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| 1 | ROR2 gene is associated with risk of non-syndromic cleft palate in an Asian population显示文摘背景受体酷氨酸象kinase一样孤儿受体 2 ( ROR2 )基因最近被显示了在动物模型在腭的开发起重要作用并且居住在连接到的 chromosomal 区域非, syndromic 劈开嘴唇与或没有在学习是调查可能的协会在之间的这的 humans.The 目的劈开腭 ROR2 基因和 non-syndromic 我们测试了的这里的口头的 clefts.Methods 在在 297 non-syndromic 的 ROR2 基因的 38 合格单个核苷酸的多型性( SNP ) | Wang Hong Hetmanski, Jacqueline B. Ruczinski, Ingo Liang, Kung Yee Fallin, M. Daniele Redett, Richard J. Raymond, Gerald V. Chou, Yah-Huei Wu Chen, Philip Kuo-Ting Yeow, Vincent Chong, Samuel S. Cheah, Felicia S. H. Jabs, Ethylin Wang Scott, Alan F. Beaty, Terri H. | 2012 | Chinese Medical Journal2012，，3： | 5 |
| 2 | 罗格列酮和全反式维甲酸对多发性骨髓瘤裸鼠移植瘤生长及血管形成的影响显示文摘目的研究罗格列酮(RGZ)和全反式维甲酸(ATRA)对多发性骨髓瘤裸鼠移植瘤生长和血管形成的影响。方法分别以不同浓度的RGZ和ATRA或RGZ+ATRA处理U266细胞24h,采用半定量RT—PCR法检测各组U266细胞中血管内皮细胞生长因子(VEGF)的表达。将U266细胞接种于4周龄Balb/c裸鼠一侧肩胛部皮下,接种1周后分别以RGZ和RGZ+ATRA腹腔注射干预,连续给药21d。第21天处死裸鼠,剥离皮下肿瘤并称重,将肿瘤组织分别进行HE和CD34、VEGF免疫组化染色。结果未经处理的对照组U266细胞中VEGFmRNA高表达;经RGZ处理后,VEGFmRNA的表达水平下调;经RGZ+ATRA处理后,VEGFmRNA的表达水平较RGZ组更低。U266细胞接种后,在裸鼠皮下均可形成肿瘤。腹腔用药后,RGZ组裸鼠移植瘤的体积和重量分别为(785±262)mm3和(1748±365)mg,均明显低于对照组(均P〈0.01);RGZ+ATRA组移植瘤的体积和再量分别为(154±89)mm3和(626±102)mg3均明显低于RGZ组(均P〈0.05)。各组裸鼠移植瘤中均有VEGF蛋白的表达,其中对照组VEGF蛋白的平均染色强度(IS)为2.20±0.40,明显高于RGZ组(1.48±0.37,P〈0.01);RGZ+ATRA组的Is为0.58±0.26,明显低于RGZ组(P〈0.01)。各组裸鼠移植瘤中均有CD34的表达,其中对照组CD34表达最强,微血管密度(MVD)为(56.4±15.2)个/高倍视野,明显高于RGZ组[(44.6±11.2)个/高倍视野,P〈0.05];RGZ+ATRA组CD34表达最弱,MVD为(21.5±8.6)个/高倍视野,明显低于RGZ组(P〈0.01)。结论RGZ和ATRA存体内环境中也能发挥抑制骨髓瘤细胞增殖和生长的作用。通过抑制骨髓瘤细胞中VEGF的表达从而阻断血管形成,可能也足RGZ和ATRA抗肿瘤作用的重要机制之一。 | 黄海雯 陈萍 李炳宗 傅晋翔 李军 张晓慧 刘睿 范银银 张宏 Howard C.H. Chow Anska Y. H. Leung Raymond Liang | 2012 | 中华肿瘤杂志2012，34，9： | 5 |
| 3 | Diversity of microbial plankton across the Three Gorges Dam of the Yangtze River,China显示文摘长江的三个峡水坝(TGD ) ,中国,在世界上是最大的灌溉和水力发电的工程工程之一。效果巨大人造象动物志和 macrophyte 上的 TGD 一样的工程是明显的,主要通过水动力学和流动模式的变化;然而,微生物怎么对如此的变化作出回应,是不太清楚的。这研究被瞄准在不同季节和地点在微生物引起的差异检验差别(在前面并且在 TGD 后面) 。另外,依附粒子、免费生活的社区之间的差别也被检验。在水列在后面并且在 TGD 前面的全部、潜在地活跃的微生物的社区结构与基于 DNA 、基于 RNA 的 16S rRNA 基因被分析在三个不同季节的种系发生的途径。16S rRNA 基因的克隆图书馆从提取 DNA 在扩大以后被准备并且为一些样品,在从提取 rRNA 准备 cDNA 以后。差别在不同季节并且在免费生活、依附粒子的社区之间在地点之间被观察。细菌并且 archaeal 社区比在冬季在夏天是更多样的,由于在夏天的更高滋养的层次和更温暖的温度比在冬季。依附粒子的微生物比免费生活的社区更多样,可能因为在粒子的更高滋养的层次和异构的 geochemical 微型环境。在细菌的社区结构的空间变化被观察,即,在 TGD 后面的水水库(在上游) 比在水坝前面招待了更多样的细菌的人口(下游) ,因为沉积和水从的多样的来源对水库在上游。这些结果在水坝建设影响的河生态系统为我们对环境变化的微生物引起的社区的回答的理解有重要含意。 | Shang Wang Raymond M. Dong Christina Z. Dong Liuqin Huang Hongchen Jiang Yuli Wei Liang Feng Deng Liu Guifang Yang Chuanlun Zhang Hailiang Dong | 2012 | Geoscience Frontiers2012，3，3： | 4 |
