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| 1 | The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline显示文摘 | Gaspar LE Mehta MP Patchell RA Burri SH Robinson PD Morris RE Ammirati M Andrews DW Asher AL Cobbs CS Kondziolka D Linskey ME Loeffler JS McDermott M Mikkelsen T Olson JJ Paleologos NA Ryken TC Kalkanis SN. | 2010 | 中国神经肿瘤杂志2010，8，1： | 98 |
| 2 | 可视耳模拟器在颞骨解剖虚拟训练中的应用显示文摘众所周知,颞骨空间构造复杂,其内部精细结构与面神经、中后颅底以及颈内动静脉等有着十分密切的关系。为了安全有效地施行手术和不断提高手术技能,耳外科医生必须熟知正常颞骨内部的解剖结构及其相互关系,并且要在真实的解剖环境中进行手术操作模拟练习。人类颞骨标本无疑是解剖手术训练最好的模型,但由于各种原因,目前在全世界范围内可用于该目的的人类颞骨资源十分有限, | 黄孝文 余洋 周良强 Sorensen MS Mosegaard J Noe K Mikkelsen PT | 2013 | 听力学及言语疾病杂志2013，21，4： | 7 |
| 3 | Subcurative radiation significantly increases cell proliferation, invasion, and migration of primary glioblastoma multiforme in vivo显示文摘Tumor cell proliferation, infiltration, migration, and neovascularization are known causes of treatment resistance in glioblastoma multiforme(GBM). The purpose of this study was to determine the effect of radiation on the growth characteristics of primary human GBM developed in a nude rat. Primary GBM cells grown from explanted GBM tissues were implanted orthotopically in nude rats. Tumor growth was confirmed by magnetic resonance imaging on day 77(baseline) after implantation. The rats underwent irradiation to a dose of 50 Gy delivered subcuratively on day 84 postimplantation(n = 8), or underwent no radiation(n = 8). Brain tissues were obtained on day 112(nonirradiated) or day 133(irradiated). Immunohistochemistry was performed to determine tumor cell proliferation(Ki-67) and to assess the expression of infiltration marker(matrix metalloproteinase-2, MMP-2) and cell migration marker(CD44). Tumor neovascularization was assessed by microvessel density using von-Willebrand factor(vWF) staining. Magnetic resonance imaging showed well-developed, infiltrative tumors in 11 weeks postimplantation. The proportion of Ki-67-positive cells in tumors undergoing radiation was(71 ± 15)% compared with(25 ± 12)% in the nonirradiated group(P = 0.02). The number of MMP-2-positive areas and proportion of CD44-positive cells were also high in tumors receiving radiation, indicating great invasion and infiltration. Microvessel density analysis did not show a significant difference between nonirradiated and irradiated tumors. Taken together, we found that subcurative radiation significantly increased proliferation, invasion, and migration of primary GBM. Our study provides insights into possible mechanisms of treatment resistance following radiation therapy for GBM. | Adarsh Shankar Sanath Kumar Asm Iskander Nadimpalli RS Varma Branislava Janic Ana deCarvalho Tom Mikkelsen Joseph A Frank Meser M Ali Robert A Knight Stephen Brown Ali S Arbab | 2014 | Chinese Journal of Cancer2014，33，3： | 5 |
| 4 | “Dietary fibre”: moving beyond the “soluble/insoluble” classification for monogastric nutrition, with an emphasis on humans and pigs显示文摘This review describes dietary fibres originating from a range of foods,particularly in relation to their plant cell walls.It explores the categorization of dietary fibres into 'soluble' or 'insoluble'.It also emphasizes dietary fibre fermentability,in terms of describing how the gastro-intestinal tract(GIT) microbiota respond to a selection of fibres from these categories.Food is categorized into cereals,legumes,fruits and vegetables.Mention is also made of example whole foods and why differences in physico-chemical characteristics between 'purified' and 'non-purified'food components are important in terms of health.Lastly,recommendations are made as to how dietary fibre could be classified differently,in relation to its functionality in terms of fermentability,rather than only its solubility. | Barbara A.Williams Deirdre Mikkelsen Bernadine M.Flanagan Michael J.Gidley | 2019 | Journal of Animal Science and Biotechnology2019，10，3： | 5 |
