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| 1 | Honokiol augments the anti-cancer effects of oxaliplatin in colon cancer cells显示文摘Oxaliplatin 是在 colorectal 癌,而是它的毒性的化疗的重要的药,特别剂量相关的 neurosensory 毒性,很好没被容忍。在这研究,我们调查了 honokiol 是否能在 vitro 在结肠癌 HT-29 房间扩充 oxaliplatin 的反肿瘤效果并且 honokiol 是否能与 oxaliplatin 被使用到减少 oxaliplatin 剂量。我们使用了正常冒号房间,人的结肠的上皮的房间(HCoEpiCs ) 作为控制房间。细胞增长, apoptosis,前列腺素 E2 (PGE2 ) 和脉管的 endothelial 生长因素(VEGF ) 层次也被调查。cyclo-oxygenase 的表示层次 2 (COX-2 ) , VEGF, AKT/p-AKT,细胞外的信号相关的 kinase (英皇家空军之阶级最低之兵) 1/2/p-ERK1/2,原子因素 kappa B (NF-B ) P65/p-P65,和 caspase-3 被测量。Honokiol 或 oxaliplatin 以一种集中依赖者方式,而是 honokiol 的仅仅高的集中压制了 HT-29 房间的增长将压制 HCoEpiCs 的增长。HT-29 房间面对 honokiol 对 oxaliplatin 治疗更敏感。与 honokiol 相结合的 Oxaliplatin 改进了 HT-29 房间的 apoptosis 率并且减少了 PGE2 和 VEGF 分泌物层次。COX-2 和 VEGF 蛋白质和 AKT, ERK1/2,和 NF-B P65 的 phosphorylation 的表示层次也被禁止。Caspase-3 层次是在 honokiol 处理以后的 upregulated。因此, honokiol 能在结肠癌的化疗与 oxaliplatin 在联合被使用。这联合在 oxaliplatin 剂量允许减小,并且从而减少它的不利效果。它可以也为这疾病提高 oxaliplatin 的化学疗法的效果。 | Hanju Hua Wenbin Chen Ling Shen Qinsong Sheng Lisong Teng | 2013 | Acta Biochimica et Biophysica Sinica2013，45，9： | 7 |
| 2 | High-quality genome assembly of 'Cuiguan' pear (Pyrus pyrifolia) as a reference genome for identifying regulatory genes and epigenetic modifications responsible for bud dormancy显示文摘Dormancy-associated MADS-box(DAM)genes serve as crucial regulators of the endodormancy cycle in rosaceous plants.Although pear DAM genes have been identified previously,the lack of a high-quality reference genome and techniques to study gene function have prevented accurate genome-wide analysis and functional verification of such genes.Additionally,the contribution of other genes to the regulation of endodormancy release remains poorly understood.In this study,a high-quality genome assembly for'Cuiguan'pear(Pyrus pyrifolia),which is a leading cultivar with a low chilling requirement cultivated in China,was constructed using PacBio and Hi-C technologies.Using this genome sequence,we revealed that pear DAM genes were tandemly clustered on Chr8 and Chr15 and were differentially expressed in the buds between'Cuiguan'and the high-chilling-requirement cultivar'Suli'during the dormancy cycle.Using a virus-induced gene silencing system,we determined the repressive effects of DAM genes on bud break.Several novel genes potentially involved in the regulation of endodormancy release were identified by RNA sequencing and H3K4me3 chromatin immunoprecipitation sequencing analyses of‘Suli'buds during artificial chilling using the new reference genome.Our findings enrich the knowledge of the regulatory mechanism underlying endodormancy release and chilling requirements and provide a foundation for the practical regulation of dormancy release in fruit trees as an adaptation to climate change. | Yuhao Gao Qinsong Yang Xinhui Yan Xinyue Wu Feng Yang Jianzhao Li Jia Wei Junbei Ni Mudassar Ahmad Songling Bai Yuanwen Teng | 2021 | Horticulture Research2021，8，1： | 5 |
| 3 | Characterization of a disease susceptibility locus for exploring an efficient way to improve rice resistance against bacterial blight显示文摘Bacterial blight caused by Xanthomonas oryzae pv.oryzae(Xoo) is the most harmful bacterial disease of rice worldwide.Previously,we characterized major disease resistance(MR) gene xa25,which confers race-specific resistance to Xoo strain PXO339.The xa25 is a recessive allele of the SWEET13 locus,but SWEET13's interaction with PXO339 and how efficiently using this locus for rice breeding still need to be defined.Here we show that the SWEET 13 allele from rice Zhenshan 97 is a susceptibility gene to PXO339.Using this allele's promoter to regulate xa25 resulted in disease,suggesting that the promoter is a key determinant in SWEET13 