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| 1 | Magnetic resonance imaging and multi-detector computed tomography assessment of extracellular compartment in ischemic and non-ischemic myocardial pathologies显示文摘Myocardial pathologies are major causes of morbidity and mortality worldwide. Early detection of loss of cellular integrity and expansion in extracellular volume(ECV) in myocardium is critical to initiate effective treatment. The three compartments in healthy myocardium are: intravascular(approximately 10% of tissue volume), interstitium(approximately 15%) and intracellular(approximately 75%). Myocardial cells, fibroblasts and vascular endothelial/smooth muscle cells represent intracellular compartment and the main proteins in the interstitium are types Ⅰ/Ⅲ collagens. Microscopic studies have shown that expansion of ECV is an important feature of diffuse physiologic fibrosis(e.g., aging and obesity) and pathologic fibrosis [heart failure, aortic valve disease, hypertrophic cardiomyopathy, myocarditis, dilated cardiomyopathy, amyloidosis, congenital heart disease, aortic stenosis, restrictive cardiomyopathy(hypereosinophilic and idiopathic types), arrythmogenic right ventricular dysplasia and hypertension]. This review addresses recent advances in measuring of ECV in ischemic and non-ischemic myocardial pathologies. Magnetic resonance imaging(MRI) has the ability to characterize tissue proton relaxation times(T1, T2, and T2*). Proton relaxation times reflect the physical and chemical environments of water protons in myocardium. Delayed contrast enhanced-MRI(DE-MRI) and multi-detector computed tomography(DE-MDCT) demonstrated hyper-enhanced infarct, hypo-enhanced microvascular obstruction zone and moderately enhanced peri-infarct zone, but are limited for visualizing diffuse fibrosis and patchy microinfarct despite the increase in ECV. ECV can be measured on equilibrium contrast enhanced MRI/MDCT and MRI longitudinal relaxation time mapping. Equilibrium contrast enhanced MRI/MDCT and MRI T1 mapping is currently used, but at a lower scale, as an alternative to invasive sub-endomyocardial biopsies to eliminate the need for anesthesia, coronary catheterization and possibility of tissue sampling error. Similar to delayed contrast enhancement, equilibrium contrast enhanced MRI/MDCT and T1 mapping is completely noninvasive and may play a specialized role in diagnosis of subclinical and other myocardial pathologies. DE-MRI and when T1-mapping demonstrated sub-epicardium, sub-endocardial and patchy mid-myocardial enhancement in myocarditis, Behcet's disease and sarcoidosis, respectively. Furthermore, recent studies showed that the combined technique of cine, T2-weighted and DE-MRI technique has high diagnostic accuracy for detecting myocarditis. When the tomographic techniques are coupled with myocardial perfusion and left ventricular function they can provide valuable information on the progression of myocardial pathologies and effectiveness of new therapies. | Maythem Saeed Steven W Hetts Robert Jablonowski Mark W Wilson | 2014 | World Journal of Cardiology2014，6，11： | 4 |
| 2 | 大堡礁和大峡谷世界遗产区的适应性管理显示文摘关于人类和环境相互关系的传统观念正在迅速改变。那种认为人类与自然是相互隔离的,自然资源是取之不尽用之不竭的,而且认为世界是稳定的、可以预测的并且是平衡的旧观点已经过时了。在动态的社会-生态景观中强调学习和灵活性管理为基础的适应性方法的新的理念框架已经迅速初现端倪。我们以两个典型的世界遗产地区(大堡礁和大峡谷)为案例来研究如何在自然资源管理中通过改善科学和社会两个方面的结合来指导多尺度管理系统的变革从而应对和处理人类越来越占据主导的世界中出现的不确定性、风险和变化。 | Terence P.Hughes Lance H.Gunderson Carl Folke Andrew H.Baird David Bellwood Fikret Berkes Beatrice Crona Ariella Helfgott Heather Leslie Jon Norberg Magnus Nystrm Per Olsson Henrik sterblom Marten Scheffer Heidi Schuttenberg Robert S.Steneck Maria Teng Max Troell Brian Walker James Wilson Boris Worm 丁莉 | 2007 | AMBIO-人类环境杂志2007，36，B11： | 4 |
