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| 1 | Advanced landfill leachate treatment using a two-stage UASB-SBR system at low temperature显示文摘A two-stage upflow anaerobic sludge blanket(UASB) and sequencing batch reactor(SBR) system was introduced to treat landfill leachate for advanced removal of COD and nitrogen at low temperature.In order to improve the total nitrogen(TN) removal efficiency and to reduce the COD requirement for denitrification,the raw leachate with recycled SBR nitrification supernatant was pumped into the first-stage UASB(UASB1) to achieve simultaneous denitrification and methanogenesis.The results showed that UASB1 played an important role in COD removal and UASB2 and SBR further enhanced the nutrient removal efficiency.When the organic loading rates of UASB1,UASB2 and SBR were 11.95,1.63 and 1.29 kg COD/(m3·day),respectively,the total COD removal efficiency of the whole system reached 96.7%.The SBR acted as the real undertaker for NH4+-N removal due to aerobic nitrification.The system obtained about 99.7% of NH4+-N removal efficiency at relatively low temperature(14.9-10.9°C).More than 98.3% TN was removed through complete denitrification in UASB1 and SBR.In addition,temperature had a significant effiect on the rates of nitrification and denitrification rather than the removal of TN and NH4+-N once the complete nitrification and denitrification were achieved. | Hongwei Sun,Qing Yang,Yongzhen Peng,Xiaoning Shi,Shuying Wang,Shujun Zhang Key Laboratory of Beijing Water Quality Science and Water Envirocnnment Recovery Engineering,Beijing University of Technology,Beijing 100124,China | 2010 | Journal of Environmental Sciences2010，22，4： | 26 |
| 2 | QTG-Seq Accelerates QTL Fine Mapping through QTL Partitioning and Whole-Genome Sequencing of Bulked Segregant Samples显示文摘Deciphering the genetic mechanisms underlying agronomic traits is of great importance for crop improvement. Most of these traits are controlled by multiple quantitative trait loci (QTLs), and identifying the underlying genes by conventional QTL fine-mapping is time-consuming and labor-intensive. Here, we devised a new method, named quantitative trait gene sequencing (QTG-seq), to accelerate QTL fine-mapping. QTGseq combines QTL partitioning to convert a quantitative trait into a near-qualitative trait, sequencing of bulked segregant pools from a large segregating population, and the use of a robust new algorithm for identifying candidate genes. Using QTG-seq, we fine-mapped a plant-height QTL in maize (Zea mays L.), qPH7, to a 300-kb genomic interval and verified that a gene encoding an NF-YC transcription factor was the functional gene. Functional analysis suggested that qPH7-encoding protein might influence plant height by interacting with a CO-like protein and an AP2 domain-containing protein. Selection footprint ana卜 ysis indicated that qPH7 was subject to strong selection during maize improvement. In summary, QTG-seq provides an efficient method for QTL fine-mapping in the era of “big data'. | Hongwei Zhang Xi Wang Qingchun Pan Pei Li Yunjun Liu Xiaoduo Lu Wanshun Zhong Minqi Li Linqian Han Juan Li Pingxi Wang Dongdong Li Yan Liu Qing Li Fang Yang Yuan-Ming Zhang Guoying Wang Lin Li | 2019 | Molecular Plant2019，12，3： | 13 |
| 3 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 4 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
| 5 | Achieving the nitrite pathway using FA inhibition and process control in UASB-SBR system removing nitrogen from landfill leachate显示文摘An up-flow sludge blanket(UASB) and sequencing batch reactor(SBR) system was introduced to remove organics and nitrogen from landfill leachate.The synergetic effect of free ammonia(FA) inhibition and process control was used to achieve the nitrite pathway in the SBR.In previous research,inhibition of FA on nitrite oxidizing bacteria(NOB) activity has been revealed and the process control parameters(DO,ORP and pH) exactly indicate the end-point of nitritation.The method was implemented in the SBR achieving stable nitrogen removal via the nitrite pathway from landfill leachate.The degree of nitrite accumulation during the nitritation