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| 1 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 2 | 桃果皮毛、果肉颜色对果实糖与酸含量的影响及相关性研究显示文摘对山桃和栽培桃品种杂交后代 10 7个个体 (分成 2 2个毛桃和 85个油桃 ,或 75个白肉桃和 3 2个黄肉桃 )的果实糖酸含量遗传规律进行了研究。结果表明 ,桃果实中的可溶性糖和酸主要是蔗糖和苹果酸 ,分别占总可溶性糖的 65%左右和总酸含量的 50 %。油桃各基因型的蔗糖、果糖、山梨糖醇、总糖、可溶性固形物及奎宁酸平均含量均显著高于毛桃 ,而毛桃和油桃基因型之间的苹果酸、柠檬酸、总酸平均含量及糖酸比没有显著差异。所有毛桃和油桃基因型的莽草酸含量都很低 ,为 0 .0 11~ 0 .0 46meq·10 0g- 1FW。果实内葡萄糖和果糖含量呈正相关 (r =0 .63 ) ,蔗糖、葡萄糖、果糖分别与山梨糖醇呈显著或极显著直线正相关 ,且苹果酸与蔗糖、山梨糖醇、总糖和可溶性固形物呈显著正相关。毛桃的平均单果重显著大于油桃 ,且可溶性固形物和总酸含量与果实的大小呈显著直线负相关。此外 。 | 吴本宏 李绍华 Quilot Bénédicte Génard Michel Kervella Jocelyne | 2003 | 中国农业科学2003，36，12： | 33 |
| 3 | Role of PRMTs in cancer: Could minor isoforms be leaving a mark?显示文摘Protein arginine methyltransferases(PRMTs) catalyze the methylation of a variety of protein substrates, many of which have been linked to the development, progression and aggressiveness of different types of cancer. Moreover, aberrant expression of PRMTs has been observed in several cancer types. While the link between PRMTs and cancer is a relatively new area of interest, the functional implications documented thus far warrant further investigations into its therapeutic potential. However, the expression of these enzymes and the regulation of their activity in cancer are still significantly understudied. Currently there are nine main members of the PRMT family. Further, the existence of alternatively spliced isoforms for several of these family members provides an additional layer of complexity. Specifically, PRMT1, PRMT2, CARM1 and PRMT7 have been shown to have alternative isoforms and others may be currently unrealized. Our knowledge with respect to the relative expression and the specific functions of these isoforms is largely lacking and needs attention. Here we present a review of the current knowledge of theknown alternative PRMT isoforms and provide a rationale for how they may impact on cancer and represent potentially useful targets for the development of novel therapeutic strategies. | R Mitchell Baldwin Alan Morettin Jocelyn C té | 2014 | World Journal of Biological Chemistry2014，5，2： | 14 |
| 4 | Stem cell-derived exosomes-an emerging tool for myocardial regeneration显示文摘Cardiovascular diseases(CVDs) continue to represent the number one cause of death and disability in industrialized countries. The most severe form of CVD is acute myocardial infarction(AMI), a devastating disease associated with high mortality and disability. In a substantial proportion of patients who survive AMI, loss of functional cardiomyocytes as a result of ischaemic injury leads to ventricular failure, resulting in significant alteration to quality of life and increased mortality. Therefore, many attempts have been made in recent years to identify new tools for the regeneration of functional cardiomyocytes. Regenerative therapy currently represents the ultimate goal for restoring the function of damaged myocardium by stimulating the regeneration of the infarcted tissue or by providing cellsthat can generate new myocardial tissue to replace the damaged tissue. Stem cells(SCs) have been proposed as a viable therapy option in these cases. However, despite the great enthusiasm at the beginning of the SC era, justified by promising initial results, this therapy has failed to demonstrate a significant benefit in large clinical trials. One interesting finding of SC studies is that exosomes released by mesenchymal SCs(MSCs) are able to enhance the viability of cardiomyocytes after ischaemia/reperfusion injury, suggesting that the beneficial effects of MSCs in the recovery of functional myocardium could be related to their capacity to secrete exosomes. Ten years ago, it was discovered that exosomes have the unique property of transferring miRNA between cells, acting as miRNA nanocarriers. Therefore, exosomebased therapy has recently been proposed as an emerging tool for cardiac regeneration as an alternative to SC therapy in the post-infarction period. This review aims to discuss the emerging role of exosomes in developing innovative therapies for cardiac regeneration as well as their potential role as candidate biomarkers or for developing new diagnostic tools. | Erzsebet Lazar Theodora Benedek Szilamer Korodi Nora Rat Jocelyn Lo Imre Benedek | 2018 | World Journal of Stem Cells2018，10，8： | 12 |