| 4 | Avalanche photodiodes on silicon photonics显示文摘Silicon photonics technology has drawn significant interest due to its potential for compact and high-performance photonic integrated circuits.The Ge-or III-V material-based avalanche photodiodes integrated on silicon photonics provide ideal high sensitivity optical receivers for telecommunication wavelengths.Herein,the last advances of monolithic and hetero-geneous avalanche photodiodes on silicon are reviewed,including different device structures and semiconductor systems. | Yuan Yuan Bassem Tossoun Zhihong Huang Xiaoge Zeng Geza Kurczveil Marco Fiorentino Di Liang Raymond G.Beausoleil | 2022 | Journal of Semiconductors2022，43，2： | 3 |
| 5 | Kinetics and Risk of De Novo Hepatitis B Infection in HBsAg–Negative Patients Undergoing Cytotoxic Chemotherapy显示文摘 | Chee–Kin Hui Winnie W.W. Cheung Hai–Ying Zhang Wing–Yan Au Yui–Hung Yueng Anskar Y.H. Leung Nancy Leung John M. Luk Albert K.W. Lie Yok–Lam Kwong Raymond Liang George K.K. Lau | 2006 | Gastroenterology2006，，1： | 2 |
| 6 | Low-frequency ultrasound increases non-viral gene transfer to the mouse lung显示文摘如果在 3035 kHz 的范围,低频率的超声(美国) 增加非病毒的基因转移到老鼠肺,学习的目的是估计。美国极大地在空气 / 织物接口由于大精力损失在肺被稀释。低频率的美国的优点,与高周波的美国相比:(i) 增加了成穴(为在房间膜的短暂毛孔的形成负责) 并且(ii ) 在肺穿入期间减少了精力损失。Cationic 类脂化合物 GL67/plasmid DNA (pDNA ) , polyethylenimine (PEI )/pDNA 和裸体 pDNA 经由 intranasal 灌输被交付,动物然后为 10 min 在 0.07 或 0.1 MPa 暴露于美国(sonoporation ) 。在这些条件下面,美国没提高 GL67 或调停 PEI 的 transfection。然而,它确实由约 4 褶层增加了裸体 pDNA 基因转移。重要地,这当 microbubbles 不在时被完成,它是关键的为通常使用高周波(1 MHz ) sonoporation 但是不能在临床上相关的安装承受 nebulization。肺出血也被估计并且出现以一种剂量依赖者方式与美国压力增加。这样,我们证实了低频率的美国能与裸体 pDNA 提高肺基因转移,这改进比更有效以前报导了 1 个 MHz 美国。 | Stefania Xenariou Hai-Dong Liang Uta Griesenbach Jie Zhu Raymond Farley Lucinda Somerton Charanjit Singh Peter K. Jeffery Ronald K. Scheule Seng H. Cheng Duncan M. Geddes Martin Blomley Eric W. F. W. Alton | 2010 | Acta Biochimica et Biophysica Sinica2010，42，1： | 2 |
| 7 | 64 Gb/s low-voltage waveguide SiGe avalanche photodiodes with distributed Bragg reflectors显示文摘We demonstrate low-voltage waveguide silicon-germanium avalanche photodiodes(APDs)integrated with distributed Bragg reflectors(DBRs).The internal quantum efficiency is improved from 60%to 90%at 1550 nm assisted with DBRs while still achieving a 25 GHz bandwidth.A low breakdown voltage of 10 V and a gain bandwidth product of near 500 GHz are obtained.APDs with DBRs at a data rate of 64 Gb/s pulse amplitude modulation with four levels(PAM4)show a 30%–40%increase in optical modulation amplitude(OMA)compared to APDs with no DBR.A sensitivity of around-13 d Bm at a data rate of 64 Gb/s PAM4 and a bit error rate of 2.4×10^-4 is realized for APDs with DBRs,which improves the sensitivity by^2 d B compared to APDs with no DBR. | Binhao Wang Zhihong Huang Yuan Yuan Di Liang Xiaoge Zeng Marco Fiorentino Raymond G.Beausoleil | 2020 | Photonics Research2020，8，7： | 2 |
