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| 1 | Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating ΔNp63 expression in Asherman's syndrome显示文摘Asherman's syndrome(AS) is a common disease that presents endometrial regeneration disorder. However, little is known about its molecular features of this aregenerative endometrium in AS and how to reconstruct the functioning endometrium for the patients with AS. Here, we report that ΔNp63 is significantly upregulated in residual epithelial cells of the impaired endometrium in AS; the upregulated-ΔNp63 induces endometrial quiescence and alteration of stemness. Importantly, we demonstrate that engrafting high density of autologous bone marrow mononuclear cells(BMNCs) loaded in collagen scaffold onto the uterine lining of patients with AS downregulates ΔNp63 expression, reverses ΔNp63-induced pathological changes, normalizes the stemness alterations and restores endometrial regeneration. Finally, five patients achieved successful pregnancies and live births. Therefore, we conclude that ΔNp63 is a crucial therapeutic target for AS. This novel treatment significantly improves the outcome for the patients with severe AS. | Guangfeng Zhao Yun Cao Xianghong Zhu Xiaoqiu Tang Lijun Ding Haixiang Sun Juan Li Xinan Li Chenyan Dai Tong Ru Hui Zhu Jingjie Lu Caimei Lin Jingmei Wang Guijun Yan Huiyan Wang Lei Wang Yimin Dai Bin Wang Ruotian Li Jianwu Dai Yan Zhou Yali Hu | 2017 | Science China(Life Sciences)2017，60，4： | 39 |
| 2 | Plant pleiotropic drug resistance transporters:Transport mechanism, gene expression,and function显示文摘Pleiotropic drug resistance(PDR) transporters belonging to the ABCG subfamily of ATP-binding cassette(ABC)transporters are identified only in fungi and plants. Members of this family are expressed in plants in response to various biotic and abiotic stresses and transport a diverse array of molecules across membranes. Although their detailed transport mechanism is largely unknown, they play important roles in detoxification processes, preventing water loss, transport of phytohormones,and secondary metabolites. This review provides insights into transport mechanisms of plant PDR transporters, their expression profiles, and multitude functions in plants. | Mohammed Nuruzzaman Ru Zhang Hong-Zhe Cao Zhi-Yong Luo | 2014 | Journal of Integrative Plant Biology2014，56，8： | 15 |
| 3 | Integration of micro-supercapacitors with triboelectric nanogenerators for a flexible self-charging power unit显示文摘便携式、便携的电子设备的快速的发展为灵活、有效的精力收获和存储单位增加了需求。通常,这些作为分离部件独立被造并且使用。此处,我们建议雕刻的简单、划算的激光为制作一个灵活自我控告的 micro-supercapacitor 力量单位(SCMPU ) 的技术,由集成摩擦电, nanogenerator (TENG ) 和 micro-supercapacitor (MSC ) 穿进一台单个设备。SCMPU 能被周围的机械运动直接控告。我们表明 SCMPU 的能力连续地驱动轻射出的二极管和商业温湿计。这调查可以支持持续自我动力的系统的开发并且为 supercapacitors 提供一个有希望的新研究应用程序。 | Jianjun Luo Feng Ru Fan Tao Jiang Zhiwei Wang Wei Tang Cuiping Zhang Mengmeng Liu Guozhong Cao Zhong Lin Wang | 2015 | Nano Research2015，8，12： | 14 |
| 4 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders:executive summary and 2019 update of the management of high-risk population显示文摘Aim Cerebrovascular disease is the leading cause of death and disability in China,causing a huge burden among patients and their families.Hence,stroke prevention is critical,especially in the high-risk population.Here,we present the evidence-based guideline suitable for the Chinese population.Methods Literature search of PubMed and Cochrane library(from January 1964 to June 2019)was done.After thorough discussion among the writing group members,recommendations were listed and summarised.This guideline was reviewed and discussed by the fellow writing committees of the Chinese Stroke Association’s Stroke.Results This evidence-based guideline was written in three parts:controlling the risk factors of stroke,utilisation of antiplatelet agents and assessing the risks of first-ever stroke.All recommendations were listed along with the recommending classes and levels of evidence.Conclusions This guideline provides recommendations for primary prevention of cerebrovascular disease among high-risk population in China.Controlling related risk factors,appropriately using antiplatelet agents,assessing the risk of developing first-ever stroke should help reduce the rate of cerebrovascular disease in China. | Yilong Wang Shangrong Han Haiqiang Qin Huaguang Zheng Bin Jiang Yong Cao Yuan Gao Ling Guan Qian Jia Yong Jiang Yuming Jiao Shuya Li Yapeng Li Zixiao Li Wei Liu Xiaojuan Ru Dongling Sun Haixin Sun Penglian Wang Tingting Wang Lixia Zong Lei Guo Xuewei Xie Yuming Xu Yuyuan Xu Xiaomeng Yang Yingying Yang Mengyuan Zhou Wenzhi Wang Chinese Stroke Association Stroke Council Guideline Writing Committee | 2020 | Stroke & Vascular Neurology2020，5，3： | 11 |