was monitored along with the simultaneous and advanced removal of organics and nitrogen in the UASB-SBR system.The nitrifying bacteria community was quantitatively analyzed by fluorescence in situ hybridization(FISH) techniques.Batch tests were carried out to investigate the denitritation kinetics of microbial bacteria in the SBR.Experimental results showed that the nitrite pathway could be repeatedly and reliably achieved by synergetic effect of FA inhibition and process control.FISH analysis showed the dominant nitrifying bacteria were ammonia-oxidizing β-Proteobacteria. Relationship between nitrite concentration and nitrite reduction rate followed the Monod-type equation.The maximum specific nitrite utilization rate(k) and half-velocity constant(Ks) were calculated as 0.44 gN gVSS-1d-1and 15.8 mg L-1,respectively. | Sun, HongWei Yang, Qing Dong, GuoRi Hou, HongXun Zhang, ShuJun Yang, YingYing Peng, YongZhen | 2010 | Science China Chemistry2010，53，5： | 8 |
| 6 | Quantitative and Functional Phosphoproteomic Analysis Reveals that Ethylene Regulates Water Transport via the C-Terminal Phosphorylation of Aquaporin PIP2;1 in Arabidopsis显示文摘乙烯参予众多的细胞的事件和生物过程的规定,包括水损失,在枯萎的叶和花花瓣期间。多样的乙烯回答可以经由在蛋白质 phosphorylation/dephosphorylation 和 ubiquitin/26S 之间的动态相互影响被调整调停 proteasome 的蛋白质降级和朊酶劈开。探讨乙烯怎么通过叉形得多的发信号的小径改变蛋白质 phosphorylation,我们执行了 15 N 稳定的同位素对待空气、对待乙烯的乙烯感觉迟钝的 Arabidopsis 双 loss-of-function 异种 ein3-1/eil1-1 上的基于标签、微分、量的 phosphoproteomics 学习。识别的 Among535 非冗余的 phosphopeptides,二和四 phosphopeptides 起来 -- 并且由乙烯的 downregulated 分别地。aquaporin PIP2 的调整乙烯的 phosphorylation; 1 断然在叶与水流动率和水损失被相关。在有量的 proteomics 的联合的基因研究, immunoblot 分析,原物胀大/缩小实验,并且长叶表示两个的转基因的植物上的水损失试金野类型并且 S280A/S283A-mutated PIP2 ; 1 在里面 Col-0 和 ein3eil1 乙烯增加浇的基因 backgroundssuggest 在由在 PIP2 的 C 终点提高 S280/S283 phosphorylation 的 Arabidopsis 房间的运输率; 1 。未知 kinase 或磷酸酶活动可以参予 EIN3/EIL1 的细胞的功能的起始的起来规定独立人士。这发现贡献我们理解那通常在植物器官的收获以后的存储期间被观察调整乙烯的叶枯萎。 | Dongjin Qing Zhu Yang Mingzhe Li Wai Shing Wong Guangyu Guo Shichang Liu Hongwei Guo Ning Li | 2016 | Molecular Plant2016，9，1： | 6 |
| 7 | eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses显示文摘It has become increasingly challenging for researchers to analyze the exponentially expanding amount of multi-omic data.Here,we describe multi-functional software named evolutionary GenotypePhenotype Systems(eGPS)that enables users to perform comprehensive multiomic and evolutionary analyses.The eGPS combines the power of cloud computing and the advantage of desktop application,has a user-friendly graphic interface and is highly interactive. | Dalang Yu Lili Dong Fangqi Yan Hailong Mu Bixia Tang Xiao Yang Tao Zeng Qing Zhou Feng Gao Zhonghuang Wang Ziqian Hao Hongen Kang Yi Zheng Hongwei Huang Yuzhang Wei Wei Pan Yaochen Xu Junwei Zhu Shilei Zhao Ciran Wang Pengyu Wang Long Dai Mushan Li Li Lan Yiwei Wang Hua Chen Yi-Xue Li Yun-Xin Fu Zhen Shao Yiming Bao Fangqing Zhao Luo-Nan Chen Guo-Qing Zhang Wenming Zhao Haipeng Li | 2019 | National Science Review2019，6，5： | 4 |
| 8 | ASAF: altered spontaneous activity fingerprinting in Alzheimer’s disease based on multisite fMRI显示文摘Several monocentric studies have noted alterations in spontaneous brain activity in Alzheimer's disease (AD), although there is no consensus on the altered amplitude of low-frequency fluctuations in AD patients. The main aim of the present study was to identify a reliable and reproducible abnormal brain activity pattern in AD. The amplitude of local brain activity (AM), which can provide fast mapping of spontaneous brain activity across the whole brain, was evaluated based on multisite rs-fMRI data for 688 subjects (215 normal controls (NCs), 221 amnestic mild cognitive impairment (aMCI) 252 AD). Two-sample t-tests were used to detect group differences between AD patients and NCs from the same site. Differences in the AM maps were statistically analyzed via the Stouffer's meta-analysis. Consistent regions of lower spontaneous brain activity in the default mode network and increased activity in the bilateral hippocampus/parahippocampus, thalamus, caudate nucleus, orbital part of the middle frontal gyrus and left fusiform were observed in the AD patients compared with those in NCs. Significant correlations (P? | Jiachen Li Dan Jin Ang Li Bing Liu Chengyuan Song Pan Wang Dawei Wang Kaibin Xu Hongwei Yang Hongxiang Yao Bo Zhou Alexandre Bejanin Gael Chetelat Tong Han Jie Lu Qing Wang Chunshui Yu Xinqing Zhang Yuying Zhou Xi Zhang Tianzi Jiang Yong Liu Ying Han | 2019 | Science Bulletin2019，64，14： | 3 |
