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| 1 | Molecular basis of von Hippel-Lindau syndrome in Chinese patients显示文摘背景 Von Hippel-Lindau ( VHL )症候群是预先安排的正染色体的主导的家庭癌症症候群影响个人到在用南部的汉语的 VHL 的基因基础大部分是的各种各样的 organs.The 的多重瘤 unknown.In 这研究,我们在九无关的南部的中国 families.Methods 描绘了 VHL 的变化光谱有 VHL 的临床的特征的九 probands ,二征兆并且八个无征状的家庭成员在这 study.Prenatal | SIU Wai-kwan MA Ronald Ching-wan LAM Ching-wan MAK Chloe Miu YUEN Yuet-ping LO Fai-man Ivan CHAN Kin-wan LAM Siu-fung LING Siu-cheung TONG Sui-fan SO Wing-yee CHOW Chun-chung TANG Mary Hoi-yin TAM wing-hung CHAN Albert Yan-wo | 2011 | Chinese Medical Journal2011，，2： | 6 |
| 2 | A GLP-1 analog lowers ER stress and enhances protein folding to ameliorate homocysteine-induced endothelial dysfunction显示文摘Hyperhomocysteinemia(HHcy)is an independent risk factor for cardiovascular diseases and increases mortality in type 2 diabetic patients.HHcy induces endoplasmic reticulum(ER)stress and oxidative stress to impair endothelial function.The glucagon-like peptide 1(GLP-1)analog exendin-4 attenuates endothelial ER stress,but the detailed vasoprotective mechanism remains elusive.The present study investigated the beneficial effects of exendin-4 against HHcy-induced endothelial dysfunction.Exendin-4 pretreatment reversed homocysteine-induced impairment of endothelium-dependent relaxations in C57BL/6 mouse aortae ex vivo.Four weeks subcutaneous injection of exendin-4 restored the impaired endothelial function in both aortae and mesenteric arteries isolated from mice with diet-induced HHcy.Exendin-4 treatment lowered superoxide anion accumulation in the mouse aortae both ex vivo and in vivo.Exendin-4 decreased the expression of ER stress markers(e.g.,ATF4,spliced XBP1,and phosphorylated eIF2α)in human umbilical vein endothelial cells(HUVECs),and this change was reversed by cotreatment with compound C(CC)(AMPK inhibitor).Exendin-4 induced phosphorylation of AMPK and endothelial nitric oxide synthase in HUVECs and arteries.Exendin-4 increased the expression of endoplasmic reticulum oxidoreductase(ERO1α),an important ER chaperone in endothelial cells,and this effect was mediated by AMPK activation.Experiments using siRNA-mediated knockdown or adenoviral overexpression revealed that ERO1αmediated the inhibitory effects of exendin-4 on ER stress and superoxide anion production,thus ameliorating HHcy-induced endothelial dysfunction.The present results demonstrate that exendin-4 reduces HHcy-induced ER stress and improves endothelial function through AMPK-dependent ERO1αupregulation in endothelial cells and arteries.AMPK activation promotes the protein folding machinery in endothelial cells to suppress ER stress. | Chak Kwong Cheng Jiang-Yun Luo Chi Wai Lau William Chi-shing Cho Chi Fai Ng Ronald Ching Wan Ma Xiao Yu Tian Yu Huang | 2021 | Acta Pharmacologica Sinica2021，42，10： | 6 |