| 5 | Guidelines for the diagnosis and treatment of chronic pancreatitis in China(2018 edition)显示文摘Chronic pancreatitis(CP)is a progressive inflammatory disease of pancreas that alters the organ’s normal structure and functions.CP seriously affects the quality of life of patients and greatly increases the public medical burden of society.In recent years,the incidence of CP has increased worldwide.The concepts of etiology and therapies have been continuously updated. | Wen-Bin Zou Nan Ru Hao Wu Liang-Hao Hu Xu Ren Gang Jin Zheng Wang Yi-Qi Du Ya-Nan Cao Lei Zhang Xiao-Yan Chang Rong-Chun Zhang Xiao-Bin Li Yan Shen Peng Li Zhao-Shen Li Zhuan Liao Pancreatitis Group of Chinese Medical Doctor Association | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，2： | 6 |
| 6 | Au nanoclusters suppress chronic lymphocytic leukaemia cells by inhibiting thioredoxin reductase 1 to induce intracellular oxidative stress and apoptosis显示文摘Chronic lymphocytic leukaemia(CLL) is a rare blood cancer that always relapses as refractory disease and eventually leads to death. To date, therapeutic options for CLL patients are scarce and there is an urgent need to develop novel chemotherapeutics that are both effective and safe. Gold-containing compounds induce a lethal oxidative and endoplasmic reticulum stress response in cultured and primary CLL cells via inhibition of thioredoxin reductase(TrxR). However, traditional gold-containing medicines have revealed side effects during clinical applications. Therefore, safer gold-containing drugs are needed to overcome this challenge. In this study, a novel peptide templated gold cluster Au_(25)Sv_9 was synthesized and its therapeutic effect on CLL cells was evaluated. This nanocluster could induce cell apoptosis in MEC-1 cells in a dose-dependent manner which correlated with the uptake amount of clusters in cells.As expected, increasing intracellular reactive oxidative species(ROS) in MEC-1 cells was exhibited with the increase of cluster dosage. Further analyses demonstrated the underlying mechanism that the nanoclusters suppress the activity of TrxR1, increase the level of intracellular ROS, destroy the mitochondrial membrane potential and finally trigger the mitochondrial apoptotic pathway in MEC-1 cells.Furthermore, the direct interaction between Au_(25)Sv_9 clusters and TrxR1 was confirmed for the first time by isothermal titration calorimetry. These findings explored the preclinical efficacy and potential mechanism of gold clusters in CLL therapy and provided a fundamental reference for the development of other novel gold-containing chemotherapeutics to treat CLL. | Qiong Li Qing Yuan Mohan Zhao Yawen Yao Liang Gao Ru Liu Yaling Wang Yong Gong Fuping Gao Xueyun Cao | 2017 | Science Bulletin2017，62，8： | 5 |
| 7 | Atomic-scale observation of a two-stage oxidation process in Cu2O显示文摘Cu 2 O nanocrystallines (NC ) 直接被观察由在 situ 高分辨率的传播电子显微镜学。一个二阶段的氧化过程被观察:(1 ) 起始的氧化阶段被 Cu 2 经由稳固固体的转变的 O NC,导致一个新中间的 CuO x 阶段的形成。CuO x 阶段的可能的水晶结构被讨论。(2 ) 随后, CuO x 被 layer-by-layer 氧化转变成 CuO。这些结果将在理解铜氧化物的氧化机制帮助并且为改进他们的结构的差异并且利用他们的潜在的工业应用铺平道路。 | Huihui Liu He Zheng Lei Li Huaping Sheng Shuangfeng Jia Fan Cao Xi Liu Boyun Chen Ru Xing Dongshan Zhao Jianbo Wang | 2017 | Nano Research2017，10，7： | 4 |