| 3 | 卒中一级预防指南美国心脏协会/美国卒中协会对医疗专业人员的声明显示文摘这份更新版指南旨在为既往无卒中或短暂性脑缺血发作史的人群提供适时的综合性卒中预防循证建议,包括危险因素控制、头颈部动脉粥样硬化性疾病的干预方法以及预防血栓形成和血栓栓塞性卒中的抗栓治疗。此外,本指南还提供了针对遗传和药理学检测以及在其他特殊情况下(包括镰状细胞疾病和卵圆孔未闭)进行卒中预防的建议。 | James F. Meschia Cheryl Bushnell Bernadette Boden-Albala Lynne T. Braun Dawn M. Bravata Seemant Chaturvedi Mark A. Creager Robert H. Eckel Mitchell S.V. Elkind Myriam Fornage Larry B Goldstein Steven M. Greenberg Susanna E. Horvath Costantino Iadecola Edward C. Jauch Wesley S. Moore John A. Wilson 李迪 高一鹭 陈政弘 霍晓川 孙海欣 孙冬玲 茹小娟 江滨 | 2015 | 国际脑血管病杂志2015，23，6： | 4 |
| 4 | Functionalization of high-moment magnetic nanodisks for cell manipulation and separation显示文摘合成 antiferromagnetic (SAF ) nanoparticles 是有高单个粒子的磁性的时刻的组织层的粒子。以便 covalently 把这些 nanoparticles 绑在房间,他们是涂的,硅石壳与 streptavidin 由变化形式列在后面。硅石涂层产生两 SAF@SiO2 核心壳 nanoparticles 和硅石没有核心的 nanoparticles。用简单磁性的分离,硅石 nanoparticles 被移开, SAF@SiO2 nanoparticles 被净化。在 streptavidin 变化形式以后,这些粒子被用来染色肺癌症房间,高度做他们有磁力地应答。染色的房间能响应一个外部磁场旋转并且当包含这些房间的一件血样品通过 sifter 流动时,能被捕获。 | Mingliang Zhang Christopher M. Earhart Chinchun Ooi Robert J. Wilson Mary Tang Shan X. Wang | 2013 | Nano Research2013，6，10： | 4 |
| 5 | Bigtable显示文摘 | Fay Chang Jeffrey Dean Sanjay Ghemawat Wilson C. Hsieh Deborah A. Wallach Mike Burrows Tushar Chandra Andrew Fikes Robert E. Gruber | 2008 | ACM Transactions on Computer Systems (TOCS)2008，，2： | 3 |
| 6 | Screening for Pancreatic Cancer in a High-Risk Cohort: An Eight-Year Experience显示文摘 | Wigdan Al-Sukhni Ayelet Borgida Heidi Rothenmund Spring Holter Kara Semotiuk Robert Grant Stephanie Wilson Malcolm Moore Steven Narod Kartik Jhaveri Masoom Haider Steven Gallinger | 2012 | Journal of Gastrointestinal Surgery2012，，4： | 3 |
| 7 | Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Statement for Health Professionals From the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association显示文摘 | Jane W. Newburger Masato Takahashi Michael A. Gerber Michael H. Gewitz Lloyd Y. Tani Jane C. Burns Stanford T. Shulman Ann F. Bolger Patricia Ferrieri Robert S. Baltimore Walter R. Wilson Larry M. Baddour Matthew E. Levison Thomas J. Pallasch Donald A. Fa | 2004 | Circulation2004，，17： | 2 |
| 8 | Do medical students studying in the United Kingdom have an adequate factual knowledge of basic life support?显示文摘BACKGROUND: Healthcare professionals have a duty to maintain basic life support(BLS) skills. This study aims to evaluate medical students' factual knowledge of BLS and the training they receive.METHODS: A cross-sectional, closed-response questionnaire was distributed to the fi rst-and fourth-year students studying at institutions in the United Kingdom. The paper questionnaire sought to quantify respondent's previous BLS training, factual knowledge of the BLS algorithm using five multiple choice questions(MCQs), and valuate their desire for further BLS training. Students received 1 point for each correctly identifi ed answer to the 5 MCQ's.RESULTS: A total of 3,732 complete responses were received from 21 medical schools. Eighty percent(n=2,999) of students completed a BLS course as part of their undergraduate medical studies. There was a signifi cant difference(P<0.001) in the percentage of the fourth-year students selecting the correct answer in all the MCQ's compared to the fi rst-year students except in identifyingthe correct depth of compressions required during CPR(P=0.095). Overall 10.3%(95% CI 9.9% to 10.7%) of respondents correctly identified the answer to 5 MCQ's on BLS: 9% of the first-year students(n=194) and 12% of the fourth-year students(n=190). On an institutional level the proportion of students answering all MCQ's correctly ranged from 2% to 54% at different universities. Eighty-one percent of students(n=3,031) wished for more BLS training in their curriculum.CONCLUSION: Factual knowledge of BLS is