| 3 | Long-term outcome of patients of over 85 years old with acute coronary syndrome undergoing percutaneous coronary stenting: a comparison of bare metal stent and drug eluting stent显示文摘超过 85 年的背景病人在经皮的冠的干预(一种总线标准) 是未被充分代表的尽管有为一种总线标准的工作分派的增加的试用。在有急性冠的症候群(交流) 的超过 85 年的病人的经皮的冠的 stenting 的长期的安全和功效仍然保持不清楚。而且是否在这特殊 population.Methods 赤裸的金属 stent (BMS ) 和药 eluting stent (DES ) 之间有差别,是未知的,有交流的 80 个病人的一个总数在经历 stenting (BMS 组 n=21 对 DES 组 n=59 ) 的 85 年变老回顾地被学习。在里面医院,一年和包括心脏的死亡的主要不利心脏的事件(权标)的全面临床的后续( 12-36 月),心肌的梗塞,目标损害 revascularization ( TLR )和象击并且另外的主要流血一样的目标容器 revascularization ( TVR )在全部队在二 groups.Results 之间被比较,过程成功率与在93.8%容器一种总线标准以后的 TIMI-3 冠的流动是93.8%,过程联系了复杂并发症是17.5%。在 BMS 组的在里面医院权标的发生更高(14.3% 对 6.8% , P=0.30 ) 。当在 BMS 组没有向时,在 DES 组的权标的 1 年的发生是 7.0% 。为 12-36 月的临床的后续证明从向免费的全面幸存是 82.9% ,在 BMS 组的向的发生更低(5.3% 对 21.1% , P=0.20 ) 。Multivariate 回归分析证明 creatinine 铺平(OR:1.013;95%C1:1.006-1.020;P=0.004 ) 并且高血压(OR:3.201;95%C1:1.000-10.663; P=0.04 ) 是二个主要因素影响在超过 85 年的病人的长期的 MACE.Conclusions 经皮的冠的 stenting 是安全的并且提供好短、长期的功效。有肾的机能障碍和高血压的病人可以有向的相对高的发生。 | MA Han-ying ZHOU Yu-jie Ronald J Dick SHI Dong-mei LIU Yu-yang CHENG Wan-jun GUO Yong-he WANG Jian-long GE Hai-long | 2008 | Chinese Medical Journal2008，，10： | 5 |
| 4 | Transrectal microwave thermotherapy causing a short-time influence on sperm quality in Chinese chronic nonbacterial prostatitis patients显示文摘长期的前列腺炎能影响精子质量。以前的研究证明了 transrectal 微波 thermotherapy (TRMT ) 在精子上与长期的前列腺炎,而是效果在病人导致征兆的地势小心地没被调查。当过去常与长期的 nonbacterial 前列腺炎对待病人时,这研究在症状的消除和精子的质量上评估 TRMT 的影响。六十个病人在学习被注册。TRMT 治疗在 5 天被管理, 1 h 每天。精液检查被执行预告的处理并且立即在 5 天的治疗的结论。另外,它被重复 1 个月, 3 个月,和 6 个月以后。治疗症状消除功效用健康长期的前列腺炎症状索引(NIH-CPSI ) 的国家研究所被评估。在治疗以后,全面 NIH-CPSI 分数与预告的处理的那些相比是更低的。另外,在表示 prostatic 分泌物的白血房间和卵磷脂在治疗以后是正常的。精子计数在治疗以后到 23.8% 3 个月被减少,精子活动性被 10.3% 在治疗以后立即减少,并且精子畸形被 17.2% 增加。精子体积和 PH 没被影响。然而,在治疗和畸形性率在在治疗以后的 6 个月也是更低的以后,精子质量恢复了。TRMT 是为有 nonbacterial 的病人的一种有利、安全的治疗选择长期的前列腺炎。它能在精子质量上减轻病人症状和影响在短期。 | Jia-Xin Jin Han-Zhang Wang Zheng-Xing Zhai Bao-Liang Ma Qin-Fang Li Nan Xiao Zhi-Ping Wang Ronald Rodriguez | 2017 | Asian Journal of Andrology2017，19，5： | 3 |
| 5 | Mechanical properties of Nylon bonded Nd-Fe-B permanent magnets显示文摘 | Monika G G Albert J S Ma B M Edgar L C Ronald O S | 2003 | Journal of Magnetism and Magnetic Materials2003，257，： | 1 |
| 6 | Update in infections diseases显示文摘 | Ronald AR | 2004 | AM Inter Med2004，140，： | 1 |
| 7 | Are we headed for resurgence of the HIV epidemic among men who have sex with men显示文摘 | Richard J Wolitiski MA Ronald O Valdiserri | 2001 | Am J Public Health2001，91，： | 1 |