| 5 | Kevlar对位芳纶浆粕增强橡胶的研究显示文摘研究Kevlar对位芳纶浆粕和精切短纤维对天然橡胶胶料的补强效果。结果表明:随着纤维用量的增大,Kevlar对位芳纶浆粕补强的胶料储能模量增加幅度大于损耗模量增加幅度,损耗角和损耗因子随着浆粕用量的增大而降低,这种效果有利于低滚动阻力轮胎或其他轮胎部件的胶料配方设计,在提高胶料定伸模量的同时不会增加滞后生热;Kevlar对位芳纶浆粕表现出的一种独特手风琴效应可能是低滞后生热的原因。 | Jeffery S. Downey Constantine W. Tsimpris Andrew L. Pollard Chloe F. Wilson Jocelyn Willis-Papi Christiane K. Hohenwarter Qin Lin 黎学东 | 2012 | 轮胎工业2012，32，7： | 11 |
| 6 | MicroRNAs, immune cells and pregnancy显示文摘在他们调整互补 RNA 的表示的地方, MicroRNAs (miRNAs ) 是在许多房间类型被表示的非编码的 RNA 的一个最近发现的班,这样 modulating mRNAs 的稳定性和翻译。miRNAs 被预言调整 ~ 的表示 50 %在哺乳动物编码基因的所有蛋白质。因此,他们几乎参予到目前为止调查的所有细胞的过程。改变的 miRNAs 表达式与两个被联系生理(怀孕) 并且病理学的进程(癌症) 。当动态母亲胎儿的接口在成功的怀孕的维护起一个关键作用,对繁殖纸巾唯一的 miRNAs 富有地被表示,这不令人吃惊。这个领域里的研究表明了联系怀孕的 miRNAs 的一个不同集合的存在和 dysregulation;然而,大多数研究在在与正常或复杂的怀孕联系的繁殖 microdomains 本地化各种各样的 miRNAs 上集中了。尽管规章的机制与子宫内膜的感受性,有免疫力的房间, angiogenesis 和胎盘的开发联系了的几独立 miRNA 被学习了,怀孕的调停 miRNA 的规定仍然保持糟糕理解。这评论象在子宫被发现的 miRNAs 的功能的侧面一样在 miRNA 规定上提供当前的数据的一篇摘要,在与到涉及 angiogenesis 和胎盘的开发的胎儿,和那些的母亲的忍耐联系的有免疫力的房间。 | Mallikarjun Bidarimath | 2014 | Cellular & Molecular Immunology2014，11，6： | 11 |
| 7 | The spatial structure of phylogenetic and functional diversity in the United States and Canada: An example using the sedge family (Cyperaceae)显示文摘越过风景的系统地确定的差异是必要的理解 clade 历史和生态的异质怎么贡献生物多样性的起源,分发,和维护。这里,我们在整个 USA 和加拿大在薹家庭(Cyperaceae ) 在所有种类之中制定差异的空间结构。我们首先识别显著种类丰富,种系发生的差异,和功能的特点差异的区域,并且加亮保存优先级的区域。我们然后基于家庭的历史的生物地理学关于这差异的空间结构测试预言。合并发展史,在从联机植物群的功能的特点 mined 的 400000 个腊叶集记录,和一个数据库上,我们发现那种丰富和功能的特点差异在东北美国的山峰,当时沿着墨西哥湾的种系发生的差异山峰。在集合之中的花的周转与距离显著地增加,但是种系发生的周转是两次象纵的坡度同样沿着纬度的坡度快速。这些模式反映 Cyperaceae 的期望的分发,它在热带发源,但是在适度的区域放射了。我们与许多识别集合稀罕, rangerestricted 系,和集合通常从多样的区域缺乏的种类创作了。我们主张这两个度量标准为开发指向的保存策略是有用的。我们使用这里产生建立未来研究优先级的数据,包括测试关于在薹划分的染色体数字,光合的小径,和资源的分发的一系列假设。 | Daniel Spalink Jocelyn Pender Marcial Escudero Andrew L. Hipp Eric H. Roalson Julian R. Starr Marcia J. Waterway Lynn Bohs Kenneth J. Sytsma | 2018 | Journal of Systematics and Evolution2018，56，5： | 10 |
| 8 | 从其他慢性疾病的研究证据看社区干预能否降低老年痴呆病的危险显示文摘目的用科学的证据支持老年痴呆病社区教育战略的开发。方法通过对国家健康优先领域的证据分析,提出慢性疾病社区干预的共性特点,并特别提出针对少数和弱势人群的干预策略。结果需要采取全方位干预策略,并通过周密的计划和评价来保证目标人群能获得足够的健康教育信息。结论应该进一步对降低老年痴呆病危险的干预策略进行深入研究。国际上各种证据一致表明,社区健康教育是现在采取的主要策略。 | Jocelyn Angus Jane Sims Susan Feldman Harriet Radermacher | 2008 | 中国全科医学2008，11，19： | 9 |
| 9 | 老年痴呆的负担以及通过社区干预降低老年痴呆的危险显示文摘本文讨论老年痴呆的病因学以及与其他疾病的关系,并讨论采用社区干预方法降低人群的老年痴呆危险。认为针对可治疗的并发症采取积极的诊断和社区教育策略,可以降低或延迟老年痴呆的发病,从而提高病人的生活质量和改善卫生资源的有效利用。 | Jane Sims Jocelyn Angus Susan Feldman Harriet Radermacher | 2008 | 中国全科医学2008，11，17： | 8 |
| 10 | Multimodal hyperspectral remote sensing:an overview and perspective显示文摘Since the advent of hyperspectral remote sensing in the 1980 s,it has made important achievements in aerospace and aviation field and been applied in many fields.Conventional hyperspectral imaging spectrometer extends the number of spectral bands to dozens or hundreds,and provides spatial distribution of the reflected solar radiation from the scene of observation at the same time.Nowadays,with the fast development of new technology in the fields of information and photoelectricity sensing,and the popularity of unmanned aerial vehicle,hyperspectral remote sensing imaging presents the new trends of multimodality and acquires integration information while keeping high or very-high spectral resolution,especially,high temporal