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| 1 | Subcurative radiation significantly increases cell proliferation, invasion, and migration of primary glioblastoma multiforme in vivo显示文摘Tumor cell proliferation, infiltration, migration, and neovascularization are known causes of treatment resistance in glioblastoma multiforme(GBM). The purpose of this study was to determine the effect of radiation on the growth characteristics of primary human GBM developed in a nude rat. Primary GBM cells grown from explanted GBM tissues were implanted orthotopically in nude rats. Tumor growth was confirmed by magnetic resonance imaging on day 77(baseline) after implantation. The rats underwent irradiation to a dose of 50 Gy delivered subcuratively on day 84 postimplantation(n = 8), or underwent no radiation(n = 8). Brain tissues were obtained on day 112(nonirradiated) or day 133(irradiated). Immunohistochemistry was performed to determine tumor cell proliferation(Ki-67) and to assess the expression of infiltration marker(matrix metalloproteinase-2, MMP-2) and cell migration marker(CD44). Tumor neovascularization was assessed by microvessel density using von-Willebrand factor(vWF) staining. Magnetic resonance imaging showed well-developed, infiltrative tumors in 11 weeks postimplantation. The proportion of Ki-67-positive cells in tumors undergoing radiation was(71 ± 15)% compared with(25 ± 12)% in the nonirradiated group(P = 0.02). The number of MMP-2-positive areas and proportion of CD44-positive cells were also high in tumors receiving radiation, indicating great invasion and infiltration. Microvessel density analysis did not show a significant difference between nonirradiated and irradiated tumors. Taken together, we found that subcurative radiation significantly increased proliferation, invasion, and migration of primary GBM. Our study provides insights into possible mechanisms of treatment resistance following radiation therapy for GBM. | Adarsh Shankar Sanath Kumar Asm Iskander Nadimpalli RS Varma Branislava Janic Ana deCarvalho Tom Mikkelsen Joseph A Frank Meser M Ali Robert A Knight Stephen Brown Ali S Arbab | 2014 | Chinese Journal of Cancer2014，33，3： | 5 |
| 2 | Processing and dry sliding wear performance of spray deposited hyper-eutectic aluminum–silicon alloys显示文摘 | Nadimpalli Raghukiran Ravi Kumar | 2013 | Journal of Materials Processing Tech2013，，3： | 2 |
| 3 | Genomic structures of viral agents in relation to the biosynthesis of selenoproteins 显示文摘 | Taylor E M Nadimpalli R G Ramanathan C S | 1997 | Biol Trace Elem Res1997，56，1： | 1 |
| 4 | Soil information system of Arunachal Pradesh in a GIS environment for land use planning显示文摘 | Amal K Maji Dulal C Nayak Nadimpalli DR Krishna Challa V Srinivas Kalpana Kamble Gangalakunta P Obi Reddy Mariappan Velayutham | 2001 | International Journal of Applied Earth Observations and Geoinformation2001，，1： | 1 |
| 5 | Effect of geometry on the fracture behavior of lead-free solder joints显示文摘 | NADIMPALLI S P V SPELT J K | 2011 | Engineering Fracture Mechanics2011，78，6： | 1 |
| 6 | Activation of apoptosis-linked caspase(s) in NMDA-injured brains in neonatal rats 显示文摘 | Nath R Scott M Nadimpalli R Gupta R Wang KK | 2000 | Neurochem Int2000，36，2： | 1 |
| 7 | ROLE OF SEA SURFACE TEMPERATURE IN MODULATING LIFE CYCLE OF TROPICAL CYCLONES OVER BAY OF BENGAL显示文摘Sea surface temperature(SST) varies significantly in the presence of tropical cyclones(TCs). Using fixed SST throughout the integration of high resolution TC models is general practice in research and operational endeavor over the North Indian Ocean. The present study is to assess the impact of updating realistic SST in TC lifetime on track, intensity and rainfall of TCs. The Hurricane Weather Research Forecast(HWRF) model of single domain with 9 km resolution is used. A total of 31 forecast cases are considered