| 5 | Production of the Cancer-Preventive Glucoraphanin in Tobacco显示文摘流行病学的研究表明了在饰有十字架的蔬菜在食谱富人的消费之上得癌症的减少的风险。这 chemoprevention 大部分被归因于自然产品 glucosinolates 的存在,特别地从花椰菜的导出蛋氨酸的 glucoraphanin。由功能的食物或支持健康的饮食的补充的改进营养是为基于生活方式的疾病的预防的一个吸引人的工具。向这个目标,我们设计了 glucoraphanin 小径进烟草。首先,我们设计了蛋氨酸的方面链的延伸生产关键中间的 dihomo 蛋氨酸。这个过程在在叶绿体在 cytosol 并且部分部分发生的一条链延伸小径通过二个周期被催化。由联合链延伸小径的五酶到 glucosinolate 小径的八酶,第二,我们证明和另外的 glucosinolates 的 glucoraphanin 的生产源于伸长链的异白氨酸或白氨酸。到 glucoraphanin 的蛋氨酸的变换经由 14 中介被获得。在一位 heterologous 主人表明高值的 glucoraphanin 的生产作为一个工具有在食物和药用的工业的大潜力为人的健康的利益产生 glucoraphanin 的稳定的、富有的来源。 | Michael Dalgaard Mikkelsen Carl Erik Olsen Barbara Ann Halkier | 2010 | Molecular Plant2010，3，4： | 3 |
| 6 | Fractionally integrated generalized autoregressive conditional heteroskedasticity显示文摘 | Richard T. Baillie Tim Bollerslev Hans Ole Mikkelsen | 1996 | Journal of Econometrics1996，，1： | 2 |
| 7 | 可视耳模拟系统:一种新颖的颞骨解剖教辅工具显示文摘学习掌握颞骨手术解剖学知识是开展耳外科手术的必要前提和必备基础。耳及颞骨的内部构造精细而复杂,并且紧邻面神经、颈部大血管和中后颅底等重要结构。为了全面准确地了解和掌握颞骨内部的复杂结构及毗邻关系。 | 黄孝文 余洋 Sorensen M S Mosegaard J Noe K Mikkelsen T P | 2011 | 临床耳鼻咽喉头颈外科杂志2011，25，22： | 2 |
| 8 | Sap flow for beech(Fagus sylvatica L.)in a natural and a managed forest—effect of spatial heterogeneity显示文摘Aims Beech(Fagus sylvatica L.)is an important species in natural and managed forests in Europe.This drought-sensitive species dominates even-aged stands as well more natural stands composed of a mixture of tree species,age and size classes.This study evaluates the extent that heterogeneity in spacing and tree diameter affect the seasonal availability and use of water.Methods Two stands were evaluated:(i)a heterogeneous forest remnant(NAT)with trees up to;300 years old,a mean top height of 28.4 m and a total of 733 stems ha1with stem diameters averaging 18 cm and(ii)an even-aged 80-year old stand(MAN),with a height of 25 m,and a total of 283 stems ha1 with diameters averaging 38 cm.Stem sap flow,Js(g m2 s1),was continuously measured in 12(MAN)and 13(NAT)trees using 20-mm long heat dissipation sensors.Individual tree measures of sap flow were correlated using non-linear statistical methods with air vapour pressure deficit(D,hPa)and global radiation(Rg,J m2 day1),along with constraints imposed by reductions in soil water content(SWC).SWC was measured as volumetric%using time domain reflectometry.Important Findings The daily integrated Js(Js-sum)for trees growing in the evenly spaced MAN stand and trees in canopy and closed forest positions in NAT stand decreased as the availability of soil moisture was reduced.In the heterogeneous NAT stand,SWC in a recently formed canopy gap remained high throughout the vegetation period.Based on regression models,the predicted relative decrease in Js-sum for dry relative to moist soil water conditions in the closed forest(at mean daily D=10 hPa)was 7–11%for trees near the gap and 39–42%for trees in the closed forest.In MAN,the reduction in Js-sum was 29%in dry relative to moist conditions.Js-sum in the outer 20 mm of the xylem in NAT was lower than that in MAN and the rate of decline in Js with xylem depth was less in NAT than in MAN.In MAN,Js-sum in deep and outer xylem was negatively affected at low soil moisture availability;in NAT,this was the case for only the outer xylem indicating that deep roots could be important in supplying water at times of low soil moisture in the upper soil. | Lise Dalsgaard Teis Nørgaard Mikkelsen Annemarie Bastrup-Birk | 2011 | Journal of Plant Ecology2011，4，1： | 2 |