| 9 | Using Interactome Big Data to Crack Genetic Mysteries and Enhance Future Crop Breeding显示文摘The functional genes underlying phenotypic variation and their interactions represent“genetic mysteries”.Understanding and utilizing these genetic mysteries are key solutions for mitigating the current threats to agriculture posed by population growth and individual food preferences.Due to advances in highthroughput multi-omics technologies,we are stepping into an Interactome Big Data era that is certain to revolutionize genetic research.In this article,we provide a brief overview of current strategies to explore genetic mysteries.We then introduce the methods for constructing and analyzing the Interactome Big Data and summarize currently available interactome resources.Next,we discuss how Interactome Big Data can be used as a versatile tool to dissect genetic mysteries.We propose an integrated strategy that could revolutionize genetic research by combining Interactome Big Data with machine learning,which involves mining information hidden in Big Data to identify the genetic models or networks that control various traits,and also provide a detailed procedure for systematic dissection of genetic mysteries,Finally,we discuss three promising future breeding strategies utilizing the Interactome Big Data to improve crop yields and quality. | Leiming Wu Linqian Han Qing Li Guoying Wang Hongwei Zhang Lin Li | 2021 | Molecular Plant2021，14，1： | 2 |
| 10 | Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy显示文摘Chimeric antigen receptor T cell(CAR T) therapy was a milestone in the treatment of relapsed and refractory B cell malignancies. However, beneficial effects of CAR T cells have not been obtained in solid tumors yet. Herein, we implement a porous microneedle patch that accommodates CAR T cells and allows in situ penetration-mediated seeding of CAR T cells when implanted in the tumor bed or in the post-surgical resection cavity. CAR T cells loaded in the pores of the microneedle tips were readily escorted to the tumor in an evenly scattered manner without losing their activity. Such microneedle-mediated local delivery enhanced infiltration and immunostimulation of CAR T cells as compared to direct intratumoral injection. This tailorable patch offers a transformative platform for scattered seeding of living cells for treating a variety of tumors. | Hongjun Li Zejun Wang Edikan A.Ogunnaike Qing Wu Guojun Chen Quanyin Hu Tianyuan Ci Zhaowei Chen Jinqiang Wang Di Wen Hongwei Du Jie Jiang Jie Sun Xingcai Zhang Gianpietro Dotti Zhen Gu | 2022 | National Science Review2022，9，3： | 2 |
| 11 | Molecular diagnosis and treatment of meningiomas:an expert consensus(2022)显示文摘Meningiomas are the most common primary intracranial neoplasm with diverse pathological types and complicated clinical manifestations.The fifth edition of the WHO Classification of Tumors of the Central Nervous System(WHO CNS5),published in 2021,introduces major changes that advance the role of molecular diagnostics in meningiomas.To follow the revision of WHO CNS5,this expert consensus statement was formed jointly by the Group of Neuro-Oncology,Society of Neurosurgery,Chinese Medical Association together with neuropathologists and evidence-based experts.The consensus provides reference points to integrate key biomarkers into stratification and clinical decision making for meningioma patients. | Jiaojao Deng Lingyang Hua Liuguan Bian Hong Chen Ligang Chen Hongwei Cheng Changwu Dou Dangmurenjiapu Geng Tao Hong Hongming Ji Yugang Jiang Qing Lan Gang Li Zhixiong Liu Songtao Qi Yan Qu Songsheng Shi Xiaochuan Sun Hajun Wang Yongping You Hualin Yu Shuyuan Yue Jianming Zhang Xiaohua Zhang Shuo Wang Ying Mao Ping Zhong Ye Gong Group of Neuro-Oncology Society of Neurosurgery Chinese Medical Association | 2022 | Chinese Medical Journal2022，135，16： | 1 |