caused disease in Zhanshan 97 after PXO339 infection.PXO339 transcriptionally induces SWEET13 to cause disease.Partial suppressing SWEET13 expression leads to a high level of resistance to PXO339.Thus,the transcriptionally suppressed SWEET13 functions as xa25 in resistance to PXO339.Hybrid rice is widely grown in many countries.However,recessive MR genes have not been efficiently used for disease resistance breeding in hybrid rice production for both parents of the hybrid have to carry the same recessive gene.However,the suppressed SWEET 13 functions dominantly,which will have advantage to improve the resistance of hybrid rice to xa25-incomptible Xoo. | Qi Cheng Weihua Mao Wenya Xie Qinsong Liu Jianbo Cao Meng Yuan Qinglu Zhang Xianghua Li Shiping Wang | 2017 | Science China(Life Sciences)2017，60，3： | 4 |
| 4 | Bud endodormancy in deciduous fruit trees:advances and prospects显示文摘Bud endodormancy is a complex physiological process that is indispensable for the survival,growth,and development of deciduous perennial plants.The timely release of endodormancy is essential for flowering and fruit production of deciduous fruit trees.A better understanding of the mechanism of endodormancy will be of great help in the artificial regulation of endodormancy to cope with climate change and in creating new cultivars with different chilling requirements.Studies in poplar have clarified the mechanism of vegetative bud endodormancy,but the endodormancy of floral buds in fruit trees needs further study.In this review,we focus on the molecular regulation of endodormancy induction,maintenance and release in floral buds of deciduous fruit trees.We also describe recent advances in quantitative trait loci analysis of chilling requirements in fruit trees.We discuss phytohormones,epigenetic regulation,and the detailed molecular network controlling endodormancy,centered on SHORT VEGETATIVE PHASE(SVP)and Dormancy-associated MADS-box(DAM)genes during endodormancy maintenance and release.Combining previous studies and our observations,we propose a regulatory model for bud endodormancy and offer some perspectives for the future. | Qinsong Yang Yuhao Gao Xinyue Wu Takaya Moriguchi Songling Bai Yuanwen Teng | 2021 | Horticulture Research2021，8，1： | 2 |
| 5 | Vacuole Integrity Maintained by DUF300 Proteins Is Required for Brassinosteroid Signaling Regulation显示文摘Brassinosteroid (BR ) 荷尔蒙发信号在植物生长和开发期间控制多重进程并且和象联系 BRI1 的受体 KINASE1 (BAK1 ) 那样的合作受体通过受体 kinase BRASSINOSTEROID INSENSITIVE1 (BRI1 ) 在血浆膜被开始。BRI1 丰富被 endosomal 再循环并且 vacuolar 指向调整,但是在 BR 受体动力学和 BR 回答的液泡相关的蛋白质的角色留下逃犯。这里,我们证明 BR 发信号的二 DUF300 包含域的 tonoplast 蛋白质, LAZARUS1 (LAZ1 ) 和 LAZ1 HOMOLOG1 (LAZ1H1 ) 的缺席,原因液泡形态学缺点,生长抑制,和组成的激活。有趣地, BAK1 的 tonoplast 累积实质地被增加并且显得有原因地在 laz1 laz1h1 植物连接了到提高的 BRI1 trafficking 和降级。因为无关的液泡异种展出了正常 BR 回答,我们的调查结果显示 DUF300 蛋白质在由维持要求平衡 subcellular BAK1 水池和 BR 受体分发的液泡正直发信号的 BR 的规定起不同作用。 | Qinsong Liu Thomas Vain Corrado Viotti Siamsa M, Doyle Danuse Tarkowska Ondrej Novak Cyril Zipfel Folke Sitbon Stephanie Robert Daniel Hofius | 2018 | Molecular Plant2018，11，4： | 2 |
| 6 | Exogenous polyamines enhance copper tolerance of Nymphoides peltatum 显示文摘 | XUE W GUOXIN S QINSONG X | 2007 | Journal of Plant Physiology2007，164，： | 1 |
| 7 | Compar- isons of hot-carrier degradation behavior in SOI-LIGBT and SOI-LDMOS with different stress conditions 显示文摘 | Liu Siyang Sun Weifeng Qian Qinsong | 2010 | Sol- M-State Electronics2010，54，12： | 1 |
| 8 | Subcellular distribution and toxicity of cadmium in Potamogeton crispus L.显示文摘 | Qinsong Xu Haili Min Sanjuan Cai Yongyang Fu Sha Sha Kaibin Xie Kaihe Du | 2012 | Chemosphere2012，，1： | 1 |
| 9 | Synthesis of LiCoMnO4 via a sol - gel method and its application in high power LiCoMnO4/Li4Ti5 O12 lithium - ion batteries 显示文摘 | Huang X K Lin M Tong Qinsong et ai | 2012 | Journal of Power Sources2012，202，： | 1 |
