIC and hy-drogen diffusion shows that medium-strength electrodes can well control thecarbon migration,and that the tendency to HIC in the joint formed by R817 issmaller than that by R347 instead.Considering the effect of weld metal transfor-mation on the restraint stress and hydrogen concentration of a joint,the hydro-gen distribution in the heat-affected zone(HAZ)is calculated by using finite ele-ment method(FEM)with stress and strain changing,and so the effect of thetransformation behaviour on HIC is revealed.In addition,newly-developedR507MoNb electrodes,tested the elevated-temperature property,oxidation re-sistance and creep rupture strength,have fulfilled the technical standards con-cerned and passed the examination of on-the-spot operation. | Zhang Zhiming Lu Daohua Li Zhonglin Harbin Institute of Technology Feng Qiting Peng Chuanliou Heilongjiang Electric Power Electrode Manufacturer,Harbin Wang Ruilin Northeast Electric Power Test Institute,Shenyang | 1992 | China Welding1992，2，2： | 0 |
| 17 | Polymorphism Analysis of RXFP2 in Different Sheep Breeds from Qinghai-Tibet Plateau of China显示文摘Relaxin/insulin-like family peptide receptor 2(RXFP2) is a robust candidate gene related to horn types in sheep.A series of independent genome-wide association studies have reported that RXFP2 underlies the existence and lack of horns.In this study,High-Resolution Melting(HRM) analysis and DNA sequencing were employed to detect the polymorphism of RXFP2 gene in three sheep breeds from Qinghai-Tibet Plateau of China(Tibetan sheep,Qinghai fine wool sheep and Alpine Merino sheep) and to determine the impacts of genotypes of RXFP2 on expression of horn phenotypes.The results showed that one single nucleotide polymorphism(SNP) was identified as RXFP 2SNP c.29389966 A > G.The frequency of genotype AA in Alpine Merino ram(polled) was significantly higher than that in Tibetan ram(horned) and Qinghai fine wool ram(horned) [x^2(1,N = 421) = 72.25,P < 0.001;x^2(1,N = 402) = 4.28,P < 0.005) ];the frequency of genotype AA in Qinghai fine wool ewe(polled) was also much higher than that in Qinghai fine wool ewe(horned) and Tibetan ewe(horned) [x^2(1,N = 196) = 42.04,P < 0.001;x^2(1,N = 192) = 24.69,P < 0.005) ].This mutation could potentially be exploited in marker-assisted selection(MAS) programs within sheep industry to breed horned or polled animals. | Megersa Ashenafi GETACHEW Tingting GUO Chao YUAN Jianbin LIU Jian GUO Ruilin FENG Chun'e NIU Xiaoping SUN Yaojing YUE Bohui YANG | 2016 | Agricultural Biotechnology2016，5，2： | 0 |
| 18 | Pusher:an augmented fuzzer based on the connection between input and comparison operand显示文摘Coverage based fuzzing is a widespread vulnerability detection technique,and it has exposed many bugs in many real-world programs.However,its attention is to eliminate the testing on the repeated paths,yet it still employs random mutation to generate inputs,which is blind to penetrate complex comparisons in the program.As a result,the testing coverage is limited.Despite some solution proposals are presented,this problem is still partially solved.This paper argues that random mutation is mainly limited by two challenges,the sizable search space and the lack of a useful feedback to direct the search.Then we present an augmented fuzzing technique by addressing these two challenges.First of all,we point out a black relationship between input contents and comparison operands,which is dubbed connection.Second,we present a novel method to collect the comparison operands during execution,which is leveraged to infer the connections.Based on the connections,the fuzzer can learn about which input byte affects on which comparison instruction to establish a smaller search space.Third,the connection provides a useful feedback to direct the search.We resort to a modern metaheuristic algorithm to satisfy this searching requirement.We developed a prototype Pusher and evaluated its performance on several benchmarks and four real-world programs.The experimental results demonstrate that Pusher works better than some other state-of-the-art fuzzers on bug detection,and can achieve a higher testing coverage.Moreover,we take a detailed statistic about the execution overhead in Pusher,and the results indicate that the execution overhead introduced by our approach is within an acceptable scope. | Bin Zhang Jiaxi Ye Ruilin Li Chao Feng Yunfei Su Chaojing Tang | 2022 | Frontiers of Computer Science2022，16，4： | 0 |
| 19 | FClassNet: a fingerprint classification network integrated with the domain knowledge显示文摘Dear editor,Ever since fingerprints were initially used as evidence in criminal proceedings in 1892,the automated fingerprint identification system has been used in a variety of contexts[1].The fingerprint classification techniques can be used to accelerate the procedure by only comparing the query fingerprint with those that have been labeled with the same class in the database.In particular,fingerprints are divided into four classes according to the Galton-Henry classification scheme[2]as Arch(Tented Arch),Left Loop,Right Loop,and Whorl.Fingerprint classification is still considered to be challenging because of the high intraclass variability and low interclass variability.Furthermore,the presence of complex noise in low-quality fingerprints,especially latent fingerprints,increases the difficulty in this task. | Yao TANG Ruilin LI Yuhang LIU Jufu FENG | 2019 | Science China(Information Sciences)2019，62，12： | 0 |
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