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| 1 | Phase Ⅲ Clinical Trials of the Cell Differentiation Agent-2 (CDA-2): Therapeutic Efficacy on Breast Cancer, Non-Small Cell Lung Cancer and Primary Hepatoma显示文摘 | Fengyi Feng Qing Lu Changquan Ling Yang Zhang Fengzhan Qin Huaqing Wang Wenxia Huang Shunchang Jiao Qiang Chen Mingzhong Li Yunzhong Zhu Meizhen Zhou Jun Ren Yetao Gao Jingpo Zhao Rongsheng Zheng Wenhua Zhao Zhiqiang Meng Fang Li Qizhong Zhang Dongli Zhao Liyan Xu Yongqiang Zhang Yanjun Zhang Zhenjiu Wang Shuonqi Liu Ming C. Liau | 2005 | Chinese Journal of Clinical Oncology2005，2，4： | 3 |
| 2 | Structural analyses of Legionella LepB reveal a new GAP fold that catalytically mimics eukaryotic RasGAP显示文摘Rab GTPases 是多样的细菌的病原体的新兴的目标。这里,我们执行 LepB 的生物化学、结构的分析,从 Legionella pneumophila 的一个 Rab 激活 GTPase 蛋白质(差距) 受动器。我们印射 LepB 差距领域到 GAP 领域比正规真核细胞的 TBC 差距和细菌的 RabGAP 受动器的最新识别的 VirA/EspG 家庭高是与一项催化活动特定的 Rab1 的残余 313-618 和表演。彻底的变化分析作为精氨酸手指,而是没有催化地必要的夫酸安残余识别 Arg444。独自一个的 LepB 313-618 和在有 Rab1-GDP-AlF 3 的建筑群的 Legionella drancourtii LepB 的 GAP 领域的水晶结构支持 Arg444 的催化角色,并且进一步也揭示 3D 体系结构和从所有已知的差距不同的一个 GTPase 有约束力的模式。Glu449,在结构上等价物到在 apo-LepB 的 TBC RabGAP 夫酸安手指,在 Rab1 绑定之上经历一个激烈的运动,它导致通过一个强壮的离子的相互作用向 GDP-AlF 3 扭动的 Rab1 Gln70 方面链。这 conformationally 重排的 Gln70 充当催化 cis 夫酸安,因此揭开为 LepB 的意外象 RasGAP 一样催化机制。我们的研究加亮 RabGAPs 的非凡的结构、催化的差异,特别地那些从细菌的病原体。 | Qin Yu Liyan Hu Qing Yao Yongqun Zhu Na Dong Da-Cheng Wang Feng Shao | 2013 | Cell Research2013，23，6： | 3 |
| 3 | FISH of 5S rDNA and telomeric(TTAGGG)n repeats in normal and translocated populations of the frog Quasipaa boulengeri(Anura,Ranidae)显示文摘Quasipaa boulengeri,a spiny frog,is widely distributed in the low mountain regions,around Sichuan Basin.Our previous study revealed five karyotypes,caused by a translocation,that are randomly distributed throughout different populations.5S rDNA and telomere sequence(TTAGGG) n are potential good markers for chromosome identification and karyological evolution.In this study,we examined the sequences of 14 populations using fluorescence in situ hybridization(FISH) to detect if there is any variation between karyologically normal and translocated populations.5S rDNA loci were located at the same position on chromosomes 1 in 7 translocated populations.In two of the seven normal populations,5S rDNA also occurred on chromosome 5 in addition to chromosome 1.Our findings further indicate that the 5S rDNA on No.1 most likely represents the ancestral condition,while the minor loci represent the derived state.Signal density variations of the 5S rDNA were observed beteween homologous chromosomes or sister chromatids of pair 1 in both normal and translocated populations.Telomere sequences were identically located on all ends of the 26 chromosomes in seven rearranged populations,however,no ITSs were observed on the translocated chromosomes 1 and 6.Two of the six normal populations were found to contain ITSs which indicates that populations with translocation events diverged prior to those with ITSs rearrangements.In the KKS and BF populations,the ITSs of chromosome 3 are not always found on both homologues.Inter-chromosomal signal strength of telomeric sequences commonly differs within all populations. | QING LiYan XIA Yun ZHENG YuChi ZENG XiaoMao | 2013 | Chinese Science Bulletin2013，58，17： | 2 |
| 4 | Development of por- cine rotavirus vp6 protein based ELISA for differentiation of this virus and other viryses显示文摘 | Zhu Jiayi Yang Qing Cao Liyan | 2013 | Virol J2013，10，： | 1 |
| 5 | Docosahexaenoic acid inhibited the Wnt/β-Catenin pathway and suppressed breast cancer cells in vitro and in vivo显示文摘 | Meilan Xue Qing Wang Jinglan Zhao Liyan Dong Yinlin Ge Lin Hou Yongchao Liu Zheng Zheng | 2013 | The Journal of Nutritional Biochemistry2013，，： | 1 |
| 6 | SPSS statistics analysis for beginner and master 显示文摘 | DU Qing JIA Liyan | 2009 | Beijing: China Posts & Telecom Press2009，，： | 1 |
| 7 | Research on framework developing technology based on MVC显示文摘 | CHEN Liyan GAO Qing | 2011 | Advances in Informa- tion Sciences and Service Sciences2011，3，3： | 1 |
| 8 | The Application of Artificial Intelligence in Alzheimer’s Research显示文摘Alzheimer's disease(AD)is an irreversible and neurodegenerative disease that slowly impairs memory and neurocognitive function,but the etiology of AD is still unclear.With the explosive growth of electronic health data,the application of artificial inteligence(Al)in the healthcare setting provides excellent potential for exploring etiology and personalized treatment approaches,and improving the disease's diagnostic and prognostic outcome.This paper first briefly introduces Al technologies and applications in medicine,and then presents a comprehensive review of Al in AD.In simple,it includes etiology discovery based on genetic data,computer-aided diagnosis(CAD),computer-aided prognosis(CAP)of AD using multi-modality data(genetic,neuroimaging and linguistic data),and pharmacological or non-pharmacological approaches for treating AD.Later,some popular publicly available AD datasets are introduced,which are important for advancing Al technologies in AD analysis.Finally,core research challenges and future research directions are discussed. | Qing Zhao Hanrui Xu Jianqiang Li Faheem Akhtar Rajput Liyan Qiao | 2024 | Tsinghua Science and Technology2024，29，1： | 0 |
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