| 8 | Microinjection of resveratrol into rostral ventrolateral medulla decreases sympathetic vasomotor tone through nitric oxide and intracellular Ca^2+ in anesthetized male rats^1显示文摘瞄准:在血压(BP ) 的中央规定上定义 resveratrol (物件) 的效果,心率(HR ) ,和肾的同情的神经活动(RSNA ) 。方法:物件是微的注入了喙的 ventrolateral 髓质(RVLM ) ,并且 BP, HR,和 RSNA 在 anesthetized 老鼠同时被记录。结果:物件的微注射(20, 40,和 80 μmol/L, 0.2 μL ) 进 RVLM,剂量依赖地减少了 BP, HR 和 RSNA。有反雌激素 tamoxifen 的预告的处理(100 μmol/L, 0.2 μL ) 没影响物件的效果。有 N G -nitro-L-arginine 甲基酉旨(100 μmol/L, 0.2 μL ) ,氮的氧化物的一个禁止者(没有) synthase,能完全废除物件的效果。海湾 K8644 的优先的微注射(500 nmol/L, 0.2 μL ) ,钙隧道的收缩筋,能也废除物件的效果。酷氨酸磷酸酶的一个有势力禁止者的优先的管理,钠 orthovanadate (1 mmol/L, 0.2 μL ) ,能部分稀释物件的禁止的效果。结论:结果建议进 RVLM 的物件的微注射禁止 BP, HR,和 RSNA。效果可以被没有合成和减少在 Ca 2+ 流入,在蛋白质,酷氨酸 kinase 涉及调停。 | Hui-juan MA Ya-kun CAO Yi-xian LIU Ru WANG Yu-ming WU | 2008 | Acta Pharmacologica Sinica2008，29，8： | 4 |
| 9 | Efficient nonlocal two-step entanglement concentration protocol for three-level atoms in an arbitrary less-entangled W state using cavity input-output process显示文摘We present an efficient two-step entanglement concentration protocol(ECP)for three-level atoms trapped in one-sided optical micro-cavities in an arbitrary three-particle less-entangled W state,using the coherent state input-output process in low-Q cavity quantum electrodynamics system.In each step of the new proposed protocol,one of the three remote users prepares the auxiliary coherent optical pulses to perform cavity input-output process and then utilizes the standard homodyne measurement to discriminate the final outgoing coherent states.When both of the two steps are successful,remote parties can deterministically concentrate the less-entangled W state atoms to a standard maximally entangled W state.Compared with previous ECPs for W state,this protocol has some advantages and can be widely used in current quantum repeater and some quantum information processing tasks. | ZHANG Ru ZHOU SuHua CAO Cong | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 3 |
| 10 | Concentrating partially entangledW-class states on nonlocal atoms using low-Q optical cavity and linear optical elements显示文摘Entanglement plays an important role in quantum information science, especially in quantum communications. Here we present an efficient entanglement concentration protocol(ECP) for nonlocal atom systems in the partially entangled W-class states, using the single-photon input-output process regarding low-Q cavity and linear optical elements. Compared with previously published ECPs for the concentration of non-maximally entangled atomic states, our protocol is much simpler and more efficient as it employs the Faraday rotation in cavity quantum electrodynamics(QED) and the parameter-splitting method. The Faraday rotation requires the cavity with low-Q factor and weak coupling to the atom, which makes the requirement for entanglement concentration much less stringent than the previous methods, and achievable with current cavity QED techniques. The parameter-splitting method resorts to linear-optical elements only. This ECP has high efficiency and fidelity in realistic experiments, and some imperfections during the experiment can be avoided efficiently with currently available techniques. | Cong Cao Xi Chen YuWen Duan Ling Fan Ru Zhang TieJunWang Chuan Wang | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，10： | 3 |
| 11 | First total synthesis of a naturally occurring nucleoside disulfide:9-(5'-Deoxy-5'-thio-β-D-xylofuranosyl)adenine disulfide显示文摘A naturally occurring nucleoside disulfide,9-(5'-deoxy-5'-thio-β-D-xylofuranosyl)adenine disulfide,was first synthesized from D-xylose over 7 steps in 20%overall yield.The key step involved Vorbriiggen glycosylation of silylated N^6-benzoyladenine with xylose diacetate moiety. | Hai Xin Ding Ling Cui Da Ru Chun Yang Ban Peng Cao Qi Sun Qiang Xiao | 2012 | Chinese Chemical Letters2012，23，9： | 2 |
| 12 | High-performance lithium-sulfur battery based on porous N-rich g-C_(3)N_(4) nan-otubes via a self-template method显示文摘The commercial development of lithium-sulfur batteries(Li-S)is severely limited by the shuttle effect of lithium polysulfides(LPSs)and the non-conductivity of sulfur.Herein,porous g-C_(3)N_(4) nanotubes(PCNNTs)are synthesized via a self-template method and utilized as an efficient sulfur host material.The one-dimensional PCNNTs have a high specific surface area(143.47 m^(2)·g^(-1))and an abundance of macro-/mesopores,which could achieve a high sulfur loading rate of 74.7wt%.A Li-S battery bearing the PCNNTs/S composite as a cathode displays a low capacity