| 9 | Kisspeptin Mediates the Photoperiodic Control of Reproduction in Hamsters显示文摘 | Florent G. Revel Michel Saboureau Mireille Masson-Pévet Paul Pévet Jens D. Mikkelsen Valérie Simonneaux | 2006 | Current Biology2006，，17： | 2 |
| 10 | Shadow Education in Denmark:In the Light of the Danish History of Pedagogy and the Skepticism Toward Competition显示文摘Purpose:This article investigates the role of private supplementary tutoring in Denmark in light of the country’s pedagogical traditions in schools and leisure spheres.Design/Approach/Methods:Although tutoring activities are increasing,the phenomenon is not as prevalent in Denmark as in many other countries.In this article,we look into the history of Danish pedagogy for answers as to why this is the case.In the analytical sections of the article,we include research on parental values of child-rearing,as well as findings from a pilot study on Danish families purchasing private supplementary tutoring,the public debate about private tutoring,and contemporary youth research.Findings:With a solid emphasis on democracy and equality in Danish pedagogy,the conditions for increasing private supplementary tutoring in Denmark have been challenged.However,a current focus on global competition,formal competencies,and higher academic performance among children and young people suggests that providers of private tutoring perhaps face a brighter future—also in Denmark.Originality/Value:This article addresses a new field of qualitative research on private supplementary tutoring in Denmark and may be a platform for further reflection and empirical research. | Sidse Hφlvig Mikkelsen David Thore Gravesen | 2021 | ECNU Review of Education2021，4，3： | 2 |
| 11 | The conversion of methanol to hydro-carbons over zeolite H-beta 显示文摘 | Mikkelsen S Kolboe | 1999 | Microporous and Mesoporous Materials1999，29，12： | 1 |
| 12 | 100 Gbir/s all-op-tical wavelength conversion with integrated SOA delayed-inter-ference configuration显示文摘 | Leuthold J Joyner CH Mikkelsen B | 2000 | Electronics Letters2000，36，13： | 1 |
| 13 | Benefit of FSH of women with PCOS to the in vitro maturation procedure and the outcome:a randomized prospective study显示文摘 | Mikkelsen A L Lindenberg S | 2001 | Reprodution2001，122，4： | 1 |
| 14 | Slow release fertilizers for a safer environment maintaining high agronomic use efficiency 显示文摘 | Shaviv A Mikkelsen R L | 1993 | Fertilizer Research1993，35，： | 1 |
| 15 | Slow release fertilizers for a safer environment maintaining high agronomic use efficiency显示文摘 | Shaviv A Mikkelsen R L | 1993 | Fertilizer Research1993，35，： | 1 |
| 16 | Tip losscorrections for wind turbine computations 显示文摘 | Shen W Z Mikkelsen R Sarensen J N | 2005 | Wind Ener-gy2005，8，45： | 1 |
| 17 | A 10-year survey, 1980- 1990, of prenatally diagnosed small supermumerary marker chro- mosomes identified by FISH analysis: Outcome and fallow-up of 14 cases diagnosed in a series of 12699 prenatal samples 显示文摘 | Brondum-Nielsen K Mikkelsen M | 1995 | Prenatal Diagn1995，15，： | 1 |
| 18 | Tailored enzymatic production of oligosaccharides from sugar beet pectin and evidence of differential effects of a single DP chain length difference on human faecal microbiota composition after in vitro fermentation显示文摘 | Holck J Hjemφ K Lorentzen A Vigsnaees L K Hemmingsen L Licht T R Mikkelsen J D Meyer A S | | 0，，05： | 1 |
| 19 | Dissecting direct reprogramming through integrative genomie analysis 显示文摘 | Mikkelsen TS Hanna J Zhang X | 2008 | Nature2008，454，7200： | 1 |
| 20 | Phosphorus Indices: Why We Need to Take Stock of How We Are Doing显示文摘 | Sharpley Andrew Beegle Doug Bolster Carl Good Laura Joern Brad Ketterings Quirine Lory John Mikkelsen Rob Osmond Deanna Vadas Peter | 2012 | Journal of Environmental Quality2012，，6： | 1 |
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