| 10 | Utility of a Modality Combining FISH and Cytology in Upper Tract Urothelial Carcinoma Detection in Voided Urine Samples of Chinese Patients显示文摘 | Chuanliang Xu Qinsong Zeng Jianguo Hou Li Gao Zhensheng Zhang Weidong Xu Bo Yang Yinghao Sun | 2011 | Urology2011，，3： | 1 |
| 11 | 显示文摘 | QINSong WANGZheng-yin SHIJun-xiong | | 中国农业科学0，，： | 1 |
| 12 | Involvement of polyamines in adaptation of Potamogeton crispus L. to cadmium stress显示文摘 | Haiyan Yang Guoxin Shi Hongxia Wang Qinsong Xu | 2010 | Aquatic Toxicology2010，，3： | 1 |
| 13 | Cloning and Bioinformatics Analysis of Resveratrol Synthase Gene from Vitis vinifera显示文摘[Objectives] To obtain a resveratrol synthase gene of Vitis vinifera and make bioinformatics analysis. [Methods] Taking total RNA of V. vinifera as the template,by RT-PCR method,a complete c DNA sequence of resveratrol synthase gene was amplified from V. vinifera,and the resveratrol synthase gene was named as RS. The nucleic acid and protein sequences were analyzed using bioinformatics software.[Results]This sequence was 1179 bp in length,the similarity with reported resveratrol synthase gene reached 94%-99%,and the similarity with amino acid sequence reached 96%-99%; the RS gene encoded 392 amino acids,and amino acid sequence contained complete characteristic sequence GVLFGPGLT and active center sequence GCYAGGTVLR of stilbene synthase family; the predicted molecular weight was42. 78 k Da,the theoretical isoelectric point was 6. 57,the instability parameter was 35. 92,and it belonged to stable protein in the classification; the secondary structure was mainly α-helix,random coil and β-folding,α-helix content was 44. 13%,the random coil content was26. 53%,and β-folding content was 17. 66%. [Conclusions] The isolated RS gene is a resveratrol synthase gene from V. vinifera. This experiment is expected to lay a certain foundation for biosynthesis of resveratrol by the genetic engineering method. | Yi ZHAI Qinsong LIU Yongkun WU Yun MA Nianqiang ZHANG Dangwei SHI Qingsheng QI | 2018 | Medicinal Plant2018，9，2： | 0 |
| 14 | Nicotinamide adenine dinucleotide replenishment rescues colon degeneration in aged mice显示文摘Susceptibility of gastrointestinal dysmotility increases with age-associated colonic degeneration.A paucity of remedies reversing colonic degeneration per se hinders the fundamental relief of symptoms.Here we discovered the correlation between colon degeneration and altered nicotinamide adenine dinucleotide(NAD)level in aged mice.Compared to 3-month-old young controls,2-year-old mice showed a spectrum of degenerative colonic phenotypes and exhibited a significant elongated transit time and slowed stool frequency in the context of Lomotil-induced slow-transit constipation.Despite upregulated colonic tryptophan hydroxylases expression,serotonin release and expression of colon-predominant type IV serotonin receptor,reduced viability of interstitial cells of Cajal while enhanced aquaporins(Aqp1,3 and 11)led to a less colonic motility and increased luminal dehydration in aged mice.Notably,this colonic degeneration was accompanied with reduced key NAD^(+)-generating enzyme expression and lowered NAD^(+)/NADH ratio in aged colon.Three-month continuous administration of beta nicotinamide mononucleotide,a NAD^(+)precursor,elevated colonic NAD^(+)level and improved defecation in aged mice.In contrast,pharmacological inhibition of nicotinamide phosphoribosyltransferase,the rate-limiting enzyme for NAD^(+)biosynthesis,induced a reduction in colonic NAD content and impaired gastrointestinal function in young mice.Taken together,these findings suggest the beneficial effect of NAD^(+)in maintaining colonic homoeostasis and reactivating NAD^(+)biosynthesis may represent a promising strategy to counteract age-related gastrointestinal degeneration. | Xudong Zhu Weiyan Shen Ying Wang Amit Jaiswal Zhenyu Ju Qinsong Sheng | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 0 |