even real time sensing and stereo sensing.Therefore,three important modes of hyperspectral imaging come into existence:(1)multitemporal hyperspectral imaging,which refers to the observation of same region at different dates;(2)hyperspectral video imaging,which captures full frame spectral images in real-time;(3)hyperspectral stereo imaging,which obtains the full dimension information(including 2D image,elevation,and spectra)of observed scene.Along this perspective,firstly,the current researches on hyperspectral remote sensing and image processing are briefly reviewed,and then,comprehensive descriptions of the aforementioned three main hyperspectral imaging modes are carried out from the following four aspects:fundamental principle of new mode of hyperspectral imaging,corresponding scientific data acquisition,data processing and application,and potential challenges in data representation,feature learning and interpretation.Through the analysis of development trend of hyperspectral imaging and current research situation,we hope to provide a direction for future research on multimodal hyperspectral remote sensing. | Yanfeng GU Tianzhu LIU Guoming GAO Guangbo REN Yi MA Jocelyn CHANUSSOT Xiuping JIA | 2021 | Science China(Information Sciences)2021，64，2： | 6 |
| 11 | ALDH1 Is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical Outcome显示文摘 | Christophe Ginestier Min Hee Hur Emmanuelle Charafe-Jauffret Florence Monville Julie Dutcher Marty Brown Jocelyne Jacquemier Patrice Viens Celina G. Kleer Suling Liu Anne Schott Dan Hayes Daniel Birnbaum Max S. Wicha Gabriela Dontu | 2007 | Cell Stem Cell2007，，5： | 5 |
| 12 | Placental Transfer of Anti–Tumor Necrosis Factor Agents in Pregnant Patients With Inflammatory Bowel Disease显示文摘 | Uma Mahadevan Douglas C. Wolf Marla Dubinsky Antoine Cortot Scott D. Lee Corey A. Siegel Thomas Ullman Sarah Glover John F. Valentine David T. Rubin Jocelyn Miller Maria T. Abreu | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 4 |
| 13 | Follow up of infection of chacma baboons with inoculum containing a and non-a genotypes of hepatitis B virus显示文摘AIM: To determine whether one genotype (A or non-A genotypes of HBV) predominated over the other during the course of HBV infection.METHODS: Four baboons were inoculated with HBV. DNA was extracted from serum obtained at monthly intervals postinoculation for 52 weeks and HBV DNA was amplified using primers specific for the core region containing an insert characteristic of genotype A (nt 2 354-2 359, numbering from the EcoRI site). The amplicons were cloned into PCRScriptTM and a minimum of 15 clones per time point were sequenced in both directions.RESULTS: Both genotypes persisted for the entire followup period of 52 weeks. Genotype non-A predominated in two baboons and genotype A in one baboon. Neither genotype predominated in the fourth baboon, as shown at a 5 % level of testing.CONCLUSION: No conclusions concerning the dominance of either genotype or the natural progression or replication rates of HBV could be drawn because the pattern of the genotypes found may have been caused by sampling fluctuations at the time of DNA extraction and cloning as a result of the very low viral loads in the baboon sera. | Marina Baptista Anna Kramvis Saffie Jammeh Jocelyn Naicker Jacqueline S. Galpin Michael C. Kew | 2003 | World Journal of Gastroenterology2003，9，4： | 4 |
| 14 | 海沃德猕猴桃的贮藏技术显示文摘猕猴桃成熟过程中,可溶性固形物显著上升,果实硬度下降。达生理成熟后,可在树上后熟,也可离开母蔓后熟。采收后果实要尽快入库,用薄膜包装,才能最大限度地延长猕猴桃的贮藏寿命。以气调贮藏和现代化冷库贮藏的效果最佳。 | 潘林娜 Patrice Blanchet Jocelyne Chartier Thirry Ramat | 1996 | 果树科学1996，13，1： | 4 |
| 15 | 社会创新如何运用设计思维显示文摘年轻的香提住在印度南部的海德拉巴城乡结合部。她每天要到离家300英尺的露天水井汲水,并将3加仑重的塑料水罐顶在头上运回家中。露天井水不如社区水站提供的经过处理的水源安全,时常导致家人生病,但她和丈夫却依然将它作为日常饮用和生活用水。 | Tim Brown Jocelyn Wyatt 王津旭 | 2015 | 中国社会组织2015，0，16： | 4 |
