|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Subcurative radiation significantly increases cell proliferation, invasion, and migration of primary glioblastoma multiforme in vivo显示文摘Tumor cell proliferation, infiltration, migration, and neovascularization are known causes of treatment resistance in glioblastoma multiforme(GBM). The purpose of this study was to determine the effect of radiation on the growth characteristics of primary human GBM developed in a nude rat. Primary GBM cells grown from explanted GBM tissues were implanted orthotopically in nude rats. Tumor growth was confirmed by magnetic resonance imaging on day 77(baseline) after implantation. The rats underwent irradiation to a dose of 50 Gy delivered subcuratively on day 84 postimplantation(n = 8), or underwent no radiation(n = 8). Brain tissues were obtained on day 112(nonirradiated) or day 133(irradiated). Immunohistochemistry was performed to determine tumor cell proliferation(Ki-67) and to assess the expression of infiltration marker(matrix metalloproteinase-2, MMP-2) and cell migration marker(CD44). Tumor neovascularization was assessed by microvessel density using von-Willebrand factor(vWF) staining. Magnetic resonance imaging showed well-developed, infiltrative tumors in 11 weeks postimplantation. The proportion of Ki-67-positive cells in tumors undergoing radiation was(71 ± 15)% compared with(25 ± 12)% in the nonirradiated group(P = 0.02). The number of MMP-2-positive areas and proportion of CD44-positive cells were also high in tumors receiving radiation, indicating great invasion and infiltration. Microvessel density analysis did not show a significant difference between nonirradiated and irradiated tumors. Taken together, we found that subcurative radiation significantly increased proliferation, invasion, and migration of primary GBM. Our study provides insights into possible mechanisms of treatment resistance following radiation therapy for GBM. | Adarsh Shankar Sanath Kumar Asm Iskander Nadimpalli RS Varma Branislava Janic Ana deCarvalho Tom Mikkelsen Joseph A Frank Meser M Ali Robert A Knight Stephen Brown Ali S Arbab | 2014 | Chinese Journal of Cancer2014，33，3： | 5 |
| 2 | 显示文摘 | Tremblay JJ Robert NM and Viger RS | 2001 | Mol Endocrinol2001，15，9： | 1 |
| 3 | The North American Vasovagal Pacemaker Study:A randomized trial of permanent cardiac pacing for the prevention of vasovagal syncope显示文摘 | Connolly SJ Shedon RS Roberts RS | 1999 | J Am coll Cardiol1999，33，： | 1 |
| 4 | A critical examination of the immunophenotype of pulmonary sclerosing hemangioma显示文摘 | Jorge RS Thomas VC Robert VR | | 0，，： | 1 |
| 5 | Cardiac surgery-associated acute kidney injury: a comparison of two consensus criteria 显示文摘 | Robert AM Kramer RS Dacey LJ | 2010 | Ann Thorac Surg2010，90，： | 1 |
| 6 | Northern New England Cardiovascular Disease Study G:Cardiac surgery-associated acute kidney injury:a comparison of two consensus criteria显示文摘 | Robert AM Kramer RS Dacey LJ | 2010 | Ann Thorac Surg2010，90，6： | 1 |
| 7 | Caffeine for apnea of prematurity trial:benefits may vary in subgroups显示文摘 | Davis PG Schmidt B Roberts RS | 2010 | J Pediatr2010，156，3： | 1 |
| 8 | Aneurysmal Subarachnoid Hemorrhage 显示文摘 | Jose IS Robert WT Warren RS | 2006 | The New England Journal of Medicine2006，354，： | 1 |
| 9 | Canadian Implantable Defibrillator Study (CIDS):A randomized trial of the implantable cardioverter against amiodarone显示文摘 | Connolly SJ Gent M Roberts RS | 2000 | Circulation2000，101，： | 1 |
| 10 | Comparison of beta-blockers, amiodarone plus beta-blockers, or sotalol for prevention of shocks from implantable cardioverter defibrillators: the OPTIC Study: a randomized trial 显示文摘 | Connolly SJ Dorian P Roberts RS | 2006 | JAMA2006，295，2： | 1 |
| 11 | Long-term effects of caffeine therapy for apnea of prematurity显示文摘 | Schmidt B Roberts RS Davis P | 2007 | N Engl J Med2007，357，19： | 1 |
| 12 | Canadian implantable defibrillator study (CIDS): a randomized trial of the implantable cardioverter defibrillator against amiodarone 显示文摘 | Connolly SJ Gent M Roberts RS | 2000 | Circulation2000，101，： | 1 |
| 13 | Caffeine therapy for apnea of prematurity显示文摘 | Schmidt B Roberts RS Davis P | 2006 | N Engl J Med2006，354，20： | 1 |
| 14 | Long- term effects of caffeine therapy for apnea of prematurity 显示文摘 | Schmidt B Roberts RS Davis P | 2007 | Nengl J Meal2007，357，19： | 1 |
| 15 | Food allergen avoidance in the prevention of food allergy in infants and children显示文摘 | Robert S Zeiger RS | | 0，，06： | 1 |
| 16 | Caffeine for apnea of prematurity trial:benefits may vary in subgroups 显示文摘 | Davis PG Schmidt B Roberts RS | 2010 | J Pediatr2010，156，3： | 1 |
| 17 | Comparison of beta- blockers,amiodarone plus beta-blockers, or sotalol for prevention of shocks from implantable cardioverter defibrillators: the OPTIC Study : a randomized trial显示文摘 | Connolly S J Dorian P Roberts RS | 2006 | JAM A2006，295，2： | 1 |
| 18 | Comparison of beta-blockers,amiodarone plus beta-blockers,or sotalol for prevention of shocks from implantable cardioverter defibrillators:the OPTIC Study:a randomized trial显示文摘 | Dorian P Roberts RS | 2006 | JAMA2006，295，16： | 1 |
| 19 | The North American Vasovagal Pacemaker Study:a randomized trial of permanent cardiac pacing for the prevention of vasovagal syncope显示文摘 | Connolly SJ Sheldon RS Roberts RS | 1999 | J Am Coll Cardiol1999，33，： | 1 |
| 20 | Posterior chamber phakic intraocular leas hyperopia 显示文摘 | Donald RS Robert GM David CB | 1999 | J Refract Surg1999，15，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员