poor among medical students in the UK. There is a disparity in standards of knowledge across institutions and respondents indicating that they would like more training. | Robert D.Willmore Damjan Veljanoski Feray Ozdes Bethan Stephens James Mooney Seamus G.Crumley Arpan Doshi Philippa Davies Shreya Badhrinarayanan Emily Day Kristian Tattam April Wilson Nathan Crang Lorna Green Craig A.Mounsey Howell Fu Joseph Williams Michelle S.D'souza Dhanya Sebastian Liam A.Mcgiveron Matthew G.Percy James Cohen Imogen J.John Alice Lethbridge Imogen Watkins Omar Amin Mubasher A.Qamar John Gerrard Hanrahan Emily Cramond-Wong | 2019 | World Journal of Emergency Medicine2019，10，2： | 2 |
| 9 | Minimally Invasive Approach Provides at Least Equivalent Results for Surgical Correction of Mitral Regurgitation: A Propensity Matched Comparison显示文摘 | Andrew B. Goldstone Pavan Atluri Wilson Y. Szeto Alen Trubelja Jessica L. Howard John W. MacArthur Craig Newcomb Joseph P. Donnelly Dale M. Kobrin Mary A. Sheridan Christiana Powers Robert C. Gorman Joseph H. Gorman Alberto Pochettino Joseph E. Bavaria Mi | 2012 | The Journal of Thoracic and Cardiovascular Surgery2012，，： | 2 |
| 10 | Surgical Therapy for Gastrointestinal Stromal Tumours of the Upper Gastrointestinal Tract显示文摘 | Amitabha Das Robert Wilson Andrew V. Biankin Neil D. Merrett | 2009 | Journal of Gastrointestinal Surgery2009，，7： | 2 |
| 11 | National Lipid Association recommendations for patient-centered management of dyslipidemia: Part 1 – executive summary显示文摘 | Terry A. Jacobson Matthew K. Ito Kevin C. Maki Carl E. Orringer Harold E. Bays Peter H. Jones James M. McKenney Scott M. Grundy Edward A. Gill Robert A. Wild Don P. Wilson W. Virgil Brown | 2014 | Journal of Clinical Lipidology2014，，： | 2 |
| 12 | Economic and ecological concepts for valuing ecosystem services显示文摘 | Stephen C. Farber Robert Costanza Matthew A. Wilson | 2002 | Ecological Economics2002，，3： | 2 |
| 13 | Effect of oxygen and nitrogen functionalization on the physical and electronic structure of graphene显示文摘graphene 的共有原子价 functionalization 为定制它的性质提供机会并且是一些 graphene 合成技术的不可避免的后果。然而, functionalization 导致的变化很好没被理解。由使用原子来源控制氧和氮 functionalization 的程度,我们在原子规模在结构和性质学习了进化。虽然,原子氧 reversibly 介绍 epoxide 组,在类似的条件下面,原子氮不可逆转地创造包括的多样的功能代理, pyridinic,和 pyrrolic 氮。原子氧在迪拉克点离开费密能量(即, undoped ) ,虽然原子氮导致网做 n;然而,试验性的结果与为两是转变从的主导的电子效果一致去除到局部性的状态,和因此签名的损失 graphene 的电子结构。 | Alexander J. Marsden Peter Brommer James J. Mudd M. Adam Dyson Robert Cook Maria Asensio Jose Avila Ana Levy Jeremy Sloan David Quigley Gavin R. Bell Neil R. Wilson | 2015 | Nano Research2015，8，8： | 2 |
| 14 | Synthetical experiments in the isoflavones part I 显示文摘 | Wilson B Robert R | 1925 | JChemSoc1925，127，： | 1 |
| 15 | Pivot hysteresis model for reinforced concrete members 显示文摘 | Robert K Dowell Friedler Seible Edward L Wilson | 1998 | ACI Structural Journal1998，95，5： | 1 |
| 16 | Re- al-time Landslide Warning During Heavy Rainfall 显示文摘 | KEEFER D K WILSON R C ROBERT K M | 1987 | Science1987，238，4829： | 1 |
| 17 | The economic impact o f local sport events:significant,limited or otherwise?A case study of four swimming events显示文摘 | Robert Wilson | 2006 | Managing Leisure2006，，11： | 1 |
| 18 | A transcriptionally active copia-like retroelement in Citrus limon显示文摘 | Bruna Felice Robert R. Wilson Carolina Argenziano Ioanis Kafantaris Clara Conicella | 2009 | Cellular & Molecular Biology Letters2009，，2： | 1 |
| 19 | Mold Contamination and Air Handling Units显示文摘 | Stephen C Wilson Robert N Palmatier Larysa A Andriychuk | 2007 | Journal of Occupational and Environmental Hygiene2007，4，7： | 1 |
| 20 | A proposed microburst nowcasting procedure using single-Doppler radar显示文摘 | Roberts R D Wilson J W | | 0，，： | 1 |
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