| 16 | Preparation of novel methyl methacrylate/fluorinated silsesquioxane copolymer film with low surface energy显示文摘Random copolymers of methyl methacrylate and fluorinated polyhedral oligomeric silsesquioxane(F-POSS) were synthesized and the corresponding thin films were prepared from solvent casting.Their microstructure was confirmed by 1H NMR,elemental analysis and GPC.Separation occurs in the bulk of the film during solvent evaporation which can be evidenced by Transmission Electron Microscopy,TEM,with POSS-rich nanophase sizes from 20 to 50 nm.Nanostructuration is attributed to the self-assembly of F-POSS due to the cluster-cluster interactions resulting from the nature of their ligands,i.e.,cycloaliphatic ligands and perfluorinated chains.Thermogravimetric analysis was used to investigate the thermal degradation temperature.It was shown that when F-POSS content is higher than 2.8 mol%,the incorporation of F-POSS could improve the thermal stability of PMMA significantly.In addition,it was shown that these fluorinated POSS-based copolymer surfaces could reduce the surface energy and could be used to design water-repellant nanocomposite coatings. | GALY Jocelyne GéRARD Jean-Franois | 2010 | Science China Chemistry2010，53，9： | 3 |
| 17 | Prospective evaluation of point-of-care ultrasound for pre-procedure identification of landmarks versus traditional palpation for lumbar puncture显示文摘BACKGROUND: The objective of this study is to determine if point-of-care ultrasound(POCUS) pre-procedure identification of landmarks can decrease failure rate, reduce procedural time, and decrease the number of needle redirections and reinsertions when performing a lumbar puncture(LP).METHODS: This was a prospective, randomized controlled trial comparing POCUS preprocedure identifi cation of landmarks versus traditional palpation for LP in a cohort of patients in the emergency department and intensive care unit.RESULTS: A total of 158 patients were enrolled. No signifi cant difference was found in time to completion, needle re-direction, or needle re-insertion when using POCUS when compared to the traditional method of palpation.CONCLUSION: Consistent with fi ndings of previous studies, our data indicate that there was no observed benefi t of using POCUS to identify pre-procedure landmarks when performing an LP. | shadi lahham priel schmalbach sean p.wilson lori ludeman mohammad subeh jocelyn chao nadeem albadawi niki mohammadi john c.fox | 2016 | World Journal of Emergency Medicine2016，7，3： | 3 |
| 18 | A new look at auranofin,dextromethorphan and rosiglitazone for reduction of glia-mediated inflammation in neurodegenerative diseases显示文摘Neurodegenerative disorders including Alzheimer's disease are characterized by chronic inflammation in the central nervous system. The two main glial types involved in inflammatory reactions are microglia and astrocytes. While these cells normally protect neurons by providing nutrients and growth factors, disease specific stimuli can induce glial secretion of neurotoxins. It has been hypothesized that reducing glia-mediated inflammation could diminish neuronal loss. This hypothesis is supported by observations that chronic use of non-steroidal anti-inflammatory drugs(NSAIDs) is linked with lower incidences of neurodegenerative disease. It is possible that the NSAIDs are not potent enough to appreciably reduce chronic neuroinflammation after disease processes are fully established. Gold thiol compounds, including auranofin, comprise another class of medications effective at reducing peripheral inflammation. We have demonstrated that auranofin inhibits human microglia- and astrocyte-mediated neurotoxicity. Other drugs which are currently used to treat peripheral inflammatory conditions could be helpful in neurodegenerative disease. Three different classes of anti-inflammatory compounds, which have a potential to inhibit neuroinflammation are highlighted below. | Jocelyn M.Madeira Stephanie M.Schindler Andis Klegeris | 2015 | Neural Regeneration Research2015，10，3： | 3 |