| 12 | Preparation and characterization of y-A1OOH nanotubes and nanorods 显示文摘 | Hou Hongwei Xie Yi Yang Qing | 2005 | Nanotechnology2005，16，6： | 1 |
| 13 | Recent progress in perovskite solar cells:from device to commercialization显示文摘Perovskite solar cells(PSCs) are undergoing rapid development and the power conversion efficiency reaches 25.7% which attracts increasing attention on their commercialization recently.In this review,we summarized the recent progress of PSCs based on device structures,perovskite-based tandem cells,large-area modules,stability,applications and industrialization.Last,the challenges and perspectives are discussed,aiming at providing a thrust for the commercialization of PSCs in the near future. | Xinhui Luo Xuesong Lin Feng Gao Yang Zhao Xiaodong Li Liqing Zhan Zexiong Qiu Jin Wang Cong Chen Lei Meng Xiaofeng Gao Yu Zhang Zijian Huang Rundong Fan Huifen Liu Yanrun Chen Xiaoxue Ren Jiahong Tang Chun-Hao Chen Dong Yang Yongguang Tu Xiao Liu Dongxue Liu Qing Zhao Jingbi You Junfeng Fang Yongzhen Wu Hongwei Han Xiaodan Zhang Dewei Zhao Fuzhi Huang Huanping Zhou Yongbo Yuan Qi Chen Zhaokui Wang Shengzhong(Frank)Liu Rui Zhu Jotaro Nakazaki Yongfang Li Liyuan Han | 2022 | Science China Chemistry2022，65，12： | 1 |
| 14 | Parecoxib sodium different timing of administration of remifentanil anesthesia in patients with a- cute postoperative opioids 显示文摘 | Chen Yajun Liu Hongwei Li Qing | 2010 | Chinese Journal of Anesthesiology2010，30，4： | 1 |
| 15 | A wavelet collocation precise integration method for laminated rectan- gular plates with four sides clamped显示文摘 | Zhang Hongwei Wang Yanli Qing Guanghui | 2013 | Adv Mater Res2013，67，1674： | 1 |
| 16 | 显示文摘 | Song Peng Qing Hongwei Huang Shanxing | 2007 | Materials Science and Engineering B2007，138，： | 1 |
| 17 | A new Mo/V-oxide-based cationic species templated by Keggin polyoxotungstates (4-) and its catalytic activity in benzene hydroxylation 显示文摘 | Wu Qing Yang Hua Chang Hongwei Liu Zhignang You Wansheng Gao Shuang | 2012 | Journal of Molecular Structure2012，1030，： | 1 |
| 18 | Preparation and characterization of γ-AlOOH nanotubes and nanorods显示文摘 | Hou Hongwei Xie Yi Yang Qing | 2005 | Nanotechnology2005，16，： | 1 |
| 19 | Invasibility and recoverability of a plant community following invasion depend on its successional stages显示文摘Exotic species invasion represent important causes of harming the structure,function,and ecological environment in ecosystems.Yet,knowledge remains limited on the invasibility(invasion advantage of exotic species)and recoverability(recovery ability of native species)of a plant community following invasion depend on its successional stages.We selected three grasses of Setaria viridis,Artemisia gmelinii,and Bothriochloa ischemum representing early(E),middle(M),and late(L)successional species,respectively.Meanwhile,the grasses of Panicum virgatum was selected to represent exotic species(invasion species).Three types of soil were collected to treat the three E,M,and L successional species,and one type of soil was collected to treat the exotic species.We compared the performance of the three native plant species and one exotic species grown in their“own”and“other”soils in a 2-year greenhouse experiment.Our study showed that exotic species performed better in soils of E and M successional species than in the soil of L successional species.After exotic species removed,E and M successional species exhibited poor growth in the soil of exotic species,while that of L successional species performed poor in field exotic species soils,but performed better in soils disturbed by exotic species.Our study demonstrated that the invasibility and recoverability of native plant communities changed with vegetation succession. | Hongwei Xu Zemin Ai Qing Qu Minggang Wang Guobin Liu Sha Xue | 2022 | Soil Ecology Letters2022，4，2： | 1 |
| 20 | The steel box girder design of Taizhou Bridge based on finite element methods 显示文摘 | Zheng Benhui Shah Hongwei Zhou Qing | 2009 | Journal of Highway and Transportation Research and Development2009，，2： | 1 |
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