decay of 0.021% per cycle over 800 cycles at 0.5 C with an initial capacity of 704.8 mAh·g^(-1).PCNNTs with a tubular structure could alleviate the volume expansion caused by sulfur and lithium sulfide during charge/discharge cycling.High N contents could greatly enhance the adsorption capacity of the carbon nitride for LPSs.These synergistic effects contribute to the excellent cycling stability and rate performance of the PCNNTs/S composite electrode. | Meng-rong Wu Ming-yue Gao Shu-ya Zhang Ru Yang Yong-ming Chen Shang-qing Sun Jin-feng Xie Xing-mei Guo Fu Cao Jun-hao Zhang | 2021 | International Journal of Minerals,Metallurgy and Materials2021，28，10： | 2 |
| 13 | Characterization of organo-montmorillonite (OMMT) modified wood flour and properties of its composites with poly(lactic acid)显示文摘 | Ru Liu Shupin Luo Jinzhen Cao Yao Peng | 2013 | Composites Part A2013，，： | 2 |
| 14 | EMC10 governs male fertility via maintaining sperm ion balance显示文摘Infertility is a severe public health problem worldwide that prevails up to 15% in reproductive-age couples,and male infertility accounts for half of total infertility.Studies on genetically modified animal models have identifed lots of genes involved in the pathogenesis of male infertility.The underlying causes,however,remain largely unclear.In this study,we provide evidence that EMCIO,one subunit of endoplasmic reticulum (ER)membrane protein complex (EMC),is required for male fertility.EMC10 is significantly decreased in spermatozoa from patients with asthenozoospermia and positively associated with human sperm motility. Male mice lacking Emc10 gene are completely sterile.Emc10-null spermatozoa exhibit multiple defects including abnormal morphology,decreased motility,impaired capacitation,and impotency of acrosome reaction,thereby which are incapable of fertilizing intact or ZP-free oocytes.However,intracytoplasmic sperm injection could rescue this defect caused by EMC10 deletion. Mechanistically,EMC10 deficiency leads to inactivation of Na/K-ATPase,in turn giving rise to an increased level of intraceltutar Na^+ in spermatozoa,which contributes to decreased sperm motility and abnormal morphology.Other mechanistic investigations demonstrate that the absence of EMC10 results in a reduction of HCO3^- entry and subsequent decreases of both cAMP-dependent protein kinase A substrate phosphorylation and protein tyrosine phosphorytation.These data demonstrate that EMC10 is indispensable to mate fertility via maintaining sperm ion balance of Na^+ and HCO3^-,and also suggest that EMC10 is a promising biomarker for male fertility and a potential pharmaceutical target to treat male infertility. | Yuchuan Zhou Fei Wu Man Zhang Zuquan Xiong Qianqian Yin Yanfei Ru Huijuan Shi Jinsong Li Shanhua Mao Yanliang Li Xinyi Cao Renming Hu Chong Wee Liew Qiang Ding Xuanchun Wang Yonglian Zhang | 2018 | Journal of Molecular Cell Biology2018，10，6： | 2 |
| 15 | Relative dynamics and initialization condition of spacecraft formations in eccentric orbits 显示文摘 | FANG RU ZHANG SHIJIE CAO XIBIN | 2006 | Aircraft Engineering and Aerospace Technology: An International Journal2006，78，6： | 1 |
| 16 | Structure of a Bmi-1-Ringl B Polycomb Group Ubiquitin Ligase Complex显示文摘 | Ru Cao Ming Wang | 2006 | J Biological Chemistry2006，281，20： | 1 |
| 17 | Antidiabetic effect of Oenanthe javanic flavone 显示文摘 | Yang Xin - bo Huang Zheng - ruing Cao Wen - bin Zheng ming Cheng Hong -yan Zhang Jing - zhen | 2000 | Acta Pharmacology Sinica2000，21，3： | 1 |
| 18 | The strategy of energy- relied carbon emismison reduction in Shanghai 显示文摘 | Guo Ru Cao Xisojing Yang Xinyu Li Yankuan Jiang Dahe Li Feengting | 2010 | Energy Policy2010，38，1： | 1 |
| 19 | The strategy of energy-related carbon emission reduction in Shanghai显示文摘 | Guo Ru Cao Xiaojing Yang Xinyu Li Yankuan Jiang Dahe Li Fengting | 2010 | Energy Policy2010，，38： | 1 |
| 20 | Association between C1019T polymorphism of the connexin37 gene and coronaryheart disease in patients with in?stent restenosis显示文摘 | Su?Xia Guo Zhen?Yu Yang Ru?Xing Wang Ying Yang Hua?Ming Cao Tao Zhang | 2013 | Experimental and Therapeutic Medicine2013，，： | 1 |
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