from 6 TCs during 2007-16 with unique track and intensity characteristics. A set of two numerical experiments are done without(CNTL) and with 6-hourly SST update(SST) in TC lifetime.Mean track and intensity errors show that there is an improvement of 3–41% in track during 12–120 h forecast length for SST run. The SST runs improve landfall position and time prediction by 20% and 33% respectively. The cross track error of SST run is comparable(44 km) with average errors available for this basin(34 km);and along track errors are improved by 60% as compared to CNTL as well as average errors of the basin. The model is biased to overestimate a weaker TC and underestimate a stronger TC, however, the bias is reduced in SST run by 5–51%. The analyses of wind, enthalpy flux and warm core structures provide insight for realistic intensity prediction of SST run unlike CNTL. Rainfall intensity and radial distribution is also improved in SST run. Thus, this study highlights the significance of ocean coupling with TC models to advance forecast guidance. | Shyama Mohanty Raghu Nadimpalli Krishna K Osuri Sujata Pattanayak U C Mohanty and Sourav Sil | 2019 | Tropical Cyclone Research and Review2019，8，2： | 1 |
| 8 | Genomic structures of viral agents in relation to the biosynthesis of selenoproteins显示文摘 | Taylor EW Nadimpalli RG Ramanathan CS | 1997 | Biological Trace Element RES1997，56，： | 1 |
| 9 | Genomic structures ofviral agents in relation to the biosynthesis of selenoproteins显示文摘 | Taylor EW Nadimpalli RQ Ramanathan CS | 1997 | Biol Trace Elem Res1997，56，： | 1 |
| 10 | Livestock-associated methicillin and mulfidrug resistant Staphylococcus aureus is present among industrial, not antibiotic-free livestock operation workers in North Carolina 显示文摘 | Rinsky JL Nadimpalli M Wing S | 2013 | PLoS One2013，8，67： | 1 |
| 11 | Leak estimation in water distribution systems by statistical analysis of flow readings显示文摘 | BUCHBERGER S G NADIMPALLI G | 2004 | Journal of Water Resources Planning and Management2004，130，4： | 1 |
| 12 | Genomic structures of viral agents in relation to the biosynthesis of selenoproteins显示文摘 | Taylor EW Nadimpalli RG Ramanathan CS | 1997 | Biol Trace Elem Res1997，56，： | 1 |
| 13 | Intraventricular neurocysticercosis mimicking colloid cyst显示文摘 | Gupta A Nadimpalli SPR Cavallino RP | | 0，，06： | 1 |
| 14 | Format:correcting protein multiple structural alignments by incorporating sequence alignment显示文摘 | DANIELS N M NADIMPALLI S COWEN L J | 2012 | BMC Bioinformatics2012，13，1： | 1 |
| 15 | Leak estimation in water distribution systems by statistical analysis of flow read-ings 显示文摘 | BUCHBERGER S G NADIMPALLI G | 2004 | Jour- nal of Water Resources Planning and Management2004，130，4： | 1 |
| 16 | An efficient method for the purification and quantification of a galactose-specific lectin from vegetative tissues of Dolichos lablab 显示文摘 | Rameshwaram N R Nadimpalli S K | 2008 | J Chromatogr B2008，861，2： | 1 |
| 17 | Prohibitins,stomatins,and plant-disease response genes compose a protein superfamily that controls cell proliferation,ion channel regulation,and death显示文摘 | Nadimpalli R Yalpani N Johal G S | 2000 | The Journal of Biology Chemistry2000，275，29： | 1 |
| 18 | Intraventricular neurocysticercosis mimicking colloid cyst 显示文摘 | Gupta A Nadimpalli SPR Cavallino RP | 2002 | J Neurosurg2002，97，： | 1 |
| 19 | Stress evolution in lithium-ion composite electrodes during electrochemical cycling and resulting internal pressures on the cell casing显示文摘 | NADIMPALLI S P V SETHURAMAN V A ABRAHAM D P | 2015 | Journal of the Electrochemical Society2015，162，14： | 1 |
| 20 | Caspase-mediated fragmentation of calpain inhibitor protein calpastatin during apoptosis显示文摘 | WANG K K POSMANTUR R NADIMPALLI R | 1998 | Archives of Biochemistry and Biophysics1998，356，2： | 1 |
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