| 15 | Epidemic Study of Chronic Kidney Disease in An Urban Population in East China显示文摘 | Yanlang Yang Xinyu Liu Yuelong Jing Qinsong Tao Yuwei Wang Hequn Zou | 2013 | 器官移植内科学杂志2013，8，1： | 0 |
| 16 | An anisotropic Chebyshev descriptor and its optimization for deformable shape correspondence显示文摘Shape descriptors have recently gained popularity in shape matching,statistical shape modeling,etc.Their discriminative ability and efficiency play a decisive role in these tasks.In this paper,we first propose a novel handcrafted anisotropic spectral descriptor using Chebyshev polynomials,called the anisotropic Chebyshev descriptor(ACD);it can effectively capture shape features in multiple directions.The ACD inherits many good characteristics of spectral descriptors,such as being intrinsic,robust to changes in surface discretization,etc.Furthermore,due to the orthogonality of Chebyshev polynomials,the ACD is compact and can disambiguate intrinsic symmetry sinces everal directions are considered.To improve the ACD’s discrimination ability,we construct a Chebyshev spectral manifold convolutional neural network(CSMCNN)that optimizes the ACD and produces a learned ACD.Our experimental results show that the ACD outperforms existing state-of-the-art handcrafted descriptors.The combination of the ACD and the CSMCNN is better than other state-of-the-art learned descriptors in terms of discrimination,efficiency,and robustness to changes in shape resolution and discretization. | Shengjun Liu Hongyan Liu Wang Chen Dong-Ming Yan Ling Hu Xinru Liu Qinsong Li | 2023 | Computational Visual Media2023，9，3： | 0 |
| 17 | Electroactive and antibacterial wound dressings based on Ti_(3)C_(2)T_(x)MXene/poly(ε-caprolactone)/gelatin coaxial electrospun nanofibrous membranes显示文摘Endogenous electric fields(EFs)are capable of regulating the behaviors of skin cells in wound healing.However,majority of current dressings are primarily engaged in the passive repair of defective tissue,as they lack the ability to actively respond to physiological electrical signals.In this work,a series of nanofibrous membranes(NFMs)were fabricated by coaxial electrospinning,combining the good mechanical properties of poly(ε-caprolactone)(PCL),the bioactivity of gelatin and the electroactivity of Ti_(3)C_(2)T_(x)MXene,as electroactive and antibacterial dressings for cutaneous wound healing.The obtained NFMs exhibited suitable mechanical properties and hydrophilicity,excellent electroactivity,antibacterial activity,and biocompatibility.Especially,Ti_(3)C_(2)T_(x)MXene/PCL/gelatin-6(MPG-6,6 wt.%of Ti_(3)C_(2)T_(x)MXene in sheath spinning liquids)showed the optimal conductivity and antibacterial activity.Excitingly,this scaffold significantly promoted the adhesion,proliferation,and migration of NIH 3T3 cells under the electrical stimulation(ES).The in vivo evaluation in a full-thickness wounds defect model demonstrated that the MPG-6 films significantly accelerated wound closure,increased granulation tissue formation,increased collagen deposition,and promoted wound vascularization.In summary,the versatile scaffold is expected to be an ideal candidate as wound dressings due to its ability to promote the transmission of physiological electrical signals and thus improved the therapeutic outcomes of wound regeneration. | Shixin Xu Chen Du Miaomiao Zhang Ruoying Wang Wei Feng Chengwei Wang Qinsong Liu Wen Zhao | 2023 | Nano Research2023，16，7： | 0 |
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