| 8 | GWAS-identified colorectal cancer susceptibility locus associates with disease prognosis显示文摘 | Jinliang Xing Ronald E. Myers Xianli He Falin Qu Feng Zhou Xi Ma Terry Hyslop Guoqiang Bao Shaogui Wan Hushan Yang Zhinan Chen | 2011 | European Journal of Cancer2011，，11： | 1 |
| 9 | Causes of type 2 diabetes in China显示文摘 | Ronald Ching Wan Ma Xu Lin Weiping Jia | 2014 | The Lancet Diabetes & Endocrinology2014，，12： | 1 |
| 10 | Diabetes in Asia显示文摘 | Ambady Ramachandran Ronald Ching Wan Ma Chamukuttan Snehalatha | 2010 | The Lancet2010，，9712： | 1 |
| 11 | Overbased Calcium Sulfonate Detergent Technology Overview显示文摘Overbased calcium sulfonate is used widely as detergent in automotive and marine lubricants,as well as various industrial oil applications.In this paper,the process to produce overbased calcium sulfonate is overviewed.The sulfonate structure and molecular weight and its molecular weight distribution,the enclosed calcium carbonate nanoparticle size and crystalline structure,properties of the carrier oil,all influence its properties,such as stability,viscosity,and detergency of the system. | MA Qing -gao MUIR Ronald J. | 2009 | 润滑油2009，24，2： | 1 |
| 12 | Goodwill-an Example of Puzzle-solving in Accounting显示文摘 | Ma Ronald Roger Hopkins | 1988 | Abacus1988，24，1： | 1 |
| 13 | Scientific collaboration in China as reflected in co-authorship显示文摘 | Yan Wang Yishan Wu Yuntao Pan Zheng Ma Ronald Rousseau | 2005 | Scientometrics2005，，2： | 1 |
| 14 | Type 2 diabetes in East Asians: similarities and differences with populations in Europe and the United States显示文摘 | Ronald C.W. Ma Juliana C.N. Chan | 2013 | Annals of the New York Academy of Sciences2013，，1： | 1 |
| 15 | Update in infectious diseases显示文摘 | Sande MA Ronald AR | 2004 | AM Inter Med2004，140，4： | 1 |
| 16 | Production of monoclaonal antibodies to the mycotoxins fumonisins B1, B2, B3 显示文摘 | Juan IA Mohamed MA Ronald DP | 1992 | J Agric Food Chem1992，40，： | 1 |
| 17 | Mild renal insufficiency is associated with increased cardiovascular mortality:the hoorn study显示文摘 | Ronald MA Henry RM Pite Y | 2002 | Kidney Int2002，62，4： | 1 |
| 18 | Increased central artery stiffness in impaired glucose metabolism and type 2 diabetes显示文摘 | Miranda T Ronald MA Rob AJM | 2004 | Hypertension2004，43，2： | 1 |
| 19 | Use of sulphonylurea and cancer in type 2 diabetes—The Hong Kong Diabetes Registry显示文摘 | Xilin Yang Wing Yee So Ronald C.W. Ma Linda W.Y. Yu Gary T.C. Ko Alice P.S. Kong Vanessa W.S. Ng Andrea O.Y. Luk Risa Ozaki Peter C.Y. Tong Chun-Chung Chow Juliana C.N. Chan | 2010 | Diabetes Research and Clinical Practice2010，，3： | 1 |
| 20 | Engineering pathogen resistance in crop plants 显示文摘 | Campbell MA Fitzgerald HA Ronald PC | 2002 | Transgenic Res2002，11，6： | 1 |
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