| 8 | Genome‐wide identification of Epstein‐Barr virus–driven promoter methylation profiles of human genes in gastric cancer cells显示文摘 | Junhong Zhao Qiaoyi Liang Kin‐Fai Cheung Wei Kang Raymond W. M. Lung Joanna H. M. Tong Ka Fai To Joseph J. Y. Sung Jun Yu | 2012 | Cancer2012，，2： | 2 |
| 9 | Mitochondrial metabolism in hematopoietic stem cells requires functional FOXO 3显示文摘 | Pauline Rimmelé Raymond Liang Carolina L Bigarella Fatih Kocabas Jingjing Xie Madhavika N Serasinghe Jerry Chipuk Hesham Sadek Cheng Cheng Zhang Saghi Ghaffari | 2015 | EMBO rep2015，，9： | 1 |
| 10 | 罗格列酮与全反式维甲酸对骨髓瘤细胞分化的影响及其可能机制显示文摘目的探讨过氧化物酶体增殖物活化受体γ(PPARγ)的配体罗格列酮(RGZ)与全反式维甲酸(ATRA)对骨髓瘤细胞分化的影响及其可能机制。方法以RGZ和ATRA处理人骨髓瘤细胞U266和RPMI-8226,用^3H-掺入法检测细胞增殖变化;碘化丙啶(PI)染色后,以流式细胞仪检测细胞周期变化;瑞氏-姬母萨染色观察细胞形态学变化;流式细胞仪分析细胞表面CD49e的表达变化;Western blot方法检测p27^Kip1和p21^Waf1的表达变化。结果RGZ能显著抑制U266和RPMI-8226细胞的增殖,并且这种抑制作用呈剂量依赖性。经5μmol/LRGZ处理后,U266和RPMI-8226细胞G0/G1期细胞的比例分别为(45.2±6.7)%和(40.3±7.3)%,较对照组明显增加(均P〈0.05);G2/M期和S期细胞的比例分别为(52.2±7.4)%和(57.4±9.5)%,较对照组明显减少(均P〈0.05);CIM9e的表达率分别为(8.7±1.5)%和(7.9±1.6)%,较对照组明显上调(均P〈0.05)。以10μmol/LRGZ处理后,U266和RPMI-8226细胞的G0/G1期、G2/M期和S期细胞比例、CD49e的表达率均较5μmol/LRGZ组的变化更加显著。同时,经RGZ处理后,U266和RPMI-8226细胞的形态学变化也符合骨髓瘤细胞分化成熟的规律,p27^Kip1和p21^Waf1蛋白的表达量也较对照组明显增加。RGZ和ATRA联合对U266和RPMI-8226细胞影响较RGZ单独作用更加明显。结论RGZ可能通过上调p27^Kip1和p21^Waf1蛋白的表达,介导骨髓瘤细胞的周期阻滞,并诱导骨髓瘤细胞分化,抑制骨髓瘤细胞增殖。ATRA能增强RGZ对骨髓瘤细胞的上述作用,两者联合具有协同效应。 | 黄海雯 陈广华 常惠荣 Howard C.H. Chow Anska Y.H. Leung Raymond Liang 吴德沛 | 2009 | 中华肿瘤杂志2009，31，12： | 1 |
| 11 | Theory for intermetallic phase growth between cu and liquid Sn-Pb solder based on grain boundary diffusion control显示文摘 | Matt Schaefer Raymond A. Fournelle Jin Liang | 1998 | Journal of Electronic Materials1998，，11： | 1 |
| 12 | Frequent Deletion of Fas Gene Sequences Encoding Death and Transmembrane Domains in Nasal Natural Killer/T-Cell Lymphoma显示文摘 | Lijun Shen Anthony C.T. Liang Liwei Lu Wing Yan Au Yok-Lam Kwong Raymond H.S. Liang Gopesh Srivastava | 2002 | The American Journal of Pathology2002，，6： | 1 |
| 13 | Ⅲ/Ⅴ-on-Si MQW lasers by using a novel photonic integration method of regrowth on a bonding template显示文摘Silicon photonics is becoming a mainstream data-transmission solution for next-generation data centers,highperformance computers,and many emerging applications.The inefficiency of light emission in silicon still requires the integration of a Ⅲ/Ⅴ laser chip or optical gain materials onto a silicon substrate.A number of integration approaches,including flip-chip bonding,molecule or polymer wafer bonding,and monolithic Ⅲ/Ⅴ epitaxy,have been extensively explored in the past decade.Here,we demonstrate a novel photonic integration method of epitaxial regrowth of Ⅲ/Ⅴ on a Ⅲ/Ⅴ-on-SOI bonding template to realize heterogeneous lasers on silicon.This method decouples the correlated root causes,i.e.,lattice,thermal,and