| 19 | The tomato HIGH PIGMENT1/DAMAGED DNA BINDING PROTEIN 1 gene contributes to regulation of fruit ripening显示文摘Fleshy fruit ripening is governed by multiple external and internal cues and accompanied by changes in color,texture,volatiles,and nutritional quality traits.While extended shelf-life and increased phytonutrients are desired,delaying ripening via genetic or postharvest means can be accompanied by reduced nutritional value.Here we report that the high pigment 1(hp1)mutation at the UV-DAMAGED DNA BINDING PROTEIN 1(DDB1)locus,previously shown to influence carotenoid and additional phytonutrient accumulation via altered light signal transduction,also results in delayed ripening and firmer texture,resulting at least in part from decreased ethylene evolution.Transcriptome analysis revealed multiple ethylene biosynthesis and signaling-associated genes downregulated in hp1.Furthermore,the hp1 mutation impedes softening of the pericarp,placenta,columella as well as the whole fruit,in addition to reduced expression of the FRUITFUL2(FUL2)MADS-box transcription factor and xyloglucan endotransglucosylase/hydrolase 5(XTH5).These results indicate that DDB1 influences a broader range of fruit development and ripening processes than previously thought and present an additional genetic target for increasing fruit quality and shelf-life. | Anquan Wang Danyang Chen Qiyue Ma Jocelyn K.C.Rose Zhangjun Fei Yongsheng Liu James J.Giovannoni | 2019 | Horticulture Research2019，6，1： | 3 |
| 20 | Trait evolution rates shape continental patterns of species richness in North America's most diverse angiosperm genus (Carex, Cyperaceae)显示文摘Ecological opportunity has been associated with increases in diversification rates across the tree of life.Under an ecological diversification model,the emergence of novel environments is hypothesized to promote morpho-and ecospace evolution.Whether this model holds at the clade level within the most species-rich angiosperm genus found in North America(Carex,Cyperaceae)is yet to be tested.Recent works demonstrate a temporal coupling of climate cooling and widespread colonization of Carex in North America,implicating ecological diversification.In addition,research has consistently found asymmetric patterns of lineage-level diversification in the genus.Why does variation in clade sizes exist in the genus?Is ecological diversification involved?In this study,we tested whether rates of morphological and ecological trait evolution are correlated with clade-level species richness in Carex of North America north of Mexico.We constructed a phylogeny of 477 species-an almost complete regional sample.We estimated rates of evolution of morphological traits,habitat,and climatic niche and assessed whether differences in rates of evolution correlate with species richness differences in replicate non-nested sister clades.Our work demonstrates significant positive correlations between climatic niche rates,habitat and reproductive morphological evolution,and species richness.This coupling of trait and niche evolution and species richness in a diverse,continental clade sample strongly suggests that the ability of clades to explore niche and functional space has shaped disparities in richness and functional diversity across the North American flora region.Our findings highlight the importance of the evolutionary history of trait and niche evolution in shaping continental and regional floras. | Jocelyn E.Pender Andrew L.Hipp Marlene Hahn Julian R.Starr | 2021 | Journal of Systematics and Evolution2021，59，4： | 3 |
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