domain mismatches,which are all responsible for a large number of detrimental dislocations in the heteroepitaxy process.The grown multi-quantum well vertical p-i-n diode laser structure shows a significantly low dislocation density of 9.5×104 cm^(−2),two orders of magnitude lower than the state-of-the-art conventional monolithic growth on Si.This low dislocation density would eliminate defect-induced laser lifetime concerns for practical applications.The fabricated lasers show room-temperature pulsed and continuous-wave lasing at 1.31μm,with a minimal threshold current density of 813 A/cm^(2).This generic concept can be applied to other material systems to provide higher integration density,more functionalities and lower total cost for photonics as well as microelectronics,MEMS,and many other applications. | Yingtao Hu Di Liang Kunal Mukherjee Youli Li Chong Zhang Geza Kurczveil Xue Huang Raymond G.Beausoleil | 2019 | Light(Science & Applications)2019，8，1： | 1 |
| 14 | Diagnosis and Management of Primary Nasal Lymphoma of T-Cell or NK-Cell Origin显示文摘 | Raymond Liang | 2000 | Clinical Lymphoma2000，，1： | 1 |
| 15 | Kinetics and Risk of De Novo Hepatitis B Infection in HBsAg–Negative Patients Undergoing Cytotoxic Chemotherapy显示文摘 | Chee–Kin Hui Winnie W.W. Cheung Hai–Ying Zhang Wing–Yan Au Yui–Hung Yueng Anskar Y.H. Leung Nancy Leung John M. Luk Albert K.W. Lie Yok–Lam Kwong Raymond Liang George K.K. Lau | 2006 | Gastroenterology2006，，1： | 1 |
| 16 | High speed continuous and interrupted dry turning of A390 Aluminum/Silicon Alloy using nanostructured diamond coated WC–6 wt.% cobalt tool inserts by MPCVD显示文摘 | Qi Liang Yogesh K. Vohra Raymond Thompson | 2008 | Diamond & Related Materials2008，，12： | 1 |
| 17 | Early is superior to deferred preemptive lamivudine therapy for hepatitis B patients undergoing chemotherapy显示文摘 | George K.K Lau Harry H.Y Yiu Daniel Y.T Fong Hoi-Ching Cheng Wing-Yan Au Lydia S.F Lai Micheal Cheung Hai-Ying Zhang Albert Lie Roger Ngan Raymond Liang | 2003 | Gastroenterology2003，，6： | 1 |
| 18 | Fluorine-18 fluorodeoxyglucose positron emission tomography in mature T-cell and natural killer cell malignancies显示文摘 | Pek-Lan Khong Clara B. Y. Pang Raymond Liang Yok-Lam Kwong Wing-Yan Au | 2008 | Annals of Hematology2008，，8： | 1 |
| 19 | Optimization of airfoil flow control using a genetic algorithm with diversity control显示文摘 | HUANG Liang George H Raymond L Thomas H | 2007 | Journal of Aircraft2007，44，4： | 1 |
| 20 | Phosphoramidate and Phosphate Prodrugs of (-)-β-d-(2R,4R)-Dioxolane-Thymine:Synthesis,Anti-HIV Activity and Stability Studies显示文摘 | Yuzeng Liang Janarthanan Narayanasamy Raymond F Schinazi | 2006 | Bioorganic & Medicinal Chemistry